HU229866B1 - Use of et743 in combination therapy with dexamethasone for treating cancer - Google Patents
Use of et743 in combination therapy with dexamethasone for treating cancer Download PDFInfo
- Publication number
- HU229866B1 HU229866B1 HU0201187A HUP0201187A HU229866B1 HU 229866 B1 HU229866 B1 HU 229866B1 HU 0201187 A HU0201187 A HU 0201187A HU P0201187 A HUP0201187 A HU P0201187A HU 229866 B1 HU229866 B1 HU 229866B1
- Authority
- HU
- Hungary
- Prior art keywords
- patients
- patient
- treatment
- cancer
- data
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 23
- 201000011510 cancer Diseases 0.000 title claims abstract description 18
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 title claims description 9
- 229960003957 dexamethasone Drugs 0.000 title claims description 8
- 238000002648 combination therapy Methods 0.000 title claims description 5
- 238000011282 treatment Methods 0.000 claims abstract description 43
- 239000003814 drug Substances 0.000 claims abstract description 16
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 claims abstract description 14
- 230000004044 response Effects 0.000 claims description 21
- 238000001802 infusion Methods 0.000 claims description 20
- 206010039491 Sarcoma Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 10
- 238000001990 intravenous administration Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 238000002512 chemotherapy Methods 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 8
- 206010006187 Breast cancer Diseases 0.000 claims description 7
- 208000026310 Breast neoplasm Diseases 0.000 claims description 7
- 229940045799 anthracyclines and related substance Drugs 0.000 claims description 6
- 231100000419 toxicity Toxicity 0.000 claims description 5
- 230000001988 toxicity Effects 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 210000000988 bone and bone Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000001394 metastastic effect Effects 0.000 claims description 4
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 4
- 210000004872 soft tissue Anatomy 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 claims description 4
- 206010027476 Metastases Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 238000002474 experimental method Methods 0.000 claims description 3
- 201000001441 melanoma Diseases 0.000 claims description 3
- 230000002441 reversible effect Effects 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 2
- 230000002349 favourable effect Effects 0.000 claims description 2
- 230000006872 improvement Effects 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 201000008482 osteoarthritis Diseases 0.000 claims description 2
- 206010010071 Coma Diseases 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 2
- 206010003549 asthenia Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 230000006641 stabilisation Effects 0.000 claims 2
- 238000011105 stabilization Methods 0.000 claims 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 241000543375 Sideroxylon Species 0.000 claims 1
- 102000003929 Transaminases Human genes 0.000 claims 1
- 108090000340 Transaminases Proteins 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 239000002111 antiemetic agent Substances 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000004224 pleura Anatomy 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 230000009278 visceral effect Effects 0.000 claims 1
- 239000002759 woven fabric Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000002246 antineoplastic agent Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 3
- 206010025323 Lymphomas Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 208000021712 Soft tissue sarcoma Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 231100000371 dose-limiting toxicity Toxicity 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 208000037819 metastatic cancer Diseases 0.000 description 3
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 239000003978 infusion fluid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 208000037821 progressive disease Diseases 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229960000977 trabectedin Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 241000251557 Ascidiacea Species 0.000 description 1
- 206010065553 Bone marrow failure Diseases 0.000 description 1
- 201000011057 Breast sarcoma Diseases 0.000 description 1
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 1
- 241001432959 Chernes Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 101000690268 Homo sapiens Proline-rich AKT1 substrate 1 Proteins 0.000 description 1
- 208000006552 Lewis Lung Carcinoma Diseases 0.000 description 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940034982 antineoplastic agent Drugs 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 206010006007 bone sarcoma Diseases 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 description 1
- 231100000026 common toxicity Toxicity 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 210000004262 dental pulp cavity Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 102000055075 human AKT1S1 Human genes 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 235000015927 pasta Nutrition 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
- 230000008791 toxic response Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUS1500001C HUS1500001I1 (hu) | 1999-05-13 | 2015-01-06 | ET743 alkalmazása kombinációs terápiában dexametazollal rákbetegség kezelésére |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9911183.3A GB9911183D0 (en) | 1999-05-13 | 1999-05-13 | Treatment of cancers |
| GBGB9911346.6A GB9911346D0 (en) | 1999-05-14 | 1999-05-14 | Treatment of cancers |
| GBGB9918534.0A GB9918534D0 (en) | 1999-08-05 | 1999-08-05 | Treatment of cancers |
| GBGB9927005.0A GB9927005D0 (en) | 1999-11-15 | 1999-11-15 | Treatment of cancers |
| GBGB9927106.6A GB9927106D0 (en) | 1999-11-16 | 1999-11-16 | Cancer treatment |
| GB0007637A GB0007637D0 (en) | 2000-03-29 | 2000-03-29 | Antitumour compound |
| PCT/GB2000/001857 WO2000069441A1 (en) | 1999-05-13 | 2000-05-15 | Compositions and uses of et743 for treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0201187A2 HUP0201187A2 (en) | 2002-09-28 |
| HUP0201187A3 HUP0201187A3 (en) | 2002-11-28 |
| HU229866B1 true HU229866B1 (en) | 2014-10-28 |
Family
ID=27546594
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0201187A HU229866B1 (en) | 1999-05-13 | 2000-05-15 | Use of et743 in combination therapy with dexamethasone for treating cancer |
| HUS1500001C HUS1500001I1 (hu) | 1999-05-13 | 2015-01-06 | ET743 alkalmazása kombinációs terápiában dexametazollal rákbetegség kezelésére |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUS1500001C HUS1500001I1 (hu) | 1999-05-13 | 2015-01-06 | ET743 alkalmazása kombinációs terápiában dexametazollal rákbetegség kezelésére |
Country Status (32)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| US20040108086A1 (en) * | 2000-11-06 | 2004-06-10 | Naoto Takahashi | Effective antitumor treatments |
| GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| KR20050038578A (ko) * | 2001-10-19 | 2005-04-27 | 파르마 마르, 에스.에이. | 항종양성 화합물의 암치료에 있어서의 향상된 용도 |
| GB0202544D0 (en) | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| SI1689404T1 (sl) * | 2003-11-13 | 2009-02-28 | Pharma Mar Sau | Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka |
| GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| US20080255132A1 (en) * | 2003-11-14 | 2008-10-16 | Eric Rowinsky | Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer |
| US20080293725A1 (en) * | 2004-07-09 | 2008-11-27 | Rafael Rosell Costa | Prognostic Molecular Markers |
| HRP20090345T1 (en) * | 2004-10-26 | 2009-08-31 | Pharma Mar S.A. | Pegylated liposomal doxorubicin in combination with ecteinescidin 743 |
| RS50510B (sr) * | 2004-10-29 | 2010-03-02 | Pharma Mar S.A., Sociedad Unipersonal | Formulacije koje sadrže ekteinascidin i disaharid |
| GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| WO2007134203A2 (en) * | 2006-05-12 | 2007-11-22 | Pharma Mar, S.A. | Anticancer treatments with a combination of docetaxel and ecteinascidin |
| US20100267732A1 (en) * | 2007-10-19 | 2010-10-21 | Pharma Mar, S.A. | Prognostic Molecular Markers for ET-743 Treatment |
| JP2019504061A (ja) * | 2016-02-04 | 2019-02-14 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | トラベクテジンの注射可能な胃腸外用医薬組成物及びその製造方法 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| WO2020239478A1 (en) | 2019-05-28 | 2020-12-03 | Pharma Mar, S.A. | Trabectedin for treating sarcomas based on genomic markers |
| CN112574234B (zh) * | 2019-09-27 | 2022-05-24 | 江苏恒瑞医药股份有限公司 | 一种海鞘素衍生物的制备方法 |
| PL4041194T3 (pl) | 2020-04-15 | 2024-09-09 | Ever Valinject Gmbh | Kompozycja zawierająca trabektedynę i aminokwas |
| EP3960177A1 (en) * | 2020-08-26 | 2022-03-02 | Anturec Pharmaceuticals GmbH | Composition comprising ttf-ngr for use in treating soft-tissue sarcoma |
| US12303506B2 (en) | 2022-01-20 | 2025-05-20 | Extrovis Ag | Trabectedin composition |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| EP0309477B1 (en) * | 1986-06-09 | 1991-11-06 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759a, 759b and 770 |
| US5149804A (en) | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| DE3635711A1 (de) | 1986-10-21 | 1988-04-28 | Knoll Ag | 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung |
| GB8805268D0 (en) * | 1988-03-04 | 1988-04-07 | Glaxo Group Ltd | Medicaments |
| GB9101221D0 (en) * | 1991-01-19 | 1991-02-27 | Smithkline Beecham Plc | Pharmaceuticals |
| US5721352A (en) | 1991-02-19 | 1998-02-24 | University Of Florida Research Foundation | Entomopoxvirus expression system |
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US5891704A (en) * | 1992-11-19 | 1999-04-06 | Anticancer, Inc. | Method to produce high levels of methioninase |
| JPH09503743A (ja) * | 1993-05-14 | 1997-04-15 | デポテック コーポレーション | 神経学的疾患の治療方法 |
| US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US20040059112A1 (en) | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| ES2313154T3 (es) * | 1996-11-05 | 2009-03-01 | The Children's Medical Center Corporation | Composiciones que comprenden talodimina y dexametasona para el tratamiento de cancer. |
| IL123740A0 (en) * | 1997-03-28 | 1998-10-30 | Pfizer | NK-1 receptor antagonists for the treatment of delayed emesis |
| US5985876A (en) * | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| DE19720312A1 (de) * | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
| GB9801231D0 (en) * | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
| CZ301083B6 (cs) | 1998-04-06 | 2009-11-04 | The Board Of Trustees Of The University Of Illinois | Ekteinascidinová sloucenina, farmaceutický prostredek ji obsahující a její použití |
| CN1195514C (zh) * | 1998-05-11 | 2005-04-06 | 法马马有限公司 | 海鞘素 743的代谢物 |
| US6124292A (en) | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| DE60111845T2 (de) | 2000-04-12 | 2006-04-27 | Pharma Mar, S.A., Tres Cantos | Ecteinaschidin derivate mit antikrebs wirkung |
| US7247892B2 (en) | 2000-04-24 | 2007-07-24 | Taylor Geoff W | Imaging array utilizing thyristor-based pixel elements |
| MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| US7420051B2 (en) | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| CA2418320A1 (en) | 2000-08-11 | 2002-02-21 | City Of Hope | The anti-neoplastic agent et-743 inhibits trans activation by sxr |
| US20040108086A1 (en) | 2000-11-06 | 2004-06-10 | Naoto Takahashi | Effective antitumor treatments |
| EP1360337A1 (en) | 2001-02-09 | 2003-11-12 | The Regents Of The University Of California | Ecteinascidin family compounds: compositions and methods |
| WO2002078678A2 (en) | 2001-03-30 | 2002-10-10 | Shire Biochem Inc. | Methods of treating cancer using cyplastin combined with a dioxolane nucleoside such as troxacitabine |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| KR20050038578A (ko) | 2001-10-19 | 2005-04-27 | 파르마 마르, 에스.에이. | 항종양성 화합물의 암치료에 있어서의 향상된 용도 |
| US20040019027A1 (en) | 2002-04-12 | 2004-01-29 | Barry Forman | Method of treating cerebrotendinous xanthomatosis |
| GB0312407D0 (en) | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| GB0324201D0 (en) | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| SI1689404T1 (sl) | 2003-11-13 | 2009-02-28 | Pharma Mar Sau | Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka |
| GB0326486D0 (en) | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| US20080255132A1 (en) | 2003-11-14 | 2008-10-16 | Eric Rowinsky | Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer |
| US20080293725A1 (en) | 2004-07-09 | 2008-11-27 | Rafael Rosell Costa | Prognostic Molecular Markers |
| JP2008514688A (ja) | 2004-09-29 | 2008-05-08 | ファルマ・マル・エス・アー， ソシエダッド・ユニペルソナル | 抗炎症剤としてのエクテイナシジン化合物 |
| HRP20090345T1 (en) | 2004-10-26 | 2009-08-31 | Pharma Mar S.A. | Pegylated liposomal doxorubicin in combination with ecteinescidin 743 |
| RS50510B (sr) | 2004-10-29 | 2010-03-02 | Pharma Mar S.A., Sociedad Unipersonal | Formulacije koje sadrže ekteinascidin i disaharid |
| WO2007062413A2 (en) | 2005-11-25 | 2007-05-31 | University Of Medicine And Dentistry Of New Jersey | Use of parp-1 inhibitors |
| WO2007134203A2 (en) | 2006-05-12 | 2007-11-22 | Pharma Mar, S.A. | Anticancer treatments with a combination of docetaxel and ecteinascidin |
-
2000
- 2000-05-13 MY MYPI20002107A patent/MY164077A/en unknown
- 2000-05-15 PT PT00927584T patent/PT1176964E/pt unknown
- 2000-05-15 AT AT06014005T patent/ATE500830T1/de active
- 2000-05-15 PT PT06011784T patent/PT1702618E/pt unknown
- 2000-05-15 HU HU0201187A patent/HU229866B1/hu active Protection Beyond IP Right Term
- 2000-05-15 AR ARP000102321A patent/AR028476A1/es not_active Application Discontinuation
- 2000-05-15 BR BR0010531-7A patent/BR0010531A/pt not_active Application Discontinuation
- 2000-05-15 AT AT00927584T patent/ATE338552T1/de active
- 2000-05-15 SI SI200030905T patent/SI1176964T1/sl unknown
- 2000-05-15 IL IL14643400A patent/IL146434A0/xx active IP Right Grant
- 2000-05-15 KR KR1020017014479A patent/KR20020019914A/ko not_active Ceased
- 2000-05-15 ES ES06011784T patent/ES2294756T3/es not_active Expired - Lifetime
- 2000-05-15 DK DK06014005.0T patent/DK1716853T3/da active
- 2000-05-15 PL PL352931A patent/PL198185B1/pl unknown
- 2000-05-15 AT AT06011784T patent/ATE375795T1/de active
- 2000-05-15 SI SI200030977T patent/SI1702618T1/sl unknown
- 2000-05-15 WO PCT/GB2000/001857 patent/WO2000069441A1/en not_active Ceased
- 2000-05-15 DE DE122008000013C patent/DE122008000013I1/de active Pending
- 2000-05-15 TR TR2001/03819T patent/TR200103819T2/xx unknown
- 2000-05-15 SK SK1644-2001A patent/SK287580B6/sk not_active IP Right Cessation
- 2000-05-15 CN CNB2005100091622A patent/CN100477993C/zh not_active Expired - Lifetime
- 2000-05-15 ES ES00927584T patent/ES2272279T3/es not_active Expired - Lifetime
- 2000-05-15 CA CA002373794A patent/CA2373794C/en not_active Expired - Lifetime
- 2000-05-15 EP EP06014005A patent/EP1716853B9/en not_active Expired - Lifetime
- 2000-05-15 PT PT06014005T patent/PT1716853E/pt unknown
- 2000-05-15 DK DK06011784T patent/DK1702618T3/da active
- 2000-05-15 EP EP06011784A patent/EP1702618B1/en not_active Expired - Lifetime
- 2000-05-15 EP EP00927584A patent/EP1176964B8/en not_active Expired - Lifetime
- 2000-05-15 SI SI200031067T patent/SI1716853T1/sl unknown
- 2000-05-15 NZ NZ515423A patent/NZ515423A/en not_active IP Right Cessation
- 2000-05-15 DE DE60045720T patent/DE60045720D1/de not_active Expired - Lifetime
- 2000-05-15 AU AU45975/00A patent/AU777417B2/en not_active Expired
- 2000-05-15 DE DE60036826T patent/DE60036826T2/de not_active Expired - Lifetime
- 2000-05-15 UA UA2001128559A patent/UA74782C2/uk unknown
- 2000-05-15 CZ CZ20014081A patent/CZ301482B6/cs not_active IP Right Cessation
- 2000-05-15 CN CN00809976A patent/CN1360503A/zh active Pending
- 2000-05-15 MX MXPA01011562A patent/MXPA01011562A/es active IP Right Grant
- 2000-05-15 DE DE60030554T patent/DE60030554T8/de active Active
- 2000-05-15 DK DK00927584T patent/DK1176964T3/da active
- 2000-05-15 JP JP2000617900A patent/JP2002544231A/ja not_active Withdrawn
-
2001
- 2001-11-11 IL IL146434A patent/IL146434A/en active Protection Beyond IP Right Term
- 2001-11-12 NO NO20015516A patent/NO324564B1/no not_active IP Right Cessation
- 2001-12-03 BG BG106171A patent/BG65680B1/bg unknown
-
2005
- 2005-01-14 AU AU2005200180A patent/AU2005200180B9/en not_active Expired
-
2006
- 2006-11-30 CY CY20061101734T patent/CY1105818T1/el unknown
-
2007
- 2007-06-28 US US11/769,873 patent/US8119638B2/en not_active Expired - Fee Related
-
2008
- 2008-01-16 CY CY20081100059T patent/CY1107143T1/el unknown
- 2008-02-22 NL NL300337C patent/NL300337I2/nl unknown
- 2008-03-10 LU LU91418C patent/LU91418I2/fr unknown
- 2008-04-07 CY CY200800007C patent/CY2008007I2/el unknown
- 2008-04-16 FR FR08C0013C patent/FR08C0013I2/fr active Active
- 2008-05-16 NO NO2008005C patent/NO2008005I1/no not_active IP Right Cessation
-
2011
- 2011-06-08 CY CY20111100545T patent/CY1112753T1/el unknown
-
2012
- 2012-05-02 JP JP2012105249A patent/JP5777562B2/ja not_active Expired - Lifetime
-
2015
- 2015-01-06 HU HUS1500001C patent/HUS1500001I1/hu unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU229866B1 (en) | Use of et743 in combination therapy with dexamethasone for treating cancer | |
| ES2124257T4 (es) | Composición, método y equipo para la estimulación de la actividad antitumoral y para el tratamiento de tumores. | |
| JP2006522026A (ja) | カンプトセシンとフルオロピリミジンとを組み合わせた組成物 | |
| JP2013543879A (ja) | 急性骨髄性白血病を治療するための単独またはシタラビンとの組合せにおけるボラセルチブ | |
| JP2023505289A (ja) | Ｅｒｋ阻害剤としてのスピロ系化合物およびその使用 | |
| AU618997B2 (en) | Pharmaceutical compositions with anti-cancer activity and method for the treatment of cancer | |
| US20240058352A1 (en) | Combination therapies for the treatment of cancer | |
| EP3129057B1 (en) | Glycolipids and pharmaceutical compositions thereof for use in therapy | |
| JP2001509479A (ja) | ヌクレオチド含有組成物 | |
| JP2002534390A (ja) | 癌治療におけるアデノシンアゴニスト類の使用 | |
| US20110009383A1 (en) | Method of treating mixed lineage leukemia gene-rearranged acute lymphoblastic leukemias | |
| JP7357386B2 (ja) | 化合物又はその薬学的に許容される塩、二量体又は三量体のがん治療用医薬品の調製における応用 | |
| TWI433678B (zh) | 用以治療白血病之新治療用途 | |
| ES3010436T3 (en) | Therapeutic agent containing pyrazolo[3,4-d]pyrimidine compound as active ingredient | |
| Mouridsen et al. | Mitoxantrone as first-line chemotherapy in advanced breast cancer: results of a collaborative European study | |
| JPWO1992004028A1 (ja) | 抗腫瘍効果増強剤及び抗腫瘍剤 | |
| US20030125305A1 (en) | Methods of treating leukemia | |
| AU2002336864A1 (en) | Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs | |
| SHIMIZU et al. | Phase II study of oral administration of 5′-deoxy-5-fluorouridine (5′-DFUR) for solid tumors | |
| RU2471486C2 (ru) | Противоопухолевое средство для непрерывного внутривенного введения, содержащее цитидиновое производное | |
| RU2266734C2 (ru) | Композиции и применение ет743 для лечения злокачественных опухолей | |
| Oster et al. | Cytosine arabinoside and cisplatin for advanced breast cancer. A phase II study of the Cancer and Leukemia Group B | |
| TW200804373A (en) | Crystalline salts of 7-4[4-(4-naphthalen-1-yl-piperazin-1-yl)-butoxy]-3,4-dihydro-1H-[1,8]naphthyridin-2-one | |
| JPS6337767B2 (enExample) | ||
| RU2482855C2 (ru) | Противоопухолевое средство, включающее производное цитидина и карбоплатин |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Change of name, address |
Owner name: PHARMA MAR, S.A., ES Free format text: FORMER OWNER(S): PHARMA MAR, S.A., ES |
|
| AA1S | Information on application for a supplementary protection certificate |
Free format text: PRODUCT NAME: TRABECTEDIN; REG. NO/DATE: EU/1/07/417 20070917 Spc suppl protection certif: S1500001 Filing date: 20150106 Expiry date: 20200515 |
|
| FG4S | Grant of supplementary protection certificate |
Free format text: PRODUCT NAME: TRABECTEDIN; REGISTRATION NO/DATE: EU/1/07/417/001-002 20070920 Spc suppl protection certif: S1500001 Filing date: 20150106 Expiry date: 20200515 Extension date: 20220920 |