CN1284084A - 棘白菌素衍生物、其制备方法及其作为抗真菌剂的用途 - Google Patents

棘白菌素衍生物、其制备方法及其作为抗真菌剂的用途 Download PDF

Info

Publication number
CN1284084A
CN1284084A CN98813413A CN98813413A CN1284084A CN 1284084 A CN1284084 A CN 1284084A CN 98813413 A CN98813413 A CN 98813413A CN 98813413 A CN98813413 A CN 98813413A CN 1284084 A CN1284084 A CN 1284084A
Authority
CN
China
Prior art keywords
formula
compound
hydrogen atom
group
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98813413A
Other languages
English (en)
Chinese (zh)
Inventor
O·库尔坦
P·福沃
A·马库斯
D·梅隆芒格尔
J·-M·米歇尔
L·施奥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novexel SA
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9715628A external-priority patent/FR2772028B1/fr
Priority claimed from FR9813361A external-priority patent/FR2784993B1/fr
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of CN1284084A publication Critical patent/CN1284084A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN98813413A 1997-12-10 1998-12-09 棘白菌素衍生物、其制备方法及其作为抗真菌剂的用途 Pending CN1284084A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9715628A FR2772028B1 (fr) 1997-12-10 1997-12-10 Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
FR97/15628 1997-12-10
FR98/13361 1998-10-26
FR9813361A FR2784993B1 (fr) 1998-10-26 1998-10-26 Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2008101305266A Division CN101333249A (zh) 1997-12-10 1998-12-09 棘白菌素衍生物、其制备方法及其作为抗真菌剂的用途

Publications (1)

Publication Number Publication Date
CN1284084A true CN1284084A (zh) 2001-02-14

Family

ID=26233984

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98813413A Pending CN1284084A (zh) 1997-12-10 1998-12-09 棘白菌素衍生物、其制备方法及其作为抗真菌剂的用途

Country Status (43)

Country Link
US (3) US6677429B1 (enExample)
EP (1) EP1036090B1 (enExample)
JP (1) JP4361679B2 (enExample)
KR (1) KR100564872B1 (enExample)
CN (1) CN1284084A (enExample)
AP (2) AP1260A (enExample)
AR (1) AR016432A1 (enExample)
AT (1) ATE321772T1 (enExample)
AU (1) AU755033B2 (enExample)
BG (1) BG65033B1 (enExample)
BR (1) BR9813531A (enExample)
CA (1) CA2311295A1 (enExample)
CO (1) CO4980875A1 (enExample)
CU (1) CU22962A3 (enExample)
CY (1) CY1105695T1 (enExample)
CZ (1) CZ301919B6 (enExample)
DE (1) DE69834057T2 (enExample)
DK (1) DK1036090T3 (enExample)
DZ (1) DZ2670A1 (enExample)
EA (1) EA002706B1 (enExample)
EE (1) EE04837B1 (enExample)
ES (1) ES2259462T3 (enExample)
GE (1) GEP20032975B (enExample)
HR (1) HRP20000384B1 (enExample)
HU (1) HUP0100263A3 (enExample)
IL (4) IL136647A0 (enExample)
MA (1) MA26575A1 (enExample)
NO (1) NO327498B1 (enExample)
NZ (1) NZ504614A (enExample)
OA (1) OA11899A (enExample)
PA (1) PA8464201A1 (enExample)
PE (1) PE130099A1 (enExample)
PL (1) PL196889B1 (enExample)
PT (1) PT1036090E (enExample)
RS (1) RS49905B (enExample)
SA (1) SA99191248B1 (enExample)
SK (1) SK286916B6 (enExample)
TN (1) TNSN98222A1 (enExample)
TR (1) TR200001655T2 (enExample)
TW (1) TW446541B (enExample)
UA (1) UA72200C2 (enExample)
UY (1) UY25292A1 (enExample)
WO (1) WO1999029716A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72200C2 (uk) * 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
WO2000024694A1 (en) * 1998-10-28 2000-05-04 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
FR2794746B1 (fr) 1999-06-09 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
FR2794747B1 (fr) 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
CN101659692B (zh) * 2008-08-27 2012-07-04 上海医药工业研究院 制备棘球康定b的方法
CN101659693B (zh) * 2008-08-27 2012-11-21 上海医药工业研究院 制备纽莫康定b0的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2241955A (en) * 1990-03-16 1991-09-18 Merck & Co Inc Cyclohexapeptide compounds
NZ247149A (en) * 1992-03-19 1996-10-28 Lilly Co Eli Cyclic peptide antifungal agents and compositions thereof
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
DE69615535T2 (de) * 1995-01-26 2002-05-02 Merck & Co., Inc. Neue fungizide cyclohexapeptide
US5646111A (en) * 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
UA72200C2 (uk) * 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
FR2794747B1 (fr) * 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques

Also Published As

Publication number Publication date
DE69834057T2 (de) 2006-12-14
CY1105695T1 (el) 2010-12-22
CZ20002113A3 (cs) 2000-11-15
AP1567A (en) 2006-02-08
NZ504614A (en) 2002-12-20
NO20002959L (no) 2000-08-09
EA002706B1 (ru) 2002-08-29
ES2259462T3 (es) 2006-10-01
EE04837B1 (et) 2007-06-15
PL196889B1 (pl) 2008-02-29
TNSN98222A1 (fr) 2005-03-15
UY25292A1 (es) 2000-12-29
AP2000001826A0 (en) 2000-06-30
SA99191248B1 (ar) 2006-08-12
PL341012A1 (en) 2001-03-12
AU1565999A (en) 1999-06-28
JP4361679B2 (ja) 2009-11-11
PT1036090E (pt) 2006-06-30
HRP20000384B1 (en) 2010-02-28
DK1036090T3 (da) 2006-07-24
US20050267019A1 (en) 2005-12-01
AU755033B2 (en) 2002-11-28
AR016432A1 (es) 2001-07-04
WO1999029716A1 (fr) 1999-06-17
BG65033B1 (bg) 2006-12-29
CO4980875A1 (es) 2000-11-27
US7285619B2 (en) 2007-10-23
OA11899A (fr) 2006-04-10
KR20010032924A (ko) 2001-04-25
IL136647A0 (en) 2001-06-14
UA72200C2 (uk) 2005-02-15
ATE321772T1 (de) 2006-04-15
TW446541B (en) 2001-07-21
AP1260A (en) 2004-03-16
CU22962A3 (es) 2004-06-21
PA8464201A1 (es) 2000-09-29
NO20002959D0 (no) 2000-06-09
SK286916B6 (sk) 2009-07-06
CA2311295A1 (fr) 1999-06-17
EP1036090B1 (fr) 2006-03-29
KR100564872B1 (ko) 2006-03-30
US6677429B1 (en) 2004-01-13
CZ301919B6 (cs) 2010-07-28
PE130099A1 (es) 1999-12-16
HUP0100263A3 (en) 2002-11-28
IL136647A (en) 2007-06-03
BR9813531A (pt) 2000-10-10
MA26575A1 (fr) 2004-12-20
YU33900A (sh) 2002-08-12
GEP20032975B (en) 2003-05-27
HUP0100263A1 (hu) 2001-08-28
US7160983B2 (en) 2007-01-09
DZ2670A1 (fr) 2003-03-22
EA200000625A1 (ru) 2000-12-25
BG104494A (en) 2001-01-31
SK8392000A3 (en) 2001-10-08
HRP20000384A2 (en) 2000-10-31
JP2001525421A (ja) 2001-12-11
TR200001655T2 (tr) 2000-11-21
IL184171A0 (en) 2007-10-31
US20040072737A1 (en) 2004-04-15
NO327498B1 (no) 2009-07-20
IL172412A (en) 2008-11-26
AP2003002874A0 (en) 2003-09-30
EE200000336A (et) 2001-08-15
DE69834057D1 (de) 2006-05-18
EP1036090A1 (fr) 2000-09-20
RS49905B (sr) 2008-08-07

Similar Documents

Publication Publication Date Title
TWI423987B (zh) 環肽ｃｘｃｒ４拮抗劑
CN1154655C (zh) k受体的阿片样肽
AU680379B2 (en) Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
CN1129606C (zh) 七肽催产素类似物
EP4512818A1 (en) Cyclic compound having selective kras inhibitory effect on hras and nras
Kyle et al. Probing the bradykinin receptor: mapping the geometric topography using ethers of hydroxyproline in novel peptides
CN102712675A (zh) 拟肽大环化合物
SK282527B6 (sk) Azacyklohexapeptidové deriváty, farmaceutické prostriedky s ich obsahom a ich použitie
CN1284084A (zh) 棘白菌素衍生物、其制备方法及其作为抗真菌剂的用途
CA2340676A1 (en) Ring modified cyclic peptide analogs
JP4619592B2 (ja) エキノカンジンの新誘導体、それらの製造方法及びそれらの抗菌剤としての使用
KR102475326B1 (ko) 신규한 펩타이드 유사체 및 이를 포함하는 알츠하이머 병 예방 조성물
JP5689892B2 (ja) ２−アミノ−３−メチル−ヘキサ−５エン酸、及びバシトラシン等のペプチドの生成におけるその使用方法
JP4493891B2 (ja) エキノカンジンの新誘導体、それらの製造方法及びそれらの抗菌剤としての使用
JP3874372B2 (ja) 制癌剤の効果増強剤
CN101333249A (zh) 棘白菌素衍生物、其制备方法及其作为抗真菌剂的用途
CN109265516A (zh) 一种杂合肽及其制备方法和应用
HK1126787A (en) Echinocandin derivatives, preparation method and application as anti-fungal agents
JPH07100715B2 (ja) シクロヘキサペプチジルヒドロキシプロピオニトリル化合物
FR2784993A1 (fr) Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
RS51950B (sr) Ciklični peptidi antagonisti cxcr4

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: VENTIS PHARMA S.A.

Free format text: FORMER OWNER: HOECHST MARION ROUSSEL INC.

Effective date: 20041112

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20041112

Address after: French Anthony

Applicant after: Aventis Pharma

Address before: French AUX

Applicant before: Hoechst Marion Roussel

ASS Succession or assignment of patent right

Owner name: SMIRNOVSURF CO., LTD.

Free format text: FORMER OWNER: VENTIS PHARMA S.A.

Effective date: 20080104

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20080104

Address after: French Roman

Applicant after: Novexel

Address before: French Anthony

Applicant before: Aventis Pharma

C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication