CH396016A - Verfahren zur Herstellung von fluorhaltigen Benzodiazepinen - Google Patents
Verfahren zur Herstellung von fluorhaltigen BenzodiazepinenInfo
- Publication number
- CH396016A CH396016A CH1389960A CH1389960A CH396016A CH 396016 A CH396016 A CH 396016A CH 1389960 A CH1389960 A CH 1389960A CH 1389960 A CH1389960 A CH 1389960A CH 396016 A CH396016 A CH 396016A
- Authority
- CH
- Switzerland
- Prior art keywords
- fluorine
- preparation
- containing benzodiazepines
- benzodiazepines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85856459A | 1959-12-10 | 1959-12-10 | |
| US260560A | 1960-01-15 | 1960-01-15 | |
| US2468660A | 1960-04-26 | 1960-04-26 | |
| US3873260A | 1960-06-27 | 1960-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH396016A true CH396016A (de) | 1965-07-31 |
Family
ID=27485190
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1349260A CH418341A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepinen |
| CH1348960A CH408940A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten |
| CH1230565A CH408045A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von Benzophenonderivaten |
| CH1349460A CH414652A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten |
| CH1349560A CH414653A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten |
| CH1349360A CH418342A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepinen |
| CH1349060A CH411910A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten |
| CH1349160A CH408029A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepinen |
| CH1389960A CH396016A (de) | 1959-12-10 | 1960-12-13 | Verfahren zur Herstellung von fluorhaltigen Benzodiazepinen |
Family Applications Before (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1349260A CH418341A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepinen |
| CH1348960A CH408940A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten |
| CH1230565A CH408045A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von Benzophenonderivaten |
| CH1349460A CH414652A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten |
| CH1349560A CH414653A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten |
| CH1349360A CH418342A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepinen |
| CH1349060A CH411910A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten |
| CH1349160A CH408029A (de) | 1959-12-10 | 1960-12-02 | Verfahren zur Herstellung von 1,4-Benzodiazepinen |
Country Status (11)
| Country | Link |
|---|---|
| BE (4) | BE598013A (de) |
| BR (1) | BR6024755D0 (de) |
| CH (9) | CH418341A (de) |
| CY (1) | CY324A (de) |
| DE (5) | DE1288609B (de) |
| ES (2) | ES263123A1 (de) |
| GB (13) | GB972962A (de) |
| MY (1) | MY6500178A (de) |
| NL (2) | NL6412250A (de) |
| OA (7) | OA00816A (de) |
| SE (2) | SE310887B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1300114B (de) * | 1963-05-29 | 1969-07-31 | American Home Prod | Verfahren zur Herstellung von 5-Chlor-2-(2'-hydroxylamino-acetamido)-benzophenon |
| GB1333501A (en) * | 1971-03-05 | 1973-10-10 | Ravizza Spa | Process for the preparation of 7-chlorobenzodiazepine de rivatives |
| CA1332410C (en) * | 1984-06-26 | 1994-10-11 | Roger M. Freidinger | Benzodiazepine analogs |
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| WO2002098865A2 (fr) * | 2001-06-07 | 2002-12-12 | Neuro3D | Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs |
| NZ536504A (en) * | 2002-05-24 | 2008-04-30 | Millennium Pharm Inc | CCR9 inhibitors and methods of use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2893992A (en) * | 1959-07-07 | I ii i i |
-
1960
- 1960-12-02 CH CH1349260A patent/CH418341A/de unknown
- 1960-12-02 CH CH1348960A patent/CH408940A/de unknown
- 1960-12-02 CH CH1230565A patent/CH408045A/de unknown
- 1960-12-02 CH CH1349460A patent/CH414652A/de unknown
- 1960-12-02 CH CH1349560A patent/CH414653A/de unknown
- 1960-12-02 CH CH1349360A patent/CH418342A/de unknown
- 1960-12-02 CH CH1349060A patent/CH411910A/de unknown
- 1960-12-02 CH CH1349160A patent/CH408029A/de unknown
- 1960-12-07 DE DEH41137A patent/DE1288609B/de active Pending
- 1960-12-07 DE DEH41139A patent/DE1288610B/de active Pending
- 1960-12-07 DE DEH41138A patent/DE1290143B/de active Pending
- 1960-12-07 BR BR124755/60A patent/BR6024755D0/pt unknown
- 1960-12-09 BE BE598013A patent/BE598013A/fr unknown
- 1960-12-09 BE BE598012A patent/BE598012A/fr unknown
- 1960-12-09 ES ES0263123A patent/ES263123A1/es not_active Expired
- 1960-12-09 GB GB42400/60A patent/GB972962A/en not_active Expired
- 1960-12-09 GB GB42405/60A patent/GB972967A/en not_active Expired
- 1960-12-09 GB GB42402/60A patent/GB972964A/en not_active Expired
- 1960-12-09 GB GB40978/62A patent/GB972972A/en not_active Expired
- 1960-12-09 GB GB42404/60A patent/GB972966A/en not_active Expired
- 1960-12-09 GB GB20071/63A patent/GB972976A/en not_active Expired
- 1960-12-09 GB GB42401/60A patent/GB972963A/en not_active Expired
- 1960-12-09 BE BE598015A patent/BE598015A/fr unknown
- 1960-12-09 GB GB42399/60A patent/GB972961A/en not_active Expired
- 1960-12-09 GB GB40979/62A patent/GB972973A/en not_active Expired
- 1960-12-09 GB GB42408/60A patent/GB972968A/en not_active Expired
- 1960-12-09 ES ES0263124A patent/ES263124A1/es not_active Expired
- 1960-12-09 GB GB42403/60A patent/GB972965A/en not_active Expired
- 1960-12-09 BE BE598008A patent/BE598008A/fr unknown
- 1960-12-13 CH CH1389960A patent/CH396016A/de unknown
- 1960-12-19 DE DE19601445073 patent/DE1445073A1/de active Pending
-
1961
- 1961-01-11 GB GB29834/62A patent/GB972970A/en not_active Expired
- 1961-01-11 GB GB1168/61A patent/GB972969A/en not_active Expired
-
1964
- 1964-09-10 DE DE19641445908 patent/DE1445908A1/de active Pending
- 1964-10-21 NL NL6412250A patent/NL6412250A/xx unknown
- 1964-10-21 NL NL6412251A patent/NL6412251A/xx unknown
- 1964-12-16 OA OA50895A patent/OA00816A/xx unknown
- 1964-12-16 OA OA50896A patent/OA00817A/xx unknown
- 1964-12-26 OA OA51054A patent/OA00959A/xx unknown
- 1964-12-26 OA OA51053A patent/OA00958A/xx unknown
- 1964-12-26 OA OA51048A patent/OA00953A/xx unknown
-
1965
- 1965-09-17 SE SE12149/65A patent/SE310887B/xx unknown
- 1965-11-03 CY CY32465A patent/CY324A/xx unknown
- 1965-12-31 MY MY1965178A patent/MY6500178A/xx unknown
-
1967
- 1967-03-30 OA OA52849A patent/OA02384A/xx unknown
- 1967-03-30 OA OA52850A patent/OA02385A/xx unknown
- 1967-11-15 SE SE1570567A patent/SE318283B/xx unknown
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