CN1660108A - 高度选择性去甲肾上腺素再摄取抑制剂及其用途 - Google Patents
高度选择性去甲肾上腺素再摄取抑制剂及其用途 Download PDFInfo
- Publication number
- CN1660108A CN1660108A CN2004101045222A CN200410104522A CN1660108A CN 1660108 A CN1660108 A CN 1660108A CN 2004101045222 A CN2004101045222 A CN 2004101045222A CN 200410104522 A CN200410104522 A CN 200410104522A CN 1660108 A CN1660108 A CN 1660108A
- Authority
- CN
- China
- Prior art keywords
- reboxetine
- disorder
- norepinephrine
- disorders
- reuptake
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
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-
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14196899P | 1999-07-01 | 1999-07-01 | |
| US60/141,968 | 1999-07-01 | ||
| US14413199P | 1999-07-16 | 1999-07-16 | |
| US60/144,131 | 1999-07-16 | ||
| US15825699P | 1999-10-06 | 1999-10-06 | |
| US60/158,256 | 1999-10-06 | ||
| US17038199P | 1999-12-13 | 1999-12-13 | |
| US60/170,381 | 1999-12-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB008084858A Division CN1205935C (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其使用方法 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510136906 Division CN1820754A (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其用途 |
| CN 200610099898 Division CN1969859A (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1660108A true CN1660108A (zh) | 2005-08-31 |
Family
ID=27495506
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004101045241A Pending CN1660110A (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其用途 |
| CN2004101045222A Pending CN1660108A (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其用途 |
| CN2004101045237A Pending CN1660109A (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其用途 |
| CNB008084858A Expired - Fee Related CN1205935C (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其使用方法 |
| CNB2004101045256A Expired - Fee Related CN1289090C (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其在制备药物方面的用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004101045241A Pending CN1660110A (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004101045237A Pending CN1660109A (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其用途 |
| CNB008084858A Expired - Fee Related CN1205935C (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其使用方法 |
| CNB2004101045256A Expired - Fee Related CN1289090C (zh) | 1999-07-01 | 2000-06-22 | 高度选择性去甲肾上腺素再摄取抑制剂及其在制备药物方面的用途 |
Country Status (30)
| Country | Link |
|---|---|
| US (18) | US6465458B1 (enExample) |
| EP (3) | EP2087892A3 (enExample) |
| JP (3) | JP2003503450A (enExample) |
| KR (5) | KR100717660B1 (enExample) |
| CN (5) | CN1660110A (enExample) |
| AR (1) | AR035158A1 (enExample) |
| AT (9) | ATE305307T1 (enExample) |
| AU (2) | AU771258B2 (enExample) |
| BR (1) | BR0012136A (enExample) |
| CA (2) | CA2643231A1 (enExample) |
| CL (3) | CL2008002868A1 (enExample) |
| CO (1) | CO5190662A1 (enExample) |
| CZ (1) | CZ299847B6 (enExample) |
| DE (9) | DE60019473T2 (enExample) |
| DK (4) | DK1632234T3 (enExample) |
| EA (6) | EA011094B1 (enExample) |
| ES (9) | ES2258010T3 (enExample) |
| GE (1) | GEP20094798B (enExample) |
| HU (1) | HUP0201623A3 (enExample) |
| IL (3) | IL147246A0 (enExample) |
| MX (1) | MXPA02000562A (enExample) |
| MY (1) | MY137348A (enExample) |
| NO (4) | NO20016406L (enExample) |
| NZ (2) | NZ533243A (enExample) |
| PE (1) | PE20010684A1 (enExample) |
| PL (1) | PL196996B1 (enExample) |
| PT (5) | PT1196172E (enExample) |
| SK (5) | SK286864B6 (enExample) |
| TW (9) | TWI298255B (enExample) |
| WO (1) | WO2001001973A2 (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA011094B1 (ru) * | 1999-07-01 | 2008-12-30 | Фармация Энд Апджон Компани | Высокоселективные ингибиторы обратного захвата норэпинефрина и способы их применения |
| EP1600168A3 (en) * | 1999-12-01 | 2009-09-23 | Ucb, S.A. | A pyrrolidineacetamide derivative alone or in combination for treatment of CNS disorder |
| AU5311401A (en) | 2000-04-21 | 2001-11-07 | Upjohn Co | Compounds for treating fibromyalgia and chronic fatigue syndrome |
| HK1054190A1 (zh) * | 2000-04-21 | 2003-11-21 | 法玛西雅厄普约翰美国公司 | 用於治疗肌纤维疼痛和慢性疲劳综合征的精选化合物 |
| WO2002036125A1 (en) * | 2000-10-31 | 2002-05-10 | Head Explorer A/S | The use of selective noradrenaline reuptake inhibitors for the treatment of tension-type headache |
| AU2002217757A1 (en) * | 2000-11-15 | 2002-05-27 | Eli Lilly And Company | Treatment of anxiety disorders |
| WO2002083141A1 (en) * | 2001-04-17 | 2002-10-24 | Pharmacia & Upjohn Company | Treatment of fibromyalgia and chronic fatigue syndrome |
| US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
| GB0216027D0 (en) * | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
| US20060167074A1 (en) * | 2001-06-19 | 2006-07-27 | Norbert Muller | Methods and compositions for the treatment of psychiatric disorders |
| EA009780B1 (ru) * | 2001-06-19 | 2008-04-28 | Норберт Мюллер | Применение ингибиторов cox-2 для лечения шизофрении, аффективных расстройств или осложнений, связанных с тиком |
| US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| CA2466649A1 (en) * | 2001-11-30 | 2003-06-12 | Eli Lilly & Company | Use of norepinephrine reuptake inhibitors for the treatment of tic disorders |
| IL161989A0 (en) * | 2001-12-11 | 2005-11-20 | Lilly Co Eli | Use of norepinephrine reuptake inhibitors for the treatment of cognitive failure |
| US20040102440A1 (en) * | 2002-07-01 | 2004-05-27 | Wong Erik Ho Fong | Method of promoting smoking cessation |
| AU2003213009A1 (en) * | 2002-02-12 | 2003-09-04 | Cypress Bioscience, Inc. | Methods of treating attention deficit/hyperactivity disorder (adhd) |
| CN1662231A (zh) * | 2002-04-24 | 2005-08-31 | 柏树生物科学公司 | 包括应激相关障碍在内的功能性躯体障碍的预防与治疗 |
| JP4545584B2 (ja) * | 2002-05-17 | 2010-09-15 | デューク ユニバーシティ | 肥満を治療するための方法 |
| AU2003227520B9 (en) * | 2002-05-30 | 2008-06-26 | Neurosearch A/S | Triple monoamine reuptake inhibitors for the treatment of chronic pain |
| KR100779786B1 (ko) * | 2002-06-17 | 2007-11-28 | 화이자 이탈리아 에스.알.엘. | 레복세틴의 제약 염 |
| US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
| MY136318A (en) * | 2002-07-25 | 2008-09-30 | Pharmacia Corp | Sustained-release tablet composition |
| MXPA05001705A (es) * | 2002-08-14 | 2005-04-19 | Pharmacia & Upjohn Co Llc | Uso de reboxetina para el tratamiento de sofocos. |
| ATE327982T1 (de) | 2002-08-23 | 2006-06-15 | Lilly Co Eli | Benzylmorpholinderivate |
| US7384941B2 (en) | 2002-08-23 | 2008-06-10 | Eli Lilly And Company | 2-(phenoxymethyl)-and 2-(phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors |
| GB0219687D0 (en) | 2002-08-23 | 2002-10-02 | Lilly Co Eli | Benzyl morpholine derivatives |
| AU2003284005B2 (en) * | 2002-10-03 | 2009-12-17 | Forest Laboratories Holdings Limited | Dosage escalation and divided daily dose of anti-depressants to treat neurological disorders |
| US20040152710A1 (en) * | 2002-10-15 | 2004-08-05 | Deecher Darlene Coleman | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
| US20040180879A1 (en) * | 2002-10-15 | 2004-09-16 | Deecher Darlene Coleman | Novel method of treating vasomotor symptoms |
| US7345096B2 (en) * | 2002-10-15 | 2008-03-18 | Wyeth | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
| US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
| PL378369A1 (pl) * | 2003-01-13 | 2006-04-03 | Dynogen Pharmaceuticals, Inc. | Sposób leczenia mdłości, wymiotów, nudności lub ich dowolnej kombinacji |
| AU2004204825B2 (en) * | 2003-01-13 | 2007-07-19 | Dynogen Pharmaceuticals, Inc. | Method of treating functional bowel disorders |
| AU2004227945B2 (en) * | 2003-04-04 | 2006-10-26 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| MXPA05011557A (es) | 2003-04-29 | 2006-03-09 | Orexigen Therapeutics Inc | Composiciones para afectar perdida de peso. |
| US8158149B2 (en) * | 2004-05-12 | 2012-04-17 | Chelsea Therapeutics, Inc. | Threo-DOPS controlled release formulation |
| WO2004100929A1 (en) | 2003-05-12 | 2004-11-25 | Synergia Pharma, Inc. | Threo-dops controlled release formulation |
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- 2004-01-16 US US10/758,864 patent/US7317011B2/en not_active Expired - Fee Related
- 2004-05-18 AU AU2004202096A patent/AU2004202096B2/en not_active Ceased
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2006
- 2006-02-07 US US11/349,331 patent/US7338953B2/en not_active Expired - Fee Related
- 2006-02-07 US US11/348,948 patent/US20060142289A1/en not_active Abandoned
- 2006-02-07 US US11/349,373 patent/US7276503B2/en not_active Expired - Fee Related
- 2006-02-07 US US11/349,022 patent/US7241762B2/en not_active Expired - Fee Related
- 2006-02-22 JP JP2006045459A patent/JP2006143749A/ja active Pending
- 2006-07-28 US US11/460,775 patent/US20060264436A1/en not_active Abandoned
- 2006-08-02 JP JP2006210418A patent/JP2006321815A/ja active Pending
-
2007
- 2007-10-30 US US11/928,781 patent/US20080103145A1/en not_active Abandoned
- 2007-10-30 US US11/928,917 patent/US7723334B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/928,980 patent/US20080103147A1/en not_active Abandoned
- 2007-10-30 US US11/928,812 patent/US20080096890A1/en not_active Abandoned
- 2007-11-20 IL IL187512A patent/IL187512A0/en unknown
- 2007-11-20 IL IL187513A patent/IL187513A0/en unknown
-
2008
- 2008-09-26 CL CL2008002868A patent/CL2008002868A1/es unknown
- 2008-09-26 CL CL2008002867A patent/CL2008002867A1/es unknown
- 2008-09-26 CL CL2008002866A patent/CL2008002866A1/es unknown
-
2009
- 2009-03-18 NO NO20091168A patent/NO20091168L/no not_active Application Discontinuation
- 2009-03-18 NO NO20091158A patent/NO20091158L/no unknown
- 2009-03-18 NO NO20091159A patent/NO20091159L/no unknown
- 2009-04-27 US US12/430,244 patent/US20090247528A1/en not_active Abandoned
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