CN101111512B - 生长素释放肽受体的大环调节剂 - Google Patents

生长素释放肽受体的大环调节剂 Download PDF

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Publication number
CN101111512B
CN101111512B CN2005800280726A CN200580028072A CN101111512B CN 101111512 B CN101111512 B CN 101111512B CN 2005800280726 A CN2005800280726 A CN 2005800280726A CN 200580028072 A CN200580028072 A CN 200580028072A CN 101111512 B CN101111512 B CN 101111512B
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conditioning agent
nnc
application
compound
ghs
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Expired - Fee Related
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CN2005800280726A
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Chinese (zh)
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CN101111512A (zh
Inventor
H·霍维达
M·彼得森
G·弗拉塞尔
M·拉马塞山
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Ocera Therapeutics Inc
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Tranzyme Pharma Inc
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Priority claimed from US10/872,142 external-priority patent/US7521420B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
CN2005800280726A 2004-06-18 2005-06-13 生长素释放肽受体的大环调节剂 Expired - Fee Related CN101111512B (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US10/872,142 US7521420B2 (en) 2003-06-18 2004-06-18 Macrocyclic antagonists of the motilin receptor
US10/872,142 2004-06-18
US62164204P 2004-10-26 2004-10-26
US60/621,642 2004-10-26
US62200504P 2004-10-27 2004-10-27
US60/622,005 2004-10-27
US60/622,055 2004-10-27
US64227105P 2005-01-07 2005-01-07
US60/642,271 2005-01-07
US11/149,731 2005-06-10
US11/149,731 US7476653B2 (en) 2003-06-18 2005-06-10 Macrocyclic modulators of the ghrelin receptor
PCT/US2005/020857 WO2006009674A1 (en) 2004-06-18 2005-06-13 Macrocyclic modulators of the ghrelin receptor

Publications (2)

Publication Number Publication Date
CN101111512A CN101111512A (zh) 2008-01-23
CN101111512B true CN101111512B (zh) 2013-05-01

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CN2005800280726A Expired - Fee Related CN101111512B (zh) 2004-06-18 2005-06-13 生长素释放肽受体的大环调节剂

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US (2) US7476653B2 (US20090221689A1-20090903-C00132.png)
EP (3) EP1773869B9 (US20090221689A1-20090903-C00132.png)
JP (1) JP5363726B2 (US20090221689A1-20090903-C00132.png)
CN (1) CN101111512B (US20090221689A1-20090903-C00132.png)
CA (1) CA2579726C (US20090221689A1-20090903-C00132.png)
ES (1) ES2393498T3 (US20090221689A1-20090903-C00132.png)
WO (1) WO2006009674A1 (US20090221689A1-20090903-C00132.png)

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US8334256B2 (en) 2012-12-18
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CN101111512A (zh) 2008-01-23
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