BR9916633A - Benzopiranos e benzoxepinas, composições farmacêuticas compreendendo-as e processo de preparação - Google Patents

Benzopiranos e benzoxepinas, composições farmacêuticas compreendendo-as e processo de preparação

Info

Publication number
BR9916633A
BR9916633A BR9916633-0A BR9916633A BR9916633A BR 9916633 A BR9916633 A BR 9916633A BR 9916633 A BR9916633 A BR 9916633A BR 9916633 A BR9916633 A BR 9916633A
Authority
BR
Brazil
Prior art keywords
benzoxepines
benzopyrans
pharmaceutical compositions
preparation process
preparation
Prior art date
Application number
BR9916633-0A
Other languages
English (en)
Inventor
Michel Brunet
Jean Jacques Zeiller
Jean Jacques Berthelon
Francis Contard
Guy Augert
Daniel Guerrier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9916633A publication Critical patent/BR9916633A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Patente de Invenção: <B>"BENZOPIRANOS E BENZOXEPINAS, COMPOSIçõES FARMACêUTICAS COMPREENDENDO-AS E PROCESSO DE PREPARAçãO"<D>. A presente invenção refere-se a benzopiranos e benzoxepinas de fórmula (I), em que X, A, R~ 1~, R~ 2~ e (R)~ p~ têm os significados como dados na reivindicação 1, que pode ser usado no tratamento de dislipidemias, aterosclerose e diabetes, a composições farmacêuticas compreendendo-as e a processos que permitem a preparação destes compostos.
BR9916633-0A 1998-12-29 1999-12-20 Benzopiranos e benzoxepinas, composições farmacêuticas compreendendo-as e processo de preparação BR9916633A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9816574A FR2787789B1 (fr) 1998-12-29 1998-12-29 Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations
PCT/EP1999/010114 WO2000039113A1 (en) 1998-12-29 1999-12-20 Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process

Publications (1)

Publication Number Publication Date
BR9916633A true BR9916633A (pt) 2001-09-25

Family

ID=9534619

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916633-0A BR9916633A (pt) 1998-12-29 1999-12-20 Benzopiranos e benzoxepinas, composições farmacêuticas compreendendo-as e processo de preparação

Country Status (19)

Country Link
US (1) US6596758B1 (pt)
EP (1) EP1140893B1 (pt)
JP (1) JP4607331B2 (pt)
KR (1) KR100684088B1 (pt)
CN (2) CN1307171C (pt)
AU (1) AU759892B2 (pt)
BR (1) BR9916633A (pt)
CA (1) CA2356680C (pt)
CZ (1) CZ300086B6 (pt)
FR (1) FR2787789B1 (pt)
HK (1) HK1047584B (pt)
HU (1) HUP0104839A3 (pt)
ID (1) ID29236A (pt)
NO (1) NO20013242D0 (pt)
PL (1) PL196524B1 (pt)
RU (1) RU2228333C2 (pt)
SK (1) SK9022001A3 (pt)
WO (1) WO2000039113A1 (pt)
ZA (1) ZA200106177B (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0213094A (pt) * 2001-10-04 2004-10-13 Wyeth Corp Derivados de cromano como ligandos de 5-hidroxi-triptamina-6
FR2845386B1 (fr) * 2002-10-07 2006-06-30 Merck Sante Sas Nouveaux derives metastables de benzoxepines utilisables dans le traitement des dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparation
JP2006514666A (ja) * 2003-02-26 2006-05-11 中国科学院上海薬物研究所 ベンゾピラン系化合物、その製造方法及び用途
AU2004278414B2 (en) 2003-10-01 2012-05-24 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US6887896B1 (en) * 2003-10-29 2005-05-03 Allergan, Inc. 7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity
PT1535612E (pt) * 2003-11-28 2006-12-29 Merck Sante Sas Tratamento da hiperuricemia
DK1591434T3 (da) 2004-04-27 2007-09-17 Merck Sante Sas Nye 1-methoxy-2-phenyl-ethener anvendelig til fremstiling af 5-carboxaldehyd-2-3-dihydrobenzoxepiner
PL1600446T3 (pl) * 2004-05-18 2008-03-31 Merck Sante Sas Nowe pochodne 3,3-dimetylo-5-cyjano-benzoksepin użyteczne do otrzymywania pochodnych 5-formylo-benzoksepin
ATE518850T1 (de) * 2004-06-25 2011-08-15 Merck Sante Sas 5-alkenon-3,3-dimethyl-benzoxepinderivate und ihre verwendung in der herstellung von antidiabetischen pentadiensäuren
US7235688B1 (en) 2004-11-04 2007-06-26 University Of Notre Dame Du Lac Process for preparing histone deacetylase inhibitors and intermediates thereof
US20070021612A1 (en) * 2004-11-04 2007-01-25 University Of Notre Dame Du Lac Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof
BRPI0519013A2 (pt) * 2004-12-13 2009-11-03 Lilly Co Eli composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto
AU2006214892B2 (en) * 2005-02-16 2013-06-27 Kt & G Co., Ltd Pharmaceutical composition for the treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2063886A2 (en) * 2006-09-12 2009-06-03 Adolor Corporation Use of n-containing spirocompounds for the enhancement of cognitive function
CN101172978A (zh) * 2006-11-02 2008-05-07 中国人民解放军军事医学科学院毒物药物研究所 六元杂环化合物,其制备方法及其医药用途
EP2120925A4 (en) * 2007-03-16 2010-04-07 Novogen Res Pty Ltd AUTOPHAGIA INDUCTION METHOD
EP2306965B1 (en) * 2008-08-09 2015-12-02 Merck Patent GmbH Use of indole compounds as a cosmetic
US20110144130A1 (en) * 2008-08-12 2011-06-16 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of 5-(7-methoxy-3,3-dimethyl-2,3-dihydro-1-benzoxepin-5-yl)-3-methyl-penta-2,4-dienoic acid as a cosmetic
WO2016140979A1 (en) * 2015-03-03 2016-09-09 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10221143B2 (en) 2015-03-03 2019-03-05 Arizona Board Of Regents On Behalf Of Arizona State University Substituted anilines for treatment of animal diseases
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
CN108371712B (zh) * 2018-01-18 2020-12-25 华北理工大学 咖啡因与PPARγ激动剂联合制备AD药物中的用途
WO2022053416A1 (en) 2020-09-08 2022-03-17 Merck Patent Gmbh Improvement of water-holding capacity of skin by oxeglitazar

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US5004744A (en) * 1988-12-13 1991-04-02 Bayer Aktiengesellschaft Pyridazinones as pesticides
EP0412939A3 (en) * 1989-08-11 1991-09-04 Ciba-Geigy Ag Certain benzopyran and benzothiopyran derivatives
US4946860A (en) * 1989-11-03 1990-08-07 Rorer Pharmaceutical Corporation Benzothiopyranyl derivatives as HMG-CoA reductase inhibitors
WO1993011755A1 (en) * 1991-12-18 1993-06-24 The Salk Institute For Biological Studies Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor
JP2594409B2 (ja) * 1992-09-29 1997-03-26 アディール エ コンパニー トリエン側鎖を有する新規クロメン化合物
MX9704878A (es) * 1994-12-30 1997-11-29 Ligand Pharm Inc Nuevos compuestos retinoides trienoicos y metodos de uso.
US5675033A (en) * 1995-06-06 1997-10-07 Allergan 2,4-pentadienoic acid derivatives having retinoid-like biological activity

Also Published As

Publication number Publication date
CN1173967C (zh) 2004-11-03
KR20010101339A (ko) 2001-11-14
AU2432900A (en) 2000-07-31
PL196524B1 (pl) 2008-01-31
HK1047584B (zh) 2005-05-27
AU759892B2 (en) 2003-05-01
EP1140893B1 (en) 2003-03-05
CN1554651A (zh) 2004-12-15
NO20013242L (no) 2001-06-28
PL349448A1 (en) 2002-07-29
HK1047584A1 (en) 2003-02-28
WO2000039113A1 (en) 2000-07-06
CA2356680A1 (en) 2000-07-06
FR2787789A1 (fr) 2000-06-30
CZ20012387A3 (cs) 2001-11-14
ZA200106177B (en) 2002-12-24
FR2787789B1 (fr) 2002-06-14
US6596758B1 (en) 2003-07-22
JP4607331B2 (ja) 2011-01-05
JP2003517449A (ja) 2003-05-27
ID29236A (id) 2001-08-16
RU2228333C2 (ru) 2004-05-10
CZ300086B6 (cs) 2009-01-28
NO20013242D0 (no) 2001-06-28
CN1307171C (zh) 2007-03-28
HUP0104839A2 (hu) 2002-04-29
KR100684088B1 (ko) 2007-02-16
SK9022001A3 (en) 2002-04-04
HUP0104839A3 (en) 2003-01-28
CN1359383A (zh) 2002-07-17
CA2356680C (en) 2010-03-23
EP1140893A1 (en) 2001-10-10

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: C07D 335/06, A61K 31/335, A61K 31/352, A61K 31/38, A61K 31/382, A61P 3/10, A61P 9/00, A61P 9/10, C07D 311/06, C07D 311/58, C07D 311/96, C07D 313/08, C07D 313/10, C07D 311/96, C07D 313/08, C07D 313/10, C07D 337/08

Ipc: C07D 313/08 (2009.01), C07D 311/58 (2009.01), C07D

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements