CN102311401B - Cetp抑制剂 - Google Patents

Cetp抑制剂 Download PDF

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Publication number
CN102311401B
CN102311401B CN201110245074.8A CN201110245074A CN102311401B CN 102311401 B CN102311401 B CN 102311401B CN 201110245074 A CN201110245074 A CN 201110245074A CN 102311401 B CN102311401 B CN 102311401B
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China
Prior art keywords
trifluoromethyl
methyl
etoac
phenyl
mmol
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Expired - Fee Related
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CN201110245074.8A
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English (en)
Chinese (zh)
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CN102311401A (zh
Inventor
A·阿利
J·M·纳波利塔诺
邓巧临
吕志俭
P·J·辛克莱尔
G·E·泰勒
C·F·汤普森
N·库赖施
C·J·史密斯
J·A·亨特
A·A·道斯特
陈奕亨
李虹
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C07—ORGANIC CHEMISTRY
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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