CN106552682B - 微流体装置以及制造方法和用途 - Google Patents

微流体装置以及制造方法和用途 Download PDF

Info

Publication number
CN106552682B
CN106552682B CN201610301218.XA CN201610301218A CN106552682B CN 106552682 B CN106552682 B CN 106552682B CN 201610301218 A CN201610301218 A CN 201610301218A CN 106552682 B CN106552682 B CN 106552682B
Authority
CN
China
Prior art keywords
flow
microfluidic device
flow channel
fluid
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201610301218.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN106552682A (zh
Inventor
M.A.普特纳姆
J.T.布兰奇富特
C.O.斯坦伍德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CyVek Inc
Original Assignee
CyVek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CyVek Inc filed Critical CyVek Inc
Publication of CN106552682A publication Critical patent/CN106552682A/zh
Application granted granted Critical
Publication of CN106552682B publication Critical patent/CN106552682B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
    • B32B37/14—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers
    • B32B37/142—Laminating of sheets, panels or inserts, e.g. stiffeners, by wrapping in at least one outer layer, or inserting into a preformed pocket
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
    • B32B37/14—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers
    • B32B37/16—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with all layers existing as coherent layers before laminating
    • B32B37/18—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with all layers existing as coherent layers before laminating involving the assembly of discrete sheets or panels only
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B38/00—Ancillary operations in connection with laminating processes
    • B32B38/0008—Electrical discharge treatment, e.g. corona, plasma treatment; wave energy or particle radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/02—Preparation of the material, in the area to be joined, prior to joining or welding
    • B29C66/026—Chemical pre-treatments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/02—Preparation of the material, in the area to be joined, prior to joining or welding
    • B29C66/028—Non-mechanical surface pre-treatments, i.e. by flame treatment, electric discharge treatment, plasma treatment, wave energy or particle radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/52—Joining tubular articles, bars or profiled elements
    • B29C66/522—Joining tubular articles
    • B29C66/5225—Joining tubular articles for forming cross-shaped connections, e.g. for making X-shaped pieces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/52—Joining tubular articles, bars or profiled elements
    • B29C66/522—Joining tubular articles
    • B29C66/5229—Joining tubular articles involving the use of a socket
    • B29C66/52298—Joining tubular articles involving the use of a socket said socket being composed by several elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B29C66/712—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined the composition of one of the parts to be joined being different from the composition of the other part
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2535/00—Medical equipment, e.g. bandage, prostheses or catheter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/058—Flat flow cell
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/494—Fluidic or fluid actuated device making

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Thermal Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201610301218.XA 2011-03-22 2012-03-22 微流体装置以及制造方法和用途 Active CN106552682B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161465688P 2011-03-22 2011-03-22
US61/465688 2011-03-22
US201261608570P 2012-03-08 2012-03-08
US61/608570 2012-03-08
CN201280024948.XA CN103649759B (zh) 2011-03-22 2012-03-22 微流体装置以及制造方法和用途

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280024948.XA Division CN103649759B (zh) 2011-03-22 2012-03-22 微流体装置以及制造方法和用途

Publications (2)

Publication Number Publication Date
CN106552682A CN106552682A (zh) 2017-04-05
CN106552682B true CN106552682B (zh) 2020-06-19

Family

ID=46880056

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610301218.XA Active CN106552682B (zh) 2011-03-22 2012-03-22 微流体装置以及制造方法和用途
CN201280024948.XA Active CN103649759B (zh) 2011-03-22 2012-03-22 微流体装置以及制造方法和用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280024948.XA Active CN103649759B (zh) 2011-03-22 2012-03-22 微流体装置以及制造方法和用途

Country Status (6)

Country Link
US (2) US9216412B2 (https=)
EP (1) EP2689253B1 (https=)
JP (1) JP5978287B2 (https=)
CN (2) CN106552682B (https=)
CA (1) CA2830533C (https=)
WO (1) WO2012129455A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
GB201014805D0 (en) 2010-09-07 2010-10-20 Multi Sense Technologies Ltd Microfluidics based assay device
US9879310B2 (en) * 2011-01-31 2018-01-30 The Regents Of The University Of California Nano/microscale vehicles for capture and isolation of target biomolecules and living organisms
CN106552682B (zh) 2011-03-22 2020-06-19 西维克公司 微流体装置以及制造方法和用途
WO2012144794A2 (ko) * 2011-04-19 2012-10-26 주식회사 바이오포커스 랩온어칩에 장착되는 마이크로밸브 소자의 제작방법 및 이로부터 제작되는 마이크로밸브 소자
DE102011109944B4 (de) * 2011-08-10 2018-10-25 Bürkert Werke GmbH Fertigungsverfahren für Mikroventile
CN103157523A (zh) * 2011-12-15 2013-06-19 三星电子株式会社 微流器件及其制造方法
KR102114734B1 (ko) * 2012-03-08 2020-05-25 싸이벡, 아이엔씨 미세유체 분석 장치용 마이크로튜브 입자 및 제조방법
WO2014150853A1 (en) * 2013-03-15 2014-09-25 Inanovate, Inc. Analyte measurement using longitudinal assay
WO2014190258A1 (en) 2013-05-23 2014-11-27 The Regents Of The University Of California Proximal degas driven microfluidic actuation
US10126220B2 (en) * 2013-07-22 2018-11-13 National Oilwell Varco, L.P. Systems and methods for determining specific gravity and minerological properties of a particle
US10518196B2 (en) * 2014-01-29 2019-12-31 General Electric Company Devices for separation of particulates, associated methods and systems
JP6548356B2 (ja) * 2014-03-20 2019-07-24 キヤノンメディカルシステムズ株式会社 送液装置
CA3140009C (en) * 2014-05-13 2023-09-05 Amgen Inc. Process control systems and methods for use with filters and filtration processes
WO2015196065A1 (en) * 2014-06-19 2015-12-23 The Trustees Of The University Of Pennsylvania Apparatus and methods for making recombinant protein-stabilized monodisperse microbubbles
CN104998701B (zh) * 2015-07-01 2017-05-10 北京工业大学 利用凹槽实现下底面可动的微通道的制作方法
US10228367B2 (en) * 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
CN105536896A (zh) * 2015-12-13 2016-05-04 北京工业大学 下壁面外凸的微流控芯片
WO2017204274A1 (ja) * 2016-05-25 2017-11-30 ユニバーサル・バイオ・リサーチ株式会社 検体処理測定システム
GB201611442D0 (en) 2016-06-30 2016-08-17 Lumiradx Tech Ltd Fluid control
US10500587B2 (en) 2016-07-20 2019-12-10 Boise State University Ferro-magnetic shape memory alloy microcavity fluid sensor
EP3523048B1 (en) * 2016-10-06 2025-03-19 The Regents of The University of California Volumetric micro-injector for capillary electrophoresis
DK3523448T3 (da) * 2016-10-07 2021-06-28 Boehringer Ingelheim Vetmedica Gmbh Fremgangsmåde og analysesystem til at teste en prøve
CN106902904B (zh) * 2017-04-01 2018-07-03 南京岚煜生物科技有限公司 用于微流控芯片的液体控制阀门装置及其微流控芯片
US10434510B2 (en) 2017-05-06 2019-10-08 International Business Machines Corporation Microfluidic probe with bypass and control channels
RU2675998C1 (ru) * 2018-02-02 2018-12-25 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" Микрофлюидный чип для культивирования и/или исследования клеток и заготовка микрофлюидного чипа
EP3812770A4 (en) * 2018-04-19 2022-01-12 The University of Tokyo METHOD AND KIT FOR AIDING THE DIAGNOSIS OF A DISEASE IN A SUBJECT
CN110006882B (zh) * 2019-04-03 2021-06-25 山东职业学院 一种检测水体中氮磷含量的微流控芯片及检测方法
WO2021038049A1 (en) * 2019-08-29 2021-03-04 Astraveus Apparatus and method for clamping a microfluidic device
CN110982667B (zh) * 2019-12-23 2023-08-22 西安医学院 一种单细胞分散微流控芯片及制备和操作方法
CN111229347A (zh) * 2020-03-12 2020-06-05 周晓颖 一种模块化微流控检测芯片
CN111389474B (zh) * 2020-04-09 2021-01-01 清华大学 一种用于样本分散的微流控芯片及其制备方法与应用
CN111826273B (zh) * 2020-07-22 2023-03-21 上海逢伙泰企业管理有限公司 一种用于核酸检测的自动化全封闭微流控芯片
CN112808335B (zh) * 2021-01-21 2022-03-01 中国科学技术大学 一种用于水体多参数检测的微流控芯片的制备方法
CN114247488B (zh) * 2021-11-23 2023-12-08 东胜神州(北京)医学诊断技术有限公司 一种袋反应器的制造方法
CN114425665B (zh) * 2022-02-14 2023-11-10 上海赛卡精密机械有限公司 水导激光系统和双层材料切割方法
DE102022202864A1 (de) 2022-03-24 2023-09-28 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung und Verfahren zum Betreiben einer mikrofluidischen Vorrichtung
TW202407329A (zh) * 2022-05-05 2024-02-16 香港商新發病毒診斷（香港）有限公司 信號檢測機構及其方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1957254A (zh) * 2004-04-07 2007-05-02 沃德劳有限合伙公司 用于分析生物流体的可置换腔
CN101263392A (zh) * 2005-09-13 2008-09-10 美特宝思科润株式会社 微流道芯片

Family Cites Families (289)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
SE343949B (https=) 1966-06-02 1972-03-20 Pharmacia Ab
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3876376A (en) 1974-05-09 1975-04-08 American Cyanamid Co Linear determination of hemolytic complement activity in undiluted serum
US4320087A (en) 1978-01-23 1982-03-16 Abbott Laboratories Laboratory assay device
US4222744A (en) 1978-09-27 1980-09-16 Becton Dickinson & Company Assay for ligands
US4254096A (en) 1979-10-04 1981-03-03 Bio-Rad Laboratories, Inc. Reagent combination for solid phase immunofluorescent assay
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4425438A (en) 1981-03-13 1984-01-10 Bauman David S Assay method and device
US4368047A (en) 1981-04-27 1983-01-11 University Of Utah Research Foundation Process for conducting fluorescence immunoassays without added labels and employing attenuated internal reflection
NZ201901A (en) 1981-09-25 1986-11-12 Commw Serum Lab Commission An apparatus suitable for performing automated heterogeneous immunoassays in a plurality of samples
DE3226407C2 (de) 1982-07-15 1985-05-15 Volker Dr. 6900 Heidelberg Daniel Mikro-Analyse-Kapillar-System
US4447546A (en) 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
AU570425B2 (en) 1982-12-21 1988-03-17 Applied Research Systems Ars Holding N.V. Assay technique
DE3484505D1 (de) 1983-12-19 1991-05-29 Daiichi Pure Chemicals Co Ltd Immuntest.
US4581624A (en) 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
US4657869A (en) 1984-05-18 1987-04-14 E. I. Du Pont De Nemours And Company Self-contained device for carrying out specific binding assays
US5004923A (en) 1985-08-05 1991-04-02 Biotrack, Inc. Capillary flow device
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US4716121A (en) 1985-09-09 1987-12-29 Ord, Inc. Fluorescent assays, including immunoassays, with feature of flowing sample
US4844869A (en) 1985-09-09 1989-07-04 Ord, Inc. Immunoassay apparatus
US5500350A (en) 1985-10-30 1996-03-19 Celltech Limited Binding assay device
US4717545A (en) 1986-09-11 1988-01-05 Miles Inc. Device and method for chemical analysis of fluids with a reagent coated light source
US4820490A (en) 1986-09-11 1989-04-11 Miles Inc. Device and method for chemical analysis of fluids with a reagent coated light source
US4797259A (en) 1986-12-15 1989-01-10 Pall Corporation Well-type diagnostic plate device
US4923819A (en) 1987-03-27 1990-05-08 Chimerix Corporation Time-resolved fluorescence immunoassay
US4857453A (en) 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
EP0312565B1 (en) 1987-04-29 1993-03-03 Celltech Limited Binding assay device
US5009998A (en) 1987-06-26 1991-04-23 E. I. Du Pont De Nemours And Company Method for performing heterogeneous immunoassay
US5041181A (en) 1987-10-06 1991-08-20 Integrated Fluidics Company Method of bonding plastics
US4908116A (en) 1989-06-01 1990-03-13 The Board Of Trustees At The Leland Stanford Junior University Capillary electrophoretic device employing structure permitting electrical contact through ionic movement
US5302349A (en) 1989-06-13 1994-04-12 Diatron Corporation Transient-state luminescence assay apparatus
US6008057A (en) 1989-08-25 1999-12-28 Roche Diagnostics Corporation Immunoassay system
US5183740A (en) 1990-02-23 1993-02-02 The United States Of America As Represented By The Secretary Of The Navy Flow immunosensor method and apparatus
SE470347B (sv) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
JPH0541984A (ja) 1990-09-07 1993-02-23 Dow Chem Co:The 攪拌容器における中空繊維においての細胞の増殖
JPH06501099A (ja) 1990-09-11 1994-01-27 ヴォアヒーズ・テクノロジース・インコーポレーテッド 被覆された毛管
JP2523227Y2 (ja) 1991-07-30 1997-01-22 株式会社堀場製作所 異物検査装置
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
JPH06108242A (ja) 1992-09-25 1994-04-19 Minolta Camera Co Ltd 薄膜電極および薄膜製造装置
US5508200A (en) 1992-10-19 1996-04-16 Tiffany; Thomas Method and apparatus for conducting multiple chemical assays
US5534328A (en) 1993-12-02 1996-07-09 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
US5493802A (en) 1993-05-26 1996-02-27 Simson; Anton K. Scroll displaying device
US5837546A (en) 1993-08-24 1998-11-17 Metrika, Inc. Electronic assay device and method
SG72684A1 (en) 1993-11-12 2000-05-23 Unipath Ltd Reading devices and assay devices for use therewith
US5976896A (en) 1994-06-06 1999-11-02 Idexx Laboratories, Inc. Immunoassays in capillary tubes
US5624850A (en) 1994-06-06 1997-04-29 Idetek, Inc. Immunoassays in capillaries
US5593290A (en) 1994-12-22 1997-01-14 Eastman Kodak Company Micro dispensing positive displacement pump
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6068751A (en) 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US5788814A (en) 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
JPH09288089A (ja) 1996-04-23 1997-11-04 Hitachi Ltd 毛細管電気泳動装置
DE69737513T2 (de) 1996-04-25 2007-12-13 Genicon Sciences Corp., San Diego Teilchenförmiges markierungsmittel verwendendes analytassay
US7341727B1 (en) 1996-05-03 2008-03-11 Emergent Product Development Gaithersburg Inc. M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
US6429025B1 (en) 1996-06-28 2002-08-06 Caliper Technologies Corp. High-throughput screening assay systems in microscale fluidic devices
US20030054376A1 (en) 1997-07-07 2003-03-20 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
DE19635646C1 (de) 1996-09-03 1997-12-04 Bruker Franzen Analytik Gmbh Korrektur der Massenbestimmung mit MALDI-Flugzeitmassenspektrometern
