RU2010149495A - Новые адъювантные композиции - Google Patents
Новые адъювантные композиции Download PDFInfo
- Publication number
- RU2010149495A RU2010149495A RU2010149495/15A RU2010149495A RU2010149495A RU 2010149495 A RU2010149495 A RU 2010149495A RU 2010149495/15 A RU2010149495/15 A RU 2010149495/15A RU 2010149495 A RU2010149495 A RU 2010149495A RU 2010149495 A RU2010149495 A RU 2010149495A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- composition according
- animal
- item
- add
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 60
- 239000002671 adjuvant Substances 0.000 title claims abstract 10
- 229960005486 vaccine Drugs 0.000 claims abstract 16
- 229930182558 Sterol Natural products 0.000 claims abstract 11
- 229920000642 polymer Polymers 0.000 claims abstract 11
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims abstract 11
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract 11
- 229930182490 saponin Natural products 0.000 claims abstract 11
- 150000007949 saponins Chemical class 0.000 claims abstract 11
- 150000003432 sterols Chemical class 0.000 claims abstract 11
- 235000003702 sterols Nutrition 0.000 claims abstract 11
- 230000000890 antigenic effect Effects 0.000 claims abstract 9
- 238000000034 method Methods 0.000 claims abstract 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract 8
- PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 claims abstract 7
- 229920002125 Sokalan® Polymers 0.000 claims abstract 4
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims abstract 4
- 235000012000 cholesterol Nutrition 0.000 claims abstract 4
- 230000002163 immunogen Effects 0.000 claims abstract 4
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical group O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims abstract 3
- 229930186217 Glycolipid Natural products 0.000 claims abstract 3
- 239000004584 polyacrylic acid Substances 0.000 claims abstract 3
- 238000002360 preparation method Methods 0.000 claims abstract 2
- 241001465754 Metazoa Species 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 8
- 241000283690 Bos taurus Species 0.000 claims 7
- 241000700605 Viruses Species 0.000 claims 6
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 claims 5
- PPBOKXIGFIBOGK-BDTUAEFFSA-N bvdv Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)C1=CN=CN1 PPBOKXIGFIBOGK-BDTUAEFFSA-N 0.000 claims 5
- 241000282465 Canis Species 0.000 claims 4
- 241000282324 Felis Species 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 241000711573 Coronaviridae Species 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 241000702670 Rotavirus Species 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 208000003495 Coccidiosis Diseases 0.000 claims 1
- 101710125507 Integrase/recombinase Proteins 0.000 claims 1
- 206010023076 Isosporiasis Diseases 0.000 claims 1
- 241000204031 Mycoplasma Species 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 229920002521 macromolecule Polymers 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/012—Coccidia antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12351—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24351—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
1. Иммуногенная композиция, содержащая адъювантную композицию и иммунологически эффективное количество антигенного компонента, где адъювантная композиция содержит сапонин, стерол, четвертичное аммониевое соединение, полимер и возможно стимулятор Th2. ! 2. Способ приготовления иммуногенной композиции по п.1, при котором: ! а) готовят композицию антигенного компонента в буфере; ! б) добавляют сапонин к композиции со стадии (а); ! в) добавляют стерол к композиции со стадии (б); ! г) добавляют четвертичное аммониевое соединение к композиции со стадии (в); ! д) добавляют полимер к композиции со стадии (г); и ! е) возможно добавляют стимулятор Th2 к композиции со стадии (д). ! 3. Вакцинная композиция, содержащая адъювантную композицию и терапевтически эффективное количество антигенного компонента, где адъювантная композиция содержит сапонин, стерол, четвертичное аммониевое соединение, полимер и возможно стимулятор Th2. ! 4. Композиция по п.1 или 3, где сапонин представляет собой Quil A или его очищенную фракцию, стерол представляет собой холестерин, четвертичное аммониевое соединение представляет собой диметилдиоктадециламмоний бромид (DDA), полимер представляет собой полиакриловую кислоту, и стимулятор Th2 представляет собой гликолипид. ! 5. Композиция по любому из пп.1 или 3, дополнительно содержащая масло. ! 6. Способ приготовления вакцинной композиции по п.3, при котором: ! а) готовят композицию антигенного компонента в буфере; ! б) добавляют сапонин к композиции со стадии (а); ! в) добавляют стерол к композиции со стадии (б); ! г) добавляют четвертичное аммониевое соединение к композиции со стадии (в); ! д) добавляют полимер к композиции
Claims (23)
1. Иммуногенная композиция, содержащая адъювантную композицию и иммунологически эффективное количество антигенного компонента, где адъювантная композиция содержит сапонин, стерол, четвертичное аммониевое соединение, полимер и возможно стимулятор Th2.
2. Способ приготовления иммуногенной композиции по п.1, при котором:
а) готовят композицию антигенного компонента в буфере;
б) добавляют сапонин к композиции со стадии (а);
в) добавляют стерол к композиции со стадии (б);
г) добавляют четвертичное аммониевое соединение к композиции со стадии (в);
д) добавляют полимер к композиции со стадии (г); и
е) возможно добавляют стимулятор Th2 к композиции со стадии (д).
3. Вакцинная композиция, содержащая адъювантную композицию и терапевтически эффективное количество антигенного компонента, где адъювантная композиция содержит сапонин, стерол, четвертичное аммониевое соединение, полимер и возможно стимулятор Th2.
4. Композиция по п.1 или 3, где сапонин представляет собой Quil A или его очищенную фракцию, стерол представляет собой холестерин, четвертичное аммониевое соединение представляет собой диметилдиоктадециламмоний бромид (DDA), полимер представляет собой полиакриловую кислоту, и стимулятор Th2 представляет собой гликолипид.
5. Композиция по любому из пп.1 или 3, дополнительно содержащая масло.
6. Способ приготовления вакцинной композиции по п.3, при котором:
а) готовят композицию антигенного компонента в буфере;
б) добавляют сапонин к композиции со стадии (а);
в) добавляют стерол к композиции со стадии (б);
г) добавляют четвертичное аммониевое соединение к композиции со стадии (в);
д) добавляют полимер к композиции со стадии (г); и
е) возможно добавляют стимулятор Th2 к композиции со стадии (д).
7. Способ по любому из п.2 или 6, где сапонин представляет собой Quil А или его очищенную фракцию, стерол представляет собой холестерин, четвертичное аммониевое соединение представляет собой диметилдиоктадециламмоний бромид (DDA), полимер представляет собой полиакриловую кислоту, и стимулятор Th2 представляет собой гликолипид.
8. Способ по п.2 или 6, при котором дополнительно осуществляют стадию добавления композиции со стадии (д) к масляной фазе.
9. Способ по п.2 или 6, при котором дополнительно осуществляют стадию добавления композиции со стадии (е) к масляной фазе.
10. Способ по п.2 или 6, при котором дополнительно осуществляют стадию, включающую микрофлюидизацию композиции со стадии (г).
11. Композиция по п.1 или п.3, где стимулятор Th2 представляет собой N-(2-дезокси-2-L-лейциламино-β-D-глюкопиранозил)-N-октадецилдодеканамида ацетат.
12. Композиция по любому из пп.1 или 3, где антигенный компонент включает:
(а) вирус лейкемии кошек;
(б) бактерин штамма J-5 Escherichia coli;
(в) вирус диареи крупного рогатого скота (BVDV);
(г) BVDV тип 1 (BVDV-1) и BVDV тип 2 (BVDV-2);
(д) Mycoplasma hyopneumonia (М.hyopneumonia);
(е) вирус кошачьего гриппа (FIV);
(ж) антиген рака;
(з) коронавирус собак (CCV);
(и) ротавирус крупного рогатого скота; или
(к) вирус собачьего гриппа (CIV).
13. Вакцинная композиция по п.12 (а) для лечения животного семейства кошачьих от инфекции, вызванной вирусом лейкемии кошек.
14. Вакцинная композиция по п.12 (б) для лечения животного, являющегося представителем крупного рогатого скота, от инфекции, вызванной Escherichia coli.
15. Вакцинная композиция по п.12 (в) или 12 (г) для лечения животного, являющегося представителем крупного рогатого скота, от инфекции, вызванной вирусом диареи крупного рогатого скота (BVDV).
16. Вакцинная композиция по п.12 (д) для лечения животного семейства свиней от инфекции, вызванной М.hyopneumonia.
17. Вакцинная композиция по п.12 (е) для лечения животного семейства кошачьих от инфекции, вызванной вирусом кошачьего гриппа (FIV).
18. Вакцинная композиция по п.12 (ж) для лечения субъекта от рака.
19. Вакцинная композиция по п.12 (з) для лечения животного семейства собачьих от инфекции, вызванной коронавирусом собак (CCV).
20. Вакцинная композиция по п.12 (и) для лечения животного, являющегося представителем крупного рогатого скота, от инфекции, вызванной ротавирусом крупного рогатого скота.
21. Вакцинная композиция по п.12 (к) для лечения животного семейства собачьих от инфекции, вызванной вирусом собачьего гриппа (CIV).
22. Вакцина против кокцидиоза птиц для введения in ovo, содержащая:
(а) адъювант, содержащий Quil А или его очищенную фракцию, включая QS21, холестерин, CARBOPOL, DDA и R1005; и
(б) антиген простейшего, выбранный из (1) одного или более чем одного рекомбинантно экспрессированного белка, (2) одного или более чем одного белка или другой макромолекулы, выделенной из указанного простейшего обычным способом, и (3) экстрактов целых клеток или препаратов указанного простейшего.
