BR112021016620A2 - Azepino-indóis e outros heterociclos para o tratamento de distúrbios cerebrais - Google Patents
Azepino-indóis e outros heterociclos para o tratamento de distúrbios cerebraisInfo
- Publication number
- BR112021016620A2 BR112021016620A2 BR112021016620A BR112021016620A BR112021016620A2 BR 112021016620 A2 BR112021016620 A2 BR 112021016620A2 BR 112021016620 A BR112021016620 A BR 112021016620A BR 112021016620 A BR112021016620 A BR 112021016620A BR 112021016620 A2 BR112021016620 A2 BR 112021016620A2
- Authority
- BR
- Brazil
- Prior art keywords
- indoles
- heterocycles
- treatment
- azepino
- brain disorders
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 3
- 208000014644 Brain disease Diseases 0.000 title abstract 2
- ISZIQZCZKOFSBT-UHFFFAOYSA-N pyrrolo[2,3-g][1]benzazepine Chemical class N1=CC=CC=C2C3=NC=CC3=CC=C21 ISZIQZCZKOFSBT-UHFFFAOYSA-N 0.000 title 1
- SQDFWBUESZGRBR-UHFFFAOYSA-N 1h-azepine;1h-indole Chemical class N1C=CC=CC=C1.C1=CC=C2NC=CC2=C1 SQDFWBUESZGRBR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
azepino-indóis e outros heterociclos para o tratamento de distúrbios cerebrais. a presente invenção refere-se azepino-indóis e outros heterociclos e métodos de uso dos compostos para tratamento de distúrbios.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962811208P | 2019-02-27 | 2019-02-27 | |
PCT/US2020/019858 WO2020176599A1 (en) | 2019-02-27 | 2020-02-26 | Azepino-indoles and other heterocycles for treating brain disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021016620A2 true BR112021016620A2 (pt) | 2021-11-03 |
Family
ID=72238561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021016620A BR112021016620A2 (pt) | 2019-02-27 | 2020-02-26 | Azepino-indóis e outros heterociclos para o tratamento de distúrbios cerebrais |
Country Status (14)
Country | Link |
---|---|
US (2) | US11414423B1 (pt) |
EP (1) | EP3931189A4 (pt) |
JP (1) | JP2022521789A (pt) |
KR (1) | KR20210134689A (pt) |
CN (1) | CN113784962A (pt) |
AR (1) | AR119697A1 (pt) |
AU (1) | AU2020229779A1 (pt) |
BR (1) | BR112021016620A2 (pt) |
CA (1) | CA3130770A1 (pt) |
IL (1) | IL285649A (pt) |
MX (1) | MX2021010193A (pt) |
SG (1) | SG11202109111VA (pt) |
TW (1) | TW202045477A (pt) |
WO (1) | WO2020176599A1 (pt) |
Families Citing this family (16)
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AU2020228289A1 (en) | 2019-02-27 | 2021-09-09 | The Regents Of The University Of California | N-substituted indoles and other heterocycles for treating brain disorders |
AU2020229779A1 (en) | 2019-02-27 | 2021-09-09 | The Regents Of The University Of California | Azepino-indoles and other heterocycles for treating brain disorders |
GB201907871D0 (en) | 2019-06-03 | 2019-07-17 | Small Pharma Ltd | Therapeutic compositions |
HRP20230281T1 (hr) | 2019-11-07 | 2023-04-28 | Small Pharma Ltd | Postupak sinteze |
KR20230012501A (ko) | 2020-05-19 | 2023-01-26 | 사이빈 아이알엘 리미티드 | 중수소화된 트립타민 유도체 및 사용 방법 |
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US11406619B2 (en) | 2020-08-28 | 2022-08-09 | Small Pharma Ltd | Injectable formulations |
US11660289B2 (en) | 2020-12-01 | 2023-05-30 | Small Pharma Ltd. | Deuterated or partially deuterated N,N-dimethyltryptamine compounds |
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TWI743484B (zh) * | 2018-06-04 | 2021-10-21 | 瑞士商Ac免疫公司 | 用於治療、改善或預防與tau聚集物相關之病症的新穎化合物 |
CN114423422A (zh) | 2019-02-22 | 2022-04-29 | Gh研究爱尔兰有限公司 | 用于治疗精神障碍的含有5-甲氧基-n,n-二甲基色胺(5-meo-dmt)的组合物 |
AU2020229779A1 (en) | 2019-02-27 | 2021-09-09 | The Regents Of The University Of California | Azepino-indoles and other heterocycles for treating brain disorders |
AU2020228289A1 (en) | 2019-02-27 | 2021-09-09 | The Regents Of The University Of California | N-substituted indoles and other heterocycles for treating brain disorders |
EP3934652A4 (en) | 2019-03-05 | 2022-12-07 | F-Star Therapeutics, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES |
CN114025750A (zh) | 2019-03-07 | 2022-02-08 | 阿伯门蒂斯有限责任公司 | 包含神经可塑性作用物质的以非迷幻/致幻觉剂量和制剂给药的组合物和使用方法 |
CN114901279A (zh) | 2019-03-13 | 2022-08-12 | 洛克菲勒大学 | 用于治疗自身炎性疾病和癌症转移的cGAS的抑制剂 |
US20230295106A1 (en) | 2019-10-14 | 2023-09-21 | The Regents Of The University Of California | Ergoline-like compounds for promoting neural plasticity |
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- 2020-02-26 CA CA3130770A patent/CA3130770A1/en active Pending
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EP3931189A4 (en) | 2022-11-30 |
CN113784962A (zh) | 2021-12-10 |
WO2020176599A1 (en) | 2020-09-03 |
US20230117791A1 (en) | 2023-04-20 |
EP3931189A1 (en) | 2022-01-05 |
TW202045477A (zh) | 2020-12-16 |
MX2021010193A (es) | 2021-09-21 |
AU2020229779A1 (en) | 2021-09-09 |
KR20210134689A (ko) | 2021-11-10 |
JP2022521789A (ja) | 2022-04-12 |
IL285649A (en) | 2021-09-30 |
SG11202109111VA (en) | 2021-09-29 |
CA3130770A1 (en) | 2020-09-03 |
US11414423B1 (en) | 2022-08-16 |
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