CN104031984A - 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 - Google Patents
用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 Download PDFInfo
- Publication number
- CN104031984A CN104031984A CN201410133658.XA CN201410133658A CN104031984A CN 104031984 A CN104031984 A CN 104031984A CN 201410133658 A CN201410133658 A CN 201410133658A CN 104031984 A CN104031984 A CN 104031984A
- Authority
- CN
- China
- Prior art keywords
- mir
- expression
- tumors
- prostate
- biomarker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6751808P | 2008-02-28 | 2008-02-28 | |
| US61/067,518 | 2008-02-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980111708.1A Division CN102027129B (zh) | 2008-02-28 | 2009-02-27 | 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104031984A true CN104031984A (zh) | 2014-09-10 |
Family
ID=41016728
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410133658.XA Pending CN104031984A (zh) | 2008-02-28 | 2009-02-27 | 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 |
| CN200980111708.1A Expired - Fee Related CN102027129B (zh) | 2008-02-28 | 2009-02-27 | 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980111708.1A Expired - Fee Related CN102027129B (zh) | 2008-02-28 | 2009-02-27 | 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US20110054009A1 (enExample) |
| EP (3) | EP2799557B1 (enExample) |
| JP (3) | JP2011517283A (enExample) |
| CN (2) | CN104031984A (enExample) |
| AU (2) | AU2009219197B2 (enExample) |
| CA (1) | CA2716938A1 (enExample) |
| ES (1) | ES2600165T3 (enExample) |
| WO (1) | WO2009108860A2 (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104278100A (zh) * | 2014-10-16 | 2015-01-14 | 上海交通大学医学院附属仁济医院 | miRNA-188作为标记分子在制备诊断试剂中的用途 |
| CN104651492A (zh) * | 2015-01-06 | 2015-05-27 | 中国人民解放军第二军医大学 | miRNA410-在制备前列腺癌诊断试剂盒中的应用 |
| CN104894251A (zh) * | 2015-05-28 | 2015-09-09 | 基因科技(上海)有限公司 | 一种避免miRNA定量检测中因荧光探针标记不彻底而引起背景扩增的方法 |
| CN105056250A (zh) * | 2015-07-15 | 2015-11-18 | 中国农业大学 | 一种microRNA在制备治疗前列腺癌的药物中的应用 |
| CN105243293A (zh) * | 2015-11-06 | 2016-01-13 | 吴志宏 | 前列腺相关癌基因信息收集及分析方法 |
| CN106636310A (zh) * | 2015-10-30 | 2017-05-10 | 益善生物技术股份有限公司 | 前列腺癌相关microRNA检测试剂盒 |
| CN111344409A (zh) * | 2017-11-12 | 2020-06-26 | 加利福尼亚大学董事会 | 用于检测癌症的非编码rna |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102533966B (zh) | 2005-08-01 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| CN103028120B (zh) | 2005-09-12 | 2015-08-12 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| ES2508893T3 (es) | 2006-01-05 | 2014-10-16 | The Ohio State University Research Foundation | Métodos basados en microARN para el diagnóstico de cánceres de estómago |
| JP5490413B2 (ja) | 2006-01-05 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常 |
| ES2554531T3 (es) | 2006-01-05 | 2015-12-21 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| EP2371971B1 (en) | 2006-03-20 | 2013-11-27 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| IL282783B2 (en) | 2006-05-18 | 2023-09-01 | Caris Mpi Inc | A system and method for determining a personalized medical intervention for a disease stage |
| EP2369017B8 (en) | 2006-07-13 | 2014-03-12 | The Ohio State University Research Foundation | Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases |
| US8071292B2 (en) | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| WO2008054828A2 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| CN105256004A (zh) | 2007-01-31 | 2016-01-20 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| CA2685840C (en) * | 2007-04-30 | 2016-12-13 | The Ohio State University Research Foundation | Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis |
| CN105950706A (zh) | 2007-06-08 | 2016-09-21 | 由卫生与公众服务部代表的美利坚合众国政府 | 确定肝细胞癌亚型和检测肝癌干细胞的方法 |
| AU2008266014B2 (en) | 2007-06-15 | 2013-06-06 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing |
| US8367632B2 (en) | 2007-07-31 | 2013-02-05 | Ohio State University Research Foundation | Methods for reverting methylation by targeting methyltransferases |
| EP2173908B1 (en) | 2007-08-03 | 2016-01-06 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncrnas |
| WO2009026487A1 (en) | 2007-08-22 | 2009-02-26 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| CA2702241A1 (en) * | 2007-10-11 | 2009-04-16 | The Ohio State University Research Foundation | Methods and compositions for the diagnosis and treatment of esophageal adenocarcinomas |
| CN103898069A (zh) | 2007-10-26 | 2014-07-02 | 俄亥俄州立大学研究基金会 | 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途 |
| US20110034538A1 (en) * | 2008-02-28 | 2011-02-10 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Gastric Cancer |
| JP5745401B2 (ja) | 2008-06-11 | 2015-07-08 | アメリカ合衆国 | 肝細胞癌についての予測マーカーとしてのMiR−26ファミリーの使用および療法に対する反応性 |
| EP2358912B1 (en) | 2008-10-30 | 2016-10-12 | Caris Life Sciences Switzerland Holdings GmbH | Methods for assessing rna patterns |
| GB2465088C (en) * | 2008-10-30 | 2016-01-27 | Caris Mpi Inc | miRNA expression in the characterisation and classification of cancer |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| GB2467704B (en) | 2008-11-07 | 2011-08-24 | Mlc Dx Inc | A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| CN102301002A (zh) | 2008-11-12 | 2011-12-28 | 卡里斯生命科学卢森堡控股有限责任公司 | 使用外来体来确定表现型的方法和系统 |
| PL2387627T3 (pl) | 2009-01-15 | 2016-10-31 | Profilowanie odporności adaptacyjnej i wytwarzanie przeciwciał monoklonalnych | |
| EP2432895A2 (en) | 2009-05-22 | 2012-03-28 | Asuragen, INC. | Mirna biomarkers of prostate disease |
| KR20120044941A (ko) | 2009-06-25 | 2012-05-08 | 프레드 헛친슨 켄서 리서치 센터 | 적응 면역의 측정방법 |
| EP2283846A1 (en) * | 2009-08-12 | 2011-02-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | miRNA compounds for treatment of prostate carcinoma |
| WO2011021177A2 (en) | 2009-08-19 | 2011-02-24 | Rosetta Genomics Ltd. | Compositions and methods for prognosis and treatment of prostate cancer |
| EP2316972A1 (en) * | 2009-10-29 | 2011-05-04 | Deutsches Krebsforschungszentrum | Circulating miRNAs as non-invasive markers for diagnosis and staging in prostate cancer |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| AU2010321555B2 (en) | 2009-11-23 | 2015-10-15 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| WO2011068918A1 (en) * | 2009-12-02 | 2011-06-09 | The Johns Hopkins University | Compositions and methods for treatment of cancer using tissue-specific oncolytic adenoviruses |
| EP2341145A1 (en) * | 2009-12-30 | 2011-07-06 | febit holding GmbH | miRNA fingerprint in the diagnosis of diseases |
| CA2791905A1 (en) | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Biomarkers for theranostics |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| CN103648505B (zh) | 2010-11-12 | 2016-09-28 | 俄亥俄州立大学研究基金会 | 与微rna-21、错配修复和结肠直肠癌相关的材料和方法 |
| AU2011329066B2 (en) | 2010-11-15 | 2017-03-09 | The Ohio State University Research Foundation | Controlled release mucoadhesive systems |
| PL237807B1 (pl) * | 2010-12-22 | 2021-05-31 | Wroclawskie Centrum Badan Eit Spolka Z Ograniczona Odpowiedzialnoscia | Sposób różnicowania zmian nowotworowych tarczycy oraz zastosowanie metalotioneiny (MT) do różnicowania zmian nowotworowych tarczycy |
| JPWO2012121178A1 (ja) * | 2011-03-04 | 2014-07-17 | 独立行政法人国立がん研究センター | 腫瘍血管形成阻害剤 |
| WO2012122239A1 (en) | 2011-03-07 | 2012-09-13 | The Ohio State University | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
| AU2012242761A1 (en) * | 2011-04-12 | 2013-10-31 | Beth Israel Deaconess Medical Center, Inc. | Micro-RNA inhibitors and their uses in disease |
| CN103797131A (zh) * | 2011-06-16 | 2014-05-14 | 卡里斯生命科学卢森堡控股有限责任公司 | 生物标志物组合物和方法 |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| WO2013056217A1 (en) | 2011-10-14 | 2013-04-18 | The Ohio State University | Methods and materials related to ovarian cancer |
| CA2853088C (en) | 2011-10-21 | 2018-03-13 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| SE536352C2 (sv) | 2011-10-24 | 2013-09-03 | Chundsell Medicals Ab | Markörgener för klassificiering av prostatacancer |
| US20140323551A1 (en) * | 2011-11-30 | 2014-10-30 | Cedars-Sinai Medical Center | Targeting micrornas mir-409-5p, mir-379 and mir-154* to treat prostate cancer bone metastasis and drug resistant lung cancer |
| US9745578B2 (en) | 2011-11-30 | 2017-08-29 | Cedars-Sinai Medical Center | Targeting microRNA miR-409-3P to treat prostate cancer |
| CN102443638B (zh) * | 2011-12-05 | 2014-04-09 | 南京医科大学 | 一种用于血清/血浆miRNA检测的内参及其应用 |
| ES2867924T3 (es) | 2011-12-09 | 2021-10-21 | Adaptive Biotechnologies Corp | Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima |
| EP2788486A4 (en) * | 2011-12-10 | 2015-08-12 | Ohio State Innovation Foundation | MIARN USEFUL IN REDUCING TUMORIGENESIS OF LUNG CANCER AND ASSOCIATED COMPOSITIONS AND METHODS |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| CN104619353A (zh) | 2011-12-13 | 2015-05-13 | 俄亥俄州国家创新基金会 | 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移 |
| WO2013110053A1 (en) | 2012-01-20 | 2013-07-25 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| ES2662128T3 (es) | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
| JP5756247B1 (ja) | 2012-05-08 | 2015-07-29 | アダプティブ バイオテクノロジーズ コーポレイション | マルチプレックスpcr反応における増幅バイアスを測定し校正する組成物及び方法 |
| US11035005B2 (en) | 2012-08-16 | 2021-06-15 | Decipher Biosciences, Inc. | Cancer diagnostics using biomarkers |
| GB2505237A (en) * | 2012-08-24 | 2014-02-26 | Stefan Grimm | Method of screening for therapeutic agents using cell lines including a reference cell line |
| CA2885429A1 (en) * | 2012-09-23 | 2014-03-27 | The Ohio State University | Use of mir-494 to modulate trail-induced apoptosis through bim down-regulation |
| ES2660027T3 (es) | 2012-10-01 | 2018-03-20 | Adaptive Biotechnologies Corporation | Evaluación de la inmunocompetencia por la diversidad de los receptores de inmunidad adaptativa y caracterización de la clonalidad |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| BR112015023275B1 (pt) * | 2013-03-15 | 2022-06-21 | Board Of Regents, The University Of Texas System | Método in vitro de detecção de biomarcador de câncer |
| CN103215359A (zh) * | 2013-04-11 | 2013-07-24 | 百瑞德(南京)生物科技有限公司 | 一种前列腺癌生物标志物miR-21*、诊断试剂盒及应用 |
| MY180365A (en) * | 2013-04-15 | 2020-11-28 | Regeneron Pharma | Markers of tumor cell response to anti-cancer therapy |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| WO2015057806A1 (en) * | 2013-10-15 | 2015-04-23 | The Board Of Trustees Of The University Of Illinois | Serum mirnas for the prognosis of prostate cancer |
| EP3114240B1 (en) | 2014-03-05 | 2019-07-24 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| WO2015165779A2 (en) * | 2014-05-01 | 2015-11-05 | Stichting Vu-Vumc | Small ncrnas as biomarkers |
| CN119220676A (zh) | 2014-06-12 | 2024-12-31 | 东丽株式会社 | 前列腺癌的检测试剂盒或装置以及检测方法 |
| CN104138603A (zh) * | 2014-07-02 | 2014-11-12 | 上海交通大学医学院附属仁济医院 | 应用microRNA-7抑制前列腺肿瘤生长及其肿瘤进程 |
| AU2015339191A1 (en) | 2014-10-29 | 2017-05-18 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| AU2015353581A1 (en) | 2014-11-25 | 2017-06-15 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| CN107207557B (zh) * | 2015-01-26 | 2020-07-10 | 中国科学院动物研究所 | miRNA对m6A修饰水平的调控方法及其应用 |
| WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| EP3277294B1 (en) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| IL256175B2 (en) | 2015-06-10 | 2024-10-01 | Univ Texas | Using exosomes to treat the disease |
| AU2016334893B2 (en) * | 2015-10-08 | 2022-11-17 | Veracyte, Inc. | Use of a genetic signature diagnostically to evaluate treatment strategies for prostate cancer |
| WO2018013865A1 (en) * | 2016-07-13 | 2018-01-18 | uBiome, Inc. | Method and system for microbial pharmacogenomics |
| US11414708B2 (en) | 2016-08-24 | 2022-08-16 | Decipher Biosciences, Inc. | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| EP3593140A4 (en) | 2017-03-09 | 2021-01-06 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| WO2018172556A1 (en) | 2017-03-24 | 2018-09-27 | Curevac Ag | Nucleic acids encoding crispr-associated proteins and uses thereof |
| EP4428157A3 (en) | 2017-08-04 | 2024-12-11 | Veracyte SD, Inc. | Use of immune cell-specific gene expression for prognosis of prostate cancer and prediction of responsiveness to radiation therapy |
| CN109593835B (zh) * | 2017-09-29 | 2023-12-12 | 深圳华大基因股份有限公司 | 用于微量ffpe rna样本评估的方法、试剂盒及应用 |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CN108018354A (zh) * | 2017-12-19 | 2018-05-11 | 贵州医科大学 | MicroRNA-34在抑制前列腺癌转移治疗中的新用途 |
| EP3835434A4 (en) | 2018-08-10 | 2022-06-08 | Toray Industries, Inc. | PROSTATE CANCER DETECTION KIT, DEVICE AND METHOD |
| EP4600650A3 (en) * | 2019-04-05 | 2025-11-26 | Earli Inc. | Improved methods and compositions for synthetic biomarkers |
| CN111249552B (zh) * | 2020-03-16 | 2020-11-17 | 南京鼓楼医院 | 基于人iPSCs诱导类肝细胞及多层多孔生物反应器的生物人工肝 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CN112094910B (zh) * | 2020-09-25 | 2023-03-24 | 无锡市中医医院 | 一种用于前列腺癌患病风险评估的miRNA标志物 |
| CN114272378B (zh) * | 2020-09-27 | 2023-06-23 | 四川大学华西医院 | 一种使cttnbp2nl功能缺失的试剂在制备治疗疾病的药物中的用途 |
| KR102844924B1 (ko) * | 2020-11-24 | 2025-08-11 | 한국과학기술연구원 | 그래핀 기반의 바이오센서 및 이를 이용한 검출방법 |
| WO2022209943A1 (ja) * | 2021-03-29 | 2022-10-06 | 東レ株式会社 | 生体試料中のマイクロrnaの検出方法、中性アミノ酸の塩酸塩の組成物および容器 |
| CN114540496A (zh) * | 2022-02-25 | 2022-05-27 | 东南大学 | miR-7在制备/筛选前列腺癌诊治产品中的应用 |
| WO2024097892A1 (en) * | 2022-11-03 | 2024-05-10 | Mirimus, Inc. | Regulation of artificial mirnas by endogenous tissue-specific mirnas and methods of using the same |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4608337A (en) * | 1980-11-07 | 1986-08-26 | The Wistar Institute | Human hybridomas and the production of human monoclonal antibodies by human hybridomas |
| US5015568A (en) * | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
| US5202429A (en) * | 1986-07-09 | 1993-04-13 | The Wistar Institute | DNA molecules having human BCL-2 gene sequences |
| US5198338A (en) * | 1989-05-31 | 1993-03-30 | Temple University | Molecular probing for human t-cell leukemia and lymphoma |
| US5633135A (en) * | 1991-12-11 | 1997-05-27 | Thomas Jefferson University | Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities |
| WO1993012136A1 (en) * | 1991-12-11 | 1993-06-24 | Thomas Jefferson University | Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region |
| US6040140A (en) * | 1991-12-11 | 2000-03-21 | Thomas Jefferson University | Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities |
| EP0667920B1 (en) * | 1992-10-29 | 2003-01-15 | Thomas Jefferson University | Methods of detecting micrometastasis of prostate cancer |
| US5674682A (en) * | 1992-10-29 | 1997-10-07 | Thomas Jefferson University | Nucleic acid primers for detecting micrometastasis of prostate cancer |
| US7175995B1 (en) * | 1994-10-27 | 2007-02-13 | Thomas Jefferson University | TCL-1 protein and related methods |
| US5985598A (en) * | 1994-10-27 | 1999-11-16 | Thomas Jefferson University | TCL-1 gene and protein and related methods and compositions |
| US5928884A (en) * | 1996-02-09 | 1999-07-27 | Croce; Carlo M. | FHIT proteins and nucleic acids and methods based thereon |
| US6242212B1 (en) * | 1996-02-09 | 2001-06-05 | Thomas Jefferson University | Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins |
| WO1998035707A1 (en) * | 1997-02-18 | 1998-08-20 | Thomas Jefferson University | Compositions that bind to pancreatic cancer cells and methods of using the same |
| WO1998045480A1 (en) * | 1997-04-04 | 1998-10-15 | The Texas A & M University System | Noninvasive detection of colonic biomarkers using fecal messenger rna |
| US6303323B1 (en) * | 1997-10-21 | 2001-10-16 | Cancer Research Campaign Technology Limited | Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies |
| WO2000003685A2 (en) * | 1998-07-20 | 2000-01-27 | Thomas Jefferson University | Nitrilase homologs |
| US6255293B1 (en) * | 1998-07-24 | 2001-07-03 | Yeda Research And Development Co., Ltd. | Prevention of metastasis with 5-aza-2′-deoxycytidine |
| US7141417B1 (en) * | 1999-02-25 | 2006-11-28 | Thomas Jefferson University | Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene |
| JP2004516002A (ja) * | 2000-04-11 | 2004-06-03 | トーマス・ジェファーソン・ユニバーシティー | Fhit欠損マウスにおけるミュア−トール様症候群 |
| WO2001087958A2 (en) * | 2000-05-16 | 2001-11-22 | Thomas Jefferson University | CRYSTAL STRUCTURE OF WORM NitFhit REVEALS THAT A Nit TETRAMER BINDS TWO Fhit DIMERS |
| US7060811B2 (en) * | 2000-10-13 | 2006-06-13 | Board Of Regents, The University Of Texas System | WWOX: a tumor suppressor gene mutated in multiple cancers |
| US20040033502A1 (en) * | 2001-03-28 | 2004-02-19 | Amanda Williams | Gene expression profiles in esophageal tissue |
| EP2428568B1 (en) * | 2001-09-28 | 2018-04-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Microrna molecules |
| US7371736B2 (en) * | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
| GB0128898D0 (en) * | 2001-12-03 | 2002-01-23 | Biotech Res Ventures Pte Ltd | Materials and methods relating to the stabilization and activation of a tumour suppressor protein |
| JP2005522677A (ja) * | 2002-04-08 | 2005-07-28 | シファーゲン バイオシステムズ, インコーポレイテッド | 肝細胞癌の血清バイオマーカー |
| JP2005523712A (ja) * | 2002-04-29 | 2005-08-11 | トマス ジェファソン ユニバーシティ | 標的tcl1発現によりマウスでモデル化されたヒト慢性リンパ球性白血病 |
| WO2003102215A2 (en) * | 2002-05-31 | 2003-12-11 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of identifying and isolating stem cells and cancer stem cells |
| AU2003284083A1 (en) * | 2002-10-11 | 2004-05-04 | Thomas Jefferson University | Novel tumor suppressor gene and compositions and methods for making and using the same |
| CA2504605C (en) * | 2002-11-13 | 2016-01-19 | Thomas Jefferson University | Treatment of chronic lymphocytic leukemia and prostate cancer with microrna mir15 |
| WO2004071464A2 (en) * | 2003-02-12 | 2004-08-26 | Johns Hopkins University School Of Medicine | Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells |
| US20050069918A1 (en) * | 2003-05-29 | 2005-03-31 | Francois Claret | JAB1 as a prognostic marker and a therapeutic target for human cancer |
| US8106180B2 (en) * | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US20050037362A1 (en) * | 2003-08-11 | 2005-02-17 | Eppendorf Array Technologies, S.A. | Detection and quantification of siRNA on microarrays |
| US20070054849A1 (en) * | 2003-09-24 | 2007-03-08 | Oncotherapy Science, Inc. | Method for diagnosing hepatocellular carcinomas |
| DE602004031881D1 (de) * | 2003-12-19 | 2011-04-28 | Univ California | Verfahren und materialien zur beurteilung von prostatakrebstherapien |
| EP2295604B1 (en) * | 2004-02-09 | 2015-04-08 | Thomas Jefferson University | Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features |
| CA2566519C (en) * | 2004-05-14 | 2020-04-21 | Rosetta Genomics Ltd. | Micrornas and uses thereof |
| US7888010B2 (en) * | 2004-05-28 | 2011-02-15 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
| US20060037088A1 (en) * | 2004-08-13 | 2006-02-16 | Shulin Li | Gene expression levels as predictors of chemoradiation response of cancer |
| US7642348B2 (en) * | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
| FR2877350B1 (fr) * | 2004-11-03 | 2010-08-27 | Centre Nat Rech Scient | IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE |
| EP2808389A1 (en) * | 2004-11-12 | 2014-12-03 | Asuragen, Inc. | Methods and compositions involving MIRNA and MIRNA inhibitor molecules |
| CA2590768A1 (en) * | 2004-12-14 | 2006-06-22 | Alnylam Pharmaceuticals, Inc. | Rnai modulation of mll-af4 and uses thereof |
| EP1838870A2 (en) * | 2004-12-29 | 2007-10-03 | Exiqon A/S | NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF MICRORNAS AND THEIR TARGET MRNAs |
| DE602006016739D1 (de) * | 2005-01-25 | 2010-10-21 | Rosetta Inpharmatics Llc | Verfahren zur quantifizierung kleiner rna-moleküle |
| US20070065840A1 (en) * | 2005-03-23 | 2007-03-22 | Irena Naguibneva | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS |
| US20090209621A1 (en) * | 2005-06-03 | 2009-08-20 | The Johns Hopkins University | Compositions and methods for decreasing microrna expression for the treatment of neoplasia |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| WO2007021896A2 (en) * | 2005-08-10 | 2007-02-22 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro rna and uses thereof |
| CN103028120B (zh) * | 2005-09-12 | 2015-08-12 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| US7390792B2 (en) * | 2005-12-15 | 2008-06-24 | Board Of Regents, The University Of Texas System | MicroRNA1 therapies |
| JP5490413B2 (ja) * | 2006-01-05 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常 |
| ES2508893T3 (es) * | 2006-01-05 | 2014-10-16 | The Ohio State University Research Foundation | Métodos basados en microARN para el diagnóstico de cánceres de estómago |
| CA2650026C (en) * | 2006-04-24 | 2013-01-22 | The Ohio State University Research Foundation | Pre-b cell proliferation and lymphoblastic leukemia/high-grade lymphoma in mir155 transgenic mice |
| JPWO2007126150A1 (ja) * | 2006-04-27 | 2009-09-17 | 国立大学法人名古屋大学 | 癌の新規治療用組成物 |
| WO2007140352A2 (en) * | 2006-05-26 | 2007-12-06 | Invitrogen Corporation | Plasma membrane and secreted cancer biomarkers |
| US9200275B2 (en) * | 2006-06-14 | 2015-12-01 | Merck Sharp & Dohme Corp. | Methods and compositions for regulating cell cycle progression |
| JP5520605B2 (ja) * | 2006-09-19 | 2014-06-11 | アシュラジェン インコーポレイテッド | 膵臓疾患で差次的に発現されるマイクロrnaおよびその使用 |
| EP2145001A2 (en) * | 2006-09-19 | 2010-01-20 | Asuragen, Inc. | Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
| CA2663878A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-200 regulated genes and pathways as targets for therapeutic intervention |
| US8071292B2 (en) * | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| WO2008054828A2 (en) * | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| US8293684B2 (en) * | 2006-11-29 | 2012-10-23 | Exiqon | Locked nucleic acid reagents for labelling nucleic acids |
| WO2008070082A2 (en) * | 2006-12-04 | 2008-06-12 | The Johns Hopkins University | Stem-progenitor cell specific micro-ribonucleic acids and uses thereof |
