ATE60999T1 - Dimethyldioctadecylammoniumbromid enthaltende stabilisierte adjuvanssuspension. - Google Patents
Dimethyldioctadecylammoniumbromid enthaltende stabilisierte adjuvanssuspension.Info
- Publication number
- ATE60999T1 ATE60999T1 AT87202523T AT87202523T ATE60999T1 AT E60999 T1 ATE60999 T1 AT E60999T1 AT 87202523 T AT87202523 T AT 87202523T AT 87202523 T AT87202523 T AT 87202523T AT E60999 T1 ATE60999 T1 AT E60999T1
- Authority
- AT
- Austria
- Prior art keywords
- stabilized
- suspension containing
- dimethyldioctadecylammonium bromide
- adjuvant
- adjuvant suspension
- Prior art date
Links
- 239000002671 adjuvant Substances 0.000 title abstract 3
- PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 title abstract 2
- 239000000725 suspension Substances 0.000 title abstract 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- ZLDPNFYTUDQDMJ-UHFFFAOYSA-N n-octadecyloctadecan-1-amine;hydrobromide Chemical compound Br.CCCCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCCCC ZLDPNFYTUDQDMJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Pyrrole Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Sorption Type Refrigeration Machines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8603232 | 1986-12-19 | ||
| EP87202523A EP0273512B1 (de) | 1986-12-19 | 1987-12-15 | Dimethyldioctadecylammoniumbromid enthaltende stabilisierte Adjuvanssuspension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE60999T1 true ATE60999T1 (de) | 1991-03-15 |
Family
ID=19849021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87202523T ATE60999T1 (de) | 1986-12-19 | 1987-12-15 | Dimethyldioctadecylammoniumbromid enthaltende stabilisierte adjuvanssuspension. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5026546A (de) |
| EP (1) | EP0273512B1 (de) |
| JP (1) | JPS63165329A (de) |
| AT (1) | ATE60999T1 (de) |
| DE (1) | DE3768232D1 (de) |
| DK (1) | DK661387A (de) |
| ES (1) | ES2037072T3 (de) |
| GR (1) | GR3001527T3 (de) |
| IE (1) | IE60698B1 (de) |
| NZ (1) | NZ222938A (de) |
| PT (1) | PT86376B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0432431B1 (de) * | 1989-11-16 | 1993-06-16 | PHIDEA S.p.A. | Flüssige Arzneimittel zur nasalen Anwendung, die ein Polypeptid als Wirksubstanz enthalten |
| NZ239643A (en) * | 1990-09-17 | 1996-05-28 | North American Vaccine Inc | Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group. |
| IL105325A (en) * | 1992-04-16 | 1996-11-14 | Minnesota Mining & Mfg | Immunogen/vaccine adjuvant composition |
| US6991797B2 (en) * | 1993-07-02 | 2006-01-31 | Statens Serum Institut | M. tuberculosis antigens |
| US5955077A (en) * | 1993-07-02 | 1999-09-21 | Statens Seruminstitut | Tuberculosis vaccine |
| BE1008977A5 (fr) * | 1994-12-27 | 1996-10-01 | Solvay | Adjuvants pour vaccins. |
| US6982085B2 (en) * | 1997-04-02 | 2006-01-03 | Statens Serum Institut | TB diagnostic based on antigens from M. tuberculosis |
| US7037510B2 (en) | 1997-04-18 | 2006-05-02 | Statens Serum Institut | Hybrids of M. tuberculosis antigens |
| US20040013685A1 (en) * | 1997-11-10 | 2004-01-22 | Peter Andersen | Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis |
| FR2814957B1 (fr) * | 2000-10-06 | 2002-12-20 | Aventis Pasteur | Composition vaccinale et procede de stabilisation |
| NZ538394A (en) * | 2002-08-26 | 2008-06-30 | Pfizer Prod Inc | Vaccine for respiratory and reproductive system infections in cattles |
| US6962608B1 (en) | 2002-10-01 | 2005-11-08 | The Regents Of The University Of California | Regenerable antimicrobial polymers and fibers with oxygen bleaches |
| US8193185B2 (en) | 2003-01-21 | 2012-06-05 | Novartis Vaccines And Diagnostics, Inc. | Use of tryptanthrin compounds for immune potentiation |
| ES2423800T3 (es) | 2003-03-28 | 2013-09-24 | Novartis Vaccines And Diagnostics, Inc. | Uso de compuestos orgánicos para la inmunopotenciación |
| WO2006002422A2 (en) | 2004-06-24 | 2006-01-05 | Novartis Vaccines And Diagnostics Inc. | Compounds for immunopotentiation |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| US7749520B2 (en) * | 2004-07-07 | 2010-07-06 | Statens Serum Institut | Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids |
| ITBO20050363A1 (it) | 2005-05-26 | 2006-11-27 | Maccaferri Spa Off | Elemento leggero di protezione filtro del tipo a materasso |
| WO2007109813A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
| US8063063B2 (en) * | 2006-03-23 | 2011-11-22 | Novartis Ag | Immunopotentiating compounds |
| EP2010530A2 (de) * | 2006-03-23 | 2009-01-07 | Novartis AG | Herstellungsverfahren für imidazolhaltige verbindungen |
| CL2008001806A1 (es) * | 2007-06-20 | 2008-09-05 | Wyeth Corp | Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion. |
| CN102076358B (zh) | 2008-06-27 | 2016-08-17 | 硕腾有限责任公司 | 新颖的佐剂组合物 |
| WO2010077613A1 (en) | 2008-12-09 | 2010-07-08 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
| RU2730011C2 (ru) | 2013-09-19 | 2020-08-14 | Зоэтис Сервисиз Ллс | Адъюванты на масляной основе |
| WO2016001907A1 (en) | 2014-07-02 | 2016-01-07 | Prendergast Patrick T | Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents. |
| FI3244920T3 (fi) | 2015-01-16 | 2023-08-04 | Zoetis Services Llc | Suu- ja sorkkatautirokote |
| TW202015725A (zh) | 2018-06-04 | 2020-05-01 | 美商亞博創新醫藥有限公司 | Tlr7 肽結合物 |
| CA3103503A1 (en) | 2018-07-02 | 2020-01-09 | Ayuvis Research, Inc. | Novel immunodulating small molecules |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919411A (en) * | 1972-01-31 | 1975-11-11 | Bayvet Corp | Injectable adjuvant and compositions including such adjuvant |
-
1987
- 1987-12-15 AT AT87202523T patent/ATE60999T1/de not_active IP Right Cessation
- 1987-12-15 ES ES198787202523T patent/ES2037072T3/es not_active Expired - Lifetime
- 1987-12-15 EP EP87202523A patent/EP0273512B1/de not_active Expired
- 1987-12-15 DE DE8787202523T patent/DE3768232D1/de not_active Expired - Fee Related
- 1987-12-16 NZ NZ222938A patent/NZ222938A/en unknown
- 1987-12-16 DK DK661387A patent/DK661387A/da not_active Application Discontinuation
- 1987-12-16 PT PT86376A patent/PT86376B/pt unknown
- 1987-12-16 IE IE340787A patent/IE60698B1/en not_active IP Right Cessation
- 1987-12-17 US US07/134,046 patent/US5026546A/en not_active Expired - Lifetime
- 1987-12-17 JP JP62317662A patent/JPS63165329A/ja active Pending
-
1991
- 1991-02-28 GR GR91400170T patent/GR3001527T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0273512A3 (en) | 1988-07-27 |
| DE3768232D1 (de) | 1991-04-04 |
| NZ222938A (en) | 1990-11-27 |
| DK661387A (da) | 1988-06-20 |
| IE60698B1 (en) | 1994-08-10 |
| PT86376A (en) | 1988-01-01 |
| DK661387D0 (da) | 1987-12-16 |
| ES2037072T3 (es) | 1993-06-16 |
| EP0273512B1 (de) | 1991-02-27 |
| US5026546A (en) | 1991-06-25 |
| EP0273512A2 (de) | 1988-07-06 |
| IE873407L (en) | 1988-06-19 |
| PT86376B (pt) | 1990-11-20 |
| GR3001527T3 (en) | 1992-11-23 |
| JPS63165329A (ja) | 1988-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |