DE69615535T2 - Neue fungizide cyclohexapeptide - Google Patents

Neue fungizide cyclohexapeptide

Info

Publication number
DE69615535T2
DE69615535T2 DE69615535T DE69615535T DE69615535T2 DE 69615535 T2 DE69615535 T2 DE 69615535T2 DE 69615535 T DE69615535 T DE 69615535T DE 69615535 T DE69615535 T DE 69615535T DE 69615535 T2 DE69615535 T2 DE 69615535T2
Authority
DE
Germany
Prior art keywords
cyclohexapeptide
new fungicides
compounds
fungicides
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69615535T
Other languages
English (en)
Other versions
DE69615535D1 (de
Inventor
A Bouffard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69615535D1 publication Critical patent/DE69615535D1/de
Application granted granted Critical
Publication of DE69615535T2 publication Critical patent/DE69615535T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69615535T 1995-01-26 1996-01-22 Neue fungizide cyclohexapeptide Expired - Fee Related DE69615535T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37868795A 1995-01-26 1995-01-26
PCT/US1996/000921 WO1996022784A1 (en) 1995-01-26 1996-01-22 Novel antifungal cyclohexapeptides

Publications (2)

Publication Number Publication Date
DE69615535D1 DE69615535D1 (de) 2001-10-31
DE69615535T2 true DE69615535T2 (de) 2002-05-02

Family

ID=23494135

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69615535T Expired - Fee Related DE69615535T2 (de) 1995-01-26 1996-01-22 Neue fungizide cyclohexapeptide

Country Status (11)

Country Link
US (1) US5854213A (de)
EP (1) EP0805685B1 (de)
JP (1) JP2966936B2 (de)
AT (1) ATE206054T1 (de)
AU (1) AU691743B2 (de)
CA (1) CA2211138A1 (de)
DE (1) DE69615535T2 (de)
DK (1) DK0805685T3 (de)
ES (1) ES2162039T3 (de)
PT (1) PT805685E (de)
WO (1) WO1996022784A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2784993B1 (fr) * 1998-10-26 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
UA72200C2 (uk) * 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
FR2772028B1 (fr) * 1997-12-10 2000-02-04 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
CA2371728C (en) * 1999-06-11 2009-06-02 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
ATE416189T1 (de) 1999-07-27 2008-12-15 Aventis Pharma Gmbh Cyclohexapeptide, deren herstellung und verwendung in pharmazeutische zusammensetzungen
EP1251827B1 (de) * 2000-01-20 2004-05-26 Basilea Pharmaceutica AG Nasal verabreichbare cyclische antimykotische peptidzusammensetzungen
AU2002249935A1 (en) 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
CA2444673C (en) * 2001-04-25 2014-10-07 Wyeth Holdings Corporation Glycopeptide antibiotics
US6914045B2 (en) * 2001-04-25 2005-07-05 Wyeth Holdings Corporation Glycopeptide antibiotics
US7045116B2 (en) 2001-12-13 2006-05-16 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
RS56426B1 (sr) 2011-03-03 2018-01-31 Cidara Therapeutics Inc Antigljivična sredstva i njihova upotreba
CA2867132A1 (en) 2012-03-19 2013-09-26 Cidara Therapeutics, Inc. Dosing regimens for echinocandin class compounds
EP3399995A4 (de) 2016-01-08 2019-08-21 Cidara Therapeutics, Inc. Verfahren zur vorbeugung und behandlung von pneumocystis-infektionen
CN109154603A (zh) 2016-03-16 2019-01-04 奇达拉治疗公司 用于治疗真菌感染的给药方案
CA3069423A1 (en) 2017-07-12 2019-01-17 Cidara Therapeutics, Inc. Formulations for the treatment of fungal infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
US5202309A (en) 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
US5194377A (en) 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
IE990233A1 (en) * 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii
US6030944A (en) * 1991-10-01 2000-02-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compounds
NZ247149A (en) * 1992-03-19 1996-10-28 Lilly Co Eli Cyclic peptide antifungal agents and compositions thereof
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
AU691743B2 (en) 1998-05-21
EP0805685A4 (de) 1998-04-29
DE69615535D1 (de) 2001-10-31
ATE206054T1 (de) 2001-10-15
EP0805685A1 (de) 1997-11-12
CA2211138A1 (en) 1996-08-01
WO1996022784A1 (en) 1996-08-01
ES2162039T3 (es) 2001-12-16
US5854213A (en) 1998-12-29
DK0805685T3 (da) 2001-11-19
EP0805685B1 (de) 2001-09-26
PT805685E (pt) 2002-02-28
AU5168196A (en) 1996-08-14
JPH10505100A (ja) 1998-05-19
JP2966936B2 (ja) 1999-10-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee