CN1360503A - 用于治疗癌症的海鞘素743的组合物和用途 - Google Patents

用于治疗癌症的海鞘素743的组合物和用途 Download PDF

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Publication number
CN1360503A
CN1360503A CN00809976A CN00809976A CN1360503A CN 1360503 A CN1360503 A CN 1360503A CN 00809976 A CN00809976 A CN 00809976A CN 00809976 A CN00809976 A CN 00809976A CN 1360503 A CN1360503 A CN 1360503A
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CN
China
Prior art keywords
cancer
patients
treating
administering
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00809976A
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English (en)
Chinese (zh)
Inventor
E·维科维克
G·D·德梅特里
C·古兹曼
J·吉门奥
L·罗佩兹拉扎罗
J·L·米斯瑟特
C·特威维斯
D·D·冯霍夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911183.3A external-priority patent/GB9911183D0/en
Priority claimed from GBGB9911346.6A external-priority patent/GB9911346D0/en
Priority claimed from GBGB9918534.0A external-priority patent/GB9918534D0/en
Priority claimed from GBGB9927005.0A external-priority patent/GB9927005D0/en
Priority claimed from GBGB9927106.6A external-priority patent/GB9927106D0/en
Priority claimed from GB0007637A external-priority patent/GB0007637D0/en
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of CN1360503A publication Critical patent/CN1360503A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
CN00809976A 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途 Pending CN1360503A (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
GB9911183.3 1999-05-13
GBGB9911183.3A GB9911183D0 (en) 1999-05-13 1999-05-13 Treatment of cancers
GB9911346.6 1999-05-14
GBGB9911346.6A GB9911346D0 (en) 1999-05-14 1999-05-14 Treatment of cancers
GB9918534.0 1999-08-05
GBGB9918534.0A GB9918534D0 (en) 1999-08-05 1999-08-05 Treatment of cancers
GB9927005.0 1999-11-15
GBGB9927005.0A GB9927005D0 (en) 1999-11-15 1999-11-15 Treatment of cancers
GBGB9927106.6A GB9927106D0 (en) 1999-11-16 1999-11-16 Cancer treatment
GB9927106.6 1999-11-16
GB0007637.2 2000-03-29
GB0007637A GB0007637D0 (en) 2000-03-29 2000-03-29 Antitumour compound

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CNB2005100091622A Division CN100477993C (zh) 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途
CNA2007101863681A Division CN101181272A (zh) 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途

Publications (1)

Publication Number Publication Date
CN1360503A true CN1360503A (zh) 2002-07-24

Family

ID=27546594

Family Applications (2)

Application Number Title Priority Date Filing Date
CN00809976A Pending CN1360503A (zh) 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途
CNB2005100091622A Expired - Lifetime CN100477993C (zh) 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途

Family Applications After (1)

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CNB2005100091622A Expired - Lifetime CN100477993C (zh) 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途

Country Status (32)

Country Link
US (1) US8119638B2 (enExample)
EP (3) EP1702618B1 (enExample)
JP (2) JP2002544231A (enExample)
KR (1) KR20020019914A (enExample)
CN (2) CN1360503A (enExample)
AR (1) AR028476A1 (enExample)
AT (3) ATE500830T1 (enExample)
AU (2) AU777417B2 (enExample)
BG (1) BG65680B1 (enExample)
BR (1) BR0010531A (enExample)
CA (1) CA2373794C (enExample)
CY (4) CY1105818T1 (enExample)
CZ (1) CZ301482B6 (enExample)
DE (4) DE60045720D1 (enExample)
DK (3) DK1702618T3 (enExample)
ES (2) ES2272279T3 (enExample)
FR (1) FR08C0013I2 (enExample)
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IL (2) IL146434A0 (enExample)
LU (1) LU91418I2 (enExample)
MX (1) MXPA01011562A (enExample)
MY (1) MY164077A (enExample)
NL (1) NL300337I2 (enExample)
NO (2) NO324564B1 (enExample)
NZ (1) NZ515423A (enExample)
PL (1) PL198185B1 (enExample)
PT (3) PT1176964E (enExample)
SI (3) SI1702618T1 (enExample)
SK (1) SK287580B6 (enExample)
TR (1) TR200103819T2 (enExample)
UA (1) UA74782C2 (enExample)
WO (1) WO2000069441A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101119750B (zh) * 2004-10-26 2013-03-06 法马马私人股份有限公司 抗癌治疗
WO2017133544A1 (zh) * 2016-02-04 2017-08-10 江苏恒瑞医药股份有限公司 一种曲贝替定的可注射胃肠外用药物组合物及其制备方法
US10538535B2 (en) 2017-04-27 2020-01-21 Pharma Mar, S.A. Antitumoral compounds

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MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
ATE495793T1 (de) * 2000-11-06 2011-02-15 Pharma Mar Sa Antitumorzusammensetzungen welche ecteinascidin 743 enthalten
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
HUP0401903A3 (en) * 2001-10-19 2008-07-28 Pharma Mar Improved use of et-743 in cancer thereapy
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
RS50692B (sr) * 2003-11-13 2010-06-30 Pharma Mar S.A.U. Kombinacija et-743 sa prolekovima 5-fluorouracila za lečenje kancera
JP2007511509A (ja) * 2003-11-14 2007-05-10 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３およびパクリタキセルの使用を含むガンの併用療法
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1768671A2 (en) * 2004-07-09 2007-04-04 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
RS50510B (sr) * 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
JP2009536956A (ja) * 2006-05-12 2009-10-22 ファルマ・マール・ソシエダード・アノニマ 抗癌治療法
WO2009050303A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for et-743 treatment
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
SI4041194T1 (sl) 2020-04-15 2024-10-30 Ever Valinject Gmbh Sestava, obsegajoča trabektedin in aminokislino
EP3960177A1 (en) * 2020-08-26 2022-03-02 Anturec Pharmaceuticals GmbH Composition comprising ttf-ngr for use in treating soft-tissue sarcoma
US12303506B2 (en) 2022-01-20 2025-05-20 Extrovis Ag Trabectedin composition

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101119750B (zh) * 2004-10-26 2013-03-06 法马马私人股份有限公司 抗癌治疗
WO2017133544A1 (zh) * 2016-02-04 2017-08-10 江苏恒瑞医药股份有限公司 一种曲贝替定的可注射胃肠外用药物组合物及其制备方法
CN107427512A (zh) * 2016-02-04 2017-12-01 江苏恒瑞医药股份有限公司 一种曲贝替定的可注射胃肠外用药物组合物及其制备方法
US10610529B2 (en) 2016-02-04 2020-04-07 Jiangsu Hengrui Medicine Co., Ltd. Trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and a method for manufacturing the same
TWI720117B (zh) * 2016-02-04 2021-03-01 大陸商江蘇恆瑞醫藥股份有限公司 一種曲貝替定的可注射胃腸外用藥物組成物及其製備方法
CN107427512B (zh) * 2016-02-04 2021-10-08 江苏恒瑞医药股份有限公司 一种曲贝替定的可注射胃肠外用药物组合物及其制备方法
US10538535B2 (en) 2017-04-27 2020-01-21 Pharma Mar, S.A. Antitumoral compounds
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
US11339180B2 (en) 2017-04-27 2022-05-24 Pharma Mar, S.A. Antitumoral compounds
US11713325B2 (en) 2017-04-27 2023-08-01 Pharma Mar, S.A. Antitumoral compounds
US12384800B2 (en) 2017-04-27 2025-08-12 Pharma Mar, S.A. Antitumoral compounds