CA2276462C (en) 1996-12-31 2007-06-12 High Throughput Genomics, Inc. Multiplexed molecular analysis system apparatus and method
US6507989B1 (en) 1997-03-13 2003-01-21 President And Fellows Of Harvard College Self-assembly of mesoscale objects
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
CN1105914C (zh) 1997-04-25 2003-04-16 卡钳技术有限公司 改进了通道几何结构的微型流体装置
US6020209A (en) 1997-04-28 2000-02-01 The United States Of America As Represented By The Secretary Of The Navy Microcapillary-based flow-through immunosensor and displacement immunoassay using the same
US5882465A (en) 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US6293012B1 (en) 1997-07-21 2001-09-25 Ysi Incorporated Method of making a fluid flow module
US6082185A (en) 1997-07-25 2000-07-04 Research International, Inc. Disposable fluidic circuit cards
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
JP3938982B2 (ja) 1997-08-29 2007-06-27 オリンパス株式会社 Ｄｎａキャピラリィ
EP1029244A4 (en) 1997-10-02 2003-07-23 Aclara Biosciences Inc CAPILLAR ASSAY WITH SEPARATION OF FREE AND TIED SPECIES
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5965237A (en) 1997-10-20 1999-10-12 Novartis Ag Microstructure device
US6143152A (en) 1997-11-07 2000-11-07 The Regents Of The University Of California Microfabricated capillary array electrophoresis device and method
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US7497994B2 (en) 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
US6100541A (en) 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6719868B1 (en) 1998-03-23 2004-04-13 President And Fellows Of Harvard College Methods for fabricating microfluidic structures
JPH11307604A (ja) 1998-04-17 1999-11-05 Toshiba Corp プロセスモニタ方法及びプロセス装置
US6787111B2 (en) 1998-07-02 2004-09-07 Amersham Biosciences (Sv) Corp. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6366924B1 (en) 1998-07-27 2002-04-02 Caliper Technologies Corp. Distributed database for analytical instruments
US7155344B1 (en) 1998-07-27 2006-12-26 Caliper Life Sciences, Inc. Distributed database for analytical instruments
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6497155B1 (en) 1999-02-09 2002-12-24 Pharmacopeia, Inc. Article comprising a particle retrieval device
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
US20050100943A1 (en) 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20040200909A1 (en) 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
WO2000073799A1 (en) 1999-06-01 2000-12-07 Caliper Technologies Corp. Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
US6520753B1 (en) 1999-06-04 2003-02-18 California Institute Of Technology Planar micropump
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
IL147302A0 (en) 1999-06-28 2002-08-14 California Inst Of Techn Microfabricated elastomeric valve and pump systems
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6533914B1 (en) 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
AU6366200A (en) 1999-07-27 2001-02-13 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US6762059B2 (en) 1999-08-13 2004-07-13 U.S. Genomics, Inc. Methods and apparatuses for characterization of single polymers
AU6932300A (en) 1999-08-25 2001-03-19 Caliper Technologies Corporation Dilutions in high throughput systems with a single vacuum source
DE19941661B4 (de) 1999-09-01 2004-06-17 Graffinity Pharmaceuticals Ag Vorrichtung und Verfahren zum Aufnehmen und Plazieren
US6383748B1 (en) 1999-09-14 2002-05-07 Pamgene B.V. Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
JP3441058B2 (ja) * 1999-12-03 2003-08-25 理化学研究所 キャピラリーゲル電気泳動用マイクロチップおよびその製造方法
EP1202803A2 (en) 1999-12-22 2002-05-08 Gene Logic, Inc. Flow-through chip cartridge, chip holder, system & method thereof
US6405608B1 (en) 2000-01-25 2002-06-18 Sandia Corporation Method and apparatus for optimized sampling of volatilizable target substances
US7087181B2 (en) 2000-01-31 2006-08-08 Diagnoswiss S.A. Method for fabricating micro-structures with various surface properties in multi-layer body by plasma etching
WO2001055701A1 (en) 2000-01-31 2001-08-02 Board Of Regents, The University Of Texas System System and method for the analysis of bodily fluids
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
AU2001284700B2 (en) 2000-08-03 2005-12-08 Caliper Life Sciences, Inc. Methods and devices for high throughput fluid delivery
US7189358B2 (en) 2000-08-08 2007-03-13 California Institute Of Technology Integrated micropump analysis chip and method of making the same
US7998746B2 (en) * 2000-08-24 2011-08-16 Robert Otillar Systems and methods for localizing and analyzing samples on a bio-sensor chip
WO2002023163A1 (en) 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
US6994826B1 (en) 2000-09-26 2006-02-07 Sandia National Laboratories Method and apparatus for controlling cross contamination of microfluid channels
US20050221385A1 (en) 2000-11-07 2005-10-06 Caliper Life Sciences, Inc. Pressure based mobility shift assays
US7378280B2 (en) 2000-11-16 2008-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
GB0028647D0 (en) 2000-11-24 2001-01-10 Nextgen Sciences Ltd Apparatus for chemical assays
US6767194B2 (en) 2001-01-08 2004-07-27 President And Fellows Of Harvard College Valves and pumps for microfluidic systems and method for making microfluidic systems
US20060207877A1 (en) 2001-01-30 2006-09-21 Walter Schmidt Microfluidic device with various surface properties fabricated in multilayer body by plasma etching
CA2434725A1 (en) 2001-02-15 2002-12-27 Caliper Technologies Corp. Microfluidic systems with enhanced detection systems
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US7318912B2 (en) 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
GB0116384D0 (en) 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
US6881579B2 (en) 2001-07-30 2005-04-19 Agilent Technologies, Inc. Sample processing apparatus and methods
GB0121189D0 (en) 2001-08-31 2001-10-24 Diagnoswiss Sa Apparatus and method for separating an analyte
WO2003031066A1 (en) 2001-10-11 2003-04-17 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
US6750661B2 (en) 2001-11-13 2004-06-15 Caliper Life Sciences, Inc. Method and apparatus for controllably effecting samples using two signals
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US7258837B2 (en) 2001-12-05 2007-08-21 University Of Washington Microfluidic device and surface decoration process for solid phase affinity binding assays
US6532997B1 (en) 2001-12-28 2003-03-18 3M Innovative Properties Company Sample processing device with integral electrophoresis channels
WO2003057931A2 (en) * 2002-01-07 2003-07-17 Watson Dennis P Cold-formed steel joists
US7622083B2 (en) 2002-01-28 2009-11-24 Biocal Technology, Inc. Multi-capillary electrophoresis cartridge interface mechanism
US7470518B2 (en) 2002-02-12 2008-12-30 Cellectricon Ab Systems and method for rapidly changing the solution environment around sensors
EP1487568A4 (en) 2002-03-12 2005-10-05 Syngenta Participations Ag Microcapillaries Hybridization Chamber
US7524462B2 (en) 2002-03-29 2009-04-28 Agilent Technologies, Inc. Capillary flow for a heterogenous assay in a micro-channel environment
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US8211657B2 (en) 2002-04-29 2012-07-03 The Board Of Trustees Of The University Of Arkansas Capillary-column-based bioseparator/bioreactor with an optical/electrochemical detector for detection of microbial pathogens
US7125510B2 (en) 2002-05-15 2006-10-24 Zhili Huang Microstructure fabrication and microsystem integration
EP2093565B1 (en) 2002-05-22 2014-11-19 Platypus Technologies, Inc. Uses of devices and methods for cellular assays
EP1513953A1 (en) 2002-06-03 2005-03-16 PamGene B.V. Method for high-throughput integrated chemical and biochemical reactions
US20060086309A1 (en) 2002-06-24 2006-04-27 Fluiding Corporation Recirculating fluidic network and methods for using the same
US20040101444A1 (en) 2002-07-15 2004-05-27 Xeotron Corporation Apparatus and method for fluid delivery to a hybridization station
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
WO2004020065A2 (en) 2002-08-28 2004-03-11 Mt Technologies, Inc. Microfluidic affinity system using polydimethylsiloxane and a surface modification process
CA2498933C (en) 2002-09-12 2012-08-28 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
AU2003270726A1 (en) 2002-09-12 2004-04-30 Cidra Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
WO2004025560A1 (en) 2002-09-12 2004-03-25 Cyvera Corporation Assay stick comprising coded microbeads
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
JP2006501056A (ja) 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
TW590982B (en) 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
US7186383B2 (en) 2002-09-27 2007-03-06 Ast Management Inc. Miniaturized fluid delivery and analysis system
US7351303B2 (en) 2002-10-09 2008-04-01 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
US7390457B2 (en) 2002-10-31 2008-06-24 Agilent Technologies, Inc. Integrated microfluidic array device
AU2003297214A1 (en) 2002-12-16 2004-07-22 Cytodiscovery, Inc. Microfluidic system with integrated permeable membrane
US20050266582A1 (en) 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
EP1608952B1 (en) 2002-12-20 2016-08-10 Life Technologies Corporation Assay apparatus and method using microfluidic arrays
EP1583950B1 (en) 2002-12-26 2017-04-05 Meso Scale Technologies, LLC. Assay cartridges and methods of using the same
KR20050088476A (ko) 2002-12-30 2005-09-06 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
US7033476B2 (en) 2002-12-31 2006-04-25 Ut-Battelle, Llc Separation and counting of single molecules through nanofluidics, programmable electrophoresis, and nanoelectrode-gated tunneling and dielectric detection
US7122153B2 (en) 2003-01-08 2006-10-17 Ho Winston Z Self-contained microfluidic biochip and apparatus
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
TW579430B (en) 2003-05-02 2004-03-11 Dr Chip Biotechnology Inc Automatic micro-fluid hybridization chip platform
WO2004103563A2 (en) 2003-05-20 2004-12-02 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
JP4049713B2 (ja) * 2003-06-27 2008-02-20 株式会社日立製作所 ビーズアレイチップ作製装置及び作製方法
US7238269B2 (en) 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
FR2857099B1 (fr) 2003-07-04 2005-10-07 Jean Marie Billiotte Procede et dispositif d'analyse chimique ou biologique par senseur a chambre monolithique en gerbe multi-micro-tubulaire et transducteur lateral de mesure integrale
US7341841B2 (en) 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US7028536B2 (en) 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
DE10345817A1 (de) * 2003-09-30 2005-05-25 Boehringer Ingelheim Microparts Gmbh Verfahren und Vorrichtung zum Koppeln von Hohlfasern an ein mikrofluidisches Netzwerk
US20050098750A1 (en) 2003-11-06 2005-05-12 Daniel Sobek Electrostatic sealing device and method of use thereof
JP4073023B2 (ja) * 2003-11-07 2008-04-09 財団法人新産業創造研究機構 微小流路デバイスおよびその作製方法
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US7736890B2 (en) 2003-12-31 2010-06-15 President And Fellows Of Harvard College Assay device and method
WO2005083390A1 (en) 2004-02-20 2005-09-09 Research Foundation Of The State University Of New York Method and device for manipulating liquids in microfluidic systems
WO2005107938A2 (en) 2004-05-02 2005-11-17 Fluidigm Corporation Thermal reaction device and method for using the same
US7887750B2 (en) * 2004-05-05 2011-02-15 Bayer Healthcare Llc Analytical systems, devices, and cartridges therefor
US7419639B2 (en) 2004-05-12 2008-09-02 The Board Of Trustees Of The Leland Stanford Junior University Multilayer microfluidic device
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
WO2006014680A1 (en) 2004-07-19 2006-02-09 Cell Biosciences, Inc. Methods and devices for analyte detection
EP2261650A3 (en) 2004-09-15 2011-07-06 IntegenX Inc. Microfluidic devices
US20060073035A1 (en) 2004-09-30 2006-04-06 Narayan Sundararajan Deformable polymer membranes
US7832429B2 (en) 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
EP1806583A4 (en) 2004-10-29 2010-08-25 Itoham Foods Inc REACTION VESSEL
EP1838431A4 (en) 2004-12-03 2012-08-22 California Inst Of Techn MICROFLUIDIC DEVICES WITH CIRCUITRY OF CHEMICAL REACTIONS
US7682817B2 (en) 2004-12-23 2010-03-23 Kimberly-Clark Worldwide, Inc. Microfluidic assay devices
DE102005049365A1 (de) 2005-03-18 2006-09-21 BAM Bundesanstalt für Materialforschung und -prüfung Kalibriereinrichtung und Farbstoffkit sowie ihre Verwendung zur Charakterisierung von Lumineszenzmesssystemen
BRPI0606335A2 (pt) 2005-03-23 2009-09-29 Velocys Inc caracterìsticas em superfìcie na tecnologia de microprocesso
US7507588B2 (en) 2005-04-20 2009-03-24 Becton, Dickinson And Company Multiplex microparticle system
CA2505657A1 (en) 2005-04-28 2006-10-28 York University Method for mixing inside a capillary and device for achieving same
WO2006122312A2 (en) 2005-05-11 2006-11-16 The Trustees Of The University Of Pennsylvania Methods of testing using a microfluidic cassette
CN101176001A (zh) 2005-05-19 2008-05-07 柯尼卡美能达医疗印刷器材株式会社 用于分析被检体中目标物质的检查芯片和微型综合分析系统
US20060263818A1 (en) 2005-05-23 2006-11-23 Axel Scherer High throughput multi-antigen microfluidic fluorescence immunoassays
EP2477029A1 (en) 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
WO2007021813A2 (en) 2005-08-11 2007-02-22 Eksigent Technologies, Llc Microfluidic system and methods
CA2557380C (en) 2005-08-27 2012-09-25 Schlumberger Canada Limited Time-of-flight stochastic correlation measurements
RO122612B1 (ro) 2005-08-29 2009-09-30 Institutul Naţional De Cercetare-Dezvoltare Pentru Microtehnologie Procedeu de realizare a unui biocip cu funcţia de amplificare a unor fragmente specifice de adn prin reacţia polimerazică în lan
WO2007033385A2 (en) 2005-09-13 2007-03-22 Fluidigm Corporation Microfluidic assay devices and methods
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US20080311585A1 (en) 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
US7763453B2 (en) * 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US8182767B2 (en) 2005-12-27 2012-05-22 Honeywell International Inc. Needle-septum interface for a fluidic analyzer
US8798338B2 (en) 2006-01-09 2014-08-05 University Of Wyoming Method and system for counting particles in a laminar flow with an imaging device
WO2007092713A2 (en) 2006-02-02 2007-08-16 Trustees Of The University Of Pennsylvania Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease
JP5063616B2 (ja) 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
WO2007093939A1 (en) 2006-02-13 2007-08-23 Koninklijke Philips Electronics N.V. Microfluidic device for molecular diagnostic applications
JP5254949B2 (ja) 2006-03-15 2013-08-07 マイクロニクス， インコーポレイテッド 一体型の核酸アッセイ
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8293524B2 (en) 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
CN101500709A (zh) 2006-05-01 2009-08-05 皇家飞利浦电子股份有限公司 用于加工、控制和/或检测流体样品并有减小的死体积的流体样品输送装置
JP5627886B2 (ja) 2006-05-16 2014-11-19 フルイディウム コーポレーション 生物学的な高速解析および高速識別のための、ｐｃｒを使用しない試料調製および検出システム
US7708944B1 (en) 2006-06-13 2010-05-04 Research Foundation Of State University Of New York Ultra-sensitive, portable capillary sensor
AU2007265628B2 (en) 2006-06-23 2012-12-06 Revvity Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
CA2656686A1 (en) 2006-07-05 2008-01-10 Aida Engineering, Ltd. Micro passage chip and fluid transferring method
US7794665B2 (en) 2006-07-17 2010-09-14 Industrial Technology Research Institute Fluidic device
US20080017512A1 (en) 2006-07-24 2008-01-24 Bordunov Andrei V Coatings for capillaries capable of capturing analytes
GR1006447B (el) 2006-09-15 2009-06-19 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος" Μεθοδος συγκολλησης
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US20080131327A1 (en) 2006-09-28 2008-06-05 California Institute Of Technology System and method for interfacing with a microfluidic chip
JP4559396B2 (ja) 2006-09-29 2010-10-06 株式会社 日立ディスプレイズ 液晶表示装置
EP2074341A4 (en) 2006-10-04 2013-04-10 Fluidigm Corp MICROFLUIDIC CHECK VALVES
WO2008043041A1 (en) * 2006-10-04 2008-04-10 University Of Washington Method and device for rapid parallel microfluidic molecular affinity assays
CA2703801A1 (en) 2006-11-03 2008-05-08 Mcgill University Electrical microvalve and method of manufacturing thereof
BRPI0720537A2 (pt) 2006-12-19 2014-01-07 Koninkl Philips Electronics Nv Dispositivo microfluídico e uso do mesmo
EP2125219B1 (en) 2007-01-19 2016-08-10 Fluidigm Corporation High precision microfluidic devices and methods
KR20100028526A (ko) 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 및 나노유체 장치, 시스템 및 응용
CA2683990A1 (en) 2007-04-25 2008-11-06 3M Innovative Properties Company Chemical component and processing device assembly
ES2453107T3 (es) 2007-06-11 2014-04-04 Wako Pure Chemical Industries, Ltd. Procedimiento de amplificación de ácidos nucleicos usando una PCR sobre microchip con detección integrada de CE en tiempo real
WO2009012340A2 (en) 2007-07-16 2009-01-22 California Institute Of Technology Microfluidic devices, methods and systems for detecting target molecules
WO2009029177A1 (en) 2007-08-24 2009-03-05 Dynamic Throughput Inc. Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy
US7736891B2 (en) 2007-09-11 2010-06-15 University Of Washington Microfluidic assay system with dispersion monitoring
KR20090030084A (ko) 2007-09-19 2009-03-24 삼성전자주식회사 미세유동장치
JP5556178B2 (ja) 2007-09-21 2014-07-23 日本電気株式会社 温度制御方法及びシステム
US20090087884A1 (en) 2007-09-27 2009-04-02 Timothy Beerling Microfluidic nucleic acid amplification and separation
WO2009068584A1 (en) 2007-11-26 2009-06-04 Atonomics A/S Integrated separation and detection cartridge with means and method for increasing signal to noise ratio
JP2011511933A (ja) 2008-01-07 2011-04-14 ダイナミック スループット インコーポレイテッド 一体型マイクロ流体バイオマーカー光学検出アレイデバイスを用いた発見ツールおよび使用方法
KR20110030415A (ko) 2008-01-22 2011-03-23 인터젠엑스 인크. 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 용도
EP2254985A4 (en) 2008-02-21 2013-09-18 Avantra Biosciences Corp ASSAYS BASED ON LIQUID CURRENT VIA ASSEMBLY
KR100952056B1 (ko) 2008-02-29 2010-04-07 아주대학교산학협력단 기계적 자극에 대한 줄기세포 분화의 최적의 조건을 검출할수 있는 셀-칩 및 이의 자동 제어 시스템
US8277759B2 (en) 2008-03-04 2012-10-02 The University Of Utah Research Foundation Microfluidic flow cell
US8628649B2 (en) 2008-03-18 2014-01-14 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Nanopore and carbon nanotube based DNA sequencer and a serial recognition sequencer
CN102056838B (zh) 2008-04-11 2013-07-03 弗卢丁公司 微流体装置和方法
EP3067694A1 (en) 2008-05-05 2016-09-14 Los Alamos National Security, LLC Lateral flow-based nucleic acid sample preparation device, integrated with passive fluid flow control
JP5383671B2 (ja) 2008-05-07 2014-01-08 パナソニック株式会社 バイオセンサ
US20090325171A1 (en) 2008-05-13 2009-12-31 Thomas Hirt Vesicles for use in biosensors
JP5190945B2 (ja) * 2008-07-14 2013-04-24 富士フイルム株式会社 検出方法、検出装置、検出用試料セルおよび検出用キット
US20110306072A1 (en) 2008-07-15 2011-12-15 L3 Technology Limited Assay test card
US8617488B2 (en) 2008-08-07 2013-12-31 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
US9180453B2 (en) 2008-08-15 2015-11-10 University Of Washington Method and apparatus for the discretization and manipulation of sample volumes
US7947492B2 (en) 2008-08-20 2011-05-24 Northeastern Ohio Universities College Of Medicine Device improving the detection of a ligand
US20110151479A1 (en) 2008-08-25 2011-06-23 University Of Washington Microfluidic systems incorporating flow-through membranes
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
WO2010042784A2 (en) 2008-10-10 2010-04-15 Massachusetts Institute Of Technology Method of hydrolytically stable bonding of elastomers to substrates
US20110300570A1 (en) 2008-11-14 2011-12-08 The Brigham And Women's Hospital, Inc. Method and system for generating spatially and temporally controllable concentration gradients
GB0821636D0 (en) 2008-11-26 2008-12-31 Ucl Business Plc Device
CN102281950B (zh) 2008-12-08 2015-05-06 富鲁达公司 可编程微流体数字阵列
US8563260B2 (en) * 2008-12-19 2013-10-22 Osaka Prefecture University Publication Corpoaration Capillary for immunoassay, and capillary immunoassay method using same
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
US8017409B2 (en) 2009-05-29 2011-09-13 Ecolab Usa Inc. Microflow analytical system
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
WO2010148252A1 (en) 2009-06-17 2010-12-23 Jody Vykoukal Method and apparatus for quantitative microimaging
US20120164036A1 (en) 2009-07-21 2012-06-28 Seth Stern Microfluidic devices and uses thereof
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
JP5456904B2 (ja) 2009-10-21 2014-04-02 バイオカルティス、ソシエテ、アノニム 平行空気圧インターフェース・プレートを備えたミクロ流体カートリッジ
US8524450B2 (en) 2009-10-30 2013-09-03 Illumina, Inc. Microvessels, microparticles, and methods of manufacturing and using the same
WO2012071069A1 (en) * 2010-11-23 2012-05-31 Cyvek, Inc. Method and apparatus for performing assays
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
JP5709894B2 (ja) 2009-12-18 2015-04-30 アボット ポイント オブ ケア インコーポレイテッド 生物学的液体分析カートリッジ
WO2011133540A2 (en) 2010-04-19 2011-10-27 Research Foundation Of State University Of New York Capillary biosensor system and its method of use
US9381687B2 (en) 2010-06-29 2016-07-05 Sio2 Medical Products, Inc. Syringe with integrated needle
WO2012020257A1 (en) 2010-08-10 2012-02-16 Forensic Science Service Limited Method and system for analyzing a sample
US8586348B2 (en) 2010-09-22 2013-11-19 California Institute Of Technology Lateral flow microfluidic assaying device and related method
CN106552682B (zh) 2011-03-22 2020-06-19 西维克公司 微流体装置以及制造方法和用途
JP5805989B2 (ja) 2011-04-26 2015-11-10 大塚電子株式会社 電気泳動移動度測定用セル並びにそれを用いた測定装置及び測定方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1957254A (zh) * 2004-04-07 2007-05-02 沃德劳有限合伙公司 用于分析生物流体的可置换腔
CN101263392A (zh) * 2005-09-13 2008-09-10 美特宝思科润株式会社 微流道芯片

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
US11911763B2 (en) 2017-03-29 2024-02-27 The Research Foundation For The State University Of New York Microfluidic device and methods

Also Published As

Publication number Publication date
CA2830533C (en) 2020-02-18
JP2014509745A (ja) 2014-04-21
EP2689253A4 (en) 2014-12-10
WO2012129455A3 (en) 2012-11-29
WO2012129455A2 (en) 2012-09-27
US9216412B2 (en) 2015-12-22
CN103649759A (zh) 2014-03-19
US20120301903A1 (en) 2012-11-29
US20150202624A9 (en) 2015-07-23
EP2689253A2 (en) 2014-01-29
WO2012129455A4 (en) 2013-01-31
CN106552682A (zh) 2017-04-05
US10252263B2 (en) 2019-04-09
US20160158750A1 (en) 2016-06-09
EP2689253B1 (en) 2021-03-10
CN103649759B (zh) 2016-08-31
JP5978287B2 (ja) 2016-08-24
CA2830533A1 (en) 2012-09-27

Similar Documents

Publication Publication Date Title
CN106552682B (zh) 微流体装置以及制造方法和用途
EP2822689B1 (en) Micro-tube particles for microfluidic assays and methods of manufacture
US20230120417A1 (en) Kits And Devices For Detecting Analytes
US20140377852A1 (en) Methods and Systems for Epi-Fluorescent Monitoring and Scanning for Microfluidic Assays
US20150083320A1 (en) Microfluidic Assay Assemblies and Methods of Manufacture
WO2009125998A2 (en) Micro-nano fluidic biochip for assaying biological sample
US20170001194A1 (en) Microfluidic device, system, and method
US9855735B2 (en) Portable microfluidic assay devices and methods of manufacture and use
EP1797955A2 (en) Microfluidic system, sample analysis device, and target substance measurement method
McDevitt et al. Multisample bionanochip platform

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant