PT1098893E - Composto ciclicos uteis n tratamento da dislipidemia, aterosclerose e diabetes, composicoes farmaceuticas e processo de preparacao - Google Patents

Composto ciclicos uteis n tratamento da dislipidemia, aterosclerose e diabetes, composicoes farmaceuticas e processo de preparacao

Info

Publication number
PT1098893E
PT1098893E PT99934643T PT99934643T PT1098893E PT 1098893 E PT1098893 E PT 1098893E PT 99934643 T PT99934643 T PT 99934643T PT 99934643 T PT99934643 T PT 99934643T PT 1098893 E PT1098893 E PT 1098893E
Authority
PT
Portugal
Prior art keywords
compositions
useful
aterosclerosis
dislipidemia
cyclical
Prior art date
Application number
PT99934643T
Other languages
English (en)
Inventor
Berthelon Dr Jean-Jacques
Daniel Guerrier
Eriv Rasp
Jean-Jacques Zeiller
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT1098893E publication Critical patent/PT1098893E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/081,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/061,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT99934643T 1998-07-17 1999-07-09 Composto ciclicos uteis n tratamento da dislipidemia, aterosclerose e diabetes, composicoes farmaceuticas e processo de preparacao PT1098893E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9809164A FR2781222A1 (fr) 1998-07-17 1998-07-17 Composes cycliques utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procede de preparation

Publications (1)

Publication Number Publication Date
PT1098893E true PT1098893E (pt) 2003-08-29

Family

ID=9528730

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99934643T PT1098893E (pt) 1998-07-17 1999-07-09 Composto ciclicos uteis n tratamento da dislipidemia, aterosclerose e diabetes, composicoes farmaceuticas e processo de preparacao

Country Status (22)

Country Link
US (1) US6528538B1 (pt)
EP (1) EP1098893B1 (pt)
JP (1) JP2002520407A (pt)
KR (1) KR20010070966A (pt)
CN (1) CN1309655A (pt)
AT (1) ATE235485T1 (pt)
AU (1) AU753287B2 (pt)
BR (1) BR9912138A (pt)
CA (1) CA2337481A1 (pt)
DE (1) DE69906303T2 (pt)
DK (1) DK1098893T3 (pt)
ES (1) ES2192853T3 (pt)
FR (1) FR2781222A1 (pt)
HK (1) HK1039615A1 (pt)
HU (1) HUP0103411A3 (pt)
ID (1) ID27854A (pt)
NO (1) NO20010266L (pt)
PL (1) PL345397A1 (pt)
PT (1) PT1098893E (pt)
SK (1) SK482001A3 (pt)
WO (1) WO2000004011A1 (pt)
ZA (1) ZA200101303B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
JPWO2003016265A1 (ja) * 2001-08-17 2004-12-02 エーザイ株式会社 環状化合物およびpparアゴニスト
GEP20094705B (en) 2003-04-24 2009-06-10 Incyte Corp Aza spiro alkane derivatives as inhibitors of metalloproteases
BRPI0506477A (pt) * 2004-01-09 2007-02-06 Cadila Healthcare Ltd compostos farmaceuticamente úteis e inovadores
JP2008510696A (ja) * 2004-08-20 2008-04-10 カディラ ヘルスケア リミティド 新規抗糖尿病化合物
CN100389112C (zh) * 2004-12-16 2008-05-21 中国石油化工股份有限公司 一类环状缩醛和缩酮化合物及其应用
ES2327187T3 (es) * 2006-02-27 2009-10-26 Cadila Healthcare Limited Acidos 1,3-dioxano carboxilicos.
MX2008014560A (es) * 2006-05-18 2008-11-28 Wellstat Therapeutics Corp Compuestos para el tratamiento de trastornos metabolicos.
WO2007143600A2 (en) * 2006-06-05 2007-12-13 Incyte Corporation Sheddase inhibitors combined with cd30-binding immunotherapeutics for the treatment of cd30 positive diseases
WO2016056031A1 (en) 2014-10-08 2016-04-14 Council Of Scientific & Industrial Research Novel diol compounds synthesis and its use for formal synthesis of (2r, 3 s)-3-hydroxypipecolic acid
US9637575B2 (en) * 2014-12-31 2017-05-02 W. R. Grace & Co. -Conn. Catalyst system, olefin polymerization catalyst components comprising at least an internal electron donor compound, and methods of making and using the same
WO2021114207A1 (en) * 2019-12-13 2021-06-17 Rhodia Operations Production of benzene derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032536A (en) 1976-07-22 1977-06-28 Janssen Pharmaceutica N.V. (1h-benzimidazol-2-yl)carbamates
US5179216A (en) * 1990-08-16 1993-01-12 American Home Products Corporation N,n', n'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-coa:cholesterol-acyl transferase
TW209868B (pt) * 1991-04-04 1993-07-21 Yoshitomi Pharmaceutical
DE19637840A1 (de) * 1996-09-17 1998-03-19 Henkel Kgaa Verwendung von geminalen Dialkoxyalkansäureestern zur Herstellung von desodorierenden Körperpflegemitteln

Also Published As

Publication number Publication date
ZA200101303B (en) 2002-05-15
HUP0103411A3 (en) 2002-08-28
US6528538B1 (en) 2003-03-04
KR20010070966A (ko) 2001-07-28
EP1098893A1 (en) 2001-05-16
AU753287B2 (en) 2002-10-17
DK1098893T3 (da) 2003-07-07
PL345397A1 (en) 2001-12-17
NO20010266D0 (no) 2001-01-16
CA2337481A1 (en) 2000-01-27
JP2002520407A (ja) 2002-07-09
ATE235485T1 (de) 2003-04-15
CN1309655A (zh) 2001-08-22
EP1098893B1 (en) 2003-03-26
SK482001A3 (en) 2001-09-11
HUP0103411A2 (hu) 2002-04-29
ES2192853T3 (es) 2003-10-16
BR9912138A (pt) 2001-04-10
DE69906303D1 (de) 2003-04-30
FR2781222A1 (fr) 2000-01-21
NO20010266L (no) 2001-01-16
DE69906303T2 (de) 2003-12-11
ID27854A (id) 2001-04-26
HK1039615A1 (zh) 2002-05-03
WO2000004011A1 (en) 2000-01-27
AU5034799A (en) 2000-02-07

Similar Documents

Publication Publication Date Title
MXPA03009840A (es) Derivados de fenilurea sustituidos con carboxamida y metodo para la produccion de los mismos como farmacos.
EA200601555A1 (ru) Замещенные индазол-о-глюкозиды
DE60204452D1 (de) Pyrazolo[1,5]pyridinderivate
AR014261A1 (es) Compuestos hipolipidemicos de benzotiazepina, composiciones y proceso para su preparacion
ATE433447T1 (de) Pyrimiidinverbindungen
PT1098893E (pt) Composto ciclicos uteis n tratamento da dislipidemia, aterosclerose e diabetes, composicoes farmaceuticas e processo de preparacao
EA200601553A1 (ru) Замещенные бензимидазол-, бензтриазол- и бензимидазолон-о-глюкозиды
DE60214179D1 (de) IMIDAZOi1,2-AöPYRIDIN-DERIVATE ZUR PROPHYLAXE UND BEHANDLUNG VON HERPES-INFEKTIONEN
BR9916633A (pt) Benzopiranos e benzoxepinas, composições farmacêuticas compreendendo-as e processo de preparação
DK1268498T3 (da) Kardioprotektive phosphater
ES2243579T3 (es) Derivados de pirazolopirideno.
EE200200208A (et) Oligosahhariidid, nende valmistamismeetod ja kasutamine ning farmatseutilised kompositsioonid
ATE364043T1 (de) Pyrazolo-pyridine für die behandlung von herpes- ansteckungen
DE60326358D1 (de) Fasern und fibride enthaltende artikel, fasern und fibride und herstellungsverfahren
YU12903A (sh) Derivati aminoalkenilbenzoil-benzofurana ili benzotiopena, postupak za njihovo pripremanje i kompozicije koje ih sadrže
IL160171A0 (en) Depsipeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
CY1105275T1 (el) Ενωσεις υποκατεστημενης γ-λακτονης ως ανταγωνισται - νμda
EA200300066A1 (ru) Производные аминоалкоксибензоил-бензофурана или бензотиофена, способ их получения и содержащие их композиции
BR0318521A (pt) arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados
ATE442355T1 (de) Herstellung von 4,5-dialkyl-3-acylpyrrol-2- carbonsäurederivaten durch synthese nach fischer- fink und anschliebende acylierung
CY1107362T1 (el) Παραγωγα ιμιδαζολυλιου χρησιμα ως συνδετες υποδοχεων ισταμινης h3
BR0016638B1 (pt) compostos anÁlogos de homopiperidilbenzimidazàis substituÍdos como relaxantes féndicos, processo para preparar os mesmos, composiÇço farmacÊutica e processo para preparÁ-la.
ATE213233T1 (de) Substituierte caprolactame und deren derivate verwendbar zur behandlung der hiv-krankheit
ATE417831T1 (de) Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittel
DE69926223D1 (de) Verfahren zur herstellung von zwischenprodukten