CN1679569A - 稳定的缓释口服给药组合物 - Google Patents

稳定的缓释口服给药组合物 Download PDF

Info

Publication number
CN1679569A
CN1679569A CNA2005100713014A CN200510071301A CN1679569A CN 1679569 A CN1679569 A CN 1679569A CN A2005100713014 A CNA2005100713014 A CN A2005100713014A CN 200510071301 A CN200510071301 A CN 200510071301A CN 1679569 A CN1679569 A CN 1679569A
Authority
CN
China
Prior art keywords
film
desloratadine
polyethylene glycol
composition
pseudoephedrine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005100713014A
Other languages
English (en)
Chinese (zh)
Inventor
J·H·顾
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22629437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1679569(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN1679569A publication Critical patent/CN1679569A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Toys (AREA)
  • Cosmetics (AREA)
CNA2005100713014A 1999-12-20 2000-12-20 稳定的缓释口服给药组合物 Pending CN1679569A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17283699P 1999-12-20 1999-12-20
US60/172836 1999-12-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB001373005A Division CN1211079C (zh) 1999-12-20 2000-12-20 稳定的缓释口服给药组合物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2006100944812A Division CN101081224B (zh) 1999-12-20 2000-12-20 稳定的缓释口服给药组合物

Publications (1)

Publication Number Publication Date
CN1679569A true CN1679569A (zh) 2005-10-12

Family

ID=22629437

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA2005100713014A Pending CN1679569A (zh) 1999-12-20 2000-12-20 稳定的缓释口服给药组合物
CN2006100944812A Expired - Fee Related CN101081224B (zh) 1999-12-20 2000-12-20 稳定的缓释口服给药组合物
CNB001373005A Expired - Fee Related CN1211079C (zh) 1999-12-20 2000-12-20 稳定的缓释口服给药组合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2006100944812A Expired - Fee Related CN101081224B (zh) 1999-12-20 2000-12-20 稳定的缓释口服给药组合物
CNB001373005A Expired - Fee Related CN1211079C (zh) 1999-12-20 2000-12-20 稳定的缓释口服给药组合物

Country Status (37)

Country Link
US (2) US6979463B2 (enExample)
EP (2) EP1112738B1 (enExample)
JP (3) JP5042403B2 (enExample)
KR (2) KR100936572B1 (enExample)
CN (3) CN1679569A (enExample)
AR (1) AR027033A1 (enExample)
AT (1) ATE463240T1 (enExample)
AU (4) AU2277101A (enExample)
BR (1) BR0006403A (enExample)
CA (1) CA2329217C (enExample)
CO (1) CO5251435A1 (enExample)
CY (1) CY1110693T1 (enExample)
CZ (1) CZ302860B6 (enExample)
DE (1) DE60044117D1 (enExample)
DK (1) DK1112738T3 (enExample)
EC (1) ECSP003836A (enExample)
EG (1) EG23759A (enExample)
ES (1) ES2341751T3 (enExample)
HU (1) HUP0004988A3 (enExample)
ID (1) ID28675A (enExample)
IL (1) IL140450A (enExample)
MX (1) MXPA00013037A (enExample)
MY (1) MY130773A (enExample)
NO (1) NO331645B1 (enExample)
NZ (1) NZ509028A (enExample)
PE (1) PE20010982A1 (enExample)
PL (1) PL211573B1 (enExample)
PT (1) PT1112738E (enExample)
RU (2) RU2303440C2 (enExample)
SA (2) SA06270069B1 (enExample)
SG (1) SG109438A1 (enExample)
SI (1) SI1112738T1 (enExample)
SK (1) SK287684B6 (enExample)
TR (1) TR200003787A2 (enExample)
TW (1) TWI225414B (enExample)
WO (1) WO2001045668A2 (enExample)
ZA (1) ZA200007715B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2277101A (en) 1999-12-20 2001-07-03 Schering Corporation Stable extended release oral dosage composition
AU2276801A (en) 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
WO2003000264A1 (en) * 2001-06-20 2003-01-03 Schering Corporation Antihistamines for the treatment of nasal congestion and nasal obstruction
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
AU2003211146B2 (en) * 2002-02-21 2007-07-19 Valeant International (Barbados) Srl Controlled release dosage forms
US8323692B2 (en) 2002-02-21 2012-12-04 Valeant International Bermuda Controlled release dosage forms
WO2004080461A2 (en) * 2003-03-12 2004-09-23 TEVA Gyógyszergyár Részvénytársaság Stable pharmaceutical compositions of desloratadine
US20050013863A1 (en) 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
WO2005053599A1 (ja) * 2003-12-01 2005-06-16 Takeda Pharmaceutical Company Limited 固形製剤の印刷前処理方法及び印刷前処理方法が施された固形製剤
MX2007004976A (es) * 2004-10-25 2007-06-14 Schering Corp Antagonistas de receptor m1 y/o m3 en combinacion con otros compuestos activos para tratar trastornos respiratorios.
US20060252830A1 (en) * 2005-05-06 2006-11-09 Brandon Stephen F Method for the treatment of magnesium and potassium deficiencies
US20060252831A1 (en) * 2005-05-06 2006-11-09 Christopher Offen Method for the treatment of magnesium and potassium deficiencies
US20070014855A1 (en) * 2005-07-12 2007-01-18 Rahul Gawande S Stable desloratadine compositions
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US7927787B2 (en) 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US8340944B2 (en) 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US8068991B2 (en) 2005-11-30 2011-11-29 The Invention Science Fund I, Llc Systems and methods for transmitting pathogen related information and responding
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US10296720B2 (en) 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US7827042B2 (en) 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
FR2894143B1 (fr) * 2005-12-01 2008-05-02 Pierre Fabre Medicament Sa Composition a liberation prolongee de l'actif, son procede de preparation et son utilisation.
CN101472561A (zh) * 2006-06-01 2009-07-01 先灵公司 去氧肾上腺素脉冲释放制剂和药物组合物
NZ573174A (en) * 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
MX2008015358A (es) * 2006-06-01 2009-03-06 Schering Corp Composiciones farmaceuticas para liberacion sostenida de fenilefrina.
CA2653953C (en) * 2006-06-01 2015-12-08 Schering-Plough Healthcare Products, Inc. Phenylephrine pharmaceutical formulations and compositions for colonic absorption
CA2658170A1 (en) * 2006-07-11 2008-01-17 Mutual Pharmaceutical Company, Inc. Controlled-release formulations
CA2697959A1 (en) * 2007-06-01 2008-12-11 Schering-Plough Healthcare Products, Inc. Pharmaceutical composition comprising a substrate and a coating containing an active ingredient and polyvinylalcohol
PE20091084A1 (es) * 2007-12-07 2009-07-23 Schering Plough Healthcare Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal
WO2010099508A1 (en) 2009-02-26 2010-09-02 Theraquest Biosciences, Inc. Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use
WO2010143202A1 (en) * 2009-06-09 2010-12-16 Sun Pharmaceutical Industries Ltd. Pharmaceutical composition
TR201009396A2 (tr) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Desloratadin granüller
DE102016107760B4 (de) * 2016-04-26 2018-09-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Essbare Funktionsschichten und Überzüge auf Hybridpolymerbasis für Pharmazie und Lebensmittel
US10463656B2 (en) 2017-01-05 2019-11-05 Iowa State University Research Foundation, Inc. Methods and compositions for prevention of feedlot bovine respiratory disease
EP4188339A1 (en) 2020-07-30 2023-06-07 Faes Farma, S.A. Decongestant drug delivery system
WO2026104388A1 (en) 2024-11-12 2026-05-21 Faes Farma, S.A. Decongestant controlled release drug delivery system

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US100000A (en) 1870-02-22 Improved sun-bonnet for horses
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3940485A (en) 1973-12-12 1976-02-24 Levinson Harold N Treatment and pre-treatment of dysmetric dyslexia by improving sequential scanning and ocular fixation abilities and therapeutic compounds
US4008796A (en) 1974-03-26 1977-02-22 General Concrete Of Canada Limited Control method for feeding items on a conveyor
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
US4282233B1 (en) 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
WO1985003707A1 (en) 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
US4552899A (en) 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4783465A (en) 1984-04-09 1988-11-08 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
SE8404467D0 (sv) 1984-09-06 1984-09-06 Ferrosan Ab Controlled-release medical preparations
US4731447A (en) 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
US4804666A (en) 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
JPS6396126A (ja) 1986-10-13 1988-04-27 Taisho Pharmaceut Co Ltd 安定化組成物
US5089496A (en) 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4777170A (en) 1987-02-03 1988-10-11 Heinrich William A Method to prevent and treat the signs and symptoms of motion sickness
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
US4863931A (en) 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US5019591A (en) 1989-02-17 1991-05-28 Pennsylvania Research Corporation Method for treating retinopathy and other small vessel disorders associated with diabetes
US4990535A (en) 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
NZ238629A (en) 1990-06-22 1993-09-27 Schering Corp Bis-benzo- or benzopyrido-cyclohepta (where z is c, o, s or n) piperidine, piperidylidene or piperazine compounds, medicaments and methods of preparation
DE69120430D1 (de) 1990-12-18 1996-07-25 Wellcome Found Mittel zur verstaerkung der wirkung von antitumoralen mittel und zur widerstandsbekaempfung von vielfachdrogen
PT100502A (pt) 1991-05-20 1993-08-31 Alza Corp Composicoes farmaceuticas para aumentar a capacidade de permeacao na pele utilizando monolinoleato de glicerol
YU48263B (sh) * 1991-06-17 1997-09-30 Byk Gulden Lomberg Chemische Fabrik Gmbh. Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
IL104192A (en) * 1992-02-17 1998-01-04 Siegfried Ag Pharma Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
ES2042421B1 (es) 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
US5314697A (en) * 1992-10-23 1994-05-24 Schering Corporation Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
IT1264517B1 (it) * 1993-05-31 1996-09-24 Ekita Investments Nv Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati
JP2646972B2 (ja) 1993-11-01 1997-08-27 日本電気株式会社 多ビットメモリ
DE4442999A1 (de) 1994-12-02 1996-06-05 Hexal Pharma Gmbh Pharmazeutische Zusammensetzung mit einem aktiven Loratidin-Metaboliten
US5595997A (en) 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
US5807579A (en) * 1995-11-16 1998-09-15 F.H. Faulding & Co. Limited Pseudoephedrine combination pharmaceutical compositions
JP3220373B2 (ja) * 1995-11-28 2001-10-22 バイエル薬品株式会社 持続性ニフエジピン製剤
BR9712705A (pt) * 1996-10-31 1999-10-26 Schering Corp Composição para o tratamento da asma, contendo loratadina e um descongestionante
TW522014B (en) * 1997-02-07 2003-03-01 Sepracor Inc Lactose-free, non-hygroscopic and anhydrous pharmaceutical unit dosage form containing descarboethoxyloratadine
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5939426A (en) 1997-02-28 1999-08-17 Sepracor Inc. Methods for treating urinary incontinence using descarboethoxyloratadine
US6506767B1 (en) 1997-07-02 2003-01-14 Schering Corporation 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine
EP1032392A4 (en) 1997-10-29 2001-05-09 J Med Pharmaceuticals Inc RHINITIS TREATMENT BY ANTIHISTAMINE / DECONGESTIVUM ADMINISTRATION
US6132758A (en) 1998-06-01 2000-10-17 Schering Corporation Stabilized antihistamine syrup
IL139407A0 (en) 1998-07-10 2001-11-25 Schering Corp 8-CHLORO-6, 11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO [5,6] CYCLOHEPTA [1, 2-b] PYRIDINE ORAL COMPOSITIONS
US6423721B1 (en) * 1998-09-10 2002-07-23 Schering Corporation Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines
US6051585A (en) 1998-12-07 2000-04-18 Weinstein; Robert E. Single-dose antihistamine/decongestant formulations for treating rhinitis
US6521254B2 (en) 1998-12-07 2003-02-18 J-Med Pharmaceuticals, Inc. Single-dose antihistamine/decongestant formulations for treating rhinitis
US6100274A (en) 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
US6114346A (en) * 1999-10-22 2000-09-05 Schering Corporation Treating sleep disorders using desloratadine
AU2277101A (en) 1999-12-20 2001-07-03 Schering Corporation Stable extended release oral dosage composition
AU2276801A (en) * 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
CN1213752C (zh) * 2000-02-03 2005-08-10 先灵公司 变应性和炎性疾病的治疗
US7405223B2 (en) * 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
EP1289945B1 (en) * 2000-05-19 2004-08-04 Alcon Inc. Aniline disulfide derivatives for treating allergic diseases
US6599913B1 (en) * 2001-06-29 2003-07-29 Schering Corporation Treating allergic and inflammatory conditions

Also Published As

Publication number Publication date
JP2012224642A (ja) 2012-11-15
WO2001045668A2 (en) 2001-06-28
CA2329217C (en) 2006-10-31
KR100936572B1 (ko) 2010-01-13
DK1112738T3 (da) 2010-06-28
ATE463240T1 (de) 2010-04-15
AU7244300A (en) 2001-06-21
CO5251435A1 (es) 2003-02-28
WO2001045668A3 (en) 2001-12-13
AU2009200460B2 (en) 2012-01-19
EP1112738A2 (en) 2001-07-04
JP2001172174A (ja) 2001-06-26
KR20010062542A (ko) 2001-07-07
PL344715A1 (en) 2001-07-02
HUP0004988A2 (hu) 2002-11-28
RU2423106C9 (ru) 2012-06-27
SK287684B6 (sk) 2011-06-06
US20030086971A1 (en) 2003-05-08
US6979463B2 (en) 2005-12-27
HUP0004988A3 (en) 2008-04-28
CZ302860B6 (cs) 2011-12-21
EP1112738A3 (en) 2001-07-18
CN101081224B (zh) 2012-05-30
RU2007104095A (ru) 2008-08-10
BR0006403A (pt) 2001-07-17
ECSP003836A (es) 2002-02-25
SI1112738T1 (sl) 2010-07-30
HU0004988D0 (enExample) 2001-02-28
ES2341751T3 (es) 2010-06-28
EP2196195A2 (en) 2010-06-16
RU2423106C2 (ru) 2011-07-10
SG109438A1 (en) 2005-03-30
CN1301534A (zh) 2001-07-04
EP1112738B1 (en) 2010-04-07
AU2005203771A1 (en) 2005-09-15
PL211573B1 (pl) 2012-05-31
NZ509028A (en) 2002-12-20
US7820199B2 (en) 2010-10-26
NO20006504L (no) 2001-06-21
CY1110693T1 (el) 2015-06-10
HK1034453A1 (en) 2001-10-26
IL140450A (en) 2011-11-30
ZA200007715B (en) 2001-06-20
NO20006504D0 (no) 2000-12-20
SA01210741A (ar) 2005-12-03
SA01210741B1 (ar) 2006-10-31
CN101081224A (zh) 2007-12-05
PT1112738E (pt) 2010-06-04
JP5042403B2 (ja) 2012-10-03
US20060159761A1 (en) 2006-07-20
AR027033A1 (es) 2003-03-12
KR101234940B1 (ko) 2013-02-19
EG23759A (en) 2007-08-08
CA2329217A1 (en) 2001-06-20
CN1211079C (zh) 2005-07-20
PE20010982A1 (es) 2001-09-28
EP2196195A3 (en) 2012-02-29
AU2009200460A1 (en) 2009-02-26
ID28675A (id) 2001-06-21
MXPA00013037A (es) 2003-06-19
NO331645B1 (no) 2012-02-13
KR20110028326A (ko) 2011-03-17
TWI225414B (en) 2004-12-21
RU2303440C2 (ru) 2007-07-27
AU2277101A (en) 2001-07-03
CZ20004812A3 (cs) 2001-08-15
SA06270069B1 (ar) 2009-06-07
SK19672000A3 (sk) 2001-09-11
MY130773A (en) 2007-07-31
AU781924B2 (en) 2005-06-23
DE60044117D1 (de) 2010-05-20
IL140450A0 (en) 2002-02-10
TR200003787A3 (tr) 2001-07-23
TR200003787A2 (tr) 2001-07-23
JP2008081510A (ja) 2008-04-10

Similar Documents

Publication Publication Date Title
CN1211079C (zh) 稳定的缓释口服给药组合物
CN1302605A (zh) 缓释的口服给药组合物
CN1155382C (zh) 阿夫唑嗪盐酸盐受控释放的片剂
CN1245958C (zh) 控释羟可酮组合物
CN1228043C (zh) 用于高溶解度药物的缓释基质
CN1323663C (zh) 含瑞波西汀的缓释片剂
CN1499960A (zh) 时间治疗剂型
CN1551770A (zh) 羟吗啡酮控释制剂
CN1277550A (zh) 非甾体抗炎药物(NSAIDs)的改进释放的复合型组合物
CN1638737A (zh) 丙哌凡林或其药学可接受盐的具有活性成分的延长释放的口服剂型
CN1091004A (zh) 水凝胶缓释剂
CN1681509A (zh) 含拉莫三嗪的缓释制剂
CN1652752A (zh) 盐酸纳曲酮组合物
CN1390119A (zh) 制备水性包被小球粒的方法
CN101039657A (zh) 含有固体分散体与聚合物基质的药物组合物，该基质含有连续聚葡萄糖相和连续的除聚葡萄糖外的聚合物的相
CN1434713A (zh) 环加氧酶－2抑制剂的缓释制剂
CN1527706A (zh) 含特比萘芬的药物组合物及其应用
CN1655767A (zh) 持续释放的包衣颗粒和含有这种颗粒的片剂
CN1555263A (zh) 治疗普通感冒的组合物
CN1942176A (zh) 用于糖皮质激素替代疗法的药物组合物
CN1652788A (zh) 治疗糖尿病的方法
CN1655765A (zh) 缓释药物制剂及其制备方法
CN1655766A (zh) 愈创甘油醚组合药物的持续释放
CN101031291A (zh) 包含甲醇化合物和至少一种nsaid的活性物质组合
CN1679525A (zh) 复方对乙酰氨基酚口腔崩解片

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1083744

Country of ref document: HK

C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Open date: 20051012

C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: new jersey

Applicant after: Schering Corporation

Address before: new jersey

Applicant before: SCHERING CORP (US)

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: SCHERING CORP (US) TO: MSD CORP.

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1083744

Country of ref document: HK