ATE500830T1 - Behandlung von krebs beim menschen mit et743 - Google Patents

Behandlung von krebs beim menschen mit et743

Info

Publication number
ATE500830T1
ATE500830T1 AT06014005T AT06014005T ATE500830T1 AT E500830 T1 ATE500830 T1 AT E500830T1 AT 06014005 T AT06014005 T AT 06014005T AT 06014005 T AT06014005 T AT 06014005T AT E500830 T1 ATE500830 T1 AT E500830T1
Authority
AT
Austria
Prior art keywords
human cancer
treating human
treating
cancer
human
Prior art date
Application number
AT06014005T
Other languages
English (en)
Inventor
Esteban Cvltkovic
George Daniel Demetri
Cecilia Guzman
Jose Jimeno
Lazaro Luis Lopez
Jean Louis Misset
Chris Clinical Twelves
Hoff Daniel D Von
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911183.3A external-priority patent/GB9911183D0/en
Priority claimed from GBGB9911346.6A external-priority patent/GB9911346D0/en
Priority claimed from GBGB9918534.0A external-priority patent/GB9918534D0/en
Priority claimed from GBGB9927005.0A external-priority patent/GB9927005D0/en
Priority claimed from GBGB9927106.6A external-priority patent/GB9927106D0/en
Priority claimed from GB0007637A external-priority patent/GB0007637D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of ATE500830T1 publication Critical patent/ATE500830T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
AT06014005T 1999-05-13 2000-05-15 Behandlung von krebs beim menschen mit et743 ATE500830T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9911183.3A GB9911183D0 (en) 1999-05-13 1999-05-13 Treatment of cancers
GBGB9911346.6A GB9911346D0 (en) 1999-05-14 1999-05-14 Treatment of cancers
GBGB9918534.0A GB9918534D0 (en) 1999-08-05 1999-08-05 Treatment of cancers
GBGB9927005.0A GB9927005D0 (en) 1999-11-15 1999-11-15 Treatment of cancers
GBGB9927106.6A GB9927106D0 (en) 1999-11-16 1999-11-16 Cancer treatment
GB0007637A GB0007637D0 (en) 2000-03-29 2000-03-29 Antitumour compound

Publications (1)

Publication Number Publication Date
ATE500830T1 true ATE500830T1 (de) 2011-03-15

Family

ID=27546594

Family Applications (3)

Application Number Title Priority Date Filing Date
AT00927584T ATE338552T1 (de) 1999-05-13 2000-05-15 Verwendungen von et743 zur behandlung von krebs
AT06011784T ATE375795T1 (de) 1999-05-13 2000-05-15 Verwendung von et743 in kombinationstherapie mit dexamethason zur behandlung von krebs
AT06014005T ATE500830T1 (de) 1999-05-13 2000-05-15 Behandlung von krebs beim menschen mit et743

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT00927584T ATE338552T1 (de) 1999-05-13 2000-05-15 Verwendungen von et743 zur behandlung von krebs
AT06011784T ATE375795T1 (de) 1999-05-13 2000-05-15 Verwendung von et743 in kombinationstherapie mit dexamethason zur behandlung von krebs

Country Status (32)

Country Link
US (1) US8119638B2 (de)
EP (3) EP1702618B1 (de)
JP (2) JP2002544231A (de)
KR (1) KR20020019914A (de)
CN (2) CN1360503A (de)
AR (1) AR028476A1 (de)
AT (3) ATE338552T1 (de)
AU (2) AU777417B2 (de)
BG (1) BG65680B1 (de)
BR (1) BR0010531A (de)
CA (1) CA2373794C (de)
CY (4) CY1105818T1 (de)
CZ (1) CZ301482B6 (de)
DE (4) DE60045720D1 (de)
DK (3) DK1176964T3 (de)
ES (2) ES2272279T3 (de)
FR (1) FR08C0013I2 (de)
HU (2) HU229866B1 (de)
IL (2) IL146434A0 (de)
LU (1) LU91418I2 (de)
MX (1) MXPA01011562A (de)
MY (1) MY164077A (de)
NL (1) NL300337I2 (de)
NO (2) NO324564B1 (de)
NZ (1) NZ515423A (de)
PL (1) PL198185B1 (de)
PT (3) PT1716853E (de)
SI (3) SI1716853T1 (de)
SK (1) SK287580B6 (de)
TR (1) TR200103819T2 (de)
UA (1) UA74782C2 (de)
WO (1) WO2000069441A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
JP4391083B2 (ja) * 2000-11-06 2009-12-24 ファルマ・マール・ソシエダード・アノニマ 効果的な抗腫瘍治療
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
HUP0401903A3 (en) * 2001-10-19 2008-07-28 Pharma Mar Improved use of et-743 in cancer thereapy
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
CA2544320A1 (en) * 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Method of treating cancer using a combination comprising et-743 and 5-fluorouracil
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (de) * 2003-11-14 2006-08-23 Pharma Mar, S.A. Kombinationstherapie mit verwendung von et-743 und paclitaxel zur behandlung von krebs
NZ552607A (en) * 2004-07-09 2009-07-31 Pharma Mar Sa Prognostic molecular markers
UA87877C2 (en) * 2004-10-26 2009-08-25 Фарма Мар С.А., Сосьедад Униперсональ Pegylated liposomal doxorubicin in combination with ecteinescidin 743
KR101188691B1 (ko) * 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
MX2008014404A (es) * 2006-05-12 2008-11-27 Pharma Mar Sa Tratamientos anticancer con combinacion de docetaxel y ecteinascidin.
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
JP2019504061A (ja) * 2016-02-04 2019-02-14 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． トラベクテジンの注射可能な胃腸外用医薬組成物及びその製造方法
TWI807411B (zh) 2017-04-27 2023-07-01 西班牙商瑪製藥股份有限公司 抗腫瘤化合物
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
ES2981253T3 (es) 2020-04-15 2024-10-08 Ever Valinject Gmbh Composición que comprende trabectedina y un aminoácido
EP3960177A1 (de) * 2020-08-26 2022-03-02 Anturec Pharmaceuticals GmbH Zusammensetzung mit ttf-ngr zur verwendung in der behandlung von weichgewebesarkom
US12303506B2 (en) 2022-01-20 2025-05-20 Extrovis Ag Trabectedin composition