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PT1176964E (pt) 2007-01-31
SK16442001A3 (sk) 2002-03-05
AU2005200180B2 (en) 2007-12-13
PL198185B1 (pl) 2008-06-30
DE60045720D1 (de) 2011-04-21
EP1702618A2 (en) 2006-09-20
IL146434A (en) 2008-03-20
SK287580B6 (sk) 2011-03-04
ES2294756T3 (es) 2008-04-01
AU777417B2 (en) 2004-10-14
EP1176964B8 (en) 2007-10-10
HU229866B1 (en) 2014-10-28
CY1107143T1 (el) 2010-07-28
AU4597500A (en) 2000-12-05
CN1679631A (zh) 2005-10-12
LU91418I2 (fr) 2008-05-13
HUS1500001I1 (hu) 2016-08-29
AU2005200180A1 (en) 2005-02-10
DK1702618T3 (da) 2008-02-25
SI1176964T1 (sl) 2007-02-28
WO2000069441A1 (en) 2000-11-23
BG65680B1 (bg) 2009-06-30
ATE500830T1 (de) 2011-03-15
PL352931A1 (en) 2003-09-22
JP2002544231A (ja) 2002-12-24
DE60036826D1 (de) 2007-11-29
MY164077A (en) 2017-11-30
BR0010531A (pt) 2002-06-04
FR08C0013I1 (enExample) 2008-05-30
EP1716853B9 (en) 2011-09-28
DE60036826T2 (de) 2008-08-28
DE60030554T2 (de) 2007-09-13
CY1105818T1 (el) 2011-02-02
DK1176964T3 (da) 2007-01-15
EP1176964A1 (en) 2002-02-06
FR08C0013I2 (fr) 2009-10-30
NO2008005I1 (no) 2008-06-09
LU91418I9 (enExample) 2019-01-02
JP5777562B2 (ja) 2015-09-09
CY2008007I2 (el) 2009-11-04
CY2008007I1 (el) 2009-11-04
NO324564B1 (no) 2007-11-19
CN100477993C (zh) 2009-04-15
NZ515423A (en) 2004-04-30
HUP0201187A2 (en) 2002-09-28
CA2373794C (en) 2005-10-11
HUP0201187A3 (en) 2002-11-28
IL146434A0 (en) 2002-07-25
NL300337I1 (nl) 2008-05-01
PT1702618E (pt) 2008-01-11
EP1716853A2 (en) 2006-11-02
BG106171A (en) 2002-06-28
AR028476A1 (es) 2003-05-14
ES2272279T3 (es) 2007-05-01
EP1716853A3 (en) 2006-11-15
CA2373794A1 (en) 2000-11-23
NO2008005I2 (enExample) 2010-09-27
NL300337I2 (nl) 2008-09-01
MXPA01011562A (es) 2002-07-30
ATE375795T1 (de) 2007-11-15
UA74782C2 (uk) 2006-02-15
JP2012149095A (ja) 2012-08-09
EP1702618B1 (en) 2007-10-17
EP1716853B1 (en) 2011-03-09
DE122008000013I1 (de) 2008-08-07
ATE338552T1 (de) 2006-09-15
DE60030554T8 (de) 2008-01-10
SI1702618T1 (sl) 2008-02-29
DK1716853T3 (da) 2011-06-27
NO20015516L (no) 2002-01-11
DE60030554D1 (de) 2006-10-19
EP1702618A3 (en) 2006-12-27
SI1716853T1 (sl) 2011-10-28
US8119638B2 (en) 2012-02-21
TR200103819T2 (tr) 2002-04-22
PT1716853E (pt) 2011-05-12
CZ301482B6 (cs) 2010-03-17
CY1112753T1 (el) 2016-02-10
US20070275942A1 (en) 2007-11-29
CZ20014081A3 (cs) 2002-11-13
AU2005200180B9 (en) 2008-05-29
KR20020019914A (ko) 2002-03-13
EP1176964B1 (en) 2006-09-06
NO20015516D0 (no) 2001-11-12

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