CN110115657A - 注射器 - Google Patents
注射器 Download PDFInfo
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- CN110115657A CN110115657A CN201910358417.8A CN201910358417A CN110115657A CN 110115657 A CN110115657 A CN 110115657A CN 201910358417 A CN201910358417 A CN 201910358417A CN 110115657 A CN110115657 A CN 110115657A
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- syringe
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- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
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Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12174860 | 2012-07-03 | ||
| EP12174860.2 | 2012-07-03 | ||
| EP12189649 | 2012-10-23 | ||
| EP12189649.2 | 2012-10-23 | ||
| DE202012011016.0 | 2012-11-16 | ||
| AU2012101677A AU2012101677B4 (en) | 2012-07-03 | 2012-11-16 | Device |
| DE202012011016U DE202012011016U1 (de) | 2012-07-03 | 2012-11-16 | Aflibercept-Spritze |
| AU2012101678A AU2012101678B4 (en) | 2012-07-03 | 2012-11-16 | Use of device |
| AU2012101677 | 2012-11-16 | ||
| AU2012101678 | 2012-11-16 | ||
| DE202012011260.0 | 2012-11-23 | ||
| DE202012011259U DE202012011259U1 (de) | 2012-07-03 | 2012-11-23 | Bevacizumab-Spritze |
| DE202012011260U DE202012011260U1 (de) | 2012-07-03 | 2012-11-23 | Ranibizumab-Spritze |
| DE202012011259.7 | 2012-11-23 | ||
| EP12195360 | 2012-12-03 | ||
| EP12195360.8 | 2012-12-03 | ||
| DE201320000688 DE202013000688U1 (de) | 2012-07-03 | 2013-01-23 | Glas-Spritze |
| AU2013100070A AU2013100070B4 (en) | 2012-07-03 | 2013-01-23 | Use of device |
| AU2013100071 | 2013-01-23 | ||
| AU2013100070 | 2013-01-23 | ||
| AU2013100071A AU2013100071C4 (en) | 2012-07-03 | 2013-01-23 | Device |
| DE202013000688.9 | 2013-01-23 | ||
| CN201380035900.3A CN104427972A (zh) | 2012-07-03 | 2013-01-25 | 注射器 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380035900.3A Division CN104427972A (zh) | 2012-07-03 | 2013-01-25 | 注射器 |
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| CN110115657A true CN110115657A (zh) | 2019-08-13 |
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| CN201910358417.8A Pending CN110115657A (zh) | 2012-07-03 | 2013-01-25 | 注射器 |
| CN202110166906.0A Pending CN112972828A (zh) | 2012-07-03 | 2013-01-25 | 注射器 |
| CN202010134846.XA Pending CN111249062A (zh) | 2012-07-03 | 2013-01-25 | 注射器 |
| CN201380035900.3A Pending CN104427972A (zh) | 2012-07-03 | 2013-01-25 | 注射器 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110166906.0A Pending CN112972828A (zh) | 2012-07-03 | 2013-01-25 | 注射器 |
| CN202010134846.XA Pending CN111249062A (zh) | 2012-07-03 | 2013-01-25 | 注射器 |
| CN201380035900.3A Pending CN104427972A (zh) | 2012-07-03 | 2013-01-25 | 注射器 |
Country Status (39)
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614134B (zh) | 2005-03-25 | 2016-09-07 | 瑞泽恩制药公司 | Vegf拮抗剂制剂 |
| RU2432155C3 (ru) | 2006-06-16 | 2017-11-17 | Ридженерон Фармасьютикалз, Инк. | Составы антагониста vegf, подходящие для интравитреального введения |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| EP2776603B1 (en) | 2011-11-11 | 2019-03-06 | SiO2 Medical Products, Inc. | PASSIVATION, pH PROTECTIVE OR LUBRICITY COATING FOR PHARMACEUTICAL PACKAGE, COATING PROCESS AND APPARATUS |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| KR102232708B1 (ko) | 2012-06-01 | 2021-03-30 | 노파르티스 아게 | 시린지 |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| EP4234753A3 (en) | 2013-03-11 | 2023-11-01 | SiO2 Medical Products, Inc. | Coated packaging |
| EP3254666B1 (en) * | 2013-03-13 | 2019-10-16 | Rush University Medical Center | Delivery device and storage system for oropharyngeal administration of mother's colostrum and milk |
| US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
| US10010447B2 (en) | 2013-12-18 | 2018-07-03 | Novartis Ag | Systems and methods for subretinal delivery of therapeutic agents |
| EP3122917B1 (en) | 2014-03-28 | 2020-05-06 | SiO2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| WO2015173260A1 (en) * | 2014-05-12 | 2015-11-19 | Formycon Ag | Pre-filled plastic syringe containing a vegf antagonist |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| TWI738632B (zh) | 2014-11-07 | 2021-09-11 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
| EP3058974A1 (en) | 2015-02-19 | 2016-08-24 | Sanofi-Aventis Deutschland GmbH | Injection device with supplementary device |
| CN107743406B (zh) * | 2015-03-23 | 2020-12-11 | 赛诺菲-安万特德国有限公司 | 注射装置 |
| MA41906A (fr) | 2015-04-10 | 2018-02-13 | Dompe Farm Spa | Dispositif de distribution de gouttes oculaires |
| CN108883057A (zh) * | 2015-11-18 | 2018-11-23 | Sio2医药产品公司 | 用于眼科配制品的药物包装 |
| WO2018218013A2 (en) | 2017-05-24 | 2018-11-29 | Sio2 Medical Products, Inc. | Sterilizable pharmaceutical package for ophthalmic formulations |
| EP3377151A1 (en) * | 2015-11-18 | 2018-09-26 | Formycon AG | Pre-filled plastic syringe containing a vegf antagonist |
| WO2017087798A1 (en) * | 2015-11-18 | 2017-05-26 | Formycon Ag | Pre-filled pharmaceutical package comprising a liquid formulation of a vegf-antagonist |
| PL3384049T3 (pl) | 2015-12-03 | 2024-01-22 | Regeneron Pharmaceuticals, Inc. | Sposoby powiązania wariantów genetycznych z wynikiem klinicznym u pacjentów cierpiących na zwyrodnienie plamki związane z wiekiem, leczonych anty-vegf |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| RU2738018C2 (ru) * | 2016-04-15 | 2020-12-07 | Сантен Фармасьютикал Ко., Лтд. | Точный, прецизионный микролитровый дозирующий шприц |
| US20170349313A1 (en) * | 2016-06-01 | 2017-12-07 | Centurion Medical Products Corporation | Methods for manufacturing non-glass prefilled syringes |
| CN109312182B (zh) | 2016-06-17 | 2021-12-24 | 花王株式会社 | 水性油墨 |
| TWI737742B (zh) * | 2016-06-22 | 2021-09-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素的預填充式注射器系統、具有其之套組以及其之使用 |
| ITUA20162072A1 (it) * | 2016-06-30 | 2017-12-30 | Platinum Corp Srl | Dropper a volume controllato |
| EP3502050B1 (en) | 2016-08-22 | 2022-12-21 | Fuji Corporation | Method for producing aqueous hydrogen peroxide |
| US10537683B2 (en) | 2016-11-03 | 2020-01-21 | Johnson & Johnson Surgical Vision, Inc. | Syringe finger grip |
| US10918754B2 (en) | 2017-03-27 | 2021-02-16 | Regeneron Pharmaceuticals, Inc. | Sterilisation method |
| EP3609483A4 (en) | 2017-04-12 | 2021-01-20 | Urigen Pharmaceuticals, Inc. | Article of manufacture comprising local anesthetic, buffer, and glycosaminoglycan in syringe with improved stability |
| JP7165142B2 (ja) | 2017-05-05 | 2022-11-02 | アルコン インコーポレイティド | 崩壊可能プランジャを含むシリンジ |
| EP3630043A1 (en) | 2017-05-24 | 2020-04-08 | Formycon AG | Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist |
| JP7098171B2 (ja) | 2017-06-16 | 2022-07-11 | クリーデンス メドシステムズ，インコーポレイテッド | 安全シリンジのシステムおよび方法 |
| US11590175B2 (en) | 2017-08-23 | 2023-02-28 | Merakris Therapeutics Llc | Compositions containing amniotic components and methods for preparation and use thereof |
| FR3072297B1 (fr) * | 2017-10-17 | 2023-05-12 | Edix Sa | Dispositif d'injection manuelle |
| WO2019118588A1 (en) | 2017-12-13 | 2019-06-20 | Regeneron Pharmaceuticals, Inc. | Devices and methods for precision dose delivery |
| EP4309707A3 (en) | 2018-02-02 | 2024-04-24 | F. Hoffmann-La Roche AG | Prefilled syringe and method of sterilizing a prefilled syringe |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| WO2019199901A1 (en) * | 2018-04-09 | 2019-10-17 | Sio2 Medical Products, Inc. | Stretchable plunger assemblies |
| US20210146054A1 (en) * | 2018-04-24 | 2021-05-20 | W. L. Gore & Associates, Inc. | Medical Delivery Devices With Inhibited Oxygen Permeation |
| KR20210021299A (ko) | 2018-05-10 | 2021-02-25 | 리제너론 파아마슈티컬스, 인크. | 고농도 vegf 수용체 융합 단백질 함유 제제 |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| US20210260300A1 (en) * | 2018-06-01 | 2021-08-26 | Sun Pharma Advanced Research Company Limited | An injection device |
| WO2020086002A1 (en) * | 2018-10-26 | 2020-04-30 | Singapore Health Services Pte Ltd | Device and method for ophthalmic extraction and injection |
| CA3119455C (en) | 2018-11-13 | 2024-07-02 | Credence Medsystems, Inc. | MULTI-SITE INJECTION SYSTEM AND METHOD |
| WO2020109343A1 (en) | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Combination therapy for treatment of macular degeneration |
| WO2020109344A1 (en) | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Occular administration device for antisense oligonucleotides |
| JOP20210152A1 (ar) | 2018-12-18 | 2023-01-30 | Novartis Ag | صياغة محلول بروتيني محتوية على تركيز عالٍ من جسم مضاد لـ vegf |
| CN110721026A (zh) * | 2018-12-21 | 2020-01-24 | 南通市第一人民医院 | 一种眼科手术用取硅油装置防滑层的制备方法 |
| EP3689397B1 (de) * | 2019-01-31 | 2025-04-23 | SCHOTT Pharma Schweiz AG | Spritzenkörper, spritze und injektionsvorrichtung zum injizieren eines hochviskosen mediums |
| GB201902355D0 (en) * | 2019-02-21 | 2019-04-10 | New Injection Systems Ltd | Modular auto injector |
| FR3093004B1 (fr) * | 2019-02-21 | 2023-04-07 | Dev Techniques Plastiques | Procede de preparation d’une seringue |
| CA3131922A1 (en) | 2019-02-28 | 2020-09-03 | William Samuel Fagg, Iv | Amniotic fluid-derived extracellular vesicles and uses thereof for wound healing |
| ES2902983T3 (es) * | 2019-03-29 | 2022-03-30 | Kortuc Inc | Jeringa precargada con una solución de peróxido de hidrógeno que tiene una excelente capacidad de preservación del peróxido de hidrógeno debido al aceite de silicona (composición de aceite que contiene dicho aceite de silicona) |
| MX2021012683A (es) | 2019-04-18 | 2021-11-12 | Boehringer Ingelheim Int | Dispositivo de administracion para la administracion de un fluido. |
| CN118718181A (zh) | 2019-06-05 | 2024-10-01 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| WO2021019576A1 (en) * | 2019-08-01 | 2021-02-04 | Gennova Biopharmaceuticals Limited | Opthalmic composition of bevacizumab |
| JP2022546082A (ja) | 2019-09-03 | 2022-11-02 | アムジエン・インコーポレーテツド | 薬物送達のための注入デバイス及び注入デバイスのためのパッケージ |
| WO2021046245A1 (en) * | 2019-09-04 | 2021-03-11 | University Of Massachusetts | Adeno-associated virus vector platform for delivery of kh902 (conbercept) and uses thereof |
| MX2022002980A (es) | 2019-09-16 | 2022-04-06 | Amgen Inc | Metodo para la esterilizacion externa de un dispositivo de suministro de farmacos. |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| EP4058108A2 (en) | 2019-11-14 | 2022-09-21 | Congruence Medical Solutions, LLC | Variable dosing syringe |
| CN115335529A (zh) * | 2019-11-26 | 2022-11-11 | 马萨诸塞大学 | 用于递送kh902(康柏西普)的重组腺相关病毒及其用途 |
| EP4069164A2 (en) | 2019-12-05 | 2022-10-12 | F. Hoffmann-La Roche AG | Syringe and tightness testing method |
| WO2021119544A1 (en) * | 2019-12-12 | 2021-06-17 | Novartis Ag | Injection device and injection solution transferring system |
| JP7488331B2 (ja) * | 2020-03-24 | 2024-05-21 | テルモ株式会社 | 注射器バレル用グリップおよびバレル組立体ならびにシリンジ |
| WO2021257911A1 (en) | 2020-06-17 | 2021-12-23 | Credence Medsystems, Inc. | System and method for microdose injection |
| JP2023550281A (ja) * | 2020-10-30 | 2023-12-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 流体の特に硝子体内投与のための投与デバイス |
| KR20230117155A (ko) | 2020-12-01 | 2023-08-07 | 베링거 인겔하임 인터내셔날 게엠베하 | 특히 유체의 유리체내 투여를 위한 투여 장치 |
| KR102720956B1 (ko) | 2020-12-15 | 2024-10-24 | 삼천당제약주식회사 | 안과용 제형을 포함하는 시린지 |
| EP4271450A1 (en) * | 2020-12-29 | 2023-11-08 | W. L. Gore & Associates, Inc. | Drug injection stopper with thin film lubricant |
| KR102419910B1 (ko) * | 2021-04-15 | 2022-07-14 | 주식회사 알테오젠 | 저용량 약액 충전 사전 충전형 주사기 및 그 제조방법 |
| US20250041523A1 (en) * | 2021-12-01 | 2025-02-06 | Sanofi Winthrop Industrie | A Lubricating Shuttle |
| CN114146220B (zh) | 2022-02-10 | 2022-04-29 | 中国远大集团有限责任公司 | 一种包含无菌pcl微球的美容产品 |
| EP4389176A1 (en) | 2022-12-20 | 2024-06-26 | W. L. Gore & Associates, Inc. | Low insertion force syringe stoppers, assemblies, and associated methods |
| EP4480517A1 (de) | 2023-06-20 | 2024-12-25 | Ypsomed AG | Autoinjektor zur intravitrealen injektion |
| CA3237624A1 (en) * | 2023-07-28 | 2025-04-24 | Genentech, Inc. | NEW USES FOR OMALIZUMAB |
| CN117942456B (zh) * | 2024-03-27 | 2024-07-12 | 山东永聚医药科技股份有限公司 | 缓释型非牛顿流体制剂用预灌封注射器及其制备工艺 |
| KR102828906B1 (ko) * | 2024-11-18 | 2025-07-04 | 주식회사 비에스리서치 | 실리콘 오일이 미적용된 프리필드 시린지 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0264273A2 (en) * | 1986-10-15 | 1988-04-20 | Daikyo Gomu Seiko Ltd. | A laminated sliding stopper for a syringe |
| US5290228A (en) * | 1990-11-17 | 1994-03-01 | Santen Seiyaku Kabushiki Kaisha | Two-compartment syringe |
| US5607400A (en) * | 1995-05-19 | 1997-03-04 | Becton, Dickinson And Company | Pre-fillable syringe and stopper assembly therefor |
| JPH10201844A (ja) * | 1997-01-22 | 1998-08-04 | Koki Eng:Kk | 注射器のシリンダとその製造方法及びシリコンオイル由来の潤滑薄層の製造方法 |
| US20060293270A1 (en) * | 2005-06-22 | 2006-12-28 | Adamis Anthony P | Methods and compositions for treating ocular disorders |
| WO2007035621A1 (en) * | 2005-09-16 | 2007-03-29 | (Osi) Eyetech, Inc. | Ophthalmic syringe |
| CN101437543A (zh) * | 2006-05-04 | 2009-05-20 | 佛维雅制药股份有限公司 | 用于治疗新生血管病的包含vegf抑制剂和丝氨酸蛋白酶的组合 |
| DE102008005938A1 (de) * | 2008-01-24 | 2009-07-30 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Vorgefüllte Spritze und Verfahren zum Verpacken einer Spritze |
| US20110257601A1 (en) * | 2006-06-16 | 2011-10-20 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations for intravitreal administration |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US31789A (en) | 1861-03-26 | Bread-slicebi | ||
| DE2629557B2 (de) | 1976-07-01 | 1980-05-14 | Paul E. Dr.Med. 8000 Muenchen Doerr | Einmai-Injektionsspritze |
| US4946441A (en) | 1988-07-21 | 1990-08-07 | Maurice Laderoute | Limited use hypodermic syringe |
| JPH0725963Y2 (ja) | 1989-11-06 | 1995-06-14 | 清坤 曽 | 緊急避難装置 |
| US5236604A (en) * | 1991-05-29 | 1993-08-17 | Sherwood Medical Company | Serum separation blood collection tube and the method of using thereof |
| JP3186422B2 (ja) | 1993-05-14 | 2001-07-11 | 武田薬品工業株式会社 | プラスチゾル |
| US5405326A (en) | 1993-08-26 | 1995-04-11 | Habley Medical Technology Corporation | Disposable safety syringe with retractable shuttle for luer lock needle |
| US5795337A (en) | 1994-02-14 | 1998-08-18 | Becton Dickinson And Company | Syringe assembly and syringe stopper |
| US5688252A (en) | 1994-09-30 | 1997-11-18 | Takeda Chemical Industries, Ltd. | Syringe |
| US5667495A (en) | 1995-04-21 | 1997-09-16 | Becton Dickinson France S.A. | Backstop device for a syringe |
| DE19622283A1 (de) | 1996-05-23 | 1997-11-27 | Schering Ag | Verfahren zur terminalen Sterilisierung von befüllten Spritzen |
| WO1998045331A2 (en) | 1997-04-07 | 1998-10-15 | Genentech, Inc. | Anti-vegf antibodies |
| JP3387775B2 (ja) * | 1997-05-22 | 2003-03-17 | 株式会社大協精工 | 注射器用密封栓及びプレフィルド注射器 |
| US6200627B1 (en) * | 1998-03-17 | 2001-03-13 | Becton, Dickinson And Company | Low silicone glass prefillable syringe |
| JP2002515268A (ja) * | 1998-04-30 | 2002-05-28 | アボット・ラボラトリーズ | 注射器アセンブリ |
| USD430015S (en) | 1998-06-11 | 2000-08-29 | Pharmacia & Upjohn Ab | Blister pack for a syringe |
| JP2001104480A (ja) | 1999-10-05 | 2001-04-17 | Daikyo Seiko Ltd | プラスチック製プレフィルド注射器の密封に使用するゴム製ピストン |
| JP2001340455A (ja) | 2000-05-31 | 2001-12-11 | Yoshino Kogyosho Co Ltd | シリンジ容器 |
| JP2002177388A (ja) | 2000-12-15 | 2002-06-25 | Daikyo Seiko Ltd | 医薬・医療用既充填注射器 |
| JP2002241264A (ja) | 2001-02-19 | 2002-08-28 | Asahi Kasei Corp | エルカトニンのプレフィルドシリンジ製剤 |
| WO2003055546A1 (en) * | 2001-12-27 | 2003-07-10 | Showa Yakuhin Kako Co., Ltd. | Cartridge syringe, cartridge and ophthalmologic syringe set having such syringe |
| JP4141156B2 (ja) | 2002-03-15 | 2008-08-27 | 日本ベクトン・ディッキンソン株式会社 | プランジャ後退制限機構付きプレフィルドシリンジ |
| US6688252B1 (en) | 2002-12-11 | 2004-02-10 | Gary Caravella | Boat cover |
| US20050010175A1 (en) | 2003-02-27 | 2005-01-13 | Beedon Daniel E. | Piston assembly for syringe |
| JP2004313369A (ja) | 2003-04-15 | 2004-11-11 | Menicon Co Ltd | カートリッジ注入器、カートリッジ及び該注入器を備えた眼科用注入器セット |
| FR2855413B1 (fr) | 2003-05-26 | 2005-12-30 | Becton Dickinson France | Seringue pre-remplie avec coiffe anti effraction |
| KR20060130648A (ko) * | 2004-01-12 | 2006-12-19 | 아이싸이언스 인터벤셔날 코포레이션 | 점성 물질용 인젝터 |
| US8124207B2 (en) | 2004-03-02 | 2012-02-28 | Sakhrani Vinay G | Article with lubricated surface and method |
| KR100897379B1 (ko) | 2004-06-08 | 2009-05-14 | 쳉두 캉홍 바이오테크놀로지스 코. 리미티드 | 혈관신생-저해 키메릭 단백질 및 그 사용 |
| EP2324848A3 (en) | 2004-10-21 | 2011-09-14 | Genentech, Inc. | Method for treating intraocular neovascular diseases |
| AU2006214658A1 (en) * | 2005-02-02 | 2006-08-24 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a VEGF inhibitor |
| US20080312607A1 (en) * | 2005-05-31 | 2008-12-18 | Baxter International Inc. | Polypropylene Hollow Barrel with Sliding Coated Rubber Piston |
| US20070060887A1 (en) * | 2005-08-22 | 2007-03-15 | Marsh David A | Ophthalmic injector |
| FR2890316B1 (fr) * | 2005-09-02 | 2007-10-05 | Aguettant Soc Par Actions Simp | Seringue destinee a etre remplie puis sterilisee par autoclavage a la vapeur. |
| WO2007035623A1 (en) | 2005-09-17 | 2007-03-29 | Technology Group Northwest Inc. | System and method for foiling code-injection attacks in a computing device |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| ZA200803814B (en) * | 2005-10-14 | 2010-02-24 | Alcon Inc | Method for treating primary and secondary forms of glaucoma |
| AT502791B1 (de) * | 2006-04-06 | 2007-05-15 | Pharma Consult Ges M B H & Co | Injektionsspritze |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| JP4131001B2 (ja) | 2006-07-28 | 2008-08-13 | 大成化工株式会社 | 定量吐出装置 |
| CN200973886Y (zh) * | 2006-11-20 | 2007-11-14 | 骆忠林 | 一种注射器 |
| WO2008077155A1 (en) | 2006-12-21 | 2008-06-26 | Genentech, Inc. | Sterilization of objects containing biological molecules |
| US8529521B2 (en) | 2007-04-23 | 2013-09-10 | Ultimed Inc. | Low-dosage syringe |
| CN100563736C (zh) * | 2007-06-02 | 2009-12-02 | 丁锐 | 一次性防刺伤注射器 |
| JP5393660B2 (ja) | 2007-06-12 | 2014-01-22 | ベクトン・ディキンソン・アンド・カンパニー | 不能化機構付き注射器 |
| EP2020245B1 (en) * | 2007-07-31 | 2011-11-30 | AL.CHI.MI.A. S.r.l. | Method for making a device for ophthalmic treatments |
| WO2009030975A1 (en) | 2007-09-03 | 2009-03-12 | Becton Dickinson France | Medical device comprising a siliconized chamber and a coated closure means |
| WO2009030976A1 (en) | 2007-09-03 | 2009-03-12 | Becton Dickinson France | Medical device and smooth coating therefor |
| ATE533963T1 (de) | 2008-01-24 | 2011-12-15 | Meflex Telecontrol Gmbh & Co Kg | Abschlusskappe für ein antriebskabel, antriebskabel, verfahren zur herstellung einer abschlusskappe sowie verfahren zur herstellung eines antriebskabels |
| CN102202643A (zh) | 2008-02-07 | 2011-09-28 | 安姆根有限公司 | 稳定化的蛋白组合物 |
| CA2728145A1 (en) | 2008-06-17 | 2009-12-23 | Denki Kagaku Kogyo Kabushiki Kaisha | Injector |
| WO2009158613A1 (en) | 2008-06-26 | 2009-12-30 | West Pharmaceutical Services, Inc. | Method of coating polyxylylene onto flouropolymer surfaces and devices coated thereby |
| US8221353B2 (en) | 2008-10-21 | 2012-07-17 | KMG Pharma, Inc | Intravitreal injection device and system |
| WO2010060748A1 (en) | 2008-11-03 | 2010-06-03 | Molecular Partners Ag | Binding proteins inhibiting the vegf-a receptor interaction |
| AU2009323307B2 (en) | 2008-12-03 | 2015-02-19 | Denki Kagaku Kogyo Kabushiki Kaisha | Syringe |
| JP2012525415A (ja) * | 2009-05-01 | 2012-10-22 | オプソテツク・コーポレイシヨン | 眼科疾患を処置または予防するための方法 |
| WO2010136492A2 (en) | 2009-05-28 | 2010-12-02 | Glaxo Group Limited | Antigen-binding proteins |
| EP2266647A1 (en) * | 2009-06-25 | 2010-12-29 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for drug delivery device |
| AR078060A1 (es) | 2009-07-14 | 2011-10-12 | Novartis Ag | Descontaminacion de superficie de contenedores previamente llenados en empaque secundario |
| CN102725012B (zh) | 2009-10-29 | 2016-01-06 | W.L.戈尔及同仁股份有限公司 | 涂覆膨胀型ptfe的注射器塞 |
| CN201578690U (zh) | 2010-01-21 | 2010-09-15 | 王建友 | 一种注射器 |
| CA2795096C (en) | 2010-03-31 | 2021-10-26 | Ocuject, Llc | Device and method for intraocular drug delivery |
| US9408746B2 (en) | 2010-03-31 | 2016-08-09 | Ocuject, Llc | Device and method for intraocular drug delivery |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| JP2012045046A (ja) | 2010-08-24 | 2012-03-08 | Gc Corp | 歯科用シリンジ |
| FR2966044B1 (fr) | 2010-10-18 | 2012-11-02 | Sanofi Pasteur | Procede de conditionnement d'un vaccin contenant un adjuvant d'aluminium |
| US10034981B2 (en) | 2011-03-01 | 2018-07-31 | Terumo Kabushiki Kaisha | Syringe and syringe assembly |
| LT2701773T (lt) | 2011-04-25 | 2019-07-10 | Icon Bioscience, Inc. | Injekcinio švirkšto dozės kreiptuvai |
| US20130012918A1 (en) | 2011-07-07 | 2013-01-10 | Gary Foster | Steady grip ophthalmic surgical syringe and method |
| ES2944088T3 (es) | 2011-09-27 | 2023-06-19 | Becton Dickinson France | Uso de aceite de silicona tratado con plasma como recubrimiento en un dispositivo médico de inyección |
| US9421129B2 (en) | 2012-04-02 | 2016-08-23 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
| US10780228B2 (en) | 2012-05-07 | 2020-09-22 | Medline Industries, Inc. | Prefilled container systems |
| KR102232708B1 (ko) | 2012-06-01 | 2021-03-30 | 노파르티스 아게 | 시린지 |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| DE202012011016U1 (de) | 2012-07-03 | 2012-11-28 | Novartis Ag | Aflibercept-Spritze |
| AU2013100070B4 (en) | 2012-07-03 | 2013-04-04 | Novartis Ag | Use of device |
| US9662450B2 (en) * | 2013-03-01 | 2017-05-30 | Sio2 Medical Products, Inc. | Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus |
-
2012
- 2012-07-03 JO JOP/2020/0175A patent/JOP20200175A1/ar unknown
-
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- 2013-01-23 DE DE201320000688 patent/DE202013000688U1/de not_active Expired - Lifetime
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Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0264273A2 (en) * | 1986-10-15 | 1988-04-20 | Daikyo Gomu Seiko Ltd. | A laminated sliding stopper for a syringe |
| US5290228A (en) * | 1990-11-17 | 1994-03-01 | Santen Seiyaku Kabushiki Kaisha | Two-compartment syringe |
| US5607400A (en) * | 1995-05-19 | 1997-03-04 | Becton, Dickinson And Company | Pre-fillable syringe and stopper assembly therefor |
| JPH10201844A (ja) * | 1997-01-22 | 1998-08-04 | Koki Eng:Kk | 注射器のシリンダとその製造方法及びシリコンオイル由来の潤滑薄層の製造方法 |
| US20060293270A1 (en) * | 2005-06-22 | 2006-12-28 | Adamis Anthony P | Methods and compositions for treating ocular disorders |
| WO2007035621A1 (en) * | 2005-09-16 | 2007-03-29 | (Osi) Eyetech, Inc. | Ophthalmic syringe |
| CN101437543A (zh) * | 2006-05-04 | 2009-05-20 | 佛维雅制药股份有限公司 | 用于治疗新生血管病的包含vegf抑制剂和丝氨酸蛋白酶的组合 |
| US20110257601A1 (en) * | 2006-06-16 | 2011-10-20 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations for intravitreal administration |
| DE102008005938A1 (de) * | 2008-01-24 | 2009-07-30 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Vorgefüllte Spritze und Verfahren zum Verpacken einer Spritze |
Non-Patent Citations (1)
| Title |
|---|
| EDWIN CHAN ET AL.: "Syringe Siliconization Process Investigation and Optimization", 《PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY》 * |
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