CN1241931C - 大环内酯抗感染药物 - Google Patents

大环内酯抗感染药物 Download PDF

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Publication number
CN1241931C
CN1241931C CNB008090718A CN00809071A CN1241931C CN 1241931 C CN1241931 C CN 1241931C CN B008090718 A CNB008090718 A CN B008090718A CN 00809071 A CN00809071 A CN 00809071A CN 1241931 C CN1241931 C CN 1241931C
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CN
China
Prior art keywords
compound
unsubstituted
methyl
added
formula
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008090718A
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English (en)
Chinese (zh)
Other versions
CN1384838A (zh
Inventor
D·T·W·褚
G·W·阿什利
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Kosan Biosciences Inc
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Kosan Biosciences Inc
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Publication date
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Publication of CN1384838A publication Critical patent/CN1384838A/zh
Application granted granted Critical
Publication of CN1241931C publication Critical patent/CN1241931C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB008090718A 1999-04-16 2000-04-14 大环内酯抗感染药物 Expired - Fee Related CN1241931C (zh)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US12972999P 1999-04-16 1999-04-16
US60/129,729 1999-04-16
US14017599P 1999-06-18 1999-06-18
US60/140,175 1999-06-18
US17215499P 1999-12-17 1999-12-17
US17215999P 1999-12-17 1999-12-17
US60/172,154 1999-12-17
US60/172,159 1999-12-17
US17380599P 1999-12-30 1999-12-30
US17380499P 1999-12-30 1999-12-30
US60/173,804 1999-12-30
US60/173,805 1999-12-30
US09/550,045 2000-04-14
US09/550,045 US6395710B1 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Publications (2)

Publication Number Publication Date
CN1384838A CN1384838A (zh) 2002-12-11
CN1241931C true CN1241931C (zh) 2006-02-15

Family

ID=27568857

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008090718A Expired - Fee Related CN1241931C (zh) 1999-04-16 2000-04-14 大环内酯抗感染药物

Country Status (16)

Country Link
US (3) US6395710B1 (https=)
EP (1) EP1171446B1 (https=)
JP (1) JP2003523938A (https=)
KR (2) KR100710605B1 (https=)
CN (1) CN1241931C (https=)
AT (1) ATE340183T1 (https=)
AU (2) AU775637B2 (https=)
BR (1) BR0010680A (https=)
CA (1) CA2369816A1 (https=)
DE (1) DE60030847T2 (https=)
ES (1) ES2272273T3 (https=)
ID (1) ID30547A (https=)
IL (2) IL145777A0 (https=)
MX (1) MXPA01010524A (https=)
NZ (1) NZ515027A (https=)
WO (2) WO2000063224A2 (https=)

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US6590083B1 (en) * 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
EP1167376B1 (en) 2000-06-30 2004-07-14 Pfizer Products Inc. Macrolide antibiotics
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
MXPA03008460A (es) * 2001-03-21 2004-06-30 Dow Agrosciences Llc Derivados pesticidas de espinosina.
WO2003024986A1 (en) 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
AU2002346475A1 (en) 2001-12-05 2003-06-23 Ortho-Mcneil Pharmaceutical, Inc. 6-o-acyl ketolide derivatives of erythromycine useful as antibacterials
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
SI1483251T1 (sl) 2002-03-12 2010-03-31 Bristol Myers Squibb Co C cian epotilonski derivati
US20040014691A1 (en) * 2002-04-25 2004-01-22 Searle Xenia Beebe 9-Oxime macrolide antibacterials
US20040009932A1 (en) * 2002-04-26 2004-01-15 Kathleen Phelan Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae
CN1671726A (zh) 2002-05-31 2005-09-21 詹森药业有限公司 3－脱克拉定糖基－6－o－氨基甲酰基和6－o－烷氧基羰基大环内酯抗菌药
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
SI1532131T1 (sl) * 2002-08-29 2009-04-30 Pfizer Motilidne spojine
EP1638549A4 (en) * 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
AU2003304705A1 (en) * 2003-12-24 2005-08-03 Enanta Pharmaceuticals, Inc. 11-csubsituted erythromycin derivatives
UA85937C2 (uk) * 2004-12-21 2009-03-10 Пфайзер Продактс Інк. Макроліди
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
CA2714389C (en) * 2008-02-08 2016-10-18 Basilea Pharmaceutica Ag Macrolides and uses of macrolides
JP5711135B2 (ja) 2008-10-24 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド 胃腸疾患を治療するための方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
MX361413B (es) 2010-03-22 2018-12-05 Cempra Pharmaceuticals Inc Star Formas cristalinas de un macrólido y usos para las mismas.
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
JP5718488B2 (ja) * 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
NZ700182A (en) 2012-03-27 2017-02-24 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
CN102718816B (zh) * 2012-07-11 2014-11-05 山东大学 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
US12559514B2 (en) 2020-05-22 2026-02-24 Merck Sharp & Dohme Llc Synthesis of fluorinated nucleotides

Family Cites Families (43)

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US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 ５−ｏ−デソサミニルエリスロノライドａ誘導体
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US6066721A (en) 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
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FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
ATE286133T1 (de) 1995-07-06 2005-01-15 Univ Leland Stanford Junior Zellfreie synthese von polyketiden
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
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Also Published As

Publication number Publication date
WO2000063225A3 (en) 2001-01-18
CA2369816A1 (en) 2000-10-26
WO2000063224A3 (en) 2001-01-18
WO2000063224A2 (en) 2000-10-26
ES2272273T3 (es) 2007-05-01
EP1171446B1 (en) 2006-09-20
ID30547A (id) 2001-12-20
AU773678B2 (en) 2004-06-03
MXPA01010524A (es) 2002-03-14
CN1384838A (zh) 2002-12-11
KR20020007372A (ko) 2002-01-26
KR20020007374A (ko) 2002-01-26
US6395710B1 (en) 2002-05-28
AU4237900A (en) 2000-11-02
EP1171446A2 (en) 2002-01-16
AU775637B2 (en) 2004-08-12
IL145777A (en) 2007-02-11
IL145777A0 (en) 2002-07-25
US6593302B2 (en) 2003-07-15
AU4457800A (en) 2000-11-02
KR100710605B1 (ko) 2007-04-24
BR0010680A (pt) 2002-02-19
DE60030847D1 (de) 2006-11-02
WO2000063225A2 (en) 2000-10-26
NZ515027A (en) 2004-01-30
US20020119938A1 (en) 2002-08-29
DE60030847T2 (de) 2007-04-19
ATE340183T1 (de) 2006-10-15
USRE39836E1 (en) 2007-09-11
JP2003523938A (ja) 2003-08-12

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Granted publication date: 20060215