BR9813531A - "derivados da equinocandina, seu processo de preparo e sua aplicação como antifúngicos" - Google Patents
"derivados da equinocandina, seu processo de preparo e sua aplicação como antifúngicos"Info
- Publication number
- BR9813531A BR9813531A BR9813531-7A BR9813531A BR9813531A BR 9813531 A BR9813531 A BR 9813531A BR 9813531 A BR9813531 A BR 9813531A BR 9813531 A BR9813531 A BR 9813531A
- Authority
- BR
- Brazil
- Prior art keywords
- antifungals
- application
- preparation process
- derivatives
- echinocandin derivatives
- Prior art date
Links
- 229940121375 antifungal agent Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 108010049047 Echinocandins Proteins 0.000 title 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Patente de Invenção: <B>"DERIVADOS DA EQUINOCANDINA, SEU PROCESSO DE PREPARO E SUA APLICAçãO COMO ANTIFúNGICOS"<D>. A invenção tem por objetivo os compostos de fórmula (I), ou R~ 1~ e R~ 2~= H, OH, alquila eventualmente substituída ou NR1 forma com o carbono portando NR 1R2 uma dupla ligação e R2 é Xra, X sendo O, NH ou N-alquila e Ra sendo H, alquila eventualmente substituída, R = cadeia contendo até 30 átomos de carbono, contendo eventualmente um ou vários heteroátomos, um ou vários heterociclos, T = H, CH~ 3~, CH~ 2~CONH~ 2~, CH~ 2~C<154>N, (CH~ 2~)2NH~ 2~ Y = H, OH, halogênio, W = H, OH, Z = H ou CH~ 3~. Os produtos apresentam propriedades antifúngicas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9715628A FR2772028B1 (fr) | 1997-12-10 | 1997-12-10 | Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides |
| FR9813361A FR2784993B1 (fr) | 1998-10-26 | 1998-10-26 | Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides |
| PCT/FR1998/002671 WO1999029716A1 (fr) | 1997-12-10 | 1998-12-09 | Derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9813531A true BR9813531A (pt) | 2000-10-10 |
Family
ID=26233984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9813531-7A BR9813531A (pt) | 1997-12-10 | 1998-12-09 | "derivados da equinocandina, seu processo de preparo e sua aplicação como antifúngicos" |
Country Status (43)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA72200C2 (uk) * | 1997-12-10 | 2005-02-15 | Авентіс Фарма С.А. | Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція |
| WO2000024694A1 (en) * | 1998-10-28 | 2000-05-04 | Eli Lilly And Company | Photochemical process for making 1-deoxy-2-keto derivatives |
| FR2794746B1 (fr) | 1999-06-09 | 2002-12-06 | Hoechst Marion Roussel Inc | Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques |
| FR2794747B1 (fr) * | 1999-06-09 | 2004-04-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques |
| FR2833596B1 (fr) * | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
| CN101659692B (zh) * | 2008-08-27 | 2012-07-04 | 上海医药工业研究院 | 制备棘球康定b的方法 |
| CN101659693B (zh) * | 2008-08-27 | 2012-11-21 | 上海医药工业研究院 | 制备纽莫康定b0的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2241955A (en) * | 1990-03-16 | 1991-09-18 | Merck & Co Inc | Cyclohexapeptide compounds |
| NZ512085A (en) * | 1992-03-19 | 2003-08-29 | Lilly Co Eli | Methods employing cyclic peptide antifungal agents |
| US5516757A (en) * | 1994-09-16 | 1996-05-14 | Merck & Co., Inc. | Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use |
| US5516756A (en) * | 1994-10-31 | 1996-05-14 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| WO1996022784A1 (en) * | 1995-01-26 | 1996-08-01 | Merck & Co., Inc. | Novel antifungal cyclohexapeptides |
| US5646111A (en) * | 1995-04-07 | 1997-07-08 | Eli Lilly And Company | Cyclic peptide antifungal Agents |
| UA72200C2 (uk) * | 1997-12-10 | 2005-02-15 | Авентіс Фарма С.А. | Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція |
| FR2794747B1 (fr) * | 1999-06-09 | 2004-04-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques |
-
1998
- 1998-09-12 UA UA2000074030A patent/UA72200C2/uk unknown
- 1998-12-08 TN TNTNSN98222A patent/TNSN98222A1/fr unknown
- 1998-12-09 AP APAP/P/2003/002874A patent/AP1567A/en active
- 1998-12-09 EP EP98959935A patent/EP1036090B1/fr not_active Expired - Lifetime
- 1998-12-09 CZ CZ20002113A patent/CZ301919B6/cs not_active IP Right Cessation
- 1998-12-09 AP APAP/P/2000/001826A patent/AP1260A/en active
- 1998-12-09 EE EEP200000336A patent/EE04837B1/xx not_active IP Right Cessation
- 1998-12-09 PT PT98959935T patent/PT1036090E/pt unknown
- 1998-12-09 PL PL341012A patent/PL196889B1/pl not_active IP Right Cessation
- 1998-12-09 KR KR1020007006268A patent/KR100564872B1/ko not_active IP Right Cessation
- 1998-12-09 EA EA200000625A patent/EA002706B1/ru not_active IP Right Cessation
- 1998-12-09 OA OA00000164A patent/OA11899A/fr unknown
- 1998-12-09 US US09/581,451 patent/US6677429B1/en not_active Expired - Fee Related
- 1998-12-09 MA MA25378A patent/MA26575A1/fr unknown
- 1998-12-09 AT AT98959935T patent/ATE321772T1/de active
- 1998-12-09 WO PCT/FR1998/002671 patent/WO1999029716A1/fr active Application Filing
- 1998-12-09 CA CA002311295A patent/CA2311295A1/fr not_active Abandoned
- 1998-12-09 PA PA19988464201A patent/PA8464201A1/es unknown
- 1998-12-09 HU HU0100263A patent/HUP0100263A3/hu unknown
- 1998-12-09 IL IL13664798A patent/IL136647A0/xx active IP Right Grant
- 1998-12-09 JP JP2000524307A patent/JP4361679B2/ja not_active Expired - Fee Related
- 1998-12-09 RS YUP-339/00A patent/RS49905B/sr unknown
- 1998-12-09 AU AU15659/99A patent/AU755033B2/en not_active Ceased
- 1998-12-09 BR BR9813531-7A patent/BR9813531A/pt not_active IP Right Cessation
- 1998-12-09 SK SK839-2000A patent/SK286916B6/sk not_active IP Right Cessation
- 1998-12-09 NZ NZ504614A patent/NZ504614A/xx unknown
- 1998-12-09 ES ES98959935T patent/ES2259462T3/es not_active Expired - Lifetime
- 1998-12-09 DZ DZ980280A patent/DZ2670A1/xx active
- 1998-12-09 DE DE69834057T patent/DE69834057T2/de not_active Expired - Lifetime
- 1998-12-09 UY UY25292A patent/UY25292A1/es not_active IP Right Cessation
- 1998-12-09 GE GEAP19985441A patent/GEP20032975B/en unknown
- 1998-12-09 CN CN98813413A patent/CN1284084A/zh active Pending
- 1998-12-09 DK DK98959935T patent/DK1036090T3/da active
- 1998-12-09 TR TR2000/01655T patent/TR200001655T2/xx unknown
- 1998-12-10 CO CO98073452A patent/CO4980875A1/es unknown
- 1998-12-10 AR ARP980106281A patent/AR016432A1/es active IP Right Grant
- 1998-12-10 PE PE1998001202A patent/PE130099A1/es not_active Application Discontinuation
-
1999
- 1999-01-22 TW TW087121185A patent/TW446541B/zh not_active IP Right Cessation
- 1999-04-05 SA SA99191248A patent/SA99191248B1/ar unknown
-
2000
- 2000-05-31 BG BG104494A patent/BG65033B1/bg unknown
- 2000-06-07 CU CU20000136A patent/CU22962A3/es unknown
- 2000-06-08 IL IL136647A patent/IL136647A/en not_active IP Right Cessation
- 2000-06-09 HR HR20000384A patent/HRP20000384B1/xx not_active IP Right Cessation
- 2000-06-09 NO NO20002959A patent/NO327498B1/no not_active IP Right Cessation
-
2003
- 2003-09-19 US US10/666,072 patent/US7160983B2/en not_active Expired - Fee Related
-
2005
- 2005-06-23 US US11/165,458 patent/US7285619B2/en not_active Expired - Fee Related
