CZ301482B6 - Prostredky a použití ET743 k lécbe rakoviny - Google Patents

Prostredky a použití ET743 k lécbe rakoviny Download PDF

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Publication number
CZ301482B6
CZ301482B6 CZ20014081A CZ20014081A CZ301482B6 CZ 301482 B6 CZ301482 B6 CZ 301482B6 CZ 20014081 A CZ20014081 A CZ 20014081A CZ 20014081 A CZ20014081 A CZ 20014081A CZ 301482 B6 CZ301482 B6 CZ 301482B6
Authority
CZ
Czechia
Prior art keywords
cancer
use according
intravenous infusion
dosed
surface area
Prior art date
Application number
CZ20014081A
Other languages
Czech (cs)
English (en)
Other versions
CZ20014081A3 (cs
Inventor
Louis Misset@Jean
Cvitkovic@Esteban
Daniel Demetri@George
Guzman@Cecilia
Jimeno@José
Twelves@Chris
Hoff@Daniel D. Von
Lázaro@Luis López
Original Assignee
Pharma Mar, S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911183.3A external-priority patent/GB9911183D0/en
Priority claimed from GBGB9911346.6A external-priority patent/GB9911346D0/en
Priority claimed from GBGB9918534.0A external-priority patent/GB9918534D0/en
Priority claimed from GBGB9927005.0A external-priority patent/GB9927005D0/en
Priority claimed from GBGB9927106.6A external-priority patent/GB9927106D0/en
Priority claimed from GB0007637A external-priority patent/GB0007637D0/en
Application filed by Pharma Mar, S. A. filed Critical Pharma Mar, S. A.
Publication of CZ20014081A3 publication Critical patent/CZ20014081A3/cs
Publication of CZ301482B6 publication Critical patent/CZ301482B6/cs

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CZ20014081A 1999-05-13 2000-05-15 Prostredky a použití ET743 k lécbe rakoviny CZ301482B6 (cs)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9911183.3A GB9911183D0 (en) 1999-05-13 1999-05-13 Treatment of cancers
GBGB9911346.6A GB9911346D0 (en) 1999-05-14 1999-05-14 Treatment of cancers
GBGB9918534.0A GB9918534D0 (en) 1999-08-05 1999-08-05 Treatment of cancers
GBGB9927005.0A GB9927005D0 (en) 1999-11-15 1999-11-15 Treatment of cancers
GBGB9927106.6A GB9927106D0 (en) 1999-11-16 1999-11-16 Cancer treatment
GB0007637A GB0007637D0 (en) 2000-03-29 2000-03-29 Antitumour compound

Publications (2)

Publication Number Publication Date
CZ20014081A3 CZ20014081A3 (cs) 2002-11-13
CZ301482B6 true CZ301482B6 (cs) 2010-03-17

Family

ID=27546594

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20014081A CZ301482B6 (cs) 1999-05-13 2000-05-15 Prostredky a použití ET743 k lécbe rakoviny

Country Status (32)

Country Link
US (1) US8119638B2 (enExample)
EP (3) EP1716853B9 (enExample)
JP (2) JP2002544231A (enExample)
KR (1) KR20020019914A (enExample)
CN (2) CN100477993C (enExample)
AR (1) AR028476A1 (enExample)
AT (3) ATE500830T1 (enExample)
AU (2) AU777417B2 (enExample)
BG (1) BG65680B1 (enExample)
BR (1) BR0010531A (enExample)
CA (1) CA2373794C (enExample)
CY (4) CY1105818T1 (enExample)
CZ (1) CZ301482B6 (enExample)
DE (4) DE122008000013I1 (enExample)
DK (3) DK1716853T3 (enExample)
ES (2) ES2294756T3 (enExample)
FR (1) FR08C0013I2 (enExample)
HU (2) HU229866B1 (enExample)
IL (2) IL146434A0 (enExample)
LU (1) LU91418I2 (enExample)
MX (1) MXPA01011562A (enExample)
MY (1) MY164077A (enExample)
NL (1) NL300337I2 (enExample)
NO (2) NO324564B1 (enExample)
NZ (1) NZ515423A (enExample)
PL (1) PL198185B1 (enExample)
PT (3) PT1176964E (enExample)
SI (3) SI1176964T1 (enExample)
SK (1) SK287580B6 (enExample)
TR (1) TR200103819T2 (enExample)
UA (1) UA74782C2 (enExample)
WO (1) WO2000069441A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US20040108086A1 (en) * 2000-11-06 2004-06-10 Naoto Takahashi Effective antitumor treatments
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
KR20050038578A (ko) * 2001-10-19 2005-04-27 파르마 마르, 에스.에이. 항종양성 화합물의 암치료에 있어서의 향상된 용도
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
SI1689404T1 (sl) * 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080255132A1 (en) * 2003-11-14 2008-10-16 Eric Rowinsky Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
HRP20090345T1 (en) * 2004-10-26 2009-08-31 Pharma Mar S.A. Pegylated liposomal doxorubicin in combination with ecteinescidin 743
RS50510B (sr) * 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
WO2007134203A2 (en) * 2006-05-12 2007-11-22 Pharma Mar, S.A. Anticancer treatments with a combination of docetaxel and ecteinascidin
US20100267732A1 (en) * 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
JP2019504061A (ja) * 2016-02-04 2019-02-14 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. トラベクテジンの注射可能な胃腸外用医薬組成物及びその製造方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
PL4041194T3 (pl) 2020-04-15 2024-09-09 Ever Valinject Gmbh Kompozycja zawierająca trabektedynę i aminokwas
EP3960177A1 (en) * 2020-08-26 2022-03-02 Anturec Pharmaceuticals GmbH Composition comprising ttf-ngr for use in treating soft-tissue sarcoma
US12303506B2 (en) 2022-01-20 2025-05-20 Extrovis Ag Trabectedin composition

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Publication number Priority date Publication date Assignee Title
WO1987007610A2 (en) * 1986-06-09 1987-12-17 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
WO1992009607A1 (en) * 1990-11-30 1992-06-11 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5654426A (en) * 1993-12-02 1997-08-05 Univ Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
WO1998046080A1 (en) * 1997-04-15 1998-10-22 The Board Of Trustees Of The University Of Illinois Nucleophile substituted ecteinascidins and n-oxide ecteinascidins

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DE3635711A1 (de) 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
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GB9801231D0 (en) * 1997-06-05 1998-03-18 Merck & Co Inc A method of treating cancer
CZ301083B6 (cs) 1998-04-06 2009-11-04 The Board Of Trustees Of The University Of Illinois Ekteinascidinová sloucenina, farmaceutický prostredek ji obsahující a její použití
CN1195514C (zh) * 1998-05-11 2005-04-06 法马马有限公司 海鞘素 743的代谢物
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
DE60111845T2 (de) 2000-04-12 2006-04-27 Pharma Mar, S.A., Tres Cantos Ecteinaschidin derivate mit antikrebs wirkung
US7247892B2 (en) 2000-04-24 2007-07-24 Taylor Geoff W Imaging array utilizing thyristor-based pixel elements
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
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CA2418320A1 (en) 2000-08-11 2002-02-21 City Of Hope The anti-neoplastic agent et-743 inhibits trans activation by sxr
US20040108086A1 (en) 2000-11-06 2004-06-10 Naoto Takahashi Effective antitumor treatments
EP1360337A1 (en) 2001-02-09 2003-11-12 The Regents Of The University Of California Ecteinascidin family compounds: compositions and methods
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GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
KR20050038578A (ko) 2001-10-19 2005-04-27 파르마 마르, 에스.에이. 항종양성 화합물의 암치료에 있어서의 향상된 용도
US20040019027A1 (en) 2002-04-12 2004-01-29 Barry Forman Method of treating cerebrotendinous xanthomatosis
GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
SI1689404T1 (sl) 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080255132A1 (en) 2003-11-14 2008-10-16 Eric Rowinsky Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer
US20080293725A1 (en) 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
JP2008514688A (ja) 2004-09-29 2008-05-08 ファルマ・マル・エス・アー, ソシエダッド・ユニペルソナル 抗炎症剤としてのエクテイナシジン化合物
HRP20090345T1 (en) 2004-10-26 2009-08-31 Pharma Mar S.A. Pegylated liposomal doxorubicin in combination with ecteinescidin 743
RS50510B (sr) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
WO2007062413A2 (en) 2005-11-25 2007-05-31 University Of Medicine And Dentistry Of New Jersey Use of parp-1 inhibitors
WO2007134203A2 (en) 2006-05-12 2007-11-22 Pharma Mar, S.A. Anticancer treatments with a combination of docetaxel and ecteinascidin

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007610A2 (en) * 1986-06-09 1987-12-17 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
WO1992009607A1 (en) * 1990-11-30 1992-06-11 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5654426A (en) * 1993-12-02 1997-08-05 Univ Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
WO1998012198A1 (en) * 1996-09-18 1998-03-26 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
WO1998046080A1 (en) * 1997-04-15 1998-10-22 The Board Of Trustees Of The University Of Illinois Nucleophile substituted ecteinascidins and n-oxide ecteinascidins

Non-Patent Citations (2)

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Title
Ann. Oncol. 9 (9) s. 981-7 (1998) (abstrakt) *
Clinical Cancer Research Vol. 4 s. 1977-1983 (August 1998) *

Also Published As

Publication number Publication date
CY1112753T1 (el) 2016-02-10
BG65680B1 (bg) 2009-06-30
DE60030554D1 (de) 2006-10-19
IL146434A0 (en) 2002-07-25
DE60030554T8 (de) 2008-01-10
CY2008007I1 (el) 2009-11-04
NL300337I1 (nl) 2008-05-01
CY1105818T1 (el) 2011-02-02
LU91418I2 (fr) 2008-05-13
AU4597500A (en) 2000-12-05
PT1702618E (pt) 2008-01-11
SI1716853T1 (sl) 2011-10-28
US20070275942A1 (en) 2007-11-29
KR20020019914A (ko) 2002-03-13
EP1176964B8 (en) 2007-10-10
HUS1500001I1 (hu) 2016-08-29
CY2008007I2 (el) 2009-11-04
AU777417B2 (en) 2004-10-14
US8119638B2 (en) 2012-02-21
EP1716853A2 (en) 2006-11-02
DK1176964T3 (da) 2007-01-15
TR200103819T2 (tr) 2002-04-22
DE60036826D1 (de) 2007-11-29
SI1176964T1 (sl) 2007-02-28
NO324564B1 (no) 2007-11-19
CY1107143T1 (el) 2010-07-28
DE60036826T2 (de) 2008-08-28
AU2005200180B2 (en) 2007-12-13
CN1360503A (zh) 2002-07-24
JP2002544231A (ja) 2002-12-24
PL198185B1 (pl) 2008-06-30
DE60045720D1 (de) 2011-04-21
JP2012149095A (ja) 2012-08-09
EP1702618A3 (en) 2006-12-27
NO2008005I2 (enExample) 2010-09-27
DE60030554T2 (de) 2007-09-13
EP1702618A2 (en) 2006-09-20
DK1716853T3 (da) 2011-06-27
ATE375795T1 (de) 2007-11-15
NO20015516D0 (no) 2001-11-12
SK16442001A3 (sk) 2002-03-05
ES2294756T3 (es) 2008-04-01
AU2005200180B9 (en) 2008-05-29
NO20015516L (no) 2002-01-11
PT1176964E (pt) 2007-01-31
AR028476A1 (es) 2003-05-14
WO2000069441A1 (en) 2000-11-23
BR0010531A (pt) 2002-06-04
LU91418I9 (enExample) 2019-01-02
PL352931A1 (en) 2003-09-22
AU2005200180A1 (en) 2005-02-10
JP5777562B2 (ja) 2015-09-09
ATE500830T1 (de) 2011-03-15
EP1702618B1 (en) 2007-10-17
SK287580B6 (sk) 2011-03-04
HUP0201187A3 (en) 2002-11-28
CA2373794C (en) 2005-10-11
DE122008000013I1 (de) 2008-08-07
EP1176964B1 (en) 2006-09-06
FR08C0013I1 (enExample) 2008-05-30
ES2272279T3 (es) 2007-05-01
EP1716853A3 (en) 2006-11-15
IL146434A (en) 2008-03-20
HU229866B1 (en) 2014-10-28
EP1176964A1 (en) 2002-02-06
NZ515423A (en) 2004-04-30
PT1716853E (pt) 2011-05-12
HUP0201187A2 (en) 2002-09-28
SI1702618T1 (sl) 2008-02-29
FR08C0013I2 (fr) 2009-10-30
MY164077A (en) 2017-11-30
BG106171A (en) 2002-06-28
CA2373794A1 (en) 2000-11-23
ATE338552T1 (de) 2006-09-15
MXPA01011562A (es) 2002-07-30
CZ20014081A3 (cs) 2002-11-13
CN100477993C (zh) 2009-04-15
NL300337I2 (nl) 2008-09-01
EP1716853B1 (en) 2011-03-09
CN1679631A (zh) 2005-10-12
DK1702618T3 (da) 2008-02-25
NO2008005I1 (no) 2008-06-09
UA74782C2 (uk) 2006-02-15
EP1716853B9 (en) 2011-09-28

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