CN103997893A - 吡咯并苯并二氮杂卓和靶向结合物 - Google Patents
吡咯并苯并二氮杂卓和靶向结合物 Download PDFInfo
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- CN103997893A CN103997893A CN201280062297.3A CN201280062297A CN103997893A CN 103997893 A CN103997893 A CN 103997893A CN 201280062297 A CN201280062297 A CN 201280062297A CN 103997893 A CN103997893 A CN 103997893A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Abstract
Description
化合物 | 786-O | Caki-1 | HL60 | HEL9217 |
4 | 50 | 20 | 8 | 8 |
14 | 200 | 400 | 30 | 50 |
Claims (46)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201161547195P | 2011-10-14 | 2011-10-14 | |
US61/547,195 | 2011-10-14 | ||
PCT/US2012/059870 WO2013055993A1 (en) | 2011-10-14 | 2012-10-12 | Pyrrolobenzodiazepines and targeted conjugates |
Publications (2)
Publication Number | Publication Date |
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CN103997893A true CN103997893A (zh) | 2014-08-20 |
CN103997893B CN103997893B (zh) | 2019-04-12 |
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CN201280062297.3A Active CN103997893B (zh) | 2011-10-14 | 2012-10-12 | 吡咯并苯并二氮杂卓和靶向结合物 |
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US (3) | US9387259B2 (zh) |
EP (2) | EP2753178B1 (zh) |
JP (2) | JP6399930B2 (zh) |
KR (1) | KR101961976B1 (zh) |
CN (1) | CN103997893B (zh) |
AU (1) | AU2012322613B2 (zh) |
BR (2) | BR112014009055B1 (zh) |
CA (1) | CA2850375C (zh) |
EA (2) | EA036202B1 (zh) |
ES (1) | ES2660233T3 (zh) |
HK (1) | HK1253715A1 (zh) |
IL (1) | IL231797A (zh) |
MX (2) | MX358757B (zh) |
WO (1) | WO2013055993A1 (zh) |
ZA (1) | ZA201402404B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111417409A (zh) * | 2017-11-14 | 2020-07-14 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂*缀合物 |
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