JP2011517283A - 前立腺関連障害の予後診断及び治療のためのマイクロrnaに基づく方法及び組成物 - Google Patents
前立腺関連障害の予後診断及び治療のためのマイクロrnaに基づく方法及び組成物 Download PDFInfo
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- JP2011517283A JP2011517283A JP2010548904A JP2010548904A JP2011517283A JP 2011517283 A JP2011517283 A JP 2011517283A JP 2010548904 A JP2010548904 A JP 2010548904A JP 2010548904 A JP2010548904 A JP 2010548904A JP 2011517283 A JP2011517283 A JP 2011517283A
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6751808P | 2008-02-28 | 2008-02-28 | |
| US61/067,518 | 2008-02-28 | ||
| PCT/US2009/035470 WO2009108860A2 (en) | 2008-02-28 | 2009-02-27 | Microrna-based methods and compositions for the diagnosis, pronosis and treatment of prostate related disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014131080A Division JP5976726B2 (ja) | 2008-02-28 | 2014-06-26 | 前立腺関連障害の予後診断及び治療のためのマイクロrnaに基づく方法及び組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011517283A true JP2011517283A (ja) | 2011-06-02 |
| JP2011517283A5 JP2011517283A5 (enExample) | 2013-03-07 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010548904A Pending JP2011517283A (ja) | 2008-02-28 | 2009-02-27 | 前立腺関連障害の予後診断及び治療のためのマイクロrnaに基づく方法及び組成物 |
| JP2014131080A Expired - Fee Related JP5976726B2 (ja) | 2008-02-28 | 2014-06-26 | 前立腺関連障害の予後診断及び治療のためのマイクロrnaに基づく方法及び組成物 |
| JP2016139495A Pending JP2016216492A (ja) | 2008-02-28 | 2016-07-14 | 前立腺関連障害の予後診断及び治療のためのマイクロrnaに基づく方法及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014131080A Expired - Fee Related JP5976726B2 (ja) | 2008-02-28 | 2014-06-26 | 前立腺関連障害の予後診断及び治療のためのマイクロrnaに基づく方法及び組成物 |
| JP2016139495A Pending JP2016216492A (ja) | 2008-02-28 | 2016-07-14 | 前立腺関連障害の予後診断及び治療のためのマイクロrnaに基づく方法及び組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US20110054009A1 (enExample) |
| EP (3) | EP2260109A4 (enExample) |
| JP (3) | JP2011517283A (enExample) |
| CN (2) | CN104031984A (enExample) |
| AU (2) | AU2009219197B2 (enExample) |
| CA (1) | CA2716938A1 (enExample) |
| ES (1) | ES2600165T3 (enExample) |
| WO (1) | WO2009108860A2 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014505866A (ja) * | 2010-12-22 | 2014-03-06 | ヴロツワフスキ セントラム バダン エイト プラス エスピー.ゼット オー.オー. | 甲状腺の癌様の変化を識別する方法、方法を具体化するためのキットおよび甲状腺の癌様の変化を識別するためのメタロチオネイン(mt)の使用 |
| JP2014519340A (ja) * | 2011-06-16 | 2014-08-14 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス.アー.エール.エル. | バイオマーカー組成物および方法 |
| JP2015501151A (ja) * | 2011-10-24 | 2015-01-15 | チュンドセル・メディカルズ・エービーChundsell Medicals AB | 前立腺癌の分類のためのマーカー遺伝子 |
| JP2016520803A (ja) * | 2013-03-15 | 2016-07-14 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 診断及び治療のためのエクソソームにおけるmiRNAバイオジェネシス |
| JP2017006137A (ja) * | 2011-12-10 | 2017-01-12 | オハイオ・ステイト・イノベーション・ファウンデーション | 肺がんの腫瘍発生および化学療法耐性を低減するために有用なmiRNAならびに関連する組成物および方法 |
| WO2022209943A1 (ja) * | 2021-03-29 | 2022-10-06 | 東レ株式会社 | 生体試料中のマイクロrnaの検出方法、中性アミノ酸の塩酸塩の組成物および容器 |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103866018B (zh) | 2005-08-01 | 2016-05-25 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| CN103028120B (zh) | 2005-09-12 | 2015-08-12 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| WO2007081720A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| EP2487260B1 (en) | 2006-01-05 | 2015-07-08 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis and treatment of solid cancers |
| ES2524018T3 (es) | 2006-01-05 | 2014-12-03 | The Ohio State University Research Foundation | Anomalías de la expresión de microARN en tumores pancreáticos endocrinos y acinares |
| EP2369012A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Micro-RNA fingerprints during human megakaryocytopoiesis |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| BRPI0711011A2 (pt) | 2006-05-18 | 2011-08-23 | Molecular Profiling Inst Inc | método para a determinação da intervenção médica para um estado de doença, método para a identificação de uma terapia de droga com capacidade de interação com um alvo molecular e sistema para a determinação da intervenção médica individualizada para um estado de doença |
| CA2657030A1 (en) | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| US8071292B2 (en) | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| JP5501766B2 (ja) | 2006-11-01 | 2014-05-28 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 肝細胞癌における生存および転移を予測するためのマイクロrna発現サイン |
| US8034560B2 (en) | 2007-01-31 | 2011-10-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) |
| JP5592251B2 (ja) * | 2007-04-30 | 2014-09-17 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵臓癌を正常な膵臓機能および/または慢性膵炎と識別する方法 |
| CA2690144A1 (en) | 2007-06-08 | 2008-12-18 | The Government Of The United States Of America As Represented By The Sec Retary Of Department Of Health And Human Services | Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells |
| US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| ES2496172T3 (es) | 2007-07-31 | 2014-09-18 | The Ohio State University Research Foundation | Métodos para invertir la metilación por selección dirigida de DNMT3A y DNMT3B |
| AU2008283997B2 (en) | 2007-08-03 | 2014-04-10 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| CN101836112A (zh) | 2007-08-22 | 2010-09-15 | 俄亥俄州立大学研究基金会 | 用于在人急性白血病中诱导epha7和erk磷酸化的脱调节的方法和组合物 |
| CA2702241A1 (en) * | 2007-10-11 | 2009-04-16 | The Ohio State University Research Foundation | Methods and compositions for the diagnosis and treatment of esophageal adenocarcinomas |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| CA2716906A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of gastric cancer |
| AU2009257410B2 (en) | 2008-06-11 | 2014-03-06 | Fudan University | Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| GB2465088C (en) * | 2008-10-30 | 2016-01-27 | Caris Mpi Inc | miRNA expression in the characterisation and classification of cancer |
| US7888035B2 (en) | 2008-10-30 | 2011-02-15 | Caris Mpi, Inc. | Methods for assessing RNA patterns |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| GB2483810B (en) | 2008-11-07 | 2012-09-05 | Sequenta Inc | Methods for correlating clonotypes with diseases in a population |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| EP3181705A1 (en) | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| PT2387627E (pt) | 2009-01-15 | 2016-06-03 | Adaptive Biotechnologies Corp | Determinação do perfil de imunidade adaptativa e métodos de geração de anticorpos monoclonais |
| CA2762986C (en) * | 2009-05-22 | 2018-03-06 | Asuragen, Inc. | Mirna biomarkers of prostate disease |
| JP2012531202A (ja) | 2009-06-25 | 2012-12-10 | フレッド ハチンソン キャンサー リサーチ センター | 適応免疫を測定する方法 |
| EP2283846A1 (en) | 2009-08-12 | 2011-02-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | miRNA compounds for treatment of prostate carcinoma |
| WO2011021177A2 (en) * | 2009-08-19 | 2011-02-24 | Rosetta Genomics Ltd. | Compositions and methods for prognosis and treatment of prostate cancer |
| EP2316972A1 (en) * | 2009-10-29 | 2011-05-04 | Deutsches Krebsforschungszentrum | Circulating miRNAs as non-invasive markers for diagnosis and staging in prostate cancer |
| US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
| JP5960060B2 (ja) | 2009-11-23 | 2016-08-02 | ジ・オハイオ・ステート・ユニバーシティ | 腫瘍細胞の増殖、遊走および浸潤に影響を与えるために有用な物質および方法 |
| WO2011068918A1 (en) * | 2009-12-02 | 2011-06-09 | The Johns Hopkins University | Compositions and methods for treatment of cancer using tissue-specific oncolytic adenoviruses |
| EP2341145A1 (en) * | 2009-12-30 | 2011-07-06 | febit holding GmbH | miRNA fingerprint in the diagnosis of diseases |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| JPWO2012121178A1 (ja) * | 2011-03-04 | 2014-07-17 | 独立行政法人国立がん研究センター | 腫瘍血管形成阻害剤 |
| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
| AU2012242761A1 (en) * | 2011-04-12 | 2013-10-31 | Beth Israel Deaconess Medical Center, Inc. | Micro-RNA inhibitors and their uses in disease |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| EP2766500A4 (en) | 2011-10-14 | 2015-10-14 | Univ Ohio State | METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER |
| EP2768982A4 (en) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS |
| EP3106168A3 (en) * | 2011-11-30 | 2017-02-22 | Cedars-Sinai Medical Center | Targeting micrornas mir-409-5p, mir-379 and mir-154* to treat prostate cancer bone metastasis and drug resistant lung cancer |
| US9745578B2 (en) | 2011-11-30 | 2017-08-29 | Cedars-Sinai Medical Center | Targeting microRNA miR-409-3P to treat prostate cancer |
| CN102443638B (zh) * | 2011-12-05 | 2014-04-09 | 南京医科大学 | 一种用于血清/血浆miRNA检测的内参及其应用 |
| AU2012347460B2 (en) | 2011-12-09 | 2017-05-25 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| CN104619353A (zh) | 2011-12-13 | 2015-05-13 | 俄亥俄州国家创新基金会 | 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移 |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| JP2015511121A (ja) | 2012-01-20 | 2015-04-16 | ジ・オハイオ・ステート・ユニバーシティ | 浸潤性および予後に関する乳がんバイオマーカーシグネチャー |
| JP6302847B2 (ja) | 2012-03-05 | 2018-03-28 | アダプティヴ バイオテクノロジーズ コーポレーション | 頻度が一致したサブユニットからの、対をなす免疫受容体鎖の決定 |
| ES2711156T3 (es) | 2012-05-08 | 2019-04-30 | Adaptive Biotechnologies Corp | Método para medir y calibrar el sesgo de amplificación en reacciones de PCR multiplexadas |
| ES2945036T3 (es) | 2012-08-16 | 2023-06-28 | Veracyte Sd Inc | Pronóstico del cáncer de próstata mediante biomarcadores |
| GB2505237A (en) * | 2012-08-24 | 2014-02-26 | Stefan Grimm | Method of screening for therapeutic agents using cell lines including a reference cell line |
| EP2897648A4 (en) * | 2012-09-23 | 2016-06-22 | Univ Ohio State | USE OF MIR-494 FOR MODULATING TRAIL-INDUCED APOPTOSIS BY BIM-DOWN REGULATION |
| EP2904111B1 (en) | 2012-10-01 | 2017-12-06 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
| CN103215359A (zh) * | 2013-04-11 | 2013-07-24 | 百瑞德(南京)生物科技有限公司 | 一种前列腺癌生物标志物miR-21*、诊断试剂盒及应用 |
| US10023916B2 (en) * | 2013-04-15 | 2018-07-17 | Regeneron Pharmaceuticals, Inc. | Markers of tumor cell response to anti-cancer therapy |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| WO2015057806A1 (en) * | 2013-10-15 | 2015-04-23 | The Board Of Trustees Of The University Of Illinois | Serum mirnas for the prognosis of prostate cancer |
| US20170292149A1 (en) | 2014-03-05 | 2017-10-12 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| ES2777529T3 (es) | 2014-04-17 | 2020-08-05 | Adaptive Biotechnologies Corp | Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células |
| CA2947512A1 (en) * | 2014-05-01 | 2015-11-05 | Stichting Vumc | Small ncrnas as biomarkers |
| KR102761162B1 (ko) * | 2014-06-12 | 2025-02-03 | 국립연구개발법인 고쿠리츠간켄큐센터 | 전립선암 검출 키트 또는 디바이스 및 검출 방법 |
| CN104138603A (zh) * | 2014-07-02 | 2014-11-12 | 上海交通大学医学院附属仁济医院 | 应用microRNA-7抑制前列腺肿瘤生长及其肿瘤进程 |
| CN104278100B (zh) * | 2014-10-16 | 2016-02-10 | 上海交通大学医学院附属仁济医院 | miRNA-188作为标记分子在制备诊断试剂中的用途 |
| WO2016069886A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corporation | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CA2968543C (en) | 2014-11-25 | 2024-04-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| CN104651492B (zh) * | 2015-01-06 | 2017-10-03 | 中国人民解放军第二军医大学 | miRNA410‑在制备前列腺癌诊断试剂盒中的应用 |
| CN107207557B (zh) * | 2015-01-26 | 2020-07-10 | 中国科学院动物研究所 | miRNA对m6A修饰水平的调控方法及其应用 |
| WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| WO2016161273A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| CN104894251A (zh) * | 2015-05-28 | 2015-09-09 | 基因科技(上海)有限公司 | 一种避免miRNA定量检测中因荧光探针标记不彻底而引起背景扩增的方法 |
| CA2988585A1 (en) | 2015-06-10 | 2016-12-15 | Raghu Kalluri | Use of exosomes for the treatment of disease |
| CN105056250B (zh) * | 2015-07-15 | 2018-01-05 | 中国农业大学 | 一种microRNA在制备治疗前列腺癌的药物中的应用 |
| AU2016334893B2 (en) * | 2015-10-08 | 2022-11-17 | Veracyte, Inc. | Use of a genetic signature diagnostically to evaluate treatment strategies for prostate cancer |
| CN106636310B (zh) * | 2015-10-30 | 2020-06-02 | 益善生物技术股份有限公司 | 前列腺癌相关microRNA检测试剂盒 |
| CN105243293B (zh) * | 2015-11-06 | 2019-04-19 | 吴志宏 | 前列腺相关癌基因信息收集及分析系统和方法 |
| CN109475305B (zh) * | 2016-07-13 | 2022-01-25 | 普梭梅根公司 | 用于微生物药物基因组学的方法和系统 |
| US11414708B2 (en) | 2016-08-24 | 2022-08-16 | Decipher Biosciences, Inc. | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11873532B2 (en) | 2017-03-09 | 2024-01-16 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| US11739335B2 (en) | 2017-03-24 | 2023-08-29 | CureVac SE | Nucleic acids encoding CRISPR-associated proteins and uses thereof |
| CN109593835B (zh) * | 2017-09-29 | 2023-12-12 | 深圳华大基因股份有限公司 | 用于微量ffpe rna样本评估的方法、试剂盒及应用 |
| CN111344409A (zh) * | 2017-11-12 | 2020-06-26 | 加利福尼亚大学董事会 | 用于检测癌症的非编码rna |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CN108018354A (zh) * | 2017-12-19 | 2018-05-11 | 贵州医科大学 | MicroRNA-34在抑制前列腺癌转移治疗中的新用途 |
| JP7378739B2 (ja) | 2018-08-10 | 2023-11-14 | 東レ株式会社 | 前立腺がんの検出のためのキット、デバイス及び方法 |
| EP3946470A4 (en) * | 2019-04-05 | 2023-05-31 | Earli Inc. | IMPROVED METHODS AND COMPOSITIONS FOR SYNTHETIC BIOMARKERS |
| CN111249552B (zh) * | 2020-03-16 | 2020-11-17 | 南京鼓楼医院 | 基于人iPSCs诱导类肝细胞及多层多孔生物反应器的生物人工肝 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CN112094910B (zh) * | 2020-09-25 | 2023-03-24 | 无锡市中医医院 | 一种用于前列腺癌患病风险评估的miRNA标志物 |
| CN114272378B (zh) * | 2020-09-27 | 2023-06-23 | 四川大学华西医院 | 一种使cttnbp2nl功能缺失的试剂在制备治疗疾病的药物中的用途 |
| KR102844924B1 (ko) * | 2020-11-24 | 2025-08-11 | 한국과학기술연구원 | 그래핀 기반의 바이오센서 및 이를 이용한 검출방법 |
| CN114540496A (zh) * | 2022-02-25 | 2022-05-27 | 东南大学 | miR-7在制备/筛选前列腺癌诊治产品中的应用 |
| WO2024097892A1 (en) * | 2022-11-03 | 2024-05-10 | Mirimus, Inc. | Regulation of artificial mirnas by endogenous tissue-specific mirnas and methods of using the same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006137941A2 (en) * | 2004-11-12 | 2006-12-28 | Ambion, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| WO2007081740A2 (en) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers |
| JP2008500837A (ja) * | 2004-05-28 | 2008-01-17 | アンビオン インコーポレーティッド | マイクロrnaに関与する方法および組成物 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4608337A (en) * | 1980-11-07 | 1986-08-26 | The Wistar Institute | Human hybridomas and the production of human monoclonal antibodies by human hybridomas |
| US5015568A (en) * | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
| US5202429A (en) * | 1986-07-09 | 1993-04-13 | The Wistar Institute | DNA molecules having human BCL-2 gene sequences |
| US5198338A (en) * | 1989-05-31 | 1993-03-30 | Temple University | Molecular probing for human t-cell leukemia and lymphoma |
| US5633135A (en) * | 1991-12-11 | 1997-05-27 | Thomas Jefferson University | Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities |
| WO1993012136A1 (en) * | 1991-12-11 | 1993-06-24 | Thomas Jefferson University | Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region |
| US6040140A (en) * | 1991-12-11 | 2000-03-21 | Thomas Jefferson University | Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities |
| WO1994010343A1 (en) * | 1992-10-29 | 1994-05-11 | Thomas Jefferson University | Methods of detecting micrometastasis of prostate cancer |
| US5674682A (en) * | 1992-10-29 | 1997-10-07 | Thomas Jefferson University | Nucleic acid primers for detecting micrometastasis of prostate cancer |
| US7175995B1 (en) * | 1994-10-27 | 2007-02-13 | Thomas Jefferson University | TCL-1 protein and related methods |
| US5985598A (en) * | 1994-10-27 | 1999-11-16 | Thomas Jefferson University | TCL-1 gene and protein and related methods and compositions |
| US5928884A (en) * | 1996-02-09 | 1999-07-27 | Croce; Carlo M. | FHIT proteins and nucleic acids and methods based thereon |
| US6242212B1 (en) * | 1996-02-09 | 2001-06-05 | Thomas Jefferson University | Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins |
| WO1998035707A1 (en) * | 1997-02-18 | 1998-08-20 | Thomas Jefferson University | Compositions that bind to pancreatic cancer cells and methods of using the same |
| EP0972083A1 (en) * | 1997-04-04 | 2000-01-19 | THE TEXAS A&M UNIVERSITY SYSTEM | Noninvasive detection of colonic biomarkers using fecal messenger rna |
| US6303323B1 (en) * | 1997-10-21 | 2001-10-16 | Cancer Research Campaign Technology Limited | Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies |
| CA2335315A1 (en) * | 1998-07-20 | 2000-01-27 | Thomas Jefferson University | Nitrilase homologs |
| WO2000005419A1 (en) * | 1998-07-24 | 2000-02-03 | Yeda Research And Development Company Ltd. | Prevention of metastasis with 5-aza-2'-deoxycytidine |
| US7141417B1 (en) * | 1999-02-25 | 2006-11-28 | Thomas Jefferson University | Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene |
| EP1276879A4 (en) * | 2000-04-11 | 2004-12-22 | Univ Jefferson | MUIR-TORRE-LIKE SYNDROME IN Fhit-DEFECTIVE MICE |
| US20020086331A1 (en) * | 2000-05-16 | 2002-07-04 | Carlo Croce | Crystal structure of worm NitFhit reveals that a Nit tetramer binds two Fhit dimers |
| US7060811B2 (en) * | 2000-10-13 | 2006-06-13 | Board Of Regents, The University Of Texas System | WWOX: a tumor suppressor gene mutated in multiple cancers |
| US20040033502A1 (en) * | 2001-03-28 | 2004-02-19 | Amanda Williams | Gene expression profiles in esophageal tissue |
| EP2390328A1 (en) * | 2001-09-28 | 2011-11-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| US7371736B2 (en) * | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
| GB0128898D0 (en) * | 2001-12-03 | 2002-01-23 | Biotech Res Ventures Pte Ltd | Materials and methods relating to the stabilization and activation of a tumour suppressor protein |
| WO2003086445A1 (en) * | 2002-04-08 | 2003-10-23 | Ciphergen Biosystems, Inc. | Serum biomarkers in hepatocellular carcinoma |
| EP1499182B1 (en) * | 2002-04-29 | 2009-10-28 | Thomas Jefferson University | Human chronic lymphocytic leukemia modeled in mouse by targeted tcl1 expression |
| EP1530418A4 (en) * | 2002-05-31 | 2005-10-12 | Univ Leland Stanford Junior | METHOD FOR IDENTIFYING AND INSULATING STEM CELLS AND CANCER STAMPS |
| WO2004033659A2 (en) * | 2002-10-11 | 2004-04-22 | Thomas Jefferson University | Novel tumor suppressor gene and compositions and methods for making and using the same |
| US20040152112A1 (en) * | 2002-11-13 | 2004-08-05 | Thomas Jefferson University | Compositions and methods for cancer diagnosis and therapy |
| WO2004071464A2 (en) * | 2003-02-12 | 2004-08-26 | Johns Hopkins University School Of Medicine | Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells |
| US20050069918A1 (en) * | 2003-05-29 | 2005-03-31 | Francois Claret | JAB1 as a prognostic marker and a therapeutic target for human cancer |
| US8106180B2 (en) * | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US20050037362A1 (en) * | 2003-08-11 | 2005-02-17 | Eppendorf Array Technologies, S.A. | Detection and quantification of siRNA on microarrays |
| JP2007506425A (ja) * | 2003-09-24 | 2007-03-22 | オンコセラピー・サイエンス株式会社 | 肝細胞癌を診断する方法 |
| DE602004031881D1 (de) * | 2003-12-19 | 2011-04-28 | Univ California | Verfahren und materialien zur beurteilung von prostatakrebstherapien |
| CA2554818A1 (en) * | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features |
| JP5697297B2 (ja) * | 2004-05-14 | 2015-04-08 | ロゼッタ ジノミクス リミテッド | マイクロnasおよびその使用 |
| US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
| US20060037088A1 (en) * | 2004-08-13 | 2006-02-16 | Shulin Li | Gene expression levels as predictors of chemoradiation response of cancer |
| US7642348B2 (en) * | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
| FR2877350B1 (fr) * | 2004-11-03 | 2010-08-27 | Centre Nat Rech Scient | IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE |
| US7361752B2 (en) * | 2004-12-14 | 2008-04-22 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of MLL-AF4 and uses thereof |
| US20070099196A1 (en) * | 2004-12-29 | 2007-05-03 | Sakari Kauppinen | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs |
| US20090123912A1 (en) * | 2005-01-25 | 2009-05-14 | Rosetta Inpharmatics Llc | Methods for quantitating small RNA molecules |
| US20070065840A1 (en) * | 2005-03-23 | 2007-03-22 | Irena Naguibneva | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS |
| EP1904111A4 (en) * | 2005-06-03 | 2009-08-19 | Univ Johns Hopkins | COMPOSITIONS AND METHODS FOR REDUCING MICRORNA EXPRESSION FOR THE TREATMENT OF NEOPLASIA |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| AU2006279906B2 (en) * | 2005-08-10 | 2012-05-10 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| CN103028120B (zh) * | 2005-09-12 | 2015-08-12 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| US7390792B2 (en) * | 2005-12-15 | 2008-06-24 | Board Of Regents, The University Of Texas System | MicroRNA1 therapies |
| ES2524018T3 (es) * | 2006-01-05 | 2014-12-03 | The Ohio State University Research Foundation | Anomalías de la expresión de microARN en tumores pancreáticos endocrinos y acinares |
| AU2007243475B2 (en) * | 2006-04-24 | 2013-02-07 | The Ohio State University Research Foundation | Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in miR155 transgenic mice |
| WO2007126150A1 (ja) * | 2006-04-27 | 2007-11-08 | National University Corporation Nagoya University | 癌の新規治療用組成物 |
| WO2007140352A2 (en) * | 2006-05-26 | 2007-12-06 | Invitrogen Corporation | Plasma membrane and secreted cancer biomarkers |
| WO2007147067A2 (en) * | 2006-06-14 | 2007-12-21 | Rosetta Inpharmatics Llc | Methods and compositions for regulating cell cycle progression |
| CA2663878A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-200 regulated genes and pathways as targets for therapeutic intervention |
| JP2010510964A (ja) * | 2006-09-19 | 2010-04-08 | アシュラジェン インコーポレイテッド | 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路 |
| AU2007299828C1 (en) * | 2006-09-19 | 2014-07-17 | Interpace Diagnostics, Llc | MicroRNAs differentially expressed in pancreatic diseases and uses thereof |
| US8071292B2 (en) * | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| JP5501766B2 (ja) * | 2006-11-01 | 2014-05-28 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 肝細胞癌における生存および転移を予測するためのマイクロrna発現サイン |
| US8293684B2 (en) * | 2006-11-29 | 2012-10-23 | Exiqon | Locked nucleic acid reagents for labelling nucleic acids |
| WO2008070082A2 (en) * | 2006-12-04 | 2008-06-12 | The Johns Hopkins University | Stem-progenitor cell specific micro-ribonucleic acids and uses thereof |
| AU2007333106A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miR-20 regulated genes and pathways as targets for therapeutic intervention |
| CA2671294A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| CA2671299A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
| CN101622350A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为干预治疗靶标的miR-126调控基因和通路 |
| US20090175827A1 (en) * | 2006-12-29 | 2009-07-09 | Byrom Mike W | miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| EP1944609A1 (en) * | 2007-01-10 | 2008-07-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | In vitro method for diagnosing prostate cancer |
| US8034560B2 (en) * | 2007-01-31 | 2011-10-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) |
| WO2008112283A2 (en) * | 2007-03-12 | 2008-09-18 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Microrna profiling of androgen responsiveness for predicting the appropriate prostate cancer treatment |
| JP5592251B2 (ja) * | 2007-04-30 | 2014-09-17 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵臓癌を正常な膵臓機能および/または慢性膵炎と識別する方法 |
| US20090005336A1 (en) * | 2007-05-08 | 2009-01-01 | Zhiguo Wang | Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions |
| US20090131354A1 (en) * | 2007-05-22 | 2009-05-21 | Bader Andreas G | miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| WO2008154098A2 (en) * | 2007-06-07 | 2008-12-18 | Wisconsin Alumni Research Foundation | Reagents and methods for mirna expression analysis and identification of cancer biomarkers |
| US8053186B2 (en) * | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| WO2009015071A1 (en) * | 2007-07-23 | 2009-01-29 | Dharmacon, Inc. | Screening of micro-rna cluster inhibitor pools |
| AU2008283997B2 (en) * | 2007-08-03 | 2014-04-10 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| US20090061424A1 (en) * | 2007-08-30 | 2009-03-05 | Sigma-Aldrich Company | Universal ligation array for analyzing gene expression or genomic variations |
| US8288356B2 (en) * | 2007-10-04 | 2012-10-16 | Santaris Pharma A/S | MicroRNAs |
| US20090123933A1 (en) * | 2007-11-12 | 2009-05-14 | Wake Forest University Health Sciences | Microrna biomarkers in lupus |
| WO2009070805A2 (en) * | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| WO2009086156A2 (en) * | 2007-12-21 | 2009-07-09 | Asuragen, Inc. | Mir-10 regulated genes and pathways as targets for therapeutic intervention |
| EP2604704B1 (en) * | 2008-02-01 | 2018-10-03 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of brain tumor |
| EP3181705A1 (en) * | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| US20110230361A1 (en) * | 2008-11-14 | 2011-09-22 | Emory University | Prostate cancer biomarkers to predict recurrence and metastatic potential |
-
2009
- 2009-02-27 WO PCT/US2009/035470 patent/WO2009108860A2/en not_active Ceased
- 2009-02-27 EP EP09715064A patent/EP2260109A4/en not_active Withdrawn
- 2009-02-27 EP EP16175539.2A patent/EP3112477A1/en not_active Withdrawn
- 2009-02-27 AU AU2009219197A patent/AU2009219197B2/en not_active Ceased
- 2009-02-27 ES ES14170625.9T patent/ES2600165T3/es active Active
- 2009-02-27 EP EP14170625.9A patent/EP2799557B1/en not_active Not-in-force
- 2009-02-27 JP JP2010548904A patent/JP2011517283A/ja active Pending
- 2009-02-27 CN CN201410133658.XA patent/CN104031984A/zh active Pending
- 2009-02-27 CN CN200980111708.1A patent/CN102027129B/zh not_active Expired - Fee Related
- 2009-02-27 CA CA2716938A patent/CA2716938A1/en not_active Abandoned
- 2009-02-27 US US12/919,888 patent/US20110054009A1/en not_active Abandoned
-
2012
- 2012-09-19 US US13/622,487 patent/US20130085077A1/en not_active Abandoned
-
2014
- 2014-05-20 AU AU2014202735A patent/AU2014202735B2/en not_active Ceased
- 2014-06-26 JP JP2014131080A patent/JP5976726B2/ja not_active Expired - Fee Related
-
2016
- 2016-03-07 US US15/062,404 patent/US20160186184A1/en not_active Abandoned
- 2016-03-07 US US15/062,407 patent/US20160177311A1/en not_active Abandoned
- 2016-03-07 US US15/062,411 patent/US20160177312A1/en not_active Abandoned
- 2016-03-07 US US15/062,414 patent/US20160177316A1/en not_active Abandoned
- 2016-07-14 JP JP2016139495A patent/JP2016216492A/ja active Pending
-
2017
- 2017-04-06 US US15/480,753 patent/US20170211066A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008500837A (ja) * | 2004-05-28 | 2008-01-17 | アンビオン インコーポレーティッド | マイクロrnaに関与する方法および組成物 |
| WO2006137941A2 (en) * | 2004-11-12 | 2006-12-28 | Ambion, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| WO2007081740A2 (en) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers |
Non-Patent Citations (1)
| Title |
|---|
| CANCER RES., (2007), 67, [13], P.6130-6135, JPN6013043198, ISSN: 0002622055 * |
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| JP2014519340A (ja) * | 2011-06-16 | 2014-08-14 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス.アー.エール.エル. | バイオマーカー組成物および方法 |
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| JP2016520803A (ja) * | 2013-03-15 | 2016-07-14 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 診断及び治療のためのエクソソームにおけるmiRNAバイオジェネシス |
| US11926824B2 (en) | 2013-03-15 | 2024-03-12 | Board Of Regents, The University Of Texas System | miRNA biogenesis in exosomes for diagnosis and therapy |
| WO2022209943A1 (ja) * | 2021-03-29 | 2022-10-06 | 東レ株式会社 | 生体試料中のマイクロrnaの検出方法、中性アミノ酸の塩酸塩の組成物および容器 |
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| AU2009219197B2 (en) | 2014-04-10 |
| AU2014202735B2 (en) | 2015-09-10 |
| CN104031984A (zh) | 2014-09-10 |
| EP2260109A2 (en) | 2010-12-15 |
| US20110054009A1 (en) | 2011-03-03 |
| WO2009108860A3 (en) | 2010-01-14 |
| US20160177311A1 (en) | 2016-06-23 |
| WO2009108860A8 (en) | 2011-01-27 |
| US20160177312A1 (en) | 2016-06-23 |
| EP2799557A1 (en) | 2014-11-05 |
| AU2014202735A1 (en) | 2014-06-12 |
| CA2716938A1 (en) | 2009-09-03 |
| ES2600165T3 (es) | 2017-02-07 |
| CN102027129A (zh) | 2011-04-20 |
| US20160186184A1 (en) | 2016-06-30 |
| US20160177316A1 (en) | 2016-06-23 |
| WO2009108860A2 (en) | 2009-09-03 |
| US20130085077A1 (en) | 2013-04-04 |
| CN102027129B (zh) | 2014-03-12 |
| EP2260109A4 (en) | 2011-06-08 |
| JP5976726B2 (ja) | 2016-08-24 |
| EP3112477A1 (en) | 2017-01-04 |
| US20170211066A1 (en) | 2017-07-27 |
| AU2009219197A1 (en) | 2009-09-03 |
| JP2016216492A (ja) | 2016-12-22 |
| EP2799557B1 (en) | 2016-09-07 |
| JP2014221786A (ja) | 2014-11-27 |
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