PT115583B - Processo contínuo para a preparação de medicamentos anticolinérgicos - Google Patents
Processo contínuo para a preparação de medicamentos anticolinérgicos Download PDFInfo
- Publication number
- PT115583B PT115583B PT115583A PT11558319A PT115583B PT 115583 B PT115583 B PT 115583B PT 115583 A PT115583 A PT 115583A PT 11558319 A PT11558319 A PT 11558319A PT 115583 B PT115583 B PT 115583B
- Authority
- PT
- Portugal
- Prior art keywords
- bromide
- preparation
- continuous process
- anticholinergic drugs
- anticholinergic
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 230000001078 anti-cholinergic effect Effects 0.000 title abstract 2
- 238000010924 continuous production Methods 0.000 title 1
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 abstract 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
- ASMXXROZKSBQIH-VITNCHFBSA-N aclidinium Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 ASMXXROZKSBQIH-VITNCHFBSA-N 0.000 abstract 1
- 229960005012 aclidinium bromide Drugs 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960002462 glycopyrronium bromide Drugs 0.000 abstract 1
- 229960001361 ipratropium bromide Drugs 0.000 abstract 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003586 protic polar solvent Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 229960000257 tiotropium bromide Drugs 0.000 abstract 1
- 229960004541 umeclidinium bromide Drugs 0.000 abstract 1
- PEJHHXHHNGORMP-AVADPIKZSA-M umeclidinium bromide Chemical compound [Br-].C=1C=CC=CC=1C([C@@]12CC[N@@+](CCOCC=3C=CC=CC=3)(CC1)CC2)(O)C1=CC=CC=C1 PEJHHXHHNGORMP-AVADPIKZSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A PRESENTE INVENÇÃO REFERE-SE A UM NOVO PROCESSO PARA A PREPARAÇÃO DE AGENTES / FÁRMACOS ANTICOLINÉRGICOS, COMO BROMETO DE UMECLIDÍNIO, BROMETO DE TIOTRÓPIO, BROMETO DE GLICOPIRRÔNIO, BROMETO DE ACLIDÍNIO, BROMETO DE IPRATRÓPIO NO MODO DE FLUXO CONTÍNUO NA PRESENÇA DE UM OU MAIS SOLVENTES PRÓTICOS POLARES. OS MEDICAMENTOS ANTICOLINÉRGICOS ESTÃO EM UMA FORMA ADEQUADA PARA USO POR INALAÇÃO NO TRATAMENTO DE DOENÇAS RESPIRATÓRIAS, COMO ASMA OU DOENÇA PULMONAR OBSTRUTIVA CRÓNICA (DPOC).
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT115583A PT115583B (pt) | 2019-06-17 | 2019-06-17 | Processo contínuo para a preparação de medicamentos anticolinérgicos |
| EP20734291.6A EP3982923B1 (en) | 2019-06-17 | 2020-06-16 | Continuous process for the preparation of anticholinergic drugs |
| US17/617,725 US20220251078A1 (en) | 2019-06-17 | 2020-06-16 | Continuous Process for the Preparation of Anticholinergic Drugs |
| AU2020296972A AU2020296972B2 (en) | 2019-06-17 | 2020-06-16 | Continuous process for the preparation of anticholinergic drugs |
| JP2021574905A JP2022549545A (ja) | 2019-06-17 | 2020-06-16 | 抗コリン薬の調製のための連続プロセス |
| KR1020227000471A KR20220024433A (ko) | 2019-06-17 | 2020-06-16 | 항콜린 약물의 연속 제조방법 |
| CN202080049646.2A CN114206863A (zh) | 2019-06-17 | 2020-06-16 | 制备抗胆碱药的连续方法 |
| PCT/GB2020/051448 WO2020254791A1 (en) | 2019-06-17 | 2020-06-16 | Continuous process for the preparation of anticholinergic drugs |
| CA3141271A CA3141271A1 (en) | 2019-06-17 | 2020-06-16 | Continuous process for the preparation of anticholinergic drugs |
| IL288972A IL288972A (en) | 2019-06-17 | 2021-12-13 | A continuous process for the preparation of anticholinergic drugs |
| JP2025025794A JP2025081547A (ja) | 2019-06-17 | 2025-02-20 | 抗コリン薬の調製のための連続方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT115583A PT115583B (pt) | 2019-06-17 | 2019-06-17 | Processo contínuo para a preparação de medicamentos anticolinérgicos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT115583A PT115583A (pt) | 2021-06-03 |
| PT115583B true PT115583B (pt) | 2022-05-02 |
Family
ID=71120199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT115583A PT115583B (pt) | 2019-06-17 | 2019-06-17 | Processo contínuo para a preparação de medicamentos anticolinérgicos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220251078A1 (pt) |
| EP (1) | EP3982923B1 (pt) |
| JP (2) | JP2022549545A (pt) |
| KR (1) | KR20220024433A (pt) |
| CN (1) | CN114206863A (pt) |
| AU (1) | AU2020296972B2 (pt) |
| CA (1) | CA3141271A1 (pt) |
| IL (1) | IL288972A (pt) |
| PT (1) | PT115583B (pt) |
| WO (1) | WO2020254791A1 (pt) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908928B2 (en) | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
| AR050902A1 (es) | 2004-04-27 | 2006-12-06 | Glaxo Group Ltd | Compuesto de quinuclidina, composicion farmaceutica que lo comprende y su usopara preparar dicha composicion |
| KR20080007656A (ko) * | 2005-05-02 | 2008-01-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 티오트로피움 브로마이드의 신규한 결정질 형태 |
| EP2085396A3 (en) | 2005-05-02 | 2009-11-25 | Boehringer Ingelheim International Gmbh | Novel crystalline forms of tiotropium bromide |
| RU2453547C2 (ru) | 2005-12-19 | 2012-06-20 | Сикор Инк. | Новые формы тиотропия бромида и способы их получения |
| MX2007009988A (es) | 2005-12-19 | 2008-02-22 | Sicor Inc | Formas novedosas de bromuro de tiotropio y procesos para su preparacion. |
| JP5333342B2 (ja) | 2009-06-29 | 2013-11-06 | 株式会社デンソー | 半導体装置 |
| LT2607351T (lt) * | 2011-12-22 | 2017-06-12 | Cerbios-Pharma S.A. | Ciklinių tretinių aminų nepertraukiamo alkilinimo būdas |
| PT106142B (pt) | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
| ES2893473T3 (es) | 2012-08-15 | 2022-02-09 | Glaxo Group Ltd | Proceso químico |
| CZ27764U1 (cs) | 2014-08-22 | 2015-02-02 | Zentiva, K.S. | uMethanolový solvát umeclidinium bromidu |
| PT108370B (pt) * | 2015-03-30 | 2018-10-25 | Hovione Farm S A | Processo de preparação de brometo de aclidínio |
| EP3248970A1 (en) | 2016-05-27 | 2017-11-29 | Zentiva K.S. | Forms of umeclidinium bromide |
| PT109740B (pt) | 2016-11-14 | 2020-07-30 | Hovione Farmaciencia Sa | Processo para a preparação de brometo de umeclidínio |
-
2019
- 2019-06-17 PT PT115583A patent/PT115583B/pt active IP Right Grant
-
2020
- 2020-06-16 CN CN202080049646.2A patent/CN114206863A/zh active Pending
- 2020-06-16 EP EP20734291.6A patent/EP3982923B1/en active Active
- 2020-06-16 CA CA3141271A patent/CA3141271A1/en active Pending
- 2020-06-16 JP JP2021574905A patent/JP2022549545A/ja active Pending
- 2020-06-16 KR KR1020227000471A patent/KR20220024433A/ko active Pending
- 2020-06-16 WO PCT/GB2020/051448 patent/WO2020254791A1/en not_active Ceased
- 2020-06-16 US US17/617,725 patent/US20220251078A1/en active Pending
- 2020-06-16 AU AU2020296972A patent/AU2020296972B2/en active Active
-
2021
- 2021-12-13 IL IL288972A patent/IL288972A/en unknown
-
2025
- 2025-02-20 JP JP2025025794A patent/JP2025081547A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020254791A1 (en) | 2020-12-24 |
| PT115583A (pt) | 2021-06-03 |
| US20220251078A1 (en) | 2022-08-11 |
| EP3982923A1 (en) | 2022-04-20 |
| AU2020296972A1 (en) | 2022-01-20 |
| EP3982923B1 (en) | 2024-05-15 |
| KR20220024433A (ko) | 2022-03-03 |
| IL288972A (en) | 2022-02-01 |
| JP2025081547A (ja) | 2025-05-27 |
| AU2020296972B2 (en) | 2025-04-24 |
| EP3982923C0 (en) | 2024-05-15 |
| CA3141271A1 (en) | 2020-12-24 |
| JP2022549545A (ja) | 2022-11-28 |
| CN114206863A (zh) | 2022-03-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112015006571A2 (pt) | composição farmacêutica, processo para preparar uma composição farmacêutica, uso de uma composição farmacêutica, e, método para a profilaxia ou tratamento de asma, doença pulmonar obstrutiva crônica e distúrbios respiratórios relacionados | |
| PH12018500088A1 (en) | Substituted tricyclics and method of use | |
| UY35963A (es) | Determinadas (2s)-n-[(1s)-1-ciano-2-feniletil]-1,4-oxazepan-2-carboxamidas como inhibidores de dipeptidil peptidasa 1 | |
| BR112018007161A2 (pt) | pirazolo[3,4-b]piridin-6-carboxamidas n-sulfoniladas e métodos de uso | |
| EA201591269A1 (ru) | Способы лечения аутоиммунных, респираторных и воспалительных расстройств ингаляцией n-оксида рофлумиласта | |
| EA201791780A1 (ru) | Ингаляционный раствор тиотропия для небулайзерного распыления | |
| BR112018007145A2 (pt) | ácidos pirazolo[3,4-b]piridin-6-carboxílicos substituídos e o seu uso | |
| BR112015028964A2 (pt) | composição de suspensão, e, método para tratar uma doença ou um distúrbio pulmonar | |
| TW200708513A (en) | Novel crystalline forms of tiotropium bromide | |
| EA201190108A1 (ru) | Фармацевтическая композиция для ингаляции | |
| WO2006117300A3 (en) | Crystalline forms of tiotropium bromide | |
| ZA202212128B (en) | Combination of alcaftadine and a corticosteroid | |
| EA201290374A1 (ru) | Аэрозольная композиция для copd | |
| ECSP066543A (es) | Nuevo anhidrato cristalino con accion anticolinergica | |
| BR112014018767A8 (pt) | Compostos de pirroldicarboxamidas fundidas e composição farmacêutica que os compreende | |
| EA201590019A1 (ru) | Ингаляторы сухого порошка, содержащие носитель, отличный от лактозы | |
| PE20170073A1 (es) | Combinaciones de bromuro de tiotropio, formoterol y budesonida para el tratamiento de la copd | |
| ECSP066545A (es) | Procedimiento para la preparación de sales de tiotropio, sales de tiotropio, así como formulaciones medicamentosas que las contienen | |
| PT115583B (pt) | Processo contínuo para a preparação de medicamentos anticolinérgicos | |
| BR112016002222A2 (pt) | partículas inaláveis compreendendo tiotrópio e indacaterol | |
| EA029678B9 (ru) | Четвертичные соли пиперидиния | |
| EA201590036A1 (ru) | Композиции для ингалятора сухого порошка, содержащие антагонисты мускариновых рецепторов длительного действия | |
| ECSP055821A (es) | Nueva formulacion pulverulenta que contiene tiotropio destinado a la inhalación | |
| BR112015004810A2 (pt) | preparações de tiotrópio | |
| WO2019098969A3 (en) | Dry powder compositions for inhalation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 20210531 |
|
| FG3A | Patent granted, date of granting |
Effective date: 20220427 |