CN102066338A - 蛋白激酶抑制剂 - Google Patents

蛋白激酶抑制剂 Download PDF

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Publication number
CN102066338A
CN102066338A CN2009801223945A CN200980122394A CN102066338A CN 102066338 A CN102066338 A CN 102066338A CN 2009801223945 A CN2009801223945 A CN 2009801223945A CN 200980122394 A CN200980122394 A CN 200980122394A CN 102066338 A CN102066338 A CN 102066338A
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alkylene
ylamino
pyrrolo
pyrimidin
compound
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CN2009801223945A
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Chinese (zh)
Inventor
宋永红
徐亲
S·M·鲍尔
Z·J·贾
M·梅赫罗特拉
A·潘迪
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Portola Pharmaceuticals LLC
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Portola Pharmaceuticals LLC
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
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  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2009801223945A 2008-04-22 2009-04-22 蛋白激酶抑制剂 Pending CN102066338A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4707708P 2008-04-22 2008-04-22
US61/047,077 2008-04-22
PCT/US2009/002512 WO2009131687A2 (en) 2008-04-22 2009-04-22 Inhibitors of protein kinases

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US (2) US8258144B2 (enExample)
EP (1) EP2271631B1 (enExample)
JP (1) JP2011518219A (enExample)
CN (2) CN102066338A (enExample)
AU (1) AU2009238590A1 (enExample)
BR (1) BRPI0910668A2 (enExample)
CA (1) CA2723185A1 (enExample)
IL (1) IL208719A0 (enExample)
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Cited By (20)

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CN104177363A (zh) * 2013-05-24 2014-12-03 江苏先声药物研究有限公司 双环杂环胺类Hedgehog信号通路抑制剂
CN105188704A (zh) * 2013-01-16 2015-12-23 西格诺药品有限公司 被取代的吡咯并嘧啶化合物、其组合物和使用其的治疗方法
CN105837577A (zh) * 2015-02-02 2016-08-10 四川大学 1-(嘧啶-4-基)3-胺基哌啶衍生物及其制备方法和用途
CN106132934A (zh) * 2014-01-23 2016-11-16 加拉帕戈斯股份有限公司 治疗炎性病症的苯并咪唑衍生物及其医药组合物
CN106187899A (zh) * 2016-06-28 2016-12-07 绍兴文理学院 一种氟代氮杂芳烃的合成方法
CN106349224A (zh) * 2016-08-03 2017-01-25 山东大学 一种含有4‑氨基‑(1h)‑吡唑结构的jak激酶抑制剂及其制备方法和应用
CN107531725A (zh) * 2015-08-13 2018-01-02 北京韩美药品有限公司 Irak4抑制剂及其应用
CN107709327A (zh) * 2015-06-22 2018-02-16 小野药品工业株式会社 Brk抑制性化合物
CN108137559A (zh) * 2015-07-09 2018-06-08 默克专利有限公司 用作btk抑制剂的嘧啶衍生物及其用途
CN109311896A (zh) * 2016-06-30 2019-02-05 株式会社大熊制药 吡唑并嘧啶衍生物作为激酶抑制剂
CN111423384A (zh) * 2019-07-04 2020-07-17 沈阳药科大学 2-氨基嘧啶类化合物及其用途
CN111527091A (zh) * 2017-12-28 2020-08-11 株式会社大熊制药 作为激酶抑制剂的氧基-氟哌啶衍生物
CN111892580A (zh) * 2020-09-29 2020-11-06 北京鑫开元医药科技有限公司 一种2-氨基-4-(异吲哚啉-2-基)嘧啶-5-甲酰胺衍生物、制备方法及应用
CN112107580A (zh) * 2020-09-29 2020-12-22 北京鑫开元医药科技有限公司 一种脾酪氨酸激酶抑制剂的制剂组合物及其制备方法
CN113557237A (zh) * 2019-01-18 2021-10-26 沃若诺伊公司 吡咯并吡啶衍生物及其预防或治疗蛋白激酶相关疾病的用途
CN113717194A (zh) * 2020-05-25 2021-11-30 上海翰森生物医药科技有限公司 杂芳类衍生物的盐及其制备方法
CN113717202A (zh) * 2020-05-25 2021-11-30 上海翰森生物医药科技有限公司 杂芳类衍生物的自由碱晶型及其制备方法
WO2021238908A1 (zh) * 2020-05-25 2021-12-02 上海翰森生物医药科技有限公司 杂芳类衍生物的盐、晶型及其制备方法
WO2022228511A1 (zh) * 2021-04-30 2022-11-03 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的稠环化合物及其制备方法和用途
WO2024099229A1 (zh) * 2022-11-09 2024-05-16 沈阳药科大学 2-氨基嘧啶类化合物及其用途

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KR20140097446A (ko) 2006-11-20 2014-08-06 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 통증 및 소양증 치료용 방법, 조성물 및 키트
JP2010518083A (ja) * 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション ピペリジン誘導体
US8063058B2 (en) 2008-04-16 2011-11-22 Portola Pharmaceuticals, Inc. Inhibitors of syk and JAK protein kinases
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
AU2009248923B2 (en) 2008-05-21 2015-01-29 Takeda Pharmaceutical Company Limited Phosphorous derivatives as kinase inhibitors
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
US20100048557A1 (en) * 2008-06-20 2010-02-25 Bing-Yan Zhu Triazolopyridine JAK Inhibitor Compounds and Methods
BRPI0909945A2 (pt) * 2008-06-20 2015-07-28 Genentech Inc "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase"
WO2010038081A2 (en) * 2008-10-03 2010-04-08 Astrazeneca Ab Heterocyclic derivatives and methods of use thereof
US8242248B2 (en) * 2009-03-23 2012-08-14 Nodality, Inc. Kits for multiparametric phospho analysis
CA2767646C (en) 2009-07-10 2019-01-29 President And Fellows Of Harvard College Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
EP2536689A1 (en) * 2010-02-17 2012-12-26 Amgen Inc. Aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain
TWI513694B (zh) 2010-05-11 2015-12-21 Amgen Inc 抑制間變性淋巴瘤激酶的嘧啶化合物
PL2589592T3 (pl) 2010-06-30 2019-03-29 Fujifilm Corporation Nowe pochodne nikotynamidu lub ich sole
US9586961B2 (en) 2010-07-09 2017-03-07 Leo Pharma A/S Homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
CN102372717B (zh) * 2010-08-20 2014-06-18 和记黄埔医药（上海）有限公司 吡咯并嘧啶类化合物及其用途
AU2011323484B2 (en) * 2010-11-01 2016-10-06 Portola Pharmaceuticals, Inc. Benzamides and nicotinamides as Syk modulators
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
CN102093364B (zh) 2011-01-07 2015-01-28 北京赛林泰医药技术有限公司 作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物
CN103476776B (zh) * 2011-01-07 2016-09-28 北京赛林泰医药技术有限公司 作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
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