HRP20190876T1 - Novi adjuvantirani pripravci - Google Patents
Novi adjuvantirani pripravci Download PDFInfo
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- HRP20190876T1 HRP20190876T1 HRP20190876TT HRP20190876T HRP20190876T1 HR P20190876 T1 HRP20190876 T1 HR P20190876T1 HR P20190876T T HRP20190876T T HR P20190876TT HR P20190876 T HRP20190876 T HR P20190876T HR P20190876 T1 HRP20190876 T1 HR P20190876T1
- Authority
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- Croatia
- Prior art keywords
- virus
- accordance
- felv
- antigen
- avian influenza
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims 4
- 239000002671 adjuvant Substances 0.000 title claims 3
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 241000712461 unidentified influenza virus Species 0.000 claims 4
- 241000714165 Feline leukemia virus Species 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 241000282326 Felis catus Species 0.000 claims 2
- 208000002979 Influenza in Birds Diseases 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 229930182558 Sterol Natural products 0.000 claims 2
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 206010064097 avian influenza Diseases 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 150000003432 sterols Chemical class 0.000 claims 2
- 235000003702 sterols Nutrition 0.000 claims 2
- 101800001467 Envelope glycoprotein E2 Proteins 0.000 claims 1
- 101900302604 Feline leukemia virus Surface protein Proteins 0.000 claims 1
- 101800001271 Surface protein Proteins 0.000 claims 1
- PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
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Claims (9)
1. Pripravak namijenjen upotrebi kao cjepivo koje sadrži formulaciju adjuvansa i terapijski djelotvornu količinu antigenske komponente, naznačen time što
a) formulacija adjuvansa sadrži Quil A ili njegovu pročišćenu fakciju, sterol, dimetil(dioktadecil)amonijev bromid (DDA), te polimer od poliakrilne kiseline; i
b) antigenska komponenta sadrži antigen FeLV (virus mačje leukemije), koji sadrži protein FeLV gp70 ili virus FeLV, ili antigen ptičje influence, koji sadrži virus ptičje influence ili protein H5 ptičje influence.
2. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što je navedeni Quil A ili njegova pročišćena fakcija prisutan u količini od otprilike 1 µg do otprilike 5.000 µg po dozi, sterol je prisutan u količini od otprilike 1 µg do otprilike 5.000 µg po dozi, DDA je prisutan u količini od otprilike 1 µg do otprilike 5.000 µg po dozi, a polimer od poliakrilne kiseline je prisutan u količini od otprilike 0,0001% vol./vol. do otprilike 75% vol./vol.
3. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1 ili 2, naznačen time što antigen FeLV sadrži gp70 kojeg proizvodi stanična linija FL-74, trajno inficirana sojem virusa mačje leukemije KT-FeLV-UCD-1 s ATCC brojem CRL-8a12.
4. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1 ili 2, naznačen time što antigen FeLV sadrži inaktivirani virus FeLV.
5. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1 ili 2, naznačen time što je antigen inaktivirani cijeli virus ptičje influence.
6. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 5, naznačen time što je virus ptičje influence H5N1 virus ili a H5N2 virus.
7. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1 ili 2, naznačen time što je antigen pročišćeni protein H5 HA.
8. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-4, naznačen time što je namijenjen upotrebi u liječenju ili sprječavanju infekcije koju uzrokuje virus mačje leukemije kod mačke.
9. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1, 2, 5-7, naznačen time što je namijenjen upotrebi u liječenju ili sprječavanju infekcije koju uzrokuje virus ptičje influence kod mačke.
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