Family Cites Families (48)

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Publication number Priority date Publication date Assignee Title
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
WO1987007610A2 (en) * 1986-06-09 1987-12-17 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
DE3635711A1 (de) 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
GB8805268D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
GB9101221D0 (en) * 1991-01-19 1991-02-27 Smithkline Beecham Plc Pharmaceuticals
US5721352A (en) 1991-02-19 1998-02-24 University Of Florida Research Foundation Entomopoxvirus expression system
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
US5891704A (en) * 1992-11-19 1999-04-06 Anticancer, Inc. Method to produce high levels of methioninase
JPH09503743A (ja) * 1993-05-14 1997-04-15 デポテック コーポレーション 神経学的疾患の治療方法
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
US5919816A (en) * 1994-11-14 1999-07-06 Bionumerik Pharmaceuticals, Inc. Formulations and methods of reducing toxicity of antineoplastic agents
GB9508195D0 (en) 1995-04-20 1995-06-07 Univ British Columbia Novel biologically active compounds and compositions,their use and derivation
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
EP1586322B1 (de) * 1996-11-05 2008-08-20 The Children's Medical Center Corporation Zusammensetzungen enthaltend Thalidomide und Dexamethason für die Behandlung von Krebs
IL123740A0 (en) * 1997-03-28 1998-10-30 Pfizer NK-1 receptor antagonists for the treatment of delayed emesis
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
DE19720312A1 (de) * 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
GB9801231D0 (en) * 1997-06-05 1998-03-18 Merck & Co Inc A method of treating cancer
SK285669B6 (sk) * 1998-04-06 2007-06-07 The Board Of Trustees Of The University Of Illinois Ekteinascidínová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie
US6316214B1 (en) * 1998-05-11 2001-11-13 The Board Of Trustees Of The University Of Illinois ETM-775 metabolite of ecteinascidin 743
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
ATE299146T1 (de) 2000-04-12 2005-07-15 Pharma Mar Sa Ecteinaschidin derivate mit antikrebs wirkung
US7247892B2 (en) 2000-04-24 2007-07-24 Taylor Geoff W Imaging array utilizing thyristor-based pixel elements
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
CA2418320A1 (en) 2000-08-11 2002-02-21 City Of Hope The anti-neoplastic agent et-743 inhibits trans activation by sxr
JP4391083B2 (ja) 2000-11-06 2009-12-24 ファルマ・マール・ソシエダード・アノニマ 効果的な抗腫瘍治療
EP1360337A1 (de) 2001-02-09 2003-11-12 The Regents Of The University Of California Mitglieder der ecteinascidin familie: zusammensetzungen und methoden
WO2002078678A2 (en) 2001-03-30 2002-10-10 Shire Biochem Inc. Methods of treating cancer using cyplastin combined with a dioxolane nucleoside such as troxacitabine
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
HUP0401903A3 (en) 2001-10-19 2008-07-28 Pharma Mar Improved use of et-743 in cancer thereapy
US20040019027A1 (en) 2002-04-12 2004-01-29 Barry Forman Method of treating cerebrotendinous xanthomatosis
GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
CA2544320A1 (en) 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Method of treating cancer using a combination comprising et-743 and 5-fluorouracil
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (de) 2003-11-14 2006-08-23 Pharma Mar, S.A. Kombinationstherapie mit verwendung von et-743 und paclitaxel zur behandlung von krebs
NZ552607A (en) 2004-07-09 2009-07-31 Pharma Mar Sa Prognostic molecular markers
US20080242670A2 (en) 2004-09-29 2008-10-02 Pharma Mar S.A., Sociedad Unipersonal Anti-Inflammatory Agents
UA87877C2 (en) 2004-10-26 2009-08-25 Фарма Мар С.А., Сосьедад Униперсональ Pegylated liposomal doxorubicin in combination with ecteinescidin 743
KR101188691B1 (ko) 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
DE602006020335D1 (de) 2005-11-25 2011-04-07 Pharma Mar Sa Verwendung von parp-1-hemmern
MX2008014404A (es) 2006-05-12 2008-11-27 Pharma Mar Sa Tratamientos anticancer con combinacion de docetaxel y ecteinascidin.

Also Published As

Publication number Publication date
DE122008000013I1 (de) 2008-08-07
NL300337I2 (nl) 2008-09-01
NO2008005I2 (de) 2010-09-27
EP1716853B9 (de) 2011-09-28
NZ515423A (en) 2004-04-30
SI1716853T1 (sl) 2011-10-28
CY2008007I1 (el) 2009-11-04
DE60045720D1 (de) 2011-04-21
US8119638B2 (en) 2012-02-21
HUS1500001I1 (hu) 2016-08-29
DE60030554T2 (de) 2007-09-13
CZ20014081A3 (cs) 2002-11-13
IL146434A (en) 2008-03-20
ES2272279T3 (es) 2007-05-01
CN1360503A (zh) 2002-07-24
PL352931A1 (en) 2003-09-22
SI1702618T1 (sl) 2008-02-29
CY2008007I2 (el) 2009-11-04
PL198185B1 (pl) 2008-06-30
MY164077A (en) 2017-11-30
KR20020019914A (ko) 2002-03-13
DE60030554T8 (de) 2008-01-10
AU777417B2 (en) 2004-10-14
EP1716853B1 (de) 2011-03-09
NL300337I1 (nl) 2008-05-01
DE60036826T2 (de) 2008-08-28
HU229866B1 (en) 2014-10-28
AU4597500A (en) 2000-12-05
ES2294756T3 (es) 2008-04-01
CY1105818T1 (el) 2011-02-02
CZ301482B6 (cs) 2010-03-17
DK1176964T3 (da) 2007-01-15
EP1702618A3 (de) 2006-12-27
EP1702618B1 (de) 2007-10-17
CA2373794C (en) 2005-10-11
EP1702618A2 (de) 2006-09-20
ATE375795T1 (de) 2007-11-15
PT1716853E (pt) 2011-05-12
WO2000069441A1 (en) 2000-11-23
EP1176964B8 (de) 2007-10-10
DK1702618T3 (da) 2008-02-25
PT1702618E (pt) 2008-01-11
CY1107143T1 (el) 2010-07-28
PT1176964E (pt) 2007-01-31
UA74782C2 (uk) 2006-02-15
BG106171A (en) 2002-06-28
LU91418I2 (fr) 2008-05-13
CY1112753T1 (el) 2016-02-10
SI1176964T1 (sl) 2007-02-28
NO324564B1 (no) 2007-11-19
BR0010531A (pt) 2002-06-04
ATE338552T1 (de) 2006-09-15
DE60036826D1 (de) 2007-11-29
SK287580B6 (sk) 2011-03-04
AU2005200180B9 (en) 2008-05-29
EP1716853A3 (de) 2006-11-15
BG65680B1 (bg) 2009-06-30
LU91418I9 (de) 2019-01-02
JP2002544231A (ja) 2002-12-24
FR08C0013I1 (de) 2008-05-30
DE60030554D1 (de) 2006-10-19
EP1176964A1 (de) 2002-02-06
NO2008005I1 (no) 2008-06-09
AU2005200180A1 (en) 2005-02-10
TR200103819T2 (tr) 2002-04-22
NO20015516L (no) 2002-01-11
AU2005200180B2 (en) 2007-12-13
EP1176964B1 (de) 2006-09-06
NO20015516D0 (no) 2001-11-12
CN1679631A (zh) 2005-10-12
CA2373794A1 (en) 2000-11-23
MXPA01011562A (es) 2002-07-30
JP2012149095A (ja) 2012-08-09
EP1716853A2 (de) 2006-11-02
FR08C0013I2 (fr) 2009-10-30
IL146434A0 (en) 2002-07-25
AR028476A1 (es) 2003-05-14
US20070275942A1 (en) 2007-11-29
HUP0201187A3 (en) 2002-11-28
CN100477993C (zh) 2009-04-15
DK1716853T3 (da) 2011-06-27
HUP0201187A2 (en) 2002-09-28
JP5777562B2 (ja) 2015-09-09
SK16442001A3 (sk) 2002-03-05

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