SG11201504709PA - Substituted pyridine and pyrazine compounds as pde4 inhibitors - Google Patents

Substituted pyridine and pyrazine compounds as pde4 inhibitors

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Publication number
SG11201504709PA
SG11201504709PA SG11201504709PA SG11201504709PA SG11201504709PA SG 11201504709P A SG11201504709P A SG 11201504709PA SG 11201504709P A SG11201504709P A SG 11201504709PA SG 11201504709P A SG11201504709P A SG 11201504709PA SG 11201504709P A SG11201504709P A SG 11201504709PA
Authority
SG
Singapore
Prior art keywords
substituted pyridine
pde4 inhibitors
pyrazine compounds
pyrazine
compounds
Prior art date
Application number
SG11201504709PA
Inventor
Venkataiah Bollu
James Breitenbucher
Alan Kaplan
Robert Lemus
Andrew Lindstrom
Troy Vickers
Mark E Wilson
James Zapf
Michael I Weinhouse
Original Assignee
Dart Neuroscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dart Neuroscience Llc filed Critical Dart Neuroscience Llc
Publication of SG11201504709PA publication Critical patent/SG11201504709PA/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201703405PA (en) * 2013-03-14 2017-05-30 Dart Neuroscience Cayman Ltd Substituted pyridine and pyrazine compounds as pde4 inhibitors
US20200030309A1 (en) * 2016-09-29 2020-01-30 The Regents Of The University Of California Compounds for increasing neural plasticity
US20210145838A1 (en) * 2018-04-05 2021-05-20 Universiteit Hasselt Selective pde4d inhibitors against demyelinating diseases
CN109438434B (en) * 2018-11-19 2021-05-04 华南农业大学 2-cyano imino thiazolidine compound containing oxazole ring and preparation method and application thereof
CN113784962A (en) 2019-02-27 2021-12-10 加利福尼亚大学董事会 Azacyclo-indoles and other heterocycles useful in the treatment of cerebral disorders
CN113840600A (en) 2019-02-27 2021-12-24 加利福尼亚大学董事会 N-substituted indoles and other heterocyclic compounds for treating brain diseases
EP3959203A1 (en) * 2019-04-23 2022-03-02 Tetra Discovery Partners, Inc. 3-hydroxy-2-phenyl-6-(pyrazol-4-ylmethyl)pyridine derivatives as pde4d inhibitors
NZ788543A (en) * 2019-11-07 2022-10-28 Small Pharma Ltd Dimethyltryptamine derivatives and their use in psychedelic-assisted psychotherapy
CN111995585B (en) * 2020-08-04 2022-01-25 常州大学 Pyrimidine acetamides and their use as inhibitors of phosphodiesterase PDE2 activity
EP4214197A1 (en) 2020-09-16 2023-07-26 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors
WO2024026368A1 (en) * 2022-07-27 2024-02-01 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
WO1999031062A1 (en) * 1997-12-17 1999-06-24 Shionogi & Co., Ltd. Novel pyridine compounds
US7868015B2 (en) 2000-08-10 2011-01-11 Cold Spring Harbor Laboratory Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
US9931318B2 (en) 2003-04-08 2018-04-03 Dart Neuroscience (Cayman) Ltd. Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
US7947731B2 (en) 2000-08-10 2011-05-24 Cold Spring Harbor Laboratory Augmented cognitive training
GB0111078D0 (en) 2001-05-04 2001-06-27 Novartis Ag Organic compounds
MY130622A (en) 2001-11-05 2007-07-31 Novartis Ag Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors
TW200304375A (en) 2001-12-06 2003-10-01 Maxia Pharmaceuticals Inc 2-Substituted thiazolidinone and oxazolidinone derivatives for the inhibition of phosphatases and the treatment of cancer
JP2006508987A (en) 2002-11-19 2006-03-16 メモリー・ファーマシューティカルズ・コーポレイション Phosphodiesterase 4 inhibitor
GB0229281D0 (en) 2002-12-16 2003-01-22 Novartis Ag Organic compounds
US20050020587A1 (en) 2003-07-25 2005-01-27 Pfizer Inc Nicotinamide derivatives useful as PDE4 inhibitors
MY141255A (en) 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
KR101267392B1 (en) * 2004-06-30 2013-05-23 주식회사 씨앤드씨신약연구소 Pyridine derivatives and process for preparing the same
GB0425572D0 (en) 2004-11-19 2004-12-22 Glaxo Group Ltd 1,7-Naphthyridines
WO2006124874A2 (en) * 2005-05-12 2006-11-23 Kalypsys, Inc. Inhibitors of b-raf kinase
BRPI0708353A8 (en) 2006-02-28 2017-09-19 Dart Neuroscience Cayman Ltd THERAPEUTIC COMPOUNDS
CA2644069A1 (en) 2006-02-28 2007-09-07 Helicon Therapeutics, Inc. Therapeutic piperazines as pde4 inhibitors
US20070254913A1 (en) * 2006-04-19 2007-11-01 Dunn Robert F Phosphodiesterase 4 inhibitors
EP1874781B9 (en) 2006-04-19 2010-09-08 Boehringer Ingelheim International GmbH Dihydrothienopyrimidines for the treatment of inflammatory diseases
WO2007135026A2 (en) 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Substituted pteridines as therapeutic agents
AU2007304365A1 (en) * 2006-10-04 2008-04-10 F. Hoffmann-La Roche Ag 3-pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as HDL-cholesterol raising agents
BRPI0811623A2 (en) 2007-05-15 2014-11-11 Helicon Therapeutics Inc METHODS FOR IDENTIFYING GENES INVOLVED IN MEMORY FORMATION USING SMALL INTERFERENT RNA (SIRNA)
CN101820764B (en) 2007-08-27 2014-06-04 海利空医疗公司 Therapeutic isoxazole compounds
CA2722591A1 (en) 2007-11-21 2009-05-28 Decode Genetics Ehf. Substituted benzoazole pde4 inhibitors for treating pulmonary and cardiovascular disorders
JP2011504505A (en) 2007-11-21 2011-02-10 デコード ジェネティクス イーエイチエフ Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders
WO2009067600A2 (en) * 2007-11-21 2009-05-28 Decode Genetics Ehf Biaryl pde4 inhibitors for treating inflammation
US8877816B2 (en) 2007-11-21 2014-11-04 Decode Genetics Ehf 4-(or 5-) substituted catechol derivatives
WO2010003084A2 (en) 2008-07-02 2010-01-07 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
US20100125087A1 (en) 2008-11-14 2010-05-20 Astrazeneca Ab New compounds 575
WO2010059836A1 (en) 2008-11-20 2010-05-27 Decode Genetics Ehf Substituted aza-bridged bicyclics for cardiovascular and cns disease
WO2012052540A1 (en) 2010-10-21 2012-04-26 Universitaet Des Saarlandes Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases
SG10201703405PA (en) 2013-03-14 2017-05-30 Dart Neuroscience Cayman Ltd Substituted pyridine and pyrazine compounds as pde4 inhibitors

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