CN1167420C - 用于调制丝氨酸/苏氨酸蛋白激酶功能的氮杂苯并咪唑类化合物 - Google Patents

用于调制丝氨酸/苏氨酸蛋白激酶功能的氮杂苯并咪唑类化合物 Download PDF

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Publication number
CN1167420C
CN1167420C CNB988107538A CN98810753A CN1167420C CN 1167420 C CN1167420 C CN 1167420C CN B988107538 A CNB988107538 A CN B988107538A CN 98810753 A CN98810753 A CN 98810753A CN 1167420 C CN1167420 C CN 1167420C
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CN
China
Prior art keywords
pyridine
imidazo
phenyl
methyl
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB988107538A
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English (en)
Chinese (zh)
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CN1278172A (zh
Inventor
G
G·迈克马弘
H·维恩伯格
ж�
B·库茨切尔
H·艾普
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Aeterna Zentaris GmbH
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Asta Medica GmbH
Zentaris AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB988107538A 1997-09-26 1998-09-23 用于调制丝氨酸/苏氨酸蛋白激酶功能的氮杂苯并咪唑类化合物 Expired - Fee Related CN1167420C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6014597P 1997-09-26 1997-09-26
US60/060,145 1997-09-26

Publications (2)

Publication Number Publication Date
CN1278172A CN1278172A (zh) 2000-12-27
CN1167420C true CN1167420C (zh) 2004-09-22

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CNB988107538A Expired - Fee Related CN1167420C (zh) 1997-09-26 1998-09-23 用于调制丝氨酸/苏氨酸蛋白激酶功能的氮杂苯并咪唑类化合物

Country Status (27)

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US (2) US6093728A (enExample)
EP (1) EP1017384B1 (enExample)
JP (1) JP2001517699A (enExample)
KR (1) KR100547929B1 (enExample)
CN (1) CN1167420C (enExample)
AR (1) AR017266A1 (enExample)
AT (1) ATE281834T1 (enExample)
AU (1) AU748849B2 (enExample)
BG (1) BG64784B1 (enExample)
BR (1) BR9812682A (enExample)
CA (1) CA2305370C (enExample)
DE (1) DE69827516T2 (enExample)
DK (1) DK1017384T3 (enExample)
ES (1) ES2230719T3 (enExample)
HU (1) HUP0004024A3 (enExample)
IL (4) IL158649A0 (enExample)
NO (1) NO325663B1 (enExample)
NZ (2) NZ503432A (enExample)
PL (1) PL191618B1 (enExample)
PT (1) PT1017384E (enExample)
RU (1) RU2230553C2 (enExample)
SK (1) SK285357B6 (enExample)
TR (1) TR200001546T2 (enExample)
TW (1) TW581815B (enExample)
UA (1) UA72448C2 (enExample)
WO (1) WO1999016438A1 (enExample)
ZA (1) ZA988797B (enExample)

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Also Published As

Publication number Publication date
CN1278172A (zh) 2000-12-27
US6855723B2 (en) 2005-02-15
CA2305370C (en) 2006-11-28
PL191618B1 (pl) 2006-06-30
ATE281834T1 (de) 2004-11-15
BG64784B1 (bg) 2006-04-28
AU748849B2 (en) 2002-06-13
SK285357B6 (sk) 2006-11-03
TR200001546T2 (tr) 2000-10-23
PL339744A1 (en) 2001-01-02
NZ517808A (en) 2003-07-25
JP2001517699A (ja) 2001-10-09
PT1017384E (pt) 2005-03-31
BR9812682A (pt) 2000-08-22
ZA988797B (en) 1999-12-02
NO325663B1 (no) 2008-07-07
AR017266A1 (es) 2001-09-05
IL135109A (en) 2007-07-04
NO20001555L (no) 2000-03-24
CA2305370A1 (en) 1999-04-08
KR100547929B1 (ko) 2006-02-02
KR20010015623A (ko) 2001-02-26
EP1017384B1 (en) 2004-11-10
IL158649A (en) 2006-12-10
UA72448C2 (en) 2005-03-15
HUP0004024A3 (en) 2001-10-29
TW581815B (en) 2004-04-01
US20030181480A1 (en) 2003-09-25
BG104356A (en) 2000-12-29
US6093728A (en) 2000-07-25
EP1017384A1 (en) 2000-07-12
HK1032206A1 (en) 2001-07-13
NO20001555D0 (no) 2000-03-24
HUP0004024A2 (hu) 2001-04-28
RU2230553C2 (ru) 2004-06-20
DK1017384T3 (da) 2005-01-31
IL158649A0 (en) 2004-05-12
DE69827516D1 (de) 2004-12-16
ES2230719T3 (es) 2005-05-01
AU9578198A (en) 1999-04-23
WO1999016438A1 (en) 1999-04-08
NZ503432A (en) 2002-11-26
IL135109A0 (en) 2001-05-20
DE69827516T2 (de) 2005-12-01
SK4152000A3 (en) 2002-02-05

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