CN102076358B - 新颖的佐剂组合物 - Google Patents
新颖的佐剂组合物 Download PDFInfo
- Publication number
- CN102076358B CN102076358B CN200980124560.5A CN200980124560A CN102076358B CN 102076358 B CN102076358 B CN 102076358B CN 200980124560 A CN200980124560 A CN 200980124560A CN 102076358 B CN102076358 B CN 102076358B
- Authority
- CN
- China
- Prior art keywords
- vaccine
- virus
- compositions
- adjuvant
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/012—Coccidia antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12351—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24351—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510098559.7A CN104758929B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
| CN201410197979.6A CN104001169B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
| CN201410198333.XA CN104001170B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7623208P | 2008-06-27 | 2008-06-27 | |
| US61/076,232 | 2008-06-27 | ||
| US21455709P | 2009-04-24 | 2009-04-24 | |
| US61/214,557 | 2009-04-24 | ||
| PCT/IB2009/052724 WO2009156960A2 (en) | 2008-06-27 | 2009-06-24 | Novel adjuvant compositions |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510098559.7A Division CN104758929B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
| CN201410197979.6A Division CN104001169B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
| CN201410198333.XA Division CN104001170B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102076358A CN102076358A (zh) | 2011-05-25 |
| CN102076358B true CN102076358B (zh) | 2016-08-17 |
Family
ID=41445049
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980124560.5A Active CN102076358B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
| CN201410198333.XA Active CN104001170B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
| CN201510098559.7A Active CN104758929B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
| CN201410197979.6A Active CN104001169B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410198333.XA Active CN104001170B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
| CN201510098559.7A Active CN104758929B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
| CN201410197979.6A Active CN104001169B (zh) | 2008-06-27 | 2009-06-24 | 新颖的佐剂组合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US8580280B2 (enExample) |
| EP (4) | EP3725328A3 (enExample) |
| JP (5) | JP5659332B2 (enExample) |
| KR (1) | KR101333852B1 (enExample) |
| CN (4) | CN102076358B (enExample) |
| AR (1) | AR072378A1 (enExample) |
| AU (1) | AU2009263759B2 (enExample) |
| BR (2) | BR122021025097B1 (enExample) |
| CA (3) | CA2960734C (enExample) |
| CL (1) | CL2010001360A1 (enExample) |
| CO (1) | CO6331297A2 (enExample) |
| CY (2) | CY1117650T1 (enExample) |
| DK (2) | DK2310046T3 (enExample) |
| ES (2) | ES2728949T3 (enExample) |
| HR (1) | HRP20190876T1 (enExample) |
| HU (2) | HUE043493T2 (enExample) |
| LT (1) | LT3056214T (enExample) |
| ME (1) | ME01199B (enExample) |
| MX (6) | MX344311B (enExample) |
| NZ (5) | NZ602945A (enExample) |
| PH (2) | PH12014501835A1 (enExample) |
| PL (2) | PL3056214T3 (enExample) |
| PT (1) | PT3056214T (enExample) |
| RU (1) | RU2510280C2 (enExample) |
| SI (2) | SI3056214T1 (enExample) |
| TW (4) | TWI622401B (enExample) |
| UY (1) | UY31942A (enExample) |
| WO (1) | WO2009156960A2 (enExample) |
| ZA (1) | ZA201007835B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8444989B1 (en) * | 2008-04-18 | 2013-05-21 | Boehringer Ingelheim Vetmedica Gmbh | One dose vaccination against mycoplasma infections of pigs |
| EP3725328A3 (en) * | 2008-06-27 | 2020-12-23 | Zoetis Services LLC | Novel adjuvant compositions |
| TWI351288B (en) * | 2008-07-04 | 2011-11-01 | Univ Nat Pingtung Sci & Tech | Cpg dna adjuvant in avian vaccines |
| CA2745096C (en) | 2008-12-09 | 2013-11-05 | Coley Pharmaceutical Group, Inc. | Immunostimulatory oligonucleotides |
| US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
| US9878036B2 (en) * | 2009-08-12 | 2018-01-30 | Sigmoid Pharma Limited | Immunomodulatory compositions comprising a polymer matrix and an oil phase |
| FR2957803B1 (fr) * | 2010-03-24 | 2012-06-01 | Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic | Diluants adjuvants de vaccins vivants pour maladies porcines |
| CA2800158C (en) | 2010-05-28 | 2020-07-21 | Coley Pharmaceutical Group, Inc. | Vaccines comprising cholesterol and cpg as sole adjuvant-carrier molecules |
| CA2836805C (en) * | 2011-06-10 | 2023-03-07 | Novartis Ag | Bovine vaccines and methods |
| PT2750683T (pt) | 2011-10-03 | 2018-06-26 | Mx Adjuvac Ab | Nanopartículas, processo de preparação e seu uso como transportadores para moléculas hidrofóbicas anfipáticas no domínio da medicina, incluindo tratamento de cancro e compostos relacionados a alimentos |
| WO2013138334A1 (en) * | 2012-03-12 | 2013-09-19 | Advanced Bioadjuvants, Llc | Adjuvant and vaccine compositions |
| UA121193C2 (uk) | 2012-12-28 | 2020-04-27 | Бьорінгер Інгельхайм Ветмедіка Гмбх | Спосіб одержання імуногенної композиції проти мікоплазми |
| KR102355614B1 (ko) | 2012-12-28 | 2022-01-27 | 베링거잉겔하임베트메디카게엠베하 | 마이코플라스마 항원을 포함하는 면역원성 조성물 |
| CN103127495B (zh) * | 2013-01-28 | 2015-04-08 | 重庆市畜牧科学院 | 二联灭活苗的制剂及其制备方法 |
| US20160199482A1 (en) * | 2013-09-05 | 2016-07-14 | Zoetis Services Llc | Hendra and nipah virus g glycoprotein immunogenic compositions |
| WO2015042369A2 (en) * | 2013-09-19 | 2015-03-26 | Zoetis Llc | Oil-based adjuvants |
| EP3057613A1 (en) | 2013-10-17 | 2016-08-24 | Zoetis Services LLC | Methods and compositions for treatment of s. equi infection |
| CN105899199A (zh) * | 2013-11-26 | 2016-08-24 | 硕腾服务有限责任公司 | 诱导免疫应答的组合物 |
| MX388527B (es) * | 2014-11-26 | 2025-03-20 | Huvepharma Inc | Composiciones adyuvantes y metodos relacionados. |
| US10195261B2 (en) | 2014-11-26 | 2019-02-05 | VaxLiant, LLC | Adjuvant compositions and related methods |
| CN114699518B (zh) * | 2015-01-16 | 2024-07-02 | 硕腾服务有限责任公司 | 口蹄疫疫苗 |
| CA2979556C (en) * | 2015-03-24 | 2023-07-18 | VaxLiant, LLC | Adjuvant compositions and related methods |
| CN104771754B (zh) * | 2015-04-02 | 2018-02-13 | 武汉科前生物股份有限公司 | 一种猪圆环病毒2型灭活疫苗水性佐剂及应用 |
| CN106267183B (zh) * | 2015-06-09 | 2023-02-28 | 普莱柯生物工程股份有限公司 | 含有佐剂的活疫苗组合物及其制备方法和应用 |
| CN106344920B (zh) * | 2015-07-16 | 2020-11-27 | 普莱柯生物工程股份有限公司 | 一种疫苗用佐剂及其应用 |
| US10456459B2 (en) | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
| AR105393A1 (es) * | 2015-07-20 | 2017-09-27 | Zoetis Services Llc | Composiciones adyuvantes liposómicas |
| SG10201913547YA (en) * | 2015-10-19 | 2020-02-27 | Cadila Healthcare Ltd | New adjuvant and vaccine composition containing the same |
| EP3402878A1 (en) | 2016-01-11 | 2018-11-21 | Zoetis Services LLC | Novel cross protective vaccine compositions for porcine epidemic diarrhea virus |
| US11013798B2 (en) | 2016-03-21 | 2021-05-25 | South Dakota Board Of Regents | Orf virus-based platform for vaccine delivery |
| EP3463446A1 (en) | 2016-06-02 | 2019-04-10 | Zoetis Services LLC | Vaccine against infectious bronchitis |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| GB201703529D0 (en) | 2017-03-06 | 2017-04-19 | Cambridge Entpr Ltd | Vaccine composition |
| US10092604B1 (en) * | 2017-12-21 | 2018-10-09 | Bioceuticals Pte. Ltd. | Methods for treatment of skin infectious diseases using microorganisms |
| BR112020017715A2 (pt) | 2018-03-16 | 2020-12-29 | Zoetis Services Llc | Vacinas de peptídeo contra interleucina-31 |
| CN108853493A (zh) * | 2018-07-26 | 2018-11-23 | 中国人民解放军陆军军医大学 | 麦冬皂苷d及其纳米乳在制备疫苗佐剂中的应用 |
| US11046734B2 (en) | 2018-07-27 | 2021-06-29 | Research Development Foundation | Chimeric immunogenic polypeptides |
| EP3849521A1 (en) | 2018-09-14 | 2021-07-21 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
| CN109675028A (zh) * | 2019-03-01 | 2019-04-26 | 龙阔(苏州)生物工程有限公司 | 疫苗佐剂及其制备方法和应用及猪繁殖与呼吸综合征疫苗 |
| US20220356231A1 (en) * | 2019-07-12 | 2022-11-10 | Research Development Foundation | Ehrlichia vaccines and immunogenic compositions |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| AU2021292703A1 (en) * | 2020-06-19 | 2023-02-09 | Kimberly-Clark Worldwide, Inc. | Saponin containing extracts prepared from hesperaloe useful in the treatment of non-human animals |
| CA3182454A1 (en) * | 2020-06-19 | 2021-12-23 | Thomas G. Shannon | Animal feed composition for reducing ammonia production |
| TWI884296B (zh) * | 2020-08-11 | 2025-05-21 | 美商碩騰服務公司 | 抗冠狀病毒疫苗 |
| CN114848807A (zh) * | 2021-02-04 | 2022-08-05 | 洛阳赛威生物科技有限公司 | 一种蜂胶佐剂组合物、及其制备方法以及应用 |
| WO2023056117A1 (en) * | 2021-10-02 | 2023-04-06 | Massachusetts Institute Of Technology | Synergistic combination of alum and non-liposome, non-micelle particle vaccine adjuvants |
| CN120712079A (zh) * | 2023-02-16 | 2025-09-26 | 瓦希纳诺公司 | 包含用于在没有任何佐剂的情况下经由阳离子多糖纳米颗粒递送灭活的完整细菌的系统的疫苗组合物 |
| US12226468B2 (en) | 2023-06-26 | 2025-02-18 | Research Development Foundation | Immunoreactive peptides |
| CN116747312B (zh) * | 2023-07-21 | 2025-08-08 | 辽宁成大生物股份有限公司 | 一种疫苗冻干保护剂、制剂及制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003003941A3 (en) * | 2001-07-02 | 2004-07-29 | Pfizer Prod Inc | One dose vaccination with mycoplasma hyopneumoniae |
| CN1835767A (zh) * | 2003-01-29 | 2006-09-20 | 辉瑞产品公司 | 对抗支气管败血性博德特氏杆菌的犬疫苗 |
Family Cites Families (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4264587A (en) * | 1979-08-01 | 1981-04-28 | Pedersen Niels C | Vaccine for preventing persistent feline leukemia viremia in cats |
| NZ221306A (en) * | 1986-08-15 | 1990-02-26 | Commw Scient Ind Res Org | 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof |
| US5084269A (en) | 1986-11-06 | 1992-01-28 | Kullenberg Fred W | Adjuvant for dose treatment with antigens |
| ATE60999T1 (de) | 1986-12-19 | 1991-03-15 | Duphar Int Res | Dimethyldioctadecylammoniumbromid enthaltende stabilisierte adjuvanssuspension. |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| RU1615918C (ru) | 1989-05-22 | 1995-07-09 | Всероссийский научно-исследовательский институт защиты животных | Адъювант |
| EP0621893A4 (en) * | 1992-01-06 | 1995-07-12 | Smithkline Beecham Corp | Vaccines against the cat's leukemia virus. |
| ZA936095B (en) | 1992-08-21 | 1994-03-14 | Univ Melbourne | Cytokine applications. |
| US6764682B1 (en) | 1994-06-16 | 2004-07-20 | Aventis Pasteur Limited | Adjuvant compositions containing more than one adjuvant |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6846489B1 (en) * | 1995-04-25 | 2005-01-25 | Smithkline Beecham Biologicals S.A. | Vaccines containing a saponin and a sterol |
| ES2241042T3 (es) | 1996-10-11 | 2005-10-16 | The Regents Of The University Of California | Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora. |
| EP0855184A1 (en) | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
| EP1039935A4 (en) | 1997-02-28 | 2005-04-27 | Univ Iowa Res Found | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| WO1998040100A1 (en) | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| BR9809426A (pt) | 1997-04-30 | 2000-06-13 | Merieux Oravax | Composição de vacina anti-helicobacter para uso pela via sistêmica subdiafragmática e método de imunização mucosal/parenteral combinado |
| DE69841002D1 (de) | 1997-05-14 | 2009-09-03 | Univ British Columbia | Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln |
| ATE432348T1 (de) | 1997-06-06 | 2009-06-15 | Univ California | Inhibitoren von immunstimulatorischen dna sequenz aktivität |
| KR20010024245A (ko) * | 1997-10-20 | 2001-03-26 | 조지 제이. 리코스 | 네오스포라 백신 |
| EP0953641A3 (en) * | 1998-03-26 | 2002-03-13 | Pfizer Products Inc. | Polynucleotide molecules encoding neospora proteins |
| NZ508650A (en) | 1998-05-14 | 2003-05-30 | Coley Pharm Gmbh | Regulating hematopoiesis using unmethylated C and G CpG-oligonucleotides with a phosphorothioate modification |
| ES2272069T3 (es) | 1998-05-22 | 2007-04-16 | Ottawa Health Research Institute | Metodos y productos para inducir inmunidad en mucosas. |
| US20040247662A1 (en) | 1998-06-25 | 2004-12-09 | Dow Steven W. | Systemic immune activation method using nucleic acid-lipid complexes |
| DE69929444T2 (de) | 1998-08-10 | 2006-09-28 | Antigenics Inc., Woburn | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
| AU769539B2 (en) | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
| EP1574210B1 (en) | 1999-02-26 | 2016-04-06 | Novartis Vaccines and Diagnostics, Inc. | Microemulsions with adsorbed macromolecules |
| ATE529130T1 (de) | 1999-04-08 | 2011-11-15 | Intercell Usa Inc | Trockenformulierung für transkutane immunisierung |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| DK1187629T3 (da) | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
| DE60013591T2 (de) | 1999-04-29 | 2005-02-03 | Coley Pharmaceutical Gmbh | Screening nach modulatoren der funktion von immunstimulatorischer dna |
| DE60131430T2 (de) | 2000-01-14 | 2008-10-16 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Oligodeoxynukleotide und ihre verwendung zur induktion einer immunreaktion |
| CA2396871A1 (en) | 2000-01-20 | 2001-12-20 | Ottawa Health Research Institute | Immunostimulatory nucleic acids for inducing a th2 immune response |
| AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| ES2248283T3 (es) | 2000-02-21 | 2006-03-16 | Pharmexa A/S | Nuevo procedimiento para reducir los niveles de amiloide. |
| AU2001257366B2 (en) | 2000-05-01 | 2006-03-16 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| GB0025577D0 (en) | 2000-10-18 | 2000-12-06 | Smithkline Beecham Biolog | Vaccine |
| ES2307568T3 (es) | 2000-12-08 | 2008-12-01 | Coley Pharmaceutical Gmbh | Acidos nucleicos de tipo cpg y metodos de uso de los mismos. |
| US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
| US7713942B2 (en) | 2001-04-04 | 2010-05-11 | Nordic Vaccine Technology A/S | Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides |
| EP1372528B1 (en) | 2001-04-05 | 2013-01-02 | Novartis Vaccines and Diagnostics, Inc. | Mucosal boosting following parenteral priming |
| US7105495B2 (en) | 2001-04-30 | 2006-09-12 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| CN1526016A (zh) | 2001-05-21 | 2004-09-01 | �����ɷ� | 稳定核酸的方法 |
| WO2002102307A2 (en) * | 2001-06-15 | 2002-12-27 | Ribapharm | Nucleoside vaccine adjuvants |
| JP2004537543A (ja) * | 2001-07-02 | 2004-12-16 | ファイザー・プロダクツ・インク | マイコプラズマ・ハイオニューモニエ・ワクチンおよび牛におけるマイコプラズマ・ボビス低減方法 |
| US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
| WO2003025119A2 (en) | 2001-08-03 | 2003-03-27 | Medarex, Inc. | Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies |
| AU2002326561B2 (en) | 2001-08-07 | 2008-04-03 | Dynavax Technologies Corporation | Immunomodulatory compositions, formulations, and methods for use thereof |
| US20030138434A1 (en) | 2001-08-13 | 2003-07-24 | Campbell Robert L. | Agents for enhancing the immune response |
| IL160157A0 (en) | 2001-08-17 | 2004-07-25 | Coley Pharm Group Inc | Combination motif immune stimulation oligonucleotides with improved activity |
| JP2005500845A (ja) | 2001-08-28 | 2005-01-13 | ファイザー・プロダクツ・インク | マイコプラズマ・ボビスチャレンジモデル並びにマイコプラズマ・ボビスの投与方法及び肺炎性肺病変の誘発方法 |
| ES2335979T3 (es) | 2001-09-14 | 2010-04-07 | Cytos Biotechnology Ag | Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso. |
| US20030119774A1 (en) | 2001-09-25 | 2003-06-26 | Marianna Foldvari | Compositions and methods for stimulating an immune response |
| GB0123580D0 (en) * | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
| CA2471968C (en) | 2001-10-06 | 2013-07-23 | Merial Limited | Immunostimulatory nucleic acids and use thereof |
| US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| JP2005516897A (ja) | 2001-11-07 | 2005-06-09 | イネックス ファーマシューティカルズ コーポレイション | 改善された粘膜のワクチン及びその使用方法 |
| EP1450821A1 (en) | 2001-12-07 | 2004-09-01 | Intercell AG | Immunostimulatory oligodeoxynucleotides |
| CA2474709A1 (en) | 2002-02-04 | 2003-08-14 | Biomira, Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| AU2003219810A1 (en) | 2002-02-19 | 2003-09-09 | Syntherica Corporation | Compositions and methods for surrogate antibody modulation of an immune response and transport |
| EP1499187B1 (en) | 2002-04-04 | 2015-06-17 | Zoetis Belgium S.A. | Immunostimulatory g,u-containing oligoribonucleotides |
| AU2003262379A1 (en) | 2002-04-16 | 2003-11-03 | Auburn University | TRANSIENT AND/OR PERMANENT MODIFICATION OF SEXUAL BEHAVIOR AND/OR FERTILITY USING RECOMBINANT CHIMERIC GnRH |
| CA2483012C (en) | 2002-04-22 | 2011-05-24 | Bioniche Life Sciences Inc. | Oligonucleotide compositions and their use for the modulation of immune responses |
| KR100456681B1 (ko) | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
| CA2487452A1 (en) | 2002-05-28 | 2003-12-04 | Robinson Ramirez-Pineda | A method for generating antigen-presenting cells |
| CA2388049A1 (en) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
| SE0201701D0 (sv) | 2002-06-05 | 2002-06-05 | Gotovax Ab | Treatment of epithelial tumors and infections |
| WO2003103586A2 (en) | 2002-06-05 | 2003-12-18 | Coley Pharmaceutical Group, Inc. | Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids |
| AU2003263963A1 (en) | 2002-08-01 | 2004-02-23 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Method of treating inflammatory arthropathies with suppressors of cpg oligonucleotides |
| EP1565406A4 (en) | 2002-11-05 | 2008-07-23 | James Hardie Int Finance Bv | PROCESS AND APPARATUS FOR PRODUCING CALCIUM SILICATE HYDRATE |
| AU2003900767A0 (en) * | 2003-02-21 | 2003-03-13 | St Vincent's Hospital Sydney Limited | Idiotypic vaccine |
| CA2517839A1 (en) | 2003-03-26 | 2004-10-07 | Martin F. Bachmann | Melan-a peptide analogue-virus-like-particle conjugates |
| CA2521051C (en) | 2003-04-04 | 2012-03-20 | Pfizer Products Inc. | Microfluidized oil-in-water emulsions and vaccine compositions |
| SE0301998D0 (sv) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| GB0323965D0 (en) * | 2003-10-13 | 2003-11-19 | Glaxosmithkline Biolog Sa | Immunogenic compositions |
| DE202005022108U1 (de) | 2004-03-09 | 2013-11-12 | Novartis Vaccines And Diagnostics, Inc. | Influenza-Virus-Impfstoffe |
| KR20110132416A (ko) * | 2004-04-05 | 2011-12-07 | 화이자 프로덕츠 인코포레이티드 | 미세유체화된 수중유 유화액 및 백신 조성물 |
| EP1799252A4 (en) * | 2004-10-06 | 2009-01-21 | Agri Biotech Pty Ltd | ANTIBODY PRODUCTION PROCESS |
| GB0426481D0 (en) * | 2004-12-02 | 2005-01-05 | Vaccine Technology Ltd | Composition |
| WO2006106424A2 (en) * | 2005-04-07 | 2006-10-12 | Pharmacia & Upjohn Company Llc | Formulations and process for production of bordetella bronchiseptica p68 antigen and vaccines |
| WO2006116458A2 (en) * | 2005-04-26 | 2006-11-02 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhances immunostimulatory activity |
| JP4667507B2 (ja) * | 2005-10-07 | 2011-04-13 | ファイザー・プロダクツ・インク | イヌインフルエンザを治療するワクチンおよび方法 |
| EP1954252B1 (en) * | 2005-12-02 | 2016-02-03 | GlaxoSmithKline Biologicals SA | Nanoparticles for use in immunogenic compositions |
| CN101379397A (zh) * | 2006-01-26 | 2009-03-04 | Hx诊断公司 | H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合活性片段及其用途 |
| PL1991266T3 (pl) * | 2006-01-26 | 2013-11-29 | Zoetis Services Llc | Nowe kompozycje adiuwantów glikolipidowych |
| NZ578380A (en) | 2006-12-15 | 2012-04-27 | Schering Plough Ltd | Method for replicating influenza virus in culture |
| WO2008074487A2 (en) * | 2006-12-19 | 2008-06-26 | Novosom Ag | Lipids and lipid assemblies comprising transfection enhancer elements |
| US20080292663A1 (en) | 2007-05-22 | 2008-11-27 | Gerber Jay D | Adjuvant compositions and methods for delivering vaccines |
| CL2008001806A1 (es) | 2007-06-20 | 2008-09-05 | Wyeth Corp | Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion. |
| EP3725328A3 (en) * | 2008-06-27 | 2020-12-23 | Zoetis Services LLC | Novel adjuvant compositions |
| AU2010218752B2 (en) | 2009-02-27 | 2015-05-28 | Toray Industries, Inc. | Immunogenic composition |
| US10456459B2 (en) * | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
-
2009
- 2009-06-24 EP EP20169980.8A patent/EP3725328A3/en active Pending
- 2009-06-24 MX MX2013014772A patent/MX344311B/es unknown
- 2009-06-24 BR BR122021025097-9A patent/BR122021025097B1/pt active IP Right Grant
- 2009-06-24 MX MX2016016408A patent/MX368220B/es unknown
- 2009-06-24 NZ NZ602945A patent/NZ602945A/en unknown
- 2009-06-24 MX MX2010014026A patent/MX2010014026A/es active IP Right Grant
- 2009-06-24 EP EP19166434.1A patent/EP3552625A1/en not_active Withdrawn
- 2009-06-24 RU RU2010149495/15A patent/RU2510280C2/ru active
- 2009-06-24 DK DK09769768.4T patent/DK2310046T3/da active
- 2009-06-24 CN CN200980124560.5A patent/CN102076358B/zh active Active
- 2009-06-24 HU HUE15197967A patent/HUE043493T2/hu unknown
- 2009-06-24 ES ES15197967T patent/ES2728949T3/es active Active
- 2009-06-24 CN CN201410198333.XA patent/CN104001170B/zh active Active
- 2009-06-24 NZ NZ727616A patent/NZ727616A/en unknown
- 2009-06-24 JP JP2011515706A patent/JP5659332B2/ja active Active
- 2009-06-24 SI SI200931968T patent/SI3056214T1/sl unknown
- 2009-06-24 EP EP15197967.1A patent/EP3056214B1/en active Active
- 2009-06-24 ME MEP-2010-194A patent/ME01199B/me unknown
- 2009-06-24 NZ NZ709547A patent/NZ709547A/en unknown
- 2009-06-24 AU AU2009263759A patent/AU2009263759B2/en active Active
- 2009-06-24 EP EP09769768.4A patent/EP2310046B1/en active Active
- 2009-06-24 CA CA2960734A patent/CA2960734C/en active Active
- 2009-06-24 DK DK15197967.1T patent/DK3056214T3/da active
- 2009-06-24 NZ NZ621834A patent/NZ621834A/en unknown
- 2009-06-24 US US12/490,767 patent/US8580280B2/en active Active
- 2009-06-24 WO PCT/IB2009/052724 patent/WO2009156960A2/en not_active Ceased
- 2009-06-24 ES ES09769768.4T patent/ES2569907T3/es active Active
- 2009-06-24 BR BRPI0913954-0A patent/BRPI0913954B1/pt active IP Right Grant
- 2009-06-24 CA CA2960846A patent/CA2960846C/en active Active
- 2009-06-24 PL PL15197967T patent/PL3056214T3/pl unknown
- 2009-06-24 PT PT15197967T patent/PT3056214T/pt unknown
- 2009-06-24 MX MX2016016410A patent/MX375202B/es unknown
- 2009-06-24 CN CN201510098559.7A patent/CN104758929B/zh active Active
- 2009-06-24 LT LTEP15197967.1T patent/LT3056214T/lt unknown
- 2009-06-24 CN CN201410197979.6A patent/CN104001169B/zh active Active
- 2009-06-24 NZ NZ589079A patent/NZ589079A/xx unknown
- 2009-06-24 SI SI200931399A patent/SI2310046T1/sl unknown
- 2009-06-24 PL PL09769768.4T patent/PL2310046T3/pl unknown
- 2009-06-24 MX MX2013014771A patent/MX349720B/es unknown
- 2009-06-24 KR KR1020107029087A patent/KR101333852B1/ko active Active
- 2009-06-24 CA CA2723786A patent/CA2723786C/en active Active
- 2009-06-24 HU HUE09769768A patent/HUE028921T2/en unknown
- 2009-06-26 UY UY0001031942A patent/UY31942A/es not_active Application Discontinuation
- 2009-06-26 TW TW104123872A patent/TWI622401B/zh active
- 2009-06-26 TW TW098121642A patent/TWI513464B/zh active
- 2009-06-26 TW TW104123873A patent/TWI614027B/zh active
- 2009-06-26 AR ARP090102382A patent/AR072378A1/es not_active Application Discontinuation
- 2009-06-26 TW TW104123871A patent/TWI622400B/zh active
-
2010
- 2010-11-02 ZA ZA2010/07835A patent/ZA201007835B/en unknown
- 2010-12-06 CL CL2010001360A patent/CL2010001360A1/es unknown
- 2010-12-16 MX MX2019011253A patent/MX2019011253A/es unknown
- 2010-12-22 CO CO10160889A patent/CO6331297A2/es not_active Application Discontinuation
-
2013
- 2013-08-29 US US14/013,299 patent/US9662385B2/en active Active
-
2014
- 2014-01-24 JP JP2014011047A patent/JP5824538B2/ja active Active
- 2014-01-24 JP JP2014011040A patent/JP5882370B2/ja active Active
- 2014-08-14 PH PH12014501835A patent/PH12014501835A1/en unknown
- 2014-08-14 PH PH12014501836A patent/PH12014501836A1/en unknown
-
2015
- 2015-03-17 JP JP2015053170A patent/JP6038211B2/ja active Active
-
2016
- 2016-05-30 CY CY20161100466T patent/CY1117650T1/el unknown
- 2016-10-26 JP JP2016209399A patent/JP6294938B2/ja active Active
-
2017
- 2017-04-26 US US15/494,920 patent/US10238736B2/en active Active
-
2018
- 2018-03-23 US US15/933,805 patent/US10940202B2/en active Active
-
2019
- 2019-05-13 HR HRP20190876TT patent/HRP20190876T1/hr unknown
- 2019-06-04 CY CY20191100589T patent/CY1121789T1/el unknown
-
2021
- 2021-03-08 US US17/195,003 patent/US11896666B2/en active Active
-
2024
- 2024-01-08 US US18/406,869 patent/US20240358825A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003003941A3 (en) * | 2001-07-02 | 2004-07-29 | Pfizer Prod Inc | One dose vaccination with mycoplasma hyopneumoniae |
| CN1835767A (zh) * | 2003-01-29 | 2006-09-20 | 辉瑞产品公司 | 对抗支气管败血性博德特氏杆菌的犬疫苗 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11896666B2 (en) | Adjuvant compositions | |
| AU2017201506B2 (en) | Novel adjuvanat compositions | |
| HK1211870B (en) | Novel adjuvant compositions | |
| HK1157240A (en) | Novel adjuvant compositions | |
| HK1157240B (en) | Novel adjuvant compositions | |
| HK1201445B (en) | Novel adjuvant compositions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1157240 Country of ref document: HK |
|
| ASS | Succession or assignment of patent right |
Owner name: AH USA 42 LLC Free format text: FORMER OWNER: PFIZER LTD. Effective date: 20130827 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Address after: American New York Applicant after: Pfizer Inc. Address before: American New York Applicant before: Ah USA 42 LLC |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: AH USA 42 LLC TO: SHUOTENG CO., LTD. |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20130827 Address after: American New York Applicant after: Ah USA 42 LLC Address before: American New York Applicant before: PFIZER Ltd. |
|
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Gram Thomas Ding Baji Inventor after: Zhang Shucheng Inventor after: Sangeeta Mitirita Inventor after: Taide Alan's Childers Inventor after: This base of Borrow Joseph domino Inventor after: Richard Li Kelaibosi Inventor after: La Masa meter Man Namannan Inventor after: Mary Catherine Mancur Olson Inventor after: James Richard Tang Pusen Inventor after: Li Sinida rice card Wella Tener Inventor after: Robert John little Yan west Inventor before: Gram Thomas Ding Baji Inventor before: Zhang Shucheng Inventor before: Taide Alan's Childers Inventor before: This base of Borrow Joseph domino Inventor before: Richard Li Kelaibosi Inventor before: La Masa meter Man Namannan Inventor before: Mary Catherine Mancur Olson Inventor before: James Richard Tang Pusen Inventor before: Li Sinida rice card Wella Tener Inventor before: Robert John little Yan west |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: MARTIN BAGI CEDO ALAN CHILDERS TEDD JOSEPH DOMINOWSKI PAUL LEE KREBS RICHARD MANNAR MANNAN RAMASAMYC KATHRYN OLSEN MARY RICHARD THOMPSON JAMES DHAMMIKA WEERATNA RISINI JOHN YANCEY ROBERT JR ZHANG SHUCHENG TO: MARTIN BAGI CEDO ALAN CHILDERS TEDD JOSEPH DOMINOWSKI PAUL LEE KREBS RICHARD MANNAR MANNAN RAMASAMYC KATHRYN OLSEN MARY RICHARD THOMPSON JAMES DHAMMIKA WEERATNA RISINI JOHN YANCEY ROBERT JR ZHANG SHUCHENG SANGITA MITERITA |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1157240 Country of ref document: HK |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20190125 Address after: New jersey, USA Patentee after: Zoetis Services LLC Address before: American New York Patentee before: Pfizer Inc. |
|
| TR01 | Transfer of patent right |