BE598015A - Procédé pour la préparation de dérivés de 1,4-benzodiazépine - Google Patents

Procédé pour la préparation de dérivés de 1,4-benzodiazépine

Info

Publication number
BE598015A
BE598015A BE598015A BE598015A BE598015A BE 598015 A BE598015 A BE 598015A BE 598015 A BE598015 A BE 598015A BE 598015 A BE598015 A BE 598015A BE 598015 A BE598015 A BE 598015A
Authority
BE
Belgium
Prior art keywords
preparation
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
BE598015A
Other languages
English (en)
Inventor
Earl Reeder
Leo Henryk Sternbach
Gabriel Saucy
Oscar Keller
Norbert Steiger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BE598015A publication Critical patent/BE598015A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/74Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/26Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BE598015A 1959-12-10 1960-12-09 Procédé pour la préparation de dérivés de 1,4-benzodiazépine BE598015A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85856459A 1959-12-10 1959-12-10
US260560A 1960-01-15 1960-01-15
US2468660A 1960-04-26 1960-04-26
US3873260A 1960-06-27 1960-06-27

Publications (1)

Publication Number Publication Date
BE598015A true BE598015A (fr) 1961-06-09

Family

ID=27485190

Family Applications (4)

Application Number Title Priority Date Filing Date
BE598013A BE598013A (fr) 1959-12-10 1960-12-09 Procédé pour la préparation de dérivés de 1,4-benzodiazépine
BE598015A BE598015A (fr) 1959-12-10 1960-12-09 Procédé pour la préparation de dérivés de 1,4-benzodiazépine
BE598012A BE598012A (fr) 1959-12-10 1960-12-09 Procédé pour la préparation de dérivés de 1,4-benzodiazépine
BE598008A BE598008A (fr) 1959-12-10 1960-12-09 Dérivés de 1,4-benzodiazépine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE598013A BE598013A (fr) 1959-12-10 1960-12-09 Procédé pour la préparation de dérivés de 1,4-benzodiazépine

Family Applications After (2)

Application Number Title Priority Date Filing Date
BE598012A BE598012A (fr) 1959-12-10 1960-12-09 Procédé pour la préparation de dérivés de 1,4-benzodiazépine
BE598008A BE598008A (fr) 1959-12-10 1960-12-09 Dérivés de 1,4-benzodiazépine

Country Status (11)

Country Link
BE (4) BE598013A (fr)
BR (1) BR6024755D0 (fr)
CH (9) CH408045A (fr)
CY (1) CY324A (fr)
DE (5) DE1288609B (fr)
ES (2) ES263123A1 (fr)
GB (13) GB972968A (fr)
MY (1) MY6500178A (fr)
NL (2) NL6412251A (fr)
OA (7) OA00817A (fr)
SE (2) SE310887B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1300114B (de) * 1963-05-29 1969-07-31 American Home Prod Verfahren zur Herstellung von 5-Chlor-2-(2'-hydroxylamino-acetamido)-benzophenon
GB1333501A (en) * 1971-03-05 1973-10-10 Ravizza Spa Process for the preparation of 7-chlorobenzodiazepine de rivatives
CA1332410C (fr) * 1984-06-26 1994-10-11 Roger M. Freidinger Analogues de benzodiazepines
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
WO2002098865A2 (fr) * 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
EP2402310A1 (fr) * 2002-05-24 2012-01-04 Millennium Pharmaceuticals, Inc. Inhibiteurs de CCR9 et leurs procédés dýutilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i

Also Published As

Publication number Publication date
ES263123A1 (es) 1961-06-01
OA00953A (fr) 1968-03-22
CH414653A (de) 1966-06-15
SE318283B (fr) 1969-12-08
DE1290143B (de) 1969-03-06
OA00959A (fr) 1968-03-22
GB972968A (en) 1964-10-21
CH396016A (de) 1965-07-31
GB972973A (en) 1964-10-21
CH414652A (de) 1966-06-15
CH418342A (de) 1966-08-15
CH408940A (de) 1966-03-15
CH418341A (de) 1966-08-15
BR6024755D0 (pt) 1973-05-24
MY6500178A (en) 1965-12-31
GB972962A (en) 1964-10-21
GB972963A (en) 1964-10-21
CH408029A (de) 1966-02-28
NL6412250A (fr) 1966-01-25
ES263124A1 (es) 1961-06-01
BE598012A (fr) 1961-06-09
BE598013A (fr) 1961-06-09
GB972970A (en) 1964-10-21
DE1288609B (de) 1969-02-06
CH408045A (de) 1966-02-28
CY324A (en) 1965-11-03
GB972972A (en) 1964-10-21
GB972969A (en) 1964-10-21
GB972961A (en) 1964-10-21
OA00958A (fr) 1968-03-22
GB972976A (en) 1964-10-21
NL6412251A (fr) 1966-01-25
GB972964A (en) 1964-10-21
BE598008A (fr) 1961-06-09
OA02385A (fr) 1970-05-05
OA02384A (fr) 1970-05-05
DE1445908A1 (de) 1969-04-17
OA00816A (fr) 1967-11-15
SE310887B (fr) 1969-05-19
OA00817A (fr) 1967-11-15
GB972965A (en) 1964-10-21
DE1288610B (de) 1969-02-06
GB972966A (en) 1964-10-21
DE1445073A1 (de) 1968-10-31
CH411910A (de) 1966-04-30
GB972967A (en) 1964-10-21

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