| CN101622350A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为干预治疗靶标的miR-126调控基因和通路 |
| WO2008073920A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| CA2671299A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
| AU2007333106A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miR-20 regulated genes and pathways as targets for therapeutic intervention |
| US20090175827A1 (en) * | 2006-12-29 | 2009-07-09 | Byrom Mike W | miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| EP1944609A1 (en) * | 2007-01-10 | 2008-07-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | In vitro method for diagnosing prostate cancer |
| CN105256004A (zh) * | 2007-01-31 | 2016-01-20 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| WO2008112283A2 (en) * | 2007-03-12 | 2008-09-18 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Microrna profiling of androgen responsiveness for predicting the appropriate prostate cancer treatment |
| CA2685840C (en) * | 2007-04-30 | 2016-12-13 | The Ohio State University Research Foundation | Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis |
| US20090005336A1 (en) * | 2007-05-08 | 2009-01-01 | Zhiguo Wang | Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions |
| US20090131354A1 (en) * | 2007-05-22 | 2009-05-21 | Bader Andreas G | miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| WO2008154098A2 (en) * | 2007-06-07 | 2008-12-18 | Wisconsin Alumni Research Foundation | Reagents and methods for mirna expression analysis and identification of cancer biomarkers |
| AU2008266014B2 (en) * | 2007-06-15 | 2013-06-06 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing |
| WO2009015071A1 (en) * | 2007-07-23 | 2009-01-29 | Dharmacon, Inc. | Screening of micro-rna cluster inhibitor pools |
| EP2173908B1 (en) * | 2007-08-03 | 2016-01-06 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncrnas |
| US20090061424A1 (en) * | 2007-08-30 | 2009-03-05 | Sigma-Aldrich Company | Universal ligation array for analyzing gene expression or genomic variations |
| ES2406686T3 (es) * | 2007-10-04 | 2013-06-07 | Santaris Pharma A/S | Micromirs |
| US20090123933A1 (en) * | 2007-11-12 | 2009-05-14 | Wake Forest University Health Sciences | Microrna biomarkers in lupus |
| WO2009070805A2 (en) * | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| US20090192114A1 (en) * | 2007-12-21 | 2009-07-30 | Dmitriy Ovcharenko | miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention |
| ES2936256T3 (es) * | 2008-02-01 | 2023-03-15 | Massachusetts Gen Hospital | Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas |
| CN102301002A (zh) * | 2008-11-12 | 2011-12-28 | 卡里斯生命科学卢森堡控股有限责任公司 | 使用外来体来确定表现型的方法和系统 |
| WO2010056993A2 (en) * | 2008-11-14 | 2010-05-20 | Emory University | Prostate cancer biomarkers to predict recurrence and metastatic potential |
-
2009
- 2009-02-27 EP EP14170625.9A patent/EP2799557B1/en not_active Not-in-force
- 2009-02-27 EP EP16175539.2A patent/EP3112477A1/en not_active Withdrawn
- 2009-02-27 CA CA2716938A patent/CA2716938A1/en not_active Abandoned
- 2009-02-27 EP EP09715064A patent/EP2260109A4/en not_active Withdrawn
- 2009-02-27 CN CN201410133658.XA patent/CN104031984A/zh active Pending
- 2009-02-27 US US12/919,888 patent/US20110054009A1/en not_active Abandoned
- 2009-02-27 CN CN200980111708.1A patent/CN102027129B/zh not_active Expired - Fee Related
- 2009-02-27 JP JP2010548904A patent/JP2011517283A/ja active Pending
- 2009-02-27 ES ES14170625.9T patent/ES2600165T3/es active Active
- 2009-02-27 AU AU2009219197A patent/AU2009219197B2/en not_active Ceased
- 2009-02-27 WO PCT/US2009/035470 patent/WO2009108860A2/en not_active Ceased
-
2012
- 2012-09-19 US US13/622,487 patent/US20130085077A1/en not_active Abandoned
-
2014
- 2014-05-20 AU AU2014202735A patent/AU2014202735B2/en not_active Ceased
- 2014-06-26 JP JP2014131080A patent/JP5976726B2/ja not_active Expired - Fee Related
-
2016
- 2016-03-07 US US15/062,414 patent/US20160177316A1/en not_active Abandoned
- 2016-03-07 US US15/062,404 patent/US20160186184A1/en not_active Abandoned
- 2016-03-07 US US15/062,407 patent/US20160177311A1/en not_active Abandoned
- 2016-03-07 US US15/062,411 patent/US20160177312A1/en not_active Abandoned
- 2016-07-14 JP JP2016139495A patent/JP2016216492A/ja active Pending
-
2017
- 2017-04-06 US US15/480,753 patent/US20170211066A1/en not_active Abandoned
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104278100A (zh) * | 2014-10-16 | 2015-01-14 | 上海交通大学医学院附属仁济医院 | miRNA-188作为标记分子在制备诊断试剂中的用途 |
| CN104651492A (zh) * | 2015-01-06 | 2015-05-27 | 中国人民解放军第二军医大学 | miRNA410-在制备前列腺癌诊断试剂盒中的应用 |
| CN104651492B (zh) * | 2015-01-06 | 2017-10-03 | 中国人民解放军第二军医大学 | miRNA410‑在制备前列腺癌诊断试剂盒中的应用 |
| CN104894251A (zh) * | 2015-05-28 | 2015-09-09 | 基因科技(上海)有限公司 | 一种避免miRNA定量检测中因荧光探针标记不彻底而引起背景扩增的方法 |
| CN105056250A (zh) * | 2015-07-15 | 2015-11-18 | 中国农业大学 | 一种microRNA在制备治疗前列腺癌的药物中的应用 |
| CN105056250B (zh) * | 2015-07-15 | 2018-01-05 | 中国农业大学 | 一种microRNA在制备治疗前列腺癌的药物中的应用 |
| CN106636310A (zh) * | 2015-10-30 | 2017-05-10 | 益善生物技术股份有限公司 | 前列腺癌相关microRNA检测试剂盒 |
| CN106636310B (zh) * | 2015-10-30 | 2020-06-02 | 益善生物技术股份有限公司 | 前列腺癌相关microRNA检测试剂盒 |
| CN105243293A (zh) * | 2015-11-06 | 2016-01-13 | 吴志宏 | 前列腺相关癌基因信息收集及分析方法 |
| CN105243293B (zh) * | 2015-11-06 | 2019-04-19 | 吴志宏 | 前列腺相关癌基因信息收集及分析系统和方法 |
| CN111344409A (zh) * | 2017-11-12 | 2020-06-26 | 加利福尼亚大学董事会 | 用于检测癌症的非编码rna |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009219197A1 (en) | 2009-09-03 |
| US20110054009A1 (en) | 2011-03-03 |
| CN102027129A (zh) | 2011-04-20 |
| JP2016216492A (ja) | 2016-12-22 |
| JP2014221786A (ja) | 2014-11-27 |
| EP2799557A1 (en) | 2014-11-05 |
| US20130085077A1 (en) | 2013-04-04 |
| JP2011517283A (ja) | 2011-06-02 |
| US20160186184A1 (en) | 2016-06-30 |
| US20160177312A1 (en) | 2016-06-23 |
| CA2716938A1 (en) | 2009-09-03 |
| AU2009219197B2 (en) | 2014-04-10 |
| JP5976726B2 (ja) | 2016-08-24 |
| CN102027129B (zh) | 2014-03-12 |
| US20170211066A1 (en) | 2017-07-27 |
| AU2014202735A1 (en) | 2014-06-12 |
| WO2009108860A3 (en) | 2010-01-14 |
| EP2260109A4 (en) | 2011-06-08 |
| EP2799557B1 (en) | 2016-09-07 |
| WO2009108860A2 (en) | 2009-09-03 |
| EP2260109A2 (en) | 2010-12-15 |
| EP3112477A1 (en) | 2017-01-04 |
| US20160177316A1 (en) | 2016-06-23 |
| AU2014202735B2 (en) | 2015-09-10 |
| US20160177311A1 (en) | 2016-06-23 |
| WO2009108860A8 (en) | 2011-01-27 |
| ES2600165T3 (es) | 2017-02-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102027129B (zh) | 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 | |
| CN102007223B (zh) | 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物 | |
| AU2009322907B2 (en) | MicroRNA-based methods and compositions for the diagnosis and treatment of ovarian cancer | |
| Prueitt et al. | Expression of microRNAs and protein‐coding genes associated with perineural invasion in prostate cancer | |
| AU2009219203B2 (en) | MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia (AML) and uses thereof | |
| CN101657547B (zh) | 用于诊断和治疗结肠癌相关疾病的基于微小rna的方法和组合物 | |
| CN102015027A (zh) | 与人慢性淋巴细胞性白血病(ccl)相关的微rna特征和其用途 | |
| JP2010535782A (ja) | Dnmt3a及びdnmt3bを標的にすることによるメチル化を元に戻す方法 | |
| WO2014085906A1 (en) | Microrna biomarkers for prostate cancer | |
| KR20110015013A (ko) | 결장직장암의 평가 방법 및 여기에 사용하기 위한 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140910 |