JP5709894B2 - 生物学的液体分析カートリッジ - Google Patents
生物学的液体分析カートリッジ Download PDFInfo
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Description
図7〜10に示すように、本実施形態の液体モジュール24は、サンプル収集ポート30と、オーバフロー流路(overflow passage)32と、イニシャル流路34と、バルブ36と、第二の流路38と、一以上のラッチ(latches)40と、圧縮空気供給源(air pressure source)42と、外部空気圧ポート(external air pressure port)44と、外側縁部46と、内側縁部48と、これら外側縁部46と内側縁部48との間に延在する第一の横側縁部50と、第二の横側縁部52とを備えている。
図4に示すように、画像処理トレイ26は、長手方向に延びる第一のサイドレール102と、長手方向に延びる第二のサイドレール104と、幅方向に延びるエンドレール106とを備えている。サイドレール102,104は互いに実質的に平行、かつ、エンドレール106に対して実質的に垂直に配置されている。
図3〜6,14,20に示すように、本実施形態のハウジング28は、ベース128と、カバー130と、液体モジュール24を受容する開口部132と、トレイ開口部134と、ボウルキャップ136と、バルブ作動機構138と、空気供給源作動機構140とを備えている。ベース128及びカバー130は、例えば接着剤や機械的固定具等により互いに取り付けられると共に、ハウジング28内に配置された内部キャビティ(internal cavity)を含むハウジング28を選択的に形成する。他の実施形態として、ベース128及びカバー130は一体形成することもできる。
上述したように、本実施形態の生物学的液体サンプルのカートリッジ20は、画像処理ハードウェアと、サンプル画像の分析及び処理を制御するプロセッサとを備える自動分析装置22の使用に適用される。本実施形態のカートリッジ20は、任意の特定の分析装置22への使用に限定されるものではないが、米国特許6,866,823号明細書に開示された分析装置22に類似するものは使用可能な装置の一例を示している。本実施形態のカートリッジ20の説明及び理解を助けるために、使用可能な分析装置22の一般的な特徴を以下に説明する。
図5,13に示すように、本実施形態のカートリッジ20は、最初に液体モジュール24が開位置にセット(もしくは配置)される。この位置において、収集ポート30は生物学的液体サンプルを受容するように配置される。ハウジング28に取り付けられた機構98と係合する液体モジュールラッチ40は、液体モジュール24を開位置(例えば、図13参照)に維持する。液体モジュール24が開位置に配置されると、バルブ36はサンプル取入口60とイニシャル流路34との間の液体通路が開放される開位置に配置される。
22 分析装置
24 液体モジュール
26 画像処理トレイ
28 ハウジング
30 サンプル収集ポート
32 オーバフロー流路
34 イニシャル流路
36 バルブ
38 第二の流路
40 ラッチ
42 圧縮空気供給源
44 外部空気圧ポート
54 ボウル
62 ボウル〜取入口流路
66 入口外側端〜取入口流路
72 サンプル計量ポート
74 ガス透過・液体非透過性膜
Claims (14)
- 生物学的液体サンプルの分析カートリッジであって、
ハウジングと、
サンプル収集ポート及びイニシャル流路を有する液体モジュールと、
分析チャンバーと、
前記ハウジング内にスライド移動可能に収容される画像処理トレイと、
を備え、
前記イニシャル流路は、毛管力によってサンプルを吸引する大きさに形成されると共に、前記サンプル収集ポートと液体連通状態にされ、かつ、前記サンプル収集ポート内に配置されたサンプルの少なくとも一部が前記イニシャル流路内に吸引されるように前記サンプル収集ポートに固定され、
前記分析チャンバーは、前記液体モジュールに対して前記イニシャル流路を通過した液体サンプルを受け取る第1位置と、前記イニシャル流路を通過した液体サンプルを受け取らない第2位置とに選択的に配置可能であると共に、前記画像処理トレイに取り付けられ、
前記画像処理トレイは、前記ハウジングに対して、前記分析チャンバーが分析のために視認可能になる開位置及び、前記分析チャンバーが分析のために視認できなくなる閉位置に選択的に配置可能であることを特徴とするカートリッジ。 - 前記イニシャル流路及び第二の流路の一方又は両方の少なくとも一部分が上表面から視認可能である請求項1記載のカートリッジ。
- 前記イニシャル流路と前記分析チャンバーとの間に配置された第二の流路をさらに備えると共に、前記イニシャル流路内の液体サンプルは前記分析チャンバーに到達する前に前記第二の流路を通過し、前記イニシャル流路と前記第二の流路との交差部分が、毛管力によるサンプルの前記イニシャル流路外、及び前記第二の流路内への吸引を阻止する請求項1記載のカートリッジ。
- a)前記イニシャル流路及び前記第二の流路内の一方又は両方に配置された一以上の流動性攪乱物質及び、又はb)前記イニシャル流路及び前記第二の流路内のサンプル流動に乱流を生じさせるための前記イニシャル流路及び第二の流路の一方又は両方の形状変化をさらに備える請求項3記載のカートリッジ。
- 前記イニシャル流路は容量を有すると共に、前記カートリッジはオーバフロー流路をさらに備え、
前記オーバフロー流路は、前記サンプル収集ポート内に流入したサンプル量が前記イニシャル流路の容量を超えたときに液体サンプルを受容するように配置される請求項1記載のカートリッジ。 - 前記オーバフロー流路は、毛管力によってサンプルを吸引する大きさに形成されている請求項5記載のカートリッジ。
- 前記イニシャル流路と液体連通状態の一以上のフラグポートをさらに備え、
前記フラグポートが、液体サンプルを受容してその存在を視覚的に示すように構成されている請求項1記載のカートリッジ。 - 少なくとも一つの拡大鏡部分をさらに備え、
前記拡大鏡部分が、前記イニシャル流路もしくはフラグポートの像を拡大するレンズを含む請求項1記載のカートリッジ。 - 前記画像処理トレイは閉位置に選択的にロック可能に構成されると共に、閉位置において前記ハウジング内に配置される請求項1記載のカートリッジ。
- 前記画像処理トレイを閉位置に選択的にロックもしくはロックを解除する磁気的に作動可能なラッチをさらに備える請求項9記載のカートリッジ。
- 前記分析チャンバーが、第一パネル及び第二パネルを含み、少なくとも一方のパネルがパネル間に配置した生物学的液体サンプルを分析目的のために画像処理できるように透明性を備えている請求項1記載のカートリッジ。
- 前記分析チャンバーが、第一パネル及び第二パネルを含み、少なくとも一方のパネルがパネル間に配置した生物学的液体サンプルを分析目的のために画像処理できるように透明性を備えている請求項1記載のカートリッジ。
- 前記第一及び第二パネルが互いに表面を対向させてチャンバー高さ距離だけ離間して配置されると共に、前記チャンバー高さ距離をパネル間に配置した生物学的液体サンプルが両方のパネル表面と接触する距離に設定した請求項12記載のカートリッジ。
- 前記分析チャンバーは、前記第一及び第二パネル間に配置される少なくとも三つのセパレータを備え、前記チャンバー高さ距離を前記セパレータの平均高さと近似させるように、少なくとも前記第一パネル、前記第二パネル又は、前記セパレータが十分な可撓性を有する請求項13記載のカートリッジ。
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JP2013515240A (ja) | 2013-05-02 |
WO2011075667A3 (en) | 2011-08-18 |
AU2010330825B2 (en) | 2014-03-06 |
CA2784353C (en) | 2015-11-03 |
US20110206557A1 (en) | 2011-08-25 |
CN102762289B (zh) | 2016-08-03 |
WO2011075667A2 (en) | 2011-06-23 |
CN106110923A (zh) | 2016-11-16 |
AU2010330825A1 (en) | 2012-07-12 |
CN102762289A (zh) | 2012-10-31 |
US9993817B2 (en) | 2018-06-12 |
EP2512647A2 (en) | 2012-10-24 |
US20170136459A1 (en) | 2017-05-18 |
US9579651B2 (en) | 2017-02-28 |
US20180353959A1 (en) | 2018-12-13 |
CA2784353A1 (en) | 2011-06-23 |
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