CH411910A - Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten - Google Patents

Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten

Info

Publication number
CH411910A
CH411910A CH1349060A CH1349060A CH411910A CH 411910 A CH411910 A CH 411910A CH 1349060 A CH1349060 A CH 1349060A CH 1349060 A CH1349060 A CH 1349060A CH 411910 A CH411910 A CH 411910A
Authority
CH
Switzerland
Prior art keywords
halogen
quinazoline
hydrogen
trifluoromethyl
solution
Prior art date
Application number
CH1349060A
Other languages
German (de)
English (en)
Inventor
Reeder Earl
Henryk Sternbach Leo
Keller Oscar
Steiger Norbert
Saucy Gabriel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to US80983A priority Critical patent/US3336295A/en
Priority to US149527A priority patent/US3136815A/en
Priority to US154921A priority patent/US3371085A/en
Priority to US502510A priority patent/US3344183A/en
Publication of CH411910A publication Critical patent/CH411910A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/74Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/26Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CH1349060A 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten CH411910A (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US80983A US3336295A (en) 1960-12-02 1961-01-06 Hydroxy or alkoxy substituted 5-phenyl-3h-1, 4-benzodiazepin-2(1h)-ones
US149527A US3136815A (en) 1959-12-10 1961-11-02 Amino substituted benzophenone oximes and derivatives thereof
US154921A US3371085A (en) 1959-12-10 1961-11-20 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
US502510A US3344183A (en) 1960-12-02 1965-10-22 2 n-substituted amino benzophenones

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
CH411910A true CH411910A (de) 1966-04-30

Family

ID=27485190

Family Applications (9)

Application Number Title Priority Date Filing Date
CH1349060A CH411910A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten
CH1349160A CH408029A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepinen
CH1349360A CH418342A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepinen
CH1348960A CH408940A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten
CH1349460A CH414652A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten
CH1230565A CH408045A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von Benzophenonderivaten
CH1349260A CH418341A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepinen
CH1349560A CH414653A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten
CH1389960A CH396016A (de) 1959-12-10 1960-12-13 Verfahren zur Herstellung von fluorhaltigen Benzodiazepinen

Family Applications After (8)

Application Number Title Priority Date Filing Date
CH1349160A CH408029A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepinen
CH1349360A CH418342A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepinen
CH1348960A CH408940A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten
CH1349460A CH414652A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten
CH1230565A CH408045A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von Benzophenonderivaten
CH1349260A CH418341A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepinen
CH1349560A CH414653A (de) 1959-12-10 1960-12-02 Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten
CH1389960A CH396016A (de) 1959-12-10 1960-12-13 Verfahren zur Herstellung von fluorhaltigen Benzodiazepinen

Country Status (11)

Country Link
BE (4) BE598012A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR6024755D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (9) CH411910A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (1) CY324A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (5) DE1290143B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (2) ES263123A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (13) GB972962A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY6500178A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (2) NL6412251A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
OA (7) OA00817A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (2) SE310887B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1295563B (de) * 1963-05-29 1969-05-22 American Home Prod Verfahren zur Herstellung von 5-Phenyl-7-chlor-1, 2-dihydro-3H-1, 4-benzodiazepinon-(2)-4-oxyd
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
AU2002317910B2 (en) 2001-06-07 2008-06-19 Via Pharmaceuticals, Inc. Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
MXPA04011465A (es) * 2002-05-24 2005-02-14 Millennium Pharm Inc Inhibidores de ccr9 y metodos de uso de los mismos.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
NL6412250A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1966-01-25
OA00817A (fr) 1967-11-15
OA00959A (fr) 1968-03-22
CH418342A (de) 1966-08-15
BE598013A (fr) 1961-06-09
GB972968A (en) 1964-10-21
GB972964A (en) 1964-10-21
GB972967A (en) 1964-10-21
NL6412251A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1966-01-25
GB972962A (en) 1964-10-21
GB972961A (en) 1964-10-21
GB972976A (en) 1964-10-21
GB972970A (en) 1964-10-21
BE598008A (fr) 1961-06-09
GB972963A (en) 1964-10-21
OA02385A (fr) 1970-05-05
ES263124A1 (es) 1961-06-01
CH418341A (de) 1966-08-15
CH408029A (de) 1966-02-28
BE598015A (fr) 1961-06-09
MY6500178A (en) 1965-12-31
BE598012A (fr) 1961-06-09
ES263123A1 (es) 1961-06-01
CH414653A (de) 1966-06-15
GB972973A (en) 1964-10-21
SE310887B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1969-05-19
CH396016A (de) 1965-07-31
DE1290143B (de) 1969-03-06
DE1288610B (de) 1969-02-06
DE1445908A1 (de) 1969-04-17
SE318283B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1969-12-08
OA00953A (fr) 1968-03-22
DE1288609B (de) 1969-02-06
CH408045A (de) 1966-02-28
CY324A (en) 1965-11-03
GB972969A (en) 1964-10-21
GB972966A (en) 1964-10-21
OA00958A (fr) 1968-03-22
GB972965A (en) 1964-10-21
GB972972A (en) 1964-10-21
CH414652A (de) 1966-06-15
BR6024755D0 (pt) 1973-05-24
OA02384A (fr) 1970-05-05
DE1445073A1 (de) 1968-10-31
CH408940A (de) 1966-03-15
OA00816A (fr) 1967-11-15

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