NO20013242L - Benzopyraner og benzoksepiner, farmasöytiske preparater som omfatter dem, og fremgangsmåte for fremstilling av dem - Google Patents

Benzopyraner og benzoksepiner, farmasöytiske preparater som omfatter dem, og fremgangsmåte for fremstilling av dem

Info

Publication number
NO20013242L
NO20013242L NO20013242A NO20013242A NO20013242L NO 20013242 L NO20013242 L NO 20013242L NO 20013242 A NO20013242 A NO 20013242A NO 20013242 A NO20013242 A NO 20013242A NO 20013242 L NO20013242 L NO 20013242L
Authority
NO
Norway
Prior art keywords
benzoxepines
benzopyrans
processes
preparation
pharmaceutical compositions
Prior art date
Application number
NO20013242A
Other languages
English (en)
Other versions
NO20013242D0 (no
Inventor
Michel Brunet
Jean Jaques Zeiller
Jean-Jacques Berthelon
Francis Contard
Guy Augert
Daniel Guerrier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20013242L publication Critical patent/NO20013242L/no
Publication of NO20013242D0 publication Critical patent/NO20013242D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
NO20013242A 1998-12-29 2001-06-28 Benzopyraner og benzoksepiner, farmasöytiske preparater som omfatter dem, og fremgangsmåte for fremstilling av dem NO20013242D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9816574A FR2787789B1 (fr) 1998-12-29 1998-12-29 Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations
PCT/EP1999/010114 WO2000039113A1 (en) 1998-12-29 1999-12-20 Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process

Publications (2)

Publication Number Publication Date
NO20013242L true NO20013242L (no) 2001-06-28
NO20013242D0 NO20013242D0 (no) 2001-06-28

Family

ID=9534619

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013242A NO20013242D0 (no) 1998-12-29 2001-06-28 Benzopyraner og benzoksepiner, farmasöytiske preparater som omfatter dem, og fremgangsmåte for fremstilling av dem

Country Status (19)

Country Link
US (1) US6596758B1 (no)
EP (1) EP1140893B1 (no)
JP (1) JP4607331B2 (no)
KR (1) KR100684088B1 (no)
CN (2) CN1173967C (no)
AU (1) AU759892B2 (no)
BR (1) BR9916633A (no)
CA (1) CA2356680C (no)
CZ (1) CZ300086B6 (no)
FR (1) FR2787789B1 (no)
HK (1) HK1047584B (no)
HU (1) HUP0104839A3 (no)
ID (1) ID29236A (no)
NO (1) NO20013242D0 (no)
PL (1) PL196524B1 (no)
RU (1) RU2228333C2 (no)
SK (1) SK9022001A3 (no)
WO (1) WO2000039113A1 (no)
ZA (1) ZA200106177B (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2461381A1 (en) * 2001-10-04 2003-04-10 Wyeth Chroman derivatives as 5-hydroxytryptamine-6 ligands
FR2845386B1 (fr) * 2002-10-07 2006-06-30 Merck Sante Sas Nouveaux derives metastables de benzoxepines utilisables dans le traitement des dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparation
EP1598345A4 (en) * 2003-02-26 2006-03-22 Shanghai Inst Materia Medica BENZOPYRANE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USES THEREOF
NZ593444A (en) * 2003-10-01 2012-12-21 Adolor Corp 4-[(2-N,N-diethylaminocarbonyl)pyrid-5-yl]-spiro[1,2-dihydronaphthalene-2,4'-piperidine] and methods of its use
US6887896B1 (en) * 2003-10-29 2005-05-03 Allergan, Inc. 7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity
DK1535612T3 (da) * 2003-11-28 2007-02-12 Merck Sante Sas Behandling af hyperurikæmi
DE602004006085T2 (de) * 2004-04-27 2007-12-27 Merck Santé Neue 1-Methoxy-2-phenyl-ethene zur Herstellung von 5-Carboxaldehyde-2-3-dihydrobenzoxepinen
DK1600446T3 (da) * 2004-05-18 2008-03-03 Merck Sante Sas Ny 3,3-dimethyl-5-cyano-benzoxepin-derivater anvendelige til fremstillingen af 5-formyl-benzoxepin- derivater
EP1609786B1 (en) 2004-06-25 2011-08-03 Merck Sante 5-alkenone-3,3-dimethyl-benzoxepines derivatives useful for the preparation of antidiabetic pentadienoic acids
US20070021612A1 (en) * 2004-11-04 2007-01-25 University Of Notre Dame Du Lac Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof
US7235688B1 (en) 2004-11-04 2007-06-26 University Of Notre Dame Du Lac Process for preparing histone deacetylase inhibitors and intermediates thereof
CA2589363A1 (en) * 2004-12-13 2006-06-22 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
EP2532388A3 (en) * 2005-02-16 2013-03-06 Md Bioalpha Co., Ltd. Pharmaceutical composition for the treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
WO2008033299A2 (en) * 2006-09-12 2008-03-20 Adolor Corporation Use of n-containing spirocompounds for the enhancement of cognitive function
CN101172978A (zh) * 2006-11-02 2008-05-07 中国人民解放军军事医学科学院毒物药物研究所 六元杂环化合物,其制备方法及其医药用途
US20100173983A1 (en) * 2007-03-16 2010-07-08 David Brown Method for inducing autophagy
ES2562798T3 (es) * 2008-08-09 2016-03-08 Merck Patent Gmbh Uso de compuestos de indol como cosmético
US20110144130A1 (en) * 2008-08-12 2011-06-16 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of 5-(7-methoxy-3,3-dimethyl-2,3-dihydro-1-benzoxepin-5-yl)-3-methyl-penta-2,4-dienoic acid as a cosmetic
US10112917B2 (en) 2015-03-03 2018-10-30 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10221143B2 (en) 2015-03-03 2019-03-05 Arizona Board Of Regents On Behalf Of Arizona State University Substituted anilines for treatment of animal diseases
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
CN108371712B (zh) * 2018-01-18 2020-12-25 华北理工大学 咖啡因与PPARγ激动剂联合制备AD药物中的用途
WO2022053416A1 (en) 2020-09-08 2022-03-17 Merck Patent Gmbh Improvement of water-holding capacity of skin by oxeglitazar

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004744A (en) * 1988-12-13 1991-04-02 Bayer Aktiengesellschaft Pyridazinones as pesticides
EP0412939A3 (en) * 1989-08-11 1991-09-04 Ciba-Geigy Ag Certain benzopyran and benzothiopyran derivatives
US4946860A (en) * 1989-11-03 1990-08-07 Rorer Pharmaceutical Corporation Benzothiopyranyl derivatives as HMG-CoA reductase inhibitors
DK0617614T3 (da) * 1991-12-18 1998-09-28 Salk Inst For Biological Studi Midler til modulering af processer medieret af retinoide receptorer og forbindelser anvendlige dertil
NZ248794A (en) * 1992-09-29 1995-01-27 Adir 3-carboxy-(and phosphonoxy-)alkatriene-substituted chromene derivatives and medicaments
AU712187B2 (en) * 1994-12-30 1999-10-28 Ligand Pharmaceuticals Incorporated Novel trienoic retinoid compounds and methods
US5675033A (en) * 1995-06-06 1997-10-07 Allergan 2,4-pentadienoic acid derivatives having retinoid-like biological activity

Also Published As

Publication number Publication date
CN1554651A (zh) 2004-12-15
HUP0104839A2 (hu) 2002-04-29
EP1140893B1 (en) 2003-03-05
CN1173967C (zh) 2004-11-03
ZA200106177B (en) 2002-12-24
US6596758B1 (en) 2003-07-22
CA2356680C (en) 2010-03-23
EP1140893A1 (en) 2001-10-10
FR2787789A1 (fr) 2000-06-30
SK9022001A3 (en) 2002-04-04
FR2787789B1 (fr) 2002-06-14
ID29236A (id) 2001-08-16
HK1047584A1 (en) 2003-02-28
KR100684088B1 (ko) 2007-02-16
JP4607331B2 (ja) 2011-01-05
AU2432900A (en) 2000-07-31
PL349448A1 (en) 2002-07-29
CN1359383A (zh) 2002-07-17
CA2356680A1 (en) 2000-07-06
BR9916633A (pt) 2001-09-25
JP2003517449A (ja) 2003-05-27
HK1047584B (zh) 2005-05-27
HUP0104839A3 (en) 2003-01-28
WO2000039113A1 (en) 2000-07-06
PL196524B1 (pl) 2008-01-31
CZ20012387A3 (cs) 2001-11-14
KR20010101339A (ko) 2001-11-14
CZ300086B6 (cs) 2009-01-28
AU759892B2 (en) 2003-05-01
NO20013242D0 (no) 2001-06-28
CN1307171C (zh) 2007-03-28
RU2228333C2 (ru) 2004-05-10

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