PT1716853E - Utiliza??o de et743 para o tratamento de cancro em seres humanos - Google Patents

Utiliza??o de et743 para o tratamento de cancro em seres humanos Download PDF

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Publication number
PT1716853E
PT1716853E PT06014005T PT06014005T PT1716853E PT 1716853 E PT1716853 E PT 1716853E PT 06014005 T PT06014005 T PT 06014005T PT 06014005 T PT06014005 T PT 06014005T PT 1716853 E PT1716853 E PT 1716853E
Authority
PT
Portugal
Prior art keywords
cancers
treatment
human body
human
Prior art date
Application number
PT06014005T
Other languages
English (en)
Inventor
George Daniel Demetri
Daniel D Von Hoff
Cecilia Guzman
Jos Jimeno
Esteban Cvltkovic
Luis L Pez L Zaro
Jean Louis Misset
Chris Twelves
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911183.3A external-priority patent/GB9911183D0/en
Priority claimed from GBGB9911346.6A external-priority patent/GB9911346D0/en
Priority claimed from GBGB9918534.0A external-priority patent/GB9918534D0/en
Priority claimed from GBGB9927005.0A external-priority patent/GB9927005D0/en
Priority claimed from GBGB9927106.6A external-priority patent/GB9927106D0/en
Priority claimed from GB0007637A external-priority patent/GB0007637D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of PT1716853E publication Critical patent/PT1716853E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PT06014005T 1999-05-13 2000-05-15 Utiliza??o de et743 para o tratamento de cancro em seres humanos PT1716853E (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9911183.3A GB9911183D0 (en) 1999-05-13 1999-05-13 Treatment of cancers
GBGB9911346.6A GB9911346D0 (en) 1999-05-14 1999-05-14 Treatment of cancers
GBGB9918534.0A GB9918534D0 (en) 1999-08-05 1999-08-05 Treatment of cancers
GBGB9927005.0A GB9927005D0 (en) 1999-11-15 1999-11-15 Treatment of cancers
GBGB9927106.6A GB9927106D0 (en) 1999-11-16 1999-11-16 Cancer treatment
GB0007637A GB0007637D0 (en) 2000-03-29 2000-03-29 Antitumour compound

Publications (1)

Publication Number Publication Date
PT1716853E true PT1716853E (pt) 2011-05-12

Family

ID=27546594

Family Applications (3)

Application Number Title Priority Date Filing Date
PT00927584T PT1176964E (pt) 1999-05-13 2000-05-15 Utilização de et743 para o tratamento de cancro
PT06014005T PT1716853E (pt) 1999-05-13 2000-05-15 Utiliza??o de et743 para o tratamento de cancro em seres humanos
PT06011784T PT1702618E (pt) 1999-05-13 2000-05-15 Utilização de et743 em terapia de combinação com dexametasona para o tratamento de cancro

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT00927584T PT1176964E (pt) 1999-05-13 2000-05-15 Utilização de et743 para o tratamento de cancro

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT06011784T PT1702618E (pt) 1999-05-13 2000-05-15 Utilização de et743 em terapia de combinação com dexametasona para o tratamento de cancro

Country Status (32)

Country Link
US (1) US8119638B2 (pt)
EP (3) EP1716853B9 (pt)
JP (2) JP2002544231A (pt)
KR (1) KR20020019914A (pt)
CN (2) CN100477993C (pt)
AR (1) AR028476A1 (pt)
AT (3) ATE375795T1 (pt)
AU (2) AU777417B2 (pt)
BG (1) BG65680B1 (pt)
BR (1) BR0010531A (pt)
CA (1) CA2373794C (pt)
CY (4) CY1105818T1 (pt)
CZ (1) CZ301482B6 (pt)
DE (4) DE60036826T2 (pt)
DK (3) DK1716853T3 (pt)
ES (2) ES2294756T3 (pt)
FR (1) FR08C0013I2 (pt)
HU (2) HU229866B1 (pt)
IL (2) IL146434A0 (pt)
LU (1) LU91418I2 (pt)
MX (1) MXPA01011562A (pt)
MY (1) MY164077A (pt)
NL (1) NL300337I2 (pt)
NO (2) NO324564B1 (pt)
NZ (1) NZ515423A (pt)
PL (1) PL198185B1 (pt)
PT (3) PT1176964E (pt)
SI (3) SI1702618T1 (pt)
SK (1) SK287580B6 (pt)
TR (1) TR200103819T2 (pt)
UA (1) UA74782C2 (pt)
WO (1) WO2000069441A1 (pt)

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MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
SK287901B6 (sk) * 2000-11-06 2012-03-02 Pharma Mar, S. A. Use of Ecteinascidin 743 for preparation of medicament for effective antitumor treatment
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
WO2003039571A1 (en) * 2001-10-19 2003-05-15 Pharmamar S.A. Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
RS50692B (sr) * 2003-11-13 2010-06-30 Pharma Mar S.A.U. Kombinacija et-743 sa prolekovima 5-fluorouracila za lečenje kancera
AU2004291037A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
CA2582452C (en) * 2004-10-26 2010-09-07 Erard Gilles Pegylated liposomal doxorubicin in combination with ecteinascidin 743
BRPI0517238B1 (pt) 2004-10-29 2021-11-09 Pharma Mar, S.A. Composições que compreendem ecteinascidina e um dissacarídeo, método para produzir um frasco que contém a referida composição e para preparar uma solução para infusão intravenosa e uso da referida solução
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
AU2007249281A1 (en) * 2006-05-12 2007-11-22 Pharma Mar, S.A. Anticancer treatments with a combination of docetaxel and ecteinascidin
EP2201141A1 (en) * 2007-10-19 2010-06-30 Pharma Mar S.A. Prognostic molecular markers for et-743 treatment
CA3011527A1 (en) 2016-02-04 2017-08-10 Jiangsu Hengrui Medicine Co., Ltd. Trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and method for manufacturing the same
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
JP2023522890A (ja) 2020-04-15 2023-06-01 エバー バリンジェクト ゲーエムベーハー トラベクテジンおよびアミノ酸を含む組成物
US20230226051A1 (en) 2022-01-20 2023-07-20 Extrovis Ag Trabectedin composition

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GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
RS50692B (sr) 2003-11-13 2010-06-30 Pharma Mar S.A.U. Kombinacija et-743 sa prolekovima 5-fluorouracila za lečenje kancera
AU2004291037A1 (en) 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
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CA2582452C (en) * 2004-10-26 2010-09-07 Erard Gilles Pegylated liposomal doxorubicin in combination with ecteinascidin 743
BRPI0517238B1 (pt) * 2004-10-29 2021-11-09 Pharma Mar, S.A. Composições que compreendem ecteinascidina e um dissacarídeo, método para produzir um frasco que contém a referida composição e para preparar uma solução para infusão intravenosa e uso da referida solução
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Also Published As

Publication number Publication date
AU2005200180B9 (en) 2008-05-29
MXPA01011562A (es) 2002-07-30
CY1107143T1 (el) 2010-07-28
DE60030554T8 (de) 2008-01-10
CY1112753T1 (el) 2016-02-10
EP1702618B1 (en) 2007-10-17
HU229866B1 (en) 2014-10-28
CA2373794A1 (en) 2000-11-23
CA2373794C (en) 2005-10-11
PL352931A1 (en) 2003-09-22
ATE338552T1 (de) 2006-09-15
KR20020019914A (ko) 2002-03-13
FR08C0013I1 (pt) 2008-05-30
US8119638B2 (en) 2012-02-21
ATE375795T1 (de) 2007-11-15
PL198185B1 (pl) 2008-06-30
AU2005200180B2 (en) 2007-12-13
IL146434A (en) 2008-03-20
DE60030554T2 (de) 2007-09-13
HUS1500001I1 (hu) 2016-08-29
BG106171A (en) 2002-06-28
NO20015516L (no) 2002-01-11
PT1176964E (pt) 2007-01-31
PT1702618E (pt) 2008-01-11
NZ515423A (en) 2004-04-30
DE60045720D1 (de) 2011-04-21
JP2002544231A (ja) 2002-12-24
IL146434A0 (en) 2002-07-25
DE60036826T2 (de) 2008-08-28
AU4597500A (en) 2000-12-05
US20070275942A1 (en) 2007-11-29
CY2008007I2 (el) 2009-11-04
EP1702618A3 (en) 2006-12-27
ES2294756T3 (es) 2008-04-01
SI1702618T1 (sl) 2008-02-29
NO324564B1 (no) 2007-11-19
EP1716853B9 (en) 2011-09-28
DE122008000013I1 (de) 2008-08-07
SI1176964T1 (sl) 2007-02-28
EP1176964B8 (en) 2007-10-10
NO20015516D0 (no) 2001-11-12
CN1360503A (zh) 2002-07-24
NL300337I1 (nl) 2008-05-01
UA74782C2 (uk) 2006-02-15
NL300337I2 (nl) 2008-09-01
CY1105818T1 (el) 2011-02-02
BG65680B1 (bg) 2009-06-30
SK287580B6 (sk) 2011-03-04
EP1176964B1 (en) 2006-09-06
EP1716853A3 (en) 2006-11-15
JP2012149095A (ja) 2012-08-09
SI1716853T1 (sl) 2011-10-28
AU2005200180A1 (en) 2005-02-10
DE60030554D1 (de) 2006-10-19
AR028476A1 (es) 2003-05-14
CN1679631A (zh) 2005-10-12
CZ20014081A3 (cs) 2002-11-13
CN100477993C (zh) 2009-04-15
WO2000069441A1 (en) 2000-11-23
HUP0201187A3 (en) 2002-11-28
DK1716853T3 (da) 2011-06-27
JP5777562B2 (ja) 2015-09-09
MY164077A (en) 2017-11-30
BR0010531A (pt) 2002-06-04
EP1176964A1 (en) 2002-02-06
EP1716853A2 (en) 2006-11-02
LU91418I9 (pt) 2019-01-02
FR08C0013I2 (fr) 2009-10-30
ATE500830T1 (de) 2011-03-15
EP1716853B1 (en) 2011-03-09
EP1702618A2 (en) 2006-09-20
DK1176964T3 (da) 2007-01-15
DE60036826D1 (de) 2007-11-29
CZ301482B6 (cs) 2010-03-17
NO2008005I2 (pt) 2010-09-27
SK16442001A3 (sk) 2002-03-05
ES2272279T3 (es) 2007-05-01
HUP0201187A2 (en) 2002-09-28
LU91418I2 (fr) 2008-05-13
CY2008007I1 (el) 2009-11-04
NO2008005I1 (no) 2008-06-09
AU777417B2 (en) 2004-10-14
TR200103819T2 (tr) 2002-04-22
DK1702618T3 (da) 2008-02-25

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