ES263123A1 - Un procedimiento para la fabricaciën de derivados de 1,4-benzodiazepinas - Google Patents

Un procedimiento para la fabricaciën de derivados de 1,4-benzodiazepinas

Info

Publication number
ES263123A1
ES263123A1 ES0263123A ES263123A ES263123A1 ES 263123 A1 ES263123 A1 ES 263123A1 ES 0263123 A ES0263123 A ES 0263123A ES 263123 A ES263123 A ES 263123A ES 263123 A1 ES263123 A1 ES 263123A1
Authority
ES
Spain
Prior art keywords
amino
substituent
nitro
halogeno
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0263123A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES263123A1 publication Critical patent/ES263123A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ES0263123A 1959-12-10 1960-12-09 Un procedimiento para la fabricaciën de derivados de 1,4-benzodiazepinas Expired ES263123A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
ES263123A1 true ES263123A1 (es) 1961-06-01

Family

ID=27485190

Family Applications (2)

Application Number Title Priority Date Filing Date
ES0263124A Expired ES263124A1 (es) 1959-12-10 1960-12-09 Un procedimiento para la fabricaciën de derivados de 1,4-benzodiazepinas
ES0263123A Expired ES263123A1 (es) 1959-12-10 1960-12-09 Un procedimiento para la fabricaciën de derivados de 1,4-benzodiazepinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES0263124A Expired ES263124A1 (es) 1959-12-10 1960-12-09 Un procedimiento para la fabricaciën de derivados de 1,4-benzodiazepinas

Country Status (11)

Country Link
BE (4) BE598015A (es)
BR (1) BR6024755D0 (es)
CH (9) CH408045A (es)
CY (1) CY324A (es)
DE (5) DE1290143B (es)
ES (2) ES263124A1 (es)
GB (13) GB972968A (es)
MY (1) MY6500178A (es)
NL (2) NL6412251A (es)
OA (7) OA00817A (es)
SE (2) SE310887B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795231C3 (de) * 1963-05-29 1978-07-13 American Home Products Corp., New York, N.Y. (V.St.A.) Verfahren zur Herstellung von 5-Aryl-1,2-dihydro -3H-1,4-benzodiazepin-2-on-4-oxyden
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
IL159105A0 (en) * 2001-06-07 2004-05-12 Neuro3D Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
EP1507756B1 (en) * 2002-05-24 2015-07-22 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
OA02385A (fr) 1970-05-05
MY6500178A (en) 1965-12-31
GB972968A (en) 1964-10-21
OA00816A (fr) 1967-11-15
OA00817A (fr) 1967-11-15
GB972972A (en) 1964-10-21
DE1445073A1 (de) 1968-10-31
NL6412250A (es) 1966-01-25
OA00959A (fr) 1968-03-22
GB972976A (en) 1964-10-21
GB972965A (en) 1964-10-21
DE1288609B (de) 1969-02-06
BE598015A (fr) 1961-06-09
CH408045A (de) 1966-02-28
BE598008A (fr) 1961-06-09
GB972970A (en) 1964-10-21
BE598012A (fr) 1961-06-09
OA00958A (fr) 1968-03-22
GB972966A (en) 1964-10-21
ES263124A1 (es) 1961-06-01
BE598013A (fr) 1961-06-09
DE1288610B (de) 1969-02-06
CH418342A (de) 1966-08-15
GB972963A (en) 1964-10-21
CH396016A (de) 1965-07-31
GB972973A (en) 1964-10-21
SE310887B (es) 1969-05-19
CH418341A (de) 1966-08-15
GB972969A (en) 1964-10-21
DE1290143B (de) 1969-03-06
CY324A (en) 1965-11-03
GB972964A (en) 1964-10-21
DE1445908A1 (de) 1969-04-17
CH408940A (de) 1966-03-15
GB972962A (en) 1964-10-21
CH411910A (de) 1966-04-30
SE318283B (es) 1969-12-08
CH408029A (de) 1966-02-28
GB972961A (en) 1964-10-21
CH414652A (de) 1966-06-15
OA02384A (fr) 1970-05-05
CH414653A (de) 1966-06-15
BR6024755D0 (pt) 1973-05-24
GB972967A (en) 1964-10-21
OA00953A (fr) 1968-03-22
NL6412251A (es) 1966-01-25

Similar Documents

Publication Publication Date Title
ES8303285A1 (es) Procedimiento para preparar una acilanilida. (como desglose y con prioridad de la patente espanola n 502.411, presentada el 22 de mayo de 1981.
GB1059146A (en) 1-aryl-3-anilino-5-pyrazolone derivatives and their use in colour development processes
ES263123A1 (es) Un procedimiento para la fabricaciën de derivados de 1,4-benzodiazepinas
GB965009A (en) New 2,3-dimercapto-quinoxalines
DE69807073D1 (de) Herstellung von tri-iodo-benzol-verbindungen
ES470738A1 (es) Procedimiento para la obtencion de nuevos derivados de ni- trosourea
GB866843A (en) Sulphonamidopyrimidines
GB532804A (en) Improvements in or relating to colour photography
GB1531161A (en) Process for the preparation of 2-(4'-amino-phenyl)-6-amino-benzimidazole
Tanaka et al. N-Acyl-1-chloro-2, 2, 2-trifluoroethylamine as a 2, 2, 2-Trifluoroethylamine-Building Block.
ES477727A1 (es) Procedimiento para la preparacion de sales metalicas de mo- no y di-nitrodihidroxidiazobencenos.
GB1139458A (en) 2-phenylamino-2-oxazolines and their production
GB1138530A (en) 2-phenylamino-2-oxazolines and their production
GB1419243A (en) Dimorpholinomethyl cyclohexenes and their use in a process for the manufacture of aldehydes
ES477191A1 (es) Un procedimiento para preparar derivados de piridina.
ES427185A1 (es) Un metodo de preparacion de butiramidas de oxi-iminocarba- moilaficidas y butiratos de oxi-iminocarbamoilo.
ES394761A1 (es) Un metodo de preparar un derivado de 2-amino-1,5-benzodia- zocina.
US2840567A (en) 1-(p-aminophenyl)-3-aminopyrazolines and process
GB1511669A (en) Dipeptide derivatives and their production
GB1109308A (en) Heterocyclic alkanoic acid amides
GB1386326A (en) Process for the production of quinazolines
ES441620A1 (es) Procedimiento para preparar 1-dimetilcarbamil-3-alcoholico ramificado-1,2,4-triazol-5 - il - sulfonamidas sustituidas en n.
GB984707A (en) Novel benzodiazepine derivatives and a process for the manufacture thereof
GB1185046A (en) Process for the Manufacture of Amine Derivatives
GB681095A (en) Propellent explosives having a high deflagration temperature