HU229866B1 - Use of et743 in combination therapy with dexamethasone for treating cancer - Google Patents

Use of et743 in combination therapy with dexamethasone for treating cancer Download PDF

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Publication number
HU229866B1
HU229866B1 HU0201187A HUP0201187A HU229866B1 HU 229866 B1 HU229866 B1 HU 229866B1 HU 0201187 A HU0201187 A HU 0201187A HU P0201187 A HUP0201187 A HU P0201187A HU 229866 B1 HU229866 B1 HU 229866B1
Authority
HU
Hungary
Prior art keywords
patients
patient
treatment
cancer
data
Prior art date
Application number
HU0201187A
Other languages
English (en)
Hungarian (hu)
Inventor
Angela Edinburgh Bowman
Esteban Cvitkovic
George Daniel Boston Demetri
Cecilia Guzman
Jose Jimeno
Lazaro Luis Lopez
Jean Louis Misset
C Glasgow Twelves
Hoff Daniel D Tucson Von
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911183.3A external-priority patent/GB9911183D0/en
Priority claimed from GBGB9911346.6A external-priority patent/GB9911346D0/en
Priority claimed from GBGB9918534.0A external-priority patent/GB9918534D0/en
Priority claimed from GBGB9927005.0A external-priority patent/GB9927005D0/en
Priority claimed from GBGB9927106.6A external-priority patent/GB9927106D0/en
Priority claimed from GB0007637A external-priority patent/GB0007637D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of HUP0201187A2 publication Critical patent/HUP0201187A2/hu
Publication of HUP0201187A3 publication Critical patent/HUP0201187A3/hu
Publication of HU229866B1 publication Critical patent/HU229866B1/hu
Priority to HUS1500001C priority Critical patent/HUS1500001I1/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU0201187A 1999-05-13 2000-05-15 Use of et743 in combination therapy with dexamethasone for treating cancer HU229866B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HUS1500001C HUS1500001I1 (hu) 1999-05-13 2015-01-06 ET743 alkalmazása kombinációs terápiában dexametazollal rákbetegség kezelésére

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9911183.3A GB9911183D0 (en) 1999-05-13 1999-05-13 Treatment of cancers
GBGB9911346.6A GB9911346D0 (en) 1999-05-14 1999-05-14 Treatment of cancers
GBGB9918534.0A GB9918534D0 (en) 1999-08-05 1999-08-05 Treatment of cancers
GBGB9927005.0A GB9927005D0 (en) 1999-11-15 1999-11-15 Treatment of cancers
GBGB9927106.6A GB9927106D0 (en) 1999-11-16 1999-11-16 Cancer treatment
GB0007637A GB0007637D0 (en) 2000-03-29 2000-03-29 Antitumour compound
PCT/GB2000/001857 WO2000069441A1 (en) 1999-05-13 2000-05-15 Compositions and uses of et743 for treating cancer

Publications (3)

Publication Number Publication Date
HUP0201187A2 HUP0201187A2 (en) 2002-09-28
HUP0201187A3 HUP0201187A3 (en) 2002-11-28
HU229866B1 true HU229866B1 (en) 2014-10-28

Family

ID=27546594

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0201187A HU229866B1 (en) 1999-05-13 2000-05-15 Use of et743 in combination therapy with dexamethasone for treating cancer
HUS1500001C HUS1500001I1 (hu) 1999-05-13 2015-01-06 ET743 alkalmazása kombinációs terápiában dexametazollal rákbetegség kezelésére

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUS1500001C HUS1500001I1 (hu) 1999-05-13 2015-01-06 ET743 alkalmazása kombinációs terápiában dexametazollal rákbetegség kezelésére

Country Status (32)

Country Link
US (1) US8119638B2 (enExample)
EP (3) EP1716853B9 (enExample)
JP (2) JP2002544231A (enExample)
KR (1) KR20020019914A (enExample)
CN (2) CN1360503A (enExample)
AR (1) AR028476A1 (enExample)
AT (3) ATE500830T1 (enExample)
AU (2) AU777417B2 (enExample)
BG (1) BG65680B1 (enExample)
BR (1) BR0010531A (enExample)
CA (1) CA2373794C (enExample)
CY (4) CY1105818T1 (enExample)
CZ (1) CZ301482B6 (enExample)
DE (4) DE122008000013I1 (enExample)
DK (3) DK1176964T3 (enExample)
ES (2) ES2272279T3 (enExample)
FR (1) FR08C0013I2 (enExample)
HU (2) HU229866B1 (enExample)
IL (2) IL146434A0 (enExample)
LU (1) LU91418I2 (enExample)
MX (1) MXPA01011562A (enExample)
MY (1) MY164077A (enExample)
NL (1) NL300337I2 (enExample)
NO (2) NO324564B1 (enExample)
NZ (1) NZ515423A (enExample)
PL (1) PL198185B1 (enExample)
PT (3) PT1176964E (enExample)
SI (3) SI1176964T1 (enExample)
SK (1) SK287580B6 (enExample)
TR (1) TR200103819T2 (enExample)
UA (1) UA74782C2 (enExample)
WO (1) WO2000069441A1 (enExample)

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MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
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GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
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GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
SI1689404T1 (sl) * 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
CN1897949A (zh) * 2003-11-14 2007-01-17 马尔药品公司 包含使用et-743和紫杉醇来治疗癌症的联合疗法
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
AU2005261860A1 (en) * 2004-07-09 2006-01-19 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of BRCA1
RU2359700C2 (ru) * 2004-10-26 2009-06-27 Фарма Мар С.А., Сосьедад Униперсональ Пегилированный липосомальный доксорубицин в комбинации с эктеинасцидином 743 (ecteinescidin 743)
KR101188691B1 (ko) * 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
MX2008014404A (es) * 2006-05-12 2008-11-27 Pharma Mar Sa Tratamientos anticancer con combinacion de docetaxel y ecteinascidin.
CA2703026A1 (en) * 2007-10-19 2009-04-23 Rafael Rosell Costa Prognostic molecular markers for et-743 treatment
AU2017215603A1 (en) * 2016-02-04 2018-08-09 Jiangsu Hengrui Medicine Co., Ltd. Trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and method for manufacturing the same
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
BR112022020812A2 (pt) 2020-04-15 2022-11-29 Ever Valinject Gmbh Composição farmacêutica compreendendo trabectedina e um aminoacido, formulação liofilizada e uma solução de injeção intravenosa compreendendo dita composição
EP3960177A1 (en) * 2020-08-26 2022-03-02 Anturec Pharmaceuticals GmbH Composition comprising ttf-ngr for use in treating soft-tissue sarcoma
AU2022277799A1 (en) * 2021-05-19 2023-12-21 Pharma Mar, S.A. Dosage regimens for ecubectedin
US12303506B2 (en) 2022-01-20 2025-05-20 Extrovis Ag Trabectedin composition

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GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
SI1689404T1 (sl) 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CN1897949A (zh) 2003-11-14 2007-01-17 马尔药品公司 包含使用et-743和紫杉醇来治疗癌症的联合疗法
AU2005261860A1 (en) 2004-07-09 2006-01-19 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of BRCA1
AU2005288696A1 (en) 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
RU2359700C2 (ru) 2004-10-26 2009-06-27 Фарма Мар С.А., Сосьедад Униперсональ Пегилированный липосомальный доксорубицин в комбинации с эктеинасцидином 743 (ecteinescidin 743)
KR101188691B1 (ko) 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
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MX2008014404A (es) 2006-05-12 2008-11-27 Pharma Mar Sa Tratamientos anticancer con combinacion de docetaxel y ecteinascidin.

Also Published As

Publication number Publication date
DE60030554D1 (de) 2006-10-19
DK1176964T3 (da) 2007-01-15
DE60036826D1 (de) 2007-11-29
SI1716853T1 (sl) 2011-10-28
MXPA01011562A (es) 2002-07-30
DE60036826T2 (de) 2008-08-28
DE60030554T2 (de) 2007-09-13
BG106171A (en) 2002-06-28
DK1716853T3 (da) 2011-06-27
CY2008007I2 (el) 2009-11-04
SI1702618T1 (sl) 2008-02-29
AU2005200180B9 (en) 2008-05-29
EP1176964A1 (en) 2002-02-06
SI1176964T1 (sl) 2007-02-28
LU91418I9 (enExample) 2019-01-02
CY1105818T1 (el) 2011-02-02
UA74782C2 (uk) 2006-02-15
IL146434A0 (en) 2002-07-25
ATE375795T1 (de) 2007-11-15
NO20015516D0 (no) 2001-11-12
AU777417B2 (en) 2004-10-14
US20070275942A1 (en) 2007-11-29
MY164077A (en) 2017-11-30
CZ20014081A3 (cs) 2002-11-13
FR08C0013I1 (enExample) 2008-05-30
EP1176964B1 (en) 2006-09-06
FR08C0013I2 (fr) 2009-10-30
CY1112753T1 (el) 2016-02-10
BR0010531A (pt) 2002-06-04
EP1716853A2 (en) 2006-11-02
DE60045720D1 (de) 2011-04-21
DK1702618T3 (da) 2008-02-25
DE60030554T8 (de) 2008-01-10
IL146434A (en) 2008-03-20
CY1107143T1 (el) 2010-07-28
NL300337I1 (nl) 2008-05-01
NL300337I2 (nl) 2008-09-01
SK287580B6 (sk) 2011-03-04
ATE500830T1 (de) 2011-03-15
JP5777562B2 (ja) 2015-09-09
EP1716853B1 (en) 2011-03-09
AU4597500A (en) 2000-12-05
ES2272279T3 (es) 2007-05-01
EP1716853A3 (en) 2006-11-15
KR20020019914A (ko) 2002-03-13
AR028476A1 (es) 2003-05-14
EP1716853B9 (en) 2011-09-28
AU2005200180A1 (en) 2005-02-10
DE122008000013I1 (de) 2008-08-07
CY2008007I1 (el) 2009-11-04
CA2373794C (en) 2005-10-11
EP1702618B1 (en) 2007-10-17
AU2005200180B2 (en) 2007-12-13
JP2012149095A (ja) 2012-08-09
LU91418I2 (fr) 2008-05-13
PT1716853E (pt) 2011-05-12
ATE338552T1 (de) 2006-09-15
WO2000069441A1 (en) 2000-11-23
US8119638B2 (en) 2012-02-21
HUP0201187A2 (en) 2002-09-28
CN1360503A (zh) 2002-07-24
CN1679631A (zh) 2005-10-12
PL198185B1 (pl) 2008-06-30
JP2002544231A (ja) 2002-12-24
CN100477993C (zh) 2009-04-15
NO20015516L (no) 2002-01-11
NZ515423A (en) 2004-04-30
CA2373794A1 (en) 2000-11-23
PT1702618E (pt) 2008-01-11
PL352931A1 (en) 2003-09-22
TR200103819T2 (tr) 2002-04-22
CZ301482B6 (cs) 2010-03-17
HUP0201187A3 (en) 2002-11-28
BG65680B1 (bg) 2009-06-30
NO2008005I1 (no) 2008-06-09
ES2294756T3 (es) 2008-04-01
HUS1500001I1 (hu) 2016-08-29
SK16442001A3 (sk) 2002-03-05
EP1702618A2 (en) 2006-09-20
PT1176964E (pt) 2007-01-31
EP1176964B8 (en) 2007-10-10
EP1702618A3 (en) 2006-12-27
NO2008005I2 (enExample) 2010-09-27
NO324564B1 (no) 2007-11-19

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