CN1976701A - 毒蕈碱性乙酰胆碱受体拮抗剂 - Google Patents

毒蕈碱性乙酰胆碱受体拮抗剂 Download PDF

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Publication number
CN1976701A
CN1976701A CNA2005800215360A CN200580021536A CN1976701A CN 1976701 A CN1976701 A CN 1976701A CN A2005800215360 A CNA2005800215360 A CN A2005800215360A CN 200580021536 A CN200580021536 A CN 200580021536A CN 1976701 A CN1976701 A CN 1976701A
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CN
China
Prior art keywords
methyl
hydroxyl
bicyclo
nitrogen
octane bromide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800215360A
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English (en)
Chinese (zh)
Inventor
德雷马尼·I·莱恩
迈克尔·R·帕洛维奇
布伦特·W·麦克利兰
克里斯托弗·E·尼普
索尼亚·M·托马斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35242158&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1976701(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CN1976701A publication Critical patent/CN1976701A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
CNA2005800215360A 2004-04-27 2005-04-27 毒蕈碱性乙酰胆碱受体拮抗剂 Pending CN1976701A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56562304P 2004-04-27 2004-04-27
US60/565,623 2004-04-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2010105580787A Division CN102040602A (zh) 2004-04-27 2005-04-27 毒蕈碱性乙酰胆碱受体拮抗剂

Publications (1)

Publication Number Publication Date
CN1976701A true CN1976701A (zh) 2007-06-06

Family

ID=35242158

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2005800215360A Pending CN1976701A (zh) 2004-04-27 2005-04-27 毒蕈碱性乙酰胆碱受体拮抗剂
CN2010105580787A Pending CN102040602A (zh) 2004-04-27 2005-04-27 毒蕈碱性乙酰胆碱受体拮抗剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2010105580787A Pending CN102040602A (zh) 2004-04-27 2005-04-27 毒蕈碱性乙酰胆碱受体拮抗剂

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US (9) US7498440B2 (enExample)
EP (3) EP1740177B1 (enExample)
JP (2) JP5014121B2 (enExample)
KR (2) KR101037026B1 (enExample)
CN (2) CN1976701A (enExample)
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AR (1) AR050902A1 (enExample)
AU (1) AU2005237576B2 (enExample)
BE (1) BE2014C063I2 (enExample)
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CY (3) CY1113196T1 (enExample)
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HU (2) HUE031304T2 (enExample)
IL (1) IL178152A (enExample)
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LU (1) LU92565I2 (enExample)
MA (1) MA28631B1 (enExample)
MX (1) MXPA06012405A (enExample)
MY (1) MY144753A (enExample)
NL (1) NL300694I1 (enExample)
NO (3) NO338959B1 (enExample)
NZ (1) NZ549997A (enExample)
PE (1) PE20060259A1 (enExample)
PL (2) PL2570128T3 (enExample)
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UA (1) UA95768C2 (enExample)
UY (1) UY28871A1 (enExample)
WO (1) WO2005104745A2 (enExample)
ZA (1) ZA200608565B (enExample)

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CN102946868A (zh) * 2010-06-22 2013-02-27 奇斯药制品公司 包含抗毒蕈碱药的干粉制剂
CN105431432A (zh) * 2013-07-13 2016-03-23 北京嘉事联博医药科技有限公司 奎宁类化合物、其光学异构体及其制备方法和医药用途
CN105461710A (zh) * 2015-10-23 2016-04-06 安徽德信佳生物医药有限公司 一种芜地溴铵的制备方法
CN105555269A (zh) * 2013-07-30 2016-05-04 葛兰素史密斯克莱知识产权发展有限公司 用于治疗过度出汗的局部组合物及其使用方法
CN107163038A (zh) * 2012-08-15 2017-09-15 葛兰素集团有限公司 化学方法
CN107200734A (zh) * 2016-03-18 2017-09-26 益方生物科技（上海）有限公司 奎宁环衍生物及其制备方法和用途
CN108558860A (zh) * 2018-06-04 2018-09-21 成都伊诺达博医药科技有限公司 一种合成芜地溴铵的新方法
CN112479983A (zh) * 2020-11-25 2021-03-12 江苏豪森药业集团有限公司 乌美溴铵中间体及其制备方法
WO2021218833A1 (zh) * 2020-04-26 2021-11-04 北京硕佰医药科技有限责任公司 一种m受体拮抗剂的晶体、制备方法及其应用

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CN115397823A (zh) * 2020-04-26 2022-11-25 北京硕佰医药科技有限责任公司 一种m受体拮抗剂的晶体、制备方法及其应用
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CN112479983A (zh) * 2020-11-25 2021-03-12 江苏豪森药业集团有限公司 乌美溴铵中间体及其制备方法
CN112479983B (zh) * 2020-11-25 2022-07-12 江苏豪森药业集团有限公司 乌美溴铵中间体及其制备方法

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