- 2005-12-06 IL IL172412A patent/IL172412A/en not_active IP Right Cessation
-
2006
- 2006-05-30 CY CY20061100686T patent/CY1105695T1/el unknown
-
2007
- 2007-06-24 IL IL184171A patent/IL184171A0/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2196396T3 (es) | Compuestos heteroaromaticos de 5 miembros conteniendo oxigeno o azufre como inhibidores del factor xa. | |
| BR0306150A (pt) | Composto, uso de um composto, e, composição farmacêutica | |
| DE69127690T2 (de) | Antiatherosklerotische und antithrombotische 1-benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on-derivate | |
| ATE334975T1 (de) | Sulfonamidderivate, ihre herstellung und verwendung | |
| MX9801716A (es) | Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina. | |
| ATE286026T1 (de) | Amid-derivate und deren medizinische verwendung | |
| RS39604A (en) | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | |
| AU2804400A (en) | Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists | |
| TR200103764T2 (tr) | Mutilin türevleri ve bunların antibakteriyeller olarak kullanımları | |
| BR0014136A (pt) | Composto, uso do mesmo, métodos para a preparação de um composto, e para inibir aurora 2 quinase em um animal de sangue quente, e, composição farmacêutica | |
| MY136141A (en) | Novel hydantoin derivatives and pharmaceutical compositions useful as metalloproteinase inhibitors | |
| ATE299890T1 (de) | Inhibitoren von gamma-secretase | |
| EP0539086A3 (en) | Condensed pyrimidine derivatives and their use as angiotensine ii antagonists | |
| ATE212991T1 (de) | Thiazolidinedione- und oxazolidinedione-derivate mit antidiabetischen, hypolipidämischen und anti hypertensiven eigenschaften | |
| BR9712507A (pt) | Derivados de aminotiazol, seu processo de preparo e as composições famacêuticas que os comtêm. | |
| IL132474A (en) | 3,4-dihydrothienopyrimidine-4-(thi) ones for combating plant fungi and a novel such compound | |
| YU52000A (sh) | Jedinjenja meta-azaciklične amino benzojeve kiseline i njihovi derivati, koji su antagonisti integrina | |
| BR9813531A (pt) | "derivados da equinocandina, seu processo de preparo e sua aplicação como antifúngicos" | |
| EP1184373A4 (en) | TRICYCLIC CONNECTIONS | |
| TR200200125T2 (tr) | Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar. | |
| PT1022276E (pt) | Derivados de epoxissuccinamida | |
| PE20010485A1 (es) | Derivados de bencimidazol sustituidos con aminocarbonilo, procedimiento para su preparacion y su utilizacion como medicamentos | |
| KR970702273A (ko) | 인돌 유도체 및 이를 함유하는 제제(indole derivative and medicine containing the same) | |
| TR199802552T2 (xx) | 5-HT-2C Resept�r kar��tlar� olarak faydal� indolin t�revleri. | |
| PT1257552E (pt) | Derivados de xantina, intermediarios e aplicacao ao tratamento de osteoporose |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: AVENTIS PHARMA S.A. (FR) Free format text: TRANSFERIDO POR FUSAO DE: HOECHST MARION ROUSSEL |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: NOVEXEL (FR) Free format text: TRANSFERIDO DE: AVENTIS PHARMA S.A. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART. 37, INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA ( ART. 8O COMBINADO COM O ART. 13 DA LPI 9279/96). |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: ARQUIVAMENTO DEFINITIVO |
|
| B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2238 DE 26/11/2013 POR TER SIDO INDEVIDA. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 14A ATE A 22A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |