ATE366308T1 - Immunostimulierende oligodeoxyribonuklein moleküle - Google Patents
Immunostimulierende oligodeoxyribonuklein moleküleInfo
- Publication number
- ATE366308T1 ATE366308T1 AT02748709T AT02748709T ATE366308T1 AT E366308 T1 ATE366308 T1 AT E366308T1 AT 02748709 T AT02748709 T AT 02748709T AT 02748709 T AT02748709 T AT 02748709T AT E366308 T1 ATE366308 T1 AT E366308T1
- Authority
- AT
- Austria
- Prior art keywords
- deoxyribosepurine
- deoxycytosine
- deoxyinosine
- deoxyguanosine
- deoxyadenosine
- Prior art date
Links
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- RPFPNGBGDKGFRI-XLPZGREQSA-N 9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methyl-3h-purin-6-one Chemical compound C12=NC(C)=NC(O)=C2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 RPFPNGBGDKGFRI-XLPZGREQSA-N 0.000 abstract 2
- FERYXNKLCFJNMG-QJPTWQEYSA-N (2r,3s,5r)-2-(hydroxymethyl)-5-[6-(3-methylbut-3-enylamino)purin-9-yl]oxolan-3-ol Chemical compound C1=NC=2C(NCCC(=C)C)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 FERYXNKLCFJNMG-QJPTWQEYSA-N 0.000 abstract 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical compound OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 abstract 1
- COVHWGAKPGOZBI-QJPTWQEYSA-N [(2r,3s,5r)-3-hydroxy-5-[6-(3-methylbut-3-enylamino)purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate Chemical compound C1=NC=2C(NCCC(=C)C)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1 COVHWGAKPGOZBI-QJPTWQEYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 229940046166 oligodeoxynucleotide Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT8052001 | 2001-05-21 | ||
| PCT/EP2002/005448 WO2002095027A2 (en) | 2001-05-21 | 2002-05-17 | Immunostimulatory oligodeoxynucleic molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE366308T1 true ATE366308T1 (de) | 2007-07-15 |
Family
ID=3681210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02748709T ATE366308T1 (de) | 2001-05-21 | 2002-05-17 | Immunostimulierende oligodeoxyribonuklein moleküle |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20050070462A1 (de) |
| EP (2) | EP1390495B1 (de) |
| JP (2) | JP2005501004A (de) |
| CN (1) | CN1526016A (de) |
| AT (1) | ATE366308T1 (de) |
| AU (1) | AU2002320762B2 (de) |
| CA (2) | CA2447793A1 (de) |
| DE (1) | DE60221004T2 (de) |
| ES (1) | ES2288555T3 (de) |
| WO (2) | WO2002094845A2 (de) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7378234B2 (en) | 2002-09-13 | 2008-05-27 | Intercell Ag | Method for isolating hepatitis C virus peptides |
| US7528223B2 (en) | 2002-07-24 | 2009-05-05 | Intercell Ag | Antigens encoded by alternative reading frames from pathogenic viruses |
| US7704514B2 (en) | 2003-03-24 | 2010-04-27 | Intercell Ag | Vaccines |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1450821A1 (de) * | 2001-12-07 | 2004-09-01 | Intercell AG | Immunstimulierende oligodeoxynukleotide |
| CA2388049A1 (en) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
| DE102004049223A1 (de) * | 2004-10-08 | 2006-04-20 | Johannes-Gutenberg-Universität Mainz | Zubereitung zum Impfen, Impfverfahren und Verwendung einer Impf-Zubereitung |
| JP2007045730A (ja) * | 2005-08-09 | 2007-02-22 | Nitto Denko Corp | 免疫誘導能増強方法 |
| WO2007031322A1 (en) * | 2005-09-14 | 2007-03-22 | Gunther Hartmann | Compositions comprising immunostimulatory rna oligonucleotides and methods for producing said rna oligonucleotides |
| CA2656771A1 (en) | 2006-07-07 | 2008-01-10 | Intercell Ag | Small streptococcus pyogenes antigens and their use |
| WO2008031133A2 (en) | 2006-09-15 | 2008-03-20 | Intercell Ag | Borrelia antigens |
| EP1923069A1 (de) | 2006-11-20 | 2008-05-21 | Intercell AG | Schutzpeptide gegen S. pneumoniae und diesbezügliche Zusammensetzungen, Verfahren und Verwendungen |
| AU2008204471B2 (en) | 2007-01-12 | 2013-02-21 | Intercell Ag | Protective proteins of S. agalactiae, combinations thereof and methods of using the same |
| EP2360177A1 (de) | 2007-05-02 | 2011-08-24 | Intercell AG | Klebsiella-Antigene |
| EP2012122A1 (de) | 2007-07-06 | 2009-01-07 | Medigene AG | Strukturproteine von mutierten Parvoviren als Impfstoffe |
| ES2602610T3 (es) | 2007-05-31 | 2017-02-21 | Medigene Ag | Proteína estructural mutada de un parvovirus |
| US20100203075A1 (en) | 2007-06-18 | 2010-08-12 | Intercell Ag | Chlamydia antigens |
| CA2718473A1 (en) | 2008-03-17 | 2009-09-24 | Intercell Ag | Peptides protective against s. pneumoniae and compositions, methods and uses relating thereto |
| NZ621834A (en) | 2008-06-27 | 2015-10-30 | Zoetis Services Llc | Novel adjuvant compositions |
| WO2010089340A2 (en) | 2009-02-05 | 2010-08-12 | Intercell Ag | Peptides protective against e. faecalis, methods and uses relating thereto |
| WO2010092176A2 (en) | 2009-02-13 | 2010-08-19 | Intercell Ag | Nontypable haemophilus influenzae antigens |
| EP2319871A1 (de) | 2009-11-05 | 2011-05-11 | Sanofi-aventis | Polypeptide zum Binden an den Rezeptor für weiterentwickelte Glykierungsendprodukte sowie Zusammensetzungen und Verfahren, die diese Polypeptide beinhalten |
| KR20120089863A (ko) | 2009-10-09 | 2012-08-14 | 사노피 | “개선된 당화반응 최종 생성물에 대한 수용체”에 결합하기 위한 폴리펩타이드 및 이를 포함하는 조성물 및 방법 |
| EP2308896A1 (de) | 2009-10-09 | 2011-04-13 | Sanofi-aventis | Polypeptides zum Binden an den Rezeptor für weiterentwickelte Glykierungsendprodukte sowie Zusammensetzungen und Verfahren, die diese Polypeptide beinhalten |
| JP5808082B2 (ja) * | 2010-04-30 | 2015-11-10 | 株式会社Adeka | 細胞への水溶性高分子量物質の導入方法及び導入剤 |
| HUE033342T2 (en) | 2010-09-03 | 2017-11-28 | Valneva Austria Gmbh | Isolated polypeptide of the toxin a and toxin b proteins of c. difficile and uses thereof |
| AR082925A1 (es) | 2010-09-08 | 2013-01-16 | Medigene Ag | Proteinas estructurales mutadas por parvovirus con epitopo de celulas b de proteccion cruzada, producto y metodos relacionados |
| NZ757210A (en) | 2013-09-19 | 2022-12-23 | Zoetis Services Llc | Oil-based adjuvants |
| JP6525455B2 (ja) * | 2013-09-20 | 2019-06-05 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 免疫賦活活性を有するオリゴヌクレオチド含有複合体及びその用途 |
| AR103427A1 (es) | 2015-01-16 | 2017-05-10 | Zoetis Services Llc | Vacuna contra la fiebre aftosa |
| CN112074295A (zh) | 2018-02-16 | 2020-12-11 | 2A制药公司 | 用于治疗自身免疫性疾病的细小病毒结构蛋白 |
| EP3527223A1 (de) | 2018-02-16 | 2019-08-21 | 2A Pharma AB | Mutiertes parvovirus-strukturprotein |
| SG11202110646PA (en) | 2019-05-20 | 2021-10-28 | Valneva Se | A subunit vaccine for treatment or prevention of a respiratory tract infection |
| US12214028B2 (en) | 2019-05-31 | 2025-02-04 | Universidad De Chile | Immunogenic formulation that induces protection against shiga toxin-producing Escherichia coli (STEC) |
| WO2022074061A1 (en) | 2020-10-07 | 2022-04-14 | Valneva Sweden Ab | Cholera vaccine formulation |
| EP4319804A2 (de) | 2021-04-09 | 2024-02-14 | Valneva SE | Impfstoff gegen humanes metapneumovirus |
| WO2023083964A1 (en) | 2021-11-11 | 2023-05-19 | 2A Pharma Ab | Parvovirus structural protein against beta- and gamma-hpv |
| WO2023232901A1 (en) | 2022-06-01 | 2023-12-07 | Valneva Austria Gmbh | Clostridium difficile vaccine |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3725545A (en) * | 1971-02-03 | 1973-04-03 | R Maes | Enhancement of antibody production by nucleic acid-polycation complexes |
| US3906092A (en) * | 1971-11-26 | 1975-09-16 | Merck & Co Inc | Stimulation of antibody response |
| EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
| WO1995026204A1 (en) * | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| DK0772619T4 (da) | 1994-07-15 | 2011-02-21 | Univ Iowa Res Found | Immunmodulatoriske oligonukleotider |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6610661B1 (en) | 1996-10-11 | 2003-08-26 | The Regents Of The University Of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| ATE441432T1 (de) | 1997-03-10 | 2009-09-15 | Ottawa Hospital Res Inst | Verwendung von nicht-methyliertem cpg dinukleotid in kombination mit aluminium als adjuvantien |
| DE69838294T2 (de) | 1997-05-20 | 2009-08-13 | Ottawa Health Research Institute, Ottawa | Verfahren zur Herstellung von Nukleinsäurekonstrukten |
| ATE432348T1 (de) | 1997-06-06 | 2009-06-15 | Univ California | Inhibitoren von immunstimulatorischen dna sequenz aktivität |
| DE69935507T2 (de) | 1998-04-03 | 2007-12-06 | University Of Iowa Research Foundation | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
| WO1999056755A1 (en) | 1998-05-06 | 1999-11-11 | University Of Iowa Research Foundation | Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides |
| US6403102B1 (en) * | 1998-10-29 | 2002-06-11 | Connaught Laboratories Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| AT408721B (de) * | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
| CA2407942A1 (en) * | 2000-05-01 | 2001-11-08 | Hybridon, Inc. | Modulation of oligonucleotide cpg-mediated immune stimulation by positional modification of nucleosides |
| HU228264B1 (en) * | 2000-06-08 | 2013-02-28 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| DE60134421D1 (de) * | 2000-12-08 | 2008-07-24 | Coley Pharmaceuticals Gmbh | Cpg-artige nukleinsäuren und verfahren zu ihrer verwendung |
| EP1450821A1 (de) | 2001-12-07 | 2004-09-01 | Intercell AG | Immunstimulierende oligodeoxynukleotide |
-
2002
- 2002-05-17 AU AU2002320762A patent/AU2002320762B2/en not_active Ceased
- 2002-05-17 EP EP02748709A patent/EP1390495B1/de not_active Expired - Lifetime
- 2002-05-17 JP JP2002591518A patent/JP2005501004A/ja not_active Withdrawn
- 2002-05-17 DE DE60221004T patent/DE60221004T2/de not_active Expired - Lifetime
- 2002-05-17 JP JP2002592489A patent/JP4188092B2/ja not_active Expired - Fee Related
- 2002-05-17 WO PCT/EP2002/005447 patent/WO2002094845A2/en not_active Ceased
- 2002-05-17 US US10/478,426 patent/US20050070462A1/en not_active Abandoned
- 2002-05-17 CA CA002447793A patent/CA2447793A1/en not_active Abandoned
- 2002-05-17 CN CNA028116976A patent/CN1526016A/zh active Pending
- 2002-05-17 ES ES02748709T patent/ES2288555T3/es not_active Expired - Lifetime
- 2002-05-17 WO PCT/EP2002/005448 patent/WO2002095027A2/en not_active Ceased
- 2002-05-17 AT AT02748709T patent/ATE366308T1/de active
- 2002-05-17 EP EP02745299A patent/EP1390494A2/de not_active Withdrawn
- 2002-05-17 CA CA002448031A patent/CA2448031A1/en not_active Abandoned
- 2002-05-17 US US10/478,771 patent/US7858588B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7528223B2 (en) | 2002-07-24 | 2009-05-05 | Intercell Ag | Antigens encoded by alternative reading frames from pathogenic viruses |
| US7378234B2 (en) | 2002-09-13 | 2008-05-27 | Intercell Ag | Method for isolating hepatitis C virus peptides |
| US7704514B2 (en) | 2003-03-24 | 2010-04-27 | Intercell Ag | Vaccines |
| US8784837B2 (en) | 2003-03-24 | 2014-07-22 | Valneva Austria Gmbh | Vaccines comprising an immunostimulatory peptide and an immunostimulatory oligodeoxynucleic acid molecule |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2288555T3 (es) | 2008-01-16 |
| WO2002095027A3 (en) | 2003-08-21 |
| WO2002094845A3 (en) | 2003-11-06 |
| DE60221004D1 (de) | 2007-08-16 |
| AU2002320762B2 (en) | 2006-09-21 |
| CA2448031A1 (en) | 2002-11-28 |
| WO2002094845A2 (en) | 2002-11-28 |
| DE60221004T2 (de) | 2008-03-13 |
| EP1390495B1 (de) | 2007-07-04 |
| US20040248831A1 (en) | 2004-12-09 |
| WO2002095027A2 (en) | 2002-11-28 |
| CN1526016A (zh) | 2004-09-01 |
| US7858588B2 (en) | 2010-12-28 |
| EP1390494A2 (de) | 2004-02-25 |
| JP2004530428A (ja) | 2004-10-07 |
| CA2447793A1 (en) | 2002-11-28 |
| US20050070462A1 (en) | 2005-03-31 |
| EP1390495A2 (de) | 2004-02-25 |
| JP4188092B2 (ja) | 2008-11-26 |
| JP2005501004A (ja) | 2005-01-13 |
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