23. Способ дифференцировки животного, инфицированного BVDV в природе, от животного, вакцинированного вакцинной композицией по п.12 (в) или 12 (г), при котором получают образец у тестируемого животного и измеряют уровни белка Е2 и белков NS2/3 в указанном образце, где отсутствие белков NS2/3 указывает на то, что животное было вакцинировано указанной вакцинной композицией.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7623208P | 2008-06-27 | 2008-06-27 | |
US61/076,232 | 2008-06-27 | ||
US21455709P | 2009-04-24 | 2009-04-24 | |
US61/214,557 | 2009-04-24 | ||
PCT/IB2009/052724 WO2009156960A2 (en) | 2008-06-27 | 2009-06-24 | Novel adjuvant compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2010149495A true RU2010149495A (ru) | 2012-08-10 |
RU2510280C2 RU2510280C2 (ru) | 2014-03-27 |
Family
ID=41445049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2010149495/15A RU2510280C2 (ru) | 2008-06-27 | 2009-06-24 | Новые адъювантные композиции |
Country Status (30)
Country | Link |
---|---|
US (5) | US8580280B2 (ru) |
EP (4) | EP3552625A1 (ru) |
JP (5) | JP5659332B2 (ru) |
KR (1) | KR101333852B1 (ru) |
CN (4) | CN102076358B (ru) |
AR (1) | AR072378A1 (ru) |
AU (1) | AU2009263759B2 (ru) |
BR (2) | BR122021025097B1 (ru) |
CA (3) | CA2960734C (ru) |
CL (1) | CL2010001360A1 (ru) |
CO (1) | CO6331297A2 (ru) |
CY (2) | CY1117650T1 (ru) |
DK (2) | DK2310046T3 (ru) |
ES (2) | ES2569907T3 (ru) |
HK (3) | HK1201444A1 (ru) |
HR (1) | HRP20190876T1 (ru) |
HU (2) | HUE043493T2 (ru) |
LT (1) | LT3056214T (ru) |
ME (1) | ME01199B (ru) |
MX (5) | MX344311B (ru) |
NZ (5) | NZ709547A (ru) |
PH (2) | PH12014501836A1 (ru) |
PL (2) | PL2310046T3 (ru) |
PT (1) | PT3056214T (ru) |
RU (1) | RU2510280C2 (ru) |
SI (2) | SI3056214T1 (ru) |
TW (4) | TWI513464B (ru) |
UY (1) | UY31942A (ru) |
WO (1) | WO2009156960A2 (ru) |
ZA (1) | ZA201007835B (ru) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8444989B1 (en) * | 2008-04-18 | 2013-05-21 | Boehringer Ingelheim Vetmedica Gmbh | One dose vaccination against mycoplasma infections of pigs |
RU2510280C2 (ru) * | 2008-06-27 | 2014-03-27 | Пфайзер Инк. | Новые адъювантные композиции |
TWI351288B (en) * | 2008-07-04 | 2011-11-01 | Univ Nat Pingtung Sci & Tech | Cpg dna adjuvant in avian vaccines |
US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
WO2010067262A1 (en) * | 2008-12-09 | 2010-06-17 | Pfizer Inc. | Immunostimulatory oligonucleotides |
JP5911799B2 (ja) * | 2009-08-12 | 2016-04-27 | シグモイド・ファーマ・リミテッドSigmoid Pharma Limited | ポリマーマトリックスおよび油相を含んで成る免疫調節組成物 |
FR2957803B1 (fr) * | 2010-03-24 | 2012-06-01 | Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic | Diluants adjuvants de vaccins vivants pour maladies porcines |
ES2683316T3 (es) | 2010-05-28 | 2018-09-26 | Zoetis Belgium S.A. | Vacunas que comprenden colesterol y CpG como únicas moléculas transportadoras de adyuvante |
WO2012170753A2 (en) * | 2011-06-10 | 2012-12-13 | Novartis Ag | Bovine vaccines and methods |
CA2850296C (en) * | 2011-10-03 | 2021-01-12 | Moreinx Ab | Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds |
CA3081072A1 (en) | 2012-03-12 | 2013-09-19 | Advanced Bioadjuvants, Llc | Adjuvant and vaccine compositions |
SG11201505089YA (en) | 2012-12-28 | 2015-07-30 | Boehringer Ingelheim Vetmed | Method of making a mycoplasma vaccine |
EP3730148A3 (en) | 2012-12-28 | 2021-03-24 | Boehringer Ingelheim Vetmedica GmbH | Immunogenic composition comprising mycoplasma antigens |
CN103127495B (zh) * | 2013-01-28 | 2015-04-08 | 重庆市畜牧科学院 | 二联灭活苗的制剂及其制备方法 |
CN109078179A (zh) * | 2013-09-05 | 2018-12-25 | 硕腾服务有限责任公司 | Hendra和Nipah病毒G糖蛋白免疫原性组合物 |
EP3049105B1 (en) | 2013-09-19 | 2020-12-30 | Moredun Research Institute | Vaccine |
RU2016114713A (ru) | 2013-10-17 | 2017-11-20 | Зоэтис Сервисиз Ллс | Способы и композиции для лечения s. equi инфекции |
WO2015080959A1 (en) | 2013-11-26 | 2015-06-04 | Zoetis Llc | Compositions for induction of immune response |
US10195261B2 (en) | 2014-11-26 | 2019-02-05 | VaxLiant, LLC | Adjuvant compositions and related methods |
ES2961965T3 (es) * | 2014-11-26 | 2024-03-14 | Huvepharma Inc | Composiciones adyuvantes y procedimientos relacionados |
MX2017009306A (es) * | 2015-01-16 | 2017-11-08 | Zoetis Services Llc | Vacuna contra la fiebre aftosa. |
BR112017020175A2 (pt) * | 2015-03-24 | 2018-06-12 | Vaxliant Llc | composições adjuvantes e métodos relacionados |
CN104771754B (zh) * | 2015-04-02 | 2018-02-13 | 武汉科前生物股份有限公司 | 一种猪圆环病毒2型灭活疫苗水性佐剂及应用 |
CN106267183B (zh) * | 2015-06-09 | 2023-02-28 | 普莱柯生物工程股份有限公司 | 含有佐剂的活疫苗组合物及其制备方法和应用 |
CN106344920B (zh) * | 2015-07-16 | 2020-11-27 | 普莱柯生物工程股份有限公司 | 一种疫苗用佐剂及其应用 |
US10456459B2 (en) | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
HUE054422T2 (hu) * | 2015-07-20 | 2021-09-28 | Zoetis Services Llc | Liposzómás adjuváns készítmények |
MX2018004802A (es) * | 2015-10-19 | 2018-09-06 | Cadila Healthcare Ltd | Nuevo adyuvante y composición de vacuna que contiene el mismo. |
CA3010977A1 (en) | 2016-01-11 | 2017-07-20 | Zoetis Services Llc | Novel cross protective vaccine compositions for porcine epidemic diarrhea virus |
BR112018069371A2 (pt) | 2016-03-21 | 2019-01-22 | South Dakota Board Of Regents | construção de ácido nucleico, vetor, vacina ou composição imunogênica, método de entrega de uma vacina, método de produção de uma construção de ácido nucleico e método para conferir imunidade contra um antígeno |
KR20210068602A (ko) | 2016-06-02 | 2021-06-09 | 조에티스 서비시즈 엘엘씨 | 감염성 기관지염에 대한 백신 |
GB201703529D0 (en) | 2017-03-06 | 2017-04-19 | Cambridge Entpr Ltd | Vaccine composition |
US10092604B1 (en) * | 2017-12-21 | 2018-10-09 | Bioceuticals Pte. Ltd. | Methods for treatment of skin infectious diseases using microorganisms |
CA3093709C (en) | 2018-03-16 | 2024-03-26 | Zoetis Services Llc | Peptide vaccines against interleukin-31 |
CN108853493A (zh) * | 2018-07-26 | 2018-11-23 | 中国人民解放军陆军军医大学 | 麦冬皂苷d及其纳米乳在制备疫苗佐剂中的应用 |
US11046734B2 (en) | 2018-07-27 | 2021-06-29 | Research Development Foundation | Chimeric immunogenic polypeptides |
WO2020055503A1 (en) * | 2018-09-14 | 2020-03-19 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
CN109675028A (zh) * | 2019-03-01 | 2019-04-26 | 龙阔(苏州)生物工程有限公司 | 疫苗佐剂及其制备方法和应用及猪繁殖与呼吸综合征疫苗 |
CN114514238A (zh) * | 2019-07-12 | 2022-05-17 | 研究发展基金会 | 埃立克体疫苗和免疫原性组合物 |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
US20230263815A1 (en) * | 2020-06-19 | 2023-08-24 | Kimberly-Clark Worldwide, Inc. | Saponin containing extracts prepared from hesperaloe useful in the treatment of non-human animals |
BR112022025821A2 (pt) * | 2020-06-19 | 2023-01-10 | Kimberly Clark Co | Uso de um extrato de uma planta não lenhosa do gênero hesperaloe , uso de uma composição compreendendo pelo menos uma saponina extraída de uma planta não lenhosa do gênero hesperaloe, uso de imunomodulador derivado de hesperaloe, e, composição imunogênica |
TW202206098A (zh) * | 2020-08-11 | 2022-02-16 | 美商碩騰服務公司 | 抗冠狀病毒疫苗 |
US20230109193A1 (en) * | 2021-10-02 | 2023-04-06 | Massachusetts Institute Of Technology | Synergistic Combination of Alum and Non-Liposome, Non-Micelle Particle Vaccine Adjuvants |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4264587A (en) * | 1979-08-01 | 1981-04-28 | Pedersen Niels C | Vaccine for preventing persistent feline leukemia viremia in cats |
NZ221306A (en) * | 1986-08-15 | 1990-02-26 | Commw Scient Ind Res Org | 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof |
US5084269A (en) | 1986-11-06 | 1992-01-28 | Kullenberg Fred W | Adjuvant for dose treatment with antigens |
EP0273512B1 (en) | 1986-12-19 | 1991-02-27 | Duphar International Research B.V | Stabilised adjuvant suspension comprising dimethyl dioctadecyl ammonium bromide |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
RU1615918C (ru) | 1989-05-22 | 1995-07-09 | Всероссийский научно-исследовательский институт защиты животных | Адъювант |
WO1993014190A1 (en) * | 1992-01-06 | 1993-07-22 | Smithkline Beecham Corporation | Feline leukemia virus vaccines |
ZA936095B (en) | 1992-08-21 | 1994-03-14 | Univ Melbourne | Cytokine applications. |
US6764682B1 (en) | 1994-06-16 | 2004-07-20 | Aventis Pasteur Limited | Adjuvant compositions containing more than one adjuvant |
US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6846489B1 (en) * | 1995-04-25 | 2005-01-25 | Smithkline Beecham Biologicals S.A. | Vaccines containing a saponin and a sterol |
WO1998016247A1 (en) | 1996-10-11 | 1998-04-23 | The Regents Of The University Of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
EP0855184A1 (en) | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
AU738513B2 (en) | 1997-02-28 | 2001-09-20 | University Of Iowa Research Foundation, The | Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
AU753688B2 (en) | 1997-03-10 | 2002-10-24 | Ottawa Civic Loeb Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
CA2289253A1 (en) | 1997-04-30 | 1998-11-05 | Merieux Oravax | Anti-helicobacter vaccine composition for use by the subdiaphragmatic systemic route, and combined mucosal/parenteral immunization method |
CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
ATE252596T1 (de) | 1997-06-06 | 2003-11-15 | Dynavax Tech Corp | Immunstimulierende oligonucleotide, zusammensetzungen davon, und verfahren zur verwendung davon |
JP2001520205A (ja) * | 1997-10-20 | 2001-10-30 | バイエル・コーポレーシヨン | ネオスポラワクチン |
EP0953641A3 (en) * | 1998-03-26 | 2002-03-13 | Pfizer Products Inc. | Polynucleotide molecules encoding neospora proteins |
DE69927495T2 (de) | 1998-05-14 | 2006-07-06 | Coley Pharmaceutical Group, Inc., Wellesley | Verfahren zur regulieren der hämatopoese mit hilfe von cpg-oligonukleotiden |
DK1077722T3 (da) | 1998-05-22 | 2006-11-27 | Ottawa Health Research Inst | Fremgangsmåder og produkter til induktion af mukosaimmunitet |
US20040247662A1 (en) | 1998-06-25 | 2004-12-09 | Dow Steven W. | Systemic immune activation method using nucleic acid-lipid complexes |
DK1104306T3 (da) | 1998-08-10 | 2006-05-22 | Antigenics Inc | Præparater af CpG- og saponinadjuvanser og fremgangsmåder til anvendelse deraf |
AU769539B2 (en) | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
US8206749B1 (en) | 1999-02-26 | 2012-06-26 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
AU4188100A (en) | 1999-04-08 | 2000-11-14 | Gregory M. Glenn | Dry formulation for transcutaneous immunization |
US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
EP2322210A1 (en) | 1999-04-19 | 2011-05-18 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
AU4978100A (en) | 1999-04-29 | 2000-11-17 | Coley Pharmaceutical Gmbh | Screening for immunostimulatory dna functional modifyers |
WO2001051500A1 (en) | 2000-01-14 | 2001-07-19 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
EP1311288A1 (en) | 2000-01-20 | 2003-05-21 | Ottawa Health Research Institute | Immunostimulatory nucleic acids for inducing a th2 immune response |
AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
ME00183B (me) | 2000-02-21 | 2011-02-10 | Pharmexa As | Novi postupak za deregulaciju amiloida |
AU5736601A (en) | 2000-05-01 | 2001-11-12 | Hybridon Inc | Modulation of oligonucleotide cpg-mediated immune stimulation by positional modification of nucleosides |
AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
GB0025577D0 (en) | 2000-10-18 | 2000-12-06 | Smithkline Beecham Biolog | Vaccine |
ES2307568T3 (es) | 2000-12-08 | 2008-12-01 | Coley Pharmaceutical Gmbh | Acidos nucleicos de tipo cpg y metodos de uso de los mismos. |
US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
US7713942B2 (en) | 2001-04-04 | 2010-05-11 | Nordic Vaccine Technology A/S | Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides |
WO2002080648A2 (en) | 2001-04-05 | 2002-10-17 | Chiron Corporation | Mucosal boosting following parenteral priming |
US7105495B2 (en) | 2001-04-30 | 2006-09-12 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
ATE366308T1 (de) | 2001-05-21 | 2007-07-15 | Intercell Ag | Immunostimulierende oligodeoxyribonuklein moleküle |
EP1395262A4 (en) | 2001-06-15 | 2006-04-12 | Ribapharm Corp | NUCLEOSIDE-VACCINE-ADJUVANTS |
WO2003004051A2 (en) * | 2001-07-02 | 2003-01-16 | Pfizer Products Inc. | Mycoplasma hyopneumoniae vaccine and methods for reducing mycoplasma bovis pneumonia in cattle |
PL209773B1 (pl) * | 2001-07-02 | 2011-10-31 | Pfizer Prod Inc | Zastosowanie bakteryny Mycoplasma hyopneumoniae do wytwarzania szczepionki |
US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
US20030072762A1 (en) | 2001-08-03 | 2003-04-17 | Van De Winkel Jan G. J. | Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance Fc receptor-mediated immunotherapies |
AU2002326561B2 (en) | 2001-08-07 | 2008-04-03 | Dynavax Technologies Corporation | Immunomodulatory compositions, formulations, and methods for use thereof |
US20030138434A1 (en) | 2001-08-13 | 2003-07-24 | Campbell Robert L. | Agents for enhancing the immune response |
EA007232B1 (ru) | 2001-08-17 | 2006-08-25 | Коли Фармасьютикал Гмбх | Иммуностимулирующие олигонуклеотиды, содержащие комбинацию мотивов и обладающие повышенной активностью |
WO2003017755A2 (en) | 2001-08-28 | 2003-03-06 | Pfizer Products Inc. | Mycoplasma bovis challenge model, methods for administering m.bovis and methods for inducing pneumonic lung lesions |
DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
US7514415B2 (en) | 2002-08-01 | 2009-04-07 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides |
US20030119774A1 (en) | 2001-09-25 | 2003-06-26 | Marianna Foldvari | Compositions and methods for stimulating an immune response |
GB0123580D0 (en) * | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
WO2003030934A2 (en) | 2001-10-06 | 2003-04-17 | Merial Limited | Cpg formulations and related methods |
US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
EP1441763A2 (en) | 2001-11-07 | 2004-08-04 | Inex Pharmaceuticals Corp. | Mucosal adjuvants comprising an oligonucleotide and a cationic lipid |
AU2002358616A1 (en) | 2001-12-07 | 2003-06-17 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
CA2474709A1 (en) | 2002-02-04 | 2003-08-14 | Biomira, Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
EP1476456A4 (en) | 2002-02-19 | 2007-06-20 | Syntherica Corp | COMPOSITIONS AND METHOD FOR SUBROGEN-ANTIBODY MODULATION OF AN IMMUNE RESPONSE AND TRANSPORT |
ES2734652T3 (es) | 2002-04-04 | 2019-12-11 | Zoetis Belgium S A | Oligorribonucleótidos inmunoestimulantes que contienen G y U |
WO2003089590A2 (en) | 2002-04-16 | 2003-10-30 | Vaxin, Inc. | TRANSIENT AND/OR PERMANENT MODIFICATION OF SEXUAL BEHAVIOR AND/OR FERTILITY USING RECOMBINANT CHIMERIC GnRH |
WO2003089642A1 (en) | 2002-04-22 | 2003-10-30 | Bioniche Life Sciences Inc. | Oligonucleotide compositions and their use for the modulation of immune responses |
KR100456681B1 (ko) | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
US20060228342A1 (en) | 2002-05-28 | 2006-10-12 | Robinson Ramirez-Pineda | Method for generating antigen-presenting cells |
CA2388049A1 (en) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
SE0201701D0 (sv) | 2002-06-05 | 2002-06-05 | Gotovax Ab | Treatment of epithelial tumors and infections |
AU2003243409A1 (en) | 2002-06-05 | 2003-12-22 | Coley Pharmaceutical Group, Inc. | Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids |
US20060107872A1 (en) | 2002-11-05 | 2006-05-25 | Hong Chen | Method and apparatus for producing calcium silicate hydrate |
WO2004067031A1 (en) * | 2003-01-29 | 2004-08-12 | Pfizer Products Inc. | Canine vaccines against bordetella bronchiseptica |
AU2003900767A0 (en) * | 2003-02-21 | 2003-03-13 | St Vincent's Hospital Sydney Limited | Idiotypic vaccine |
EP1606398A1 (en) | 2003-03-26 | 2005-12-21 | Cytos Biotechnology AG | Melan-a peptide analogue-virus-like-particle conjugates |
PL1613346T3 (pl) | 2003-04-04 | 2013-03-29 | Zoetis Services Llc | Poddane mikrofluidyzacji emulsje typu olej w wodzie i kompozycje szczepionek |
SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
GB0323965D0 (en) * | 2003-10-13 | 2003-11-19 | Glaxosmithkline Biolog Sa | Immunogenic compositions |
US20080254065A1 (en) * | 2004-03-09 | 2008-10-16 | Chiron Corporation | Influenza Virus Vaccines |
SI1742659T1 (sl) | 2004-04-05 | 2013-07-31 | Zoetis P Llc | Mikrofluidizirane emulzije olja v vodi in sestavki cepiv |
NZ554142A (en) * | 2004-10-06 | 2009-12-24 | Agri Biotech Pty Ltd | Antibody production method comprising inserting antigen releasing device into mammal so antibodies are released into its milk |
GB0426481D0 (en) * | 2004-12-02 | 2005-01-05 | Vaccine Technology Ltd | Composition |
WO2006106424A2 (en) | 2005-04-07 | 2006-10-12 | Pharmacia & Upjohn Company Llc | Formulations and process for production of bordetella bronchiseptica p68 antigen and vaccines |
AU2006241149A1 (en) * | 2005-04-26 | 2006-11-02 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhanced immunostimulatory activity |
RU2396976C2 (ru) * | 2005-10-07 | 2010-08-20 | Пфайзер Продактс Инк. | Вакцины и способы лечения собачьего гриппа |
ES2564241T3 (es) * | 2005-12-02 | 2016-03-21 | Glaxosmithkline Biologicals Sa | Nanopartículas para su uso en composiciones inmunogénicas |
CN101379397A (zh) * | 2006-01-26 | 2009-03-04 | Hx诊断公司 | H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合活性片段及其用途 |
RS20080318A (en) * | 2006-01-26 | 2009-05-06 | Pfizer Products Inc., | Novel glycolipid ajuvant compositions |
WO2008076371A2 (en) | 2006-12-15 | 2008-06-26 | Schering-Plough Ltd. | Method for replicating influenza virus in culture |
WO2008074487A2 (en) * | 2006-12-19 | 2008-06-26 | Novosom Ag | Lipids and lipid assemblies comprising transfection enhancer elements |
US20080292663A1 (en) | 2007-05-22 | 2008-11-27 | Gerber Jay D | Adjuvant compositions and methods for delivering vaccines |
CL2008001806A1 (es) | 2007-06-20 | 2008-09-05 | Wyeth Corp | Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion. |
RU2510280C2 (ru) * | 2008-06-27 | 2014-03-27 | Пфайзер Инк. | Новые адъювантные композиции |
BRPI1005919B1 (pt) | 2009-02-27 | 2021-06-22 | Toray Industries, Inc | Composição imunogênica |
US10456459B2 (en) * | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
-
2009
- 2009-06-24 RU RU2010149495/15A patent/RU2510280C2/ru active
- 2009-06-24 ES ES09769768.4T patent/ES2569907T3/es active Active
- 2009-06-24 CA CA2960734A patent/CA2960734C/en active Active
- 2009-06-24 EP EP19166434.1A patent/EP3552625A1/en not_active Withdrawn
- 2009-06-24 NZ NZ709547A patent/NZ709547A/en unknown
- 2009-06-24 CA CA2723786A patent/CA2723786C/en active Active
- 2009-06-24 MX MX2013014772A patent/MX344311B/es unknown
- 2009-06-24 NZ NZ589079A patent/NZ589079A/xx unknown
- 2009-06-24 NZ NZ727616A patent/NZ727616A/en unknown
- 2009-06-24 NZ NZ621834A patent/NZ621834A/en unknown
- 2009-06-24 MX MX2016016408A patent/MX368220B/es unknown
- 2009-06-24 BR BR122021025097-9A patent/BR122021025097B1/pt active IP Right Grant
- 2009-06-24 PL PL09769768.4T patent/PL2310046T3/pl unknown
- 2009-06-24 EP EP09769768.4A patent/EP2310046B1/en active Active
- 2009-06-24 CA CA2960846A patent/CA2960846C/en active Active
- 2009-06-24 PT PT15197967T patent/PT3056214T/pt unknown
- 2009-06-24 SI SI200931968T patent/SI3056214T1/sl unknown
- 2009-06-24 LT LTEP15197967.1T patent/LT3056214T/lt unknown
- 2009-06-24 MX MX2010014026A patent/MX2010014026A/es active IP Right Grant
- 2009-06-24 ME MEP-2010-194A patent/ME01199B/me unknown
- 2009-06-24 MX MX2013014771A patent/MX349720B/es unknown
- 2009-06-24 JP JP2011515706A patent/JP5659332B2/ja active Active
- 2009-06-24 DK DK09769768.4T patent/DK2310046T3/da active
- 2009-06-24 BR BRPI0913954-0A patent/BRPI0913954B1/pt active IP Right Grant
- 2009-06-24 HU HUE15197967A patent/HUE043493T2/hu unknown
- 2009-06-24 CN CN200980124560.5A patent/CN102076358B/zh active Active
- 2009-06-24 CN CN201410197979.6A patent/CN104001169B/zh active Active
- 2009-06-24 CN CN201410198333.XA patent/CN104001170B/zh active Active
- 2009-06-24 SI SI200931399A patent/SI2310046T1/sl unknown
- 2009-06-24 NZ NZ602945A patent/NZ602945A/en unknown
- 2009-06-24 CN CN201510098559.7A patent/CN104758929B/zh active Active
- 2009-06-24 EP EP15197967.1A patent/EP3056214B1/en active Active
- 2009-06-24 DK DK15197967.1T patent/DK3056214T3/da active
- 2009-06-24 KR KR1020107029087A patent/KR101333852B1/ko active IP Right Grant
- 2009-06-24 EP EP20169980.8A patent/EP3725328A3/en active Pending
- 2009-06-24 PL PL15197967T patent/PL3056214T3/pl unknown
- 2009-06-24 US US12/490,767 patent/US8580280B2/en active Active
- 2009-06-24 WO PCT/IB2009/052724 patent/WO2009156960A2/en active Application Filing
- 2009-06-24 AU AU2009263759A patent/AU2009263759B2/en active Active
- 2009-06-24 HU HUE09769768A patent/HUE028921T2/en unknown
- 2009-06-24 ES ES15197967T patent/ES2728949T3/es active Active
- 2009-06-26 UY UY0001031942A patent/UY31942A/es not_active Application Discontinuation
- 2009-06-26 TW TW098121642A patent/TWI513464B/zh active
- 2009-06-26 AR ARP090102382A patent/AR072378A1/es not_active Application Discontinuation
- 2009-06-26 TW TW104123873A patent/TWI614027B/zh active
- 2009-06-26 TW TW104123871A patent/TWI622400B/zh active
- 2009-06-26 TW TW104123872A patent/TWI622401B/zh active
-
2010
- 2010-11-02 ZA ZA2010/07835A patent/ZA201007835B/en unknown
- 2010-12-06 CL CL2010001360A patent/CL2010001360A1/es unknown
- 2010-12-16 MX MX2019011253A patent/MX2019011253A/es unknown
- 2010-12-22 CO CO10160889A patent/CO6331297A2/es not_active Application Discontinuation
-
2013
- 2013-08-29 US US14/013,299 patent/US9662385B2/en active Active
-
2014
- 2014-01-24 JP JP2014011047A patent/JP5824538B2/ja active Active
- 2014-01-24 JP JP2014011040A patent/JP5882370B2/ja active Active
- 2014-08-14 PH PH12014501836A patent/PH12014501836A1/en unknown
- 2014-08-14 PH PH12014501835A patent/PH12014501835A1/en unknown
-
2015
- 2015-02-26 HK HK15101931.3A patent/HK1201444A1/zh unknown
- 2015-02-26 HK HK15101932.2A patent/HK1201445A1/xx unknown
- 2015-03-17 JP JP2015053170A patent/JP6038211B2/ja active Active
-
2016
- 2016-01-04 HK HK16100012.6A patent/HK1211870A1/xx unknown
- 2016-05-30 CY CY20161100466T patent/CY1117650T1/el unknown
- 2016-10-26 JP JP2016209399A patent/JP6294938B2/ja active Active
-
2017
- 2017-04-26 US US15/494,920 patent/US10238736B2/en active Active
-
2018
- 2018-03-23 US US15/933,805 patent/US10940202B2/en active Active
-
2019
- 2019-05-13 HR HRP20190876TT patent/HRP20190876T1/hr unknown
- 2019-06-04 CY CY20191100589T patent/CY1121789T1/el unknown
-
2021
- 2021-03-08 US US17/195,003 patent/US11896666B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2010149495A (ru) | Новые адъювантные композиции | |
RU2434638C2 (ru) | Вакцина альфа токсоида с.perfringens | |
CN1056085C (zh) | 母育酚在疫苗中用作佐剂 | |
US9273281B2 (en) | Method of making a mycoplasma vaccine | |
EA200301324A1 (ru) | Вакцина mycoplasma bovis и способы сокращения пневмонии у животных | |
US5807551A (en) | Method to provide artificial passive immunity in birds | |
ES2808673T3 (es) | Composición inmunogénica que comprende antígenos de micoplasma | |
JP2017501985A (ja) | PRRSおよびローソニア・イントラセルラリス(Lawsonia intracellularis)に対するブタワクチン | |
Basso et al. | Vaccination of dogs with Trypanosoma rangeli induces antibodies against Trypanosoma cruzi in a rural area of Córdoba, Argentina | |
KR20110081233A (ko) | 어류의 스쿠티카증 예방 치료 백신 | |
JP2913229B2 (ja) | 油性アジュバントワクチン製剤 | |
US4328208A (en) | Vaccine against chlamydous infections of farm animals | |
BR112015024882B1 (pt) | Composição, vacina contra carrapatos rhipicephalus, métodos para a preparação de uma composição e de uma vacina contra carrapatos rhipicephalus, proteína bm86 ou homólogo da mesma e uma proteína subolesina ou homólogo da mesma, uso de proteína bm86 ou homólogo da mesma e de uma proteína subolesina ou homólogo da mesma, e, kit de partes | |
Umali et al. | Antibody response and protective immunity of chickens vaccinated with booster dose of recombinant oil-adjuvanted Leucocytozoon caulleryi subunit vaccine | |
Muhammad et al. | Effect of different adjuvants used in Foot and Mouth Disease virus vaccine on antibody response of buffalo calves. | |
EP1923070A1 (en) | Vaccine for vaccinating feline against influenza virus | |
JP2000219637A (ja) | エリシペロスリクス・ルシオパシエ抗原及びワクチン組成物 | |
Shah et al. | Volume 2 Animal Health Perspectives | |
Araghi et al. | Evaluation of Immunogenicity of Clostridium perfringens Type B Toxoid and Inactivated FMD (O) Virus with Adjuvant (ISA70-MF59) | |
Curtis | Examination of the impact of bovine anaplasmosis on dairy and beef operations, and evaluation of control with antimicrobial chemosterilization or vaccination with an ear-implant delivery platform | |
RU2554055C1 (ru) | Способ иммунизации животных против бруцеллеза | |
JPH0681731B2 (ja) | 動物用ワクチン | |
RU1615919C (ru) | Вакцина против вирусного энтерита, ботулизма и чумы плотоядных, способ ее изготовления и способ профилактики этих заболеваний | |
RU2570630C2 (ru) | Способ снижения серопозитивности живых противобруцеллезных вакцин для сельскохозяйственных животных | |
US20170290895A1 (en) | Heartworm vaccine, methods and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC41 | Official registration of the transfer of exclusive right |
Effective date: 20150617 |
|
TC4A | Change in inventorship |
Effective date: 20151026 |
|
PC41 | Official registration of the transfer of exclusive right |
Effective date: 20151120 |
|
PD4A | Correction of name of patent owner |