CA3010183A1 - Systems and methods for long term transdermal administration - Google Patents
Systems and methods for long term transdermal administration Download PDFInfo
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- CA3010183A1 CA3010183A1 CA3010183A CA3010183A CA3010183A1 CA 3010183 A1 CA3010183 A1 CA 3010183A1 CA 3010183 A CA3010183 A CA 3010183A CA 3010183 A CA3010183 A CA 3010183A CA 3010183 A1 CA3010183 A1 CA 3010183A1
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- mil
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- adhesive
- transdermal patch
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Classifications
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Landscapes
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- Heart & Thoracic Surgery (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| CA3028436A1 (en) | 2016-06-23 | 2017-12-28 | Corium International, Inc. | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| MX2019001104A (es) | 2016-07-27 | 2019-10-02 | Corium Int Inc | Sistemas de suministro transdermico de memantina. |
| WO2018022814A1 (en) | 2016-07-27 | 2018-02-01 | Corium International, Inc. | Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery |
| US9993466B2 (en) | 2016-07-27 | 2018-06-12 | Corium International, Inc. | Donepezil transdermal delivery system |
| EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| US11052054B2 (en) * | 2017-04-19 | 2021-07-06 | Inep Europe Sarl | Method for manufacturing a transdermal device |
| US20180303764A1 (en) * | 2017-04-19 | 2018-10-25 | Inep Europe Sarl | Method for manufacturing a transdermal device |
| CN111132669A (zh) * | 2017-07-26 | 2020-05-08 | 考里安公司 | 具有带溶剂填充孔的微孔膜的透皮递送系统 |
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| US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
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| CN112206222A (zh) * | 2018-11-09 | 2021-01-12 | 北京德默高科医药技术有限公司 | 含有布洛芬结构类似物的多层经皮给药系统 |
| CA3119992A1 (en) | 2018-11-16 | 2020-05-22 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| US12390422B2 (en) * | 2019-06-28 | 2025-08-19 | Passport Technologies, Inc. | Transdermal drug delivery patch, drug delivery system and drug delivery |
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Family Cites Families (265)
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| US1880808A (en) | 1927-03-28 | 1932-10-04 | Eastman Kodak Co | Process of making cellulose esters of carboxylic acids |
| US1683347A (en) | 1927-08-25 | 1928-09-04 | Eastman Kodak Co | Process of making chloroform-soluble cellulose acetate |
| US1698049A (en) | 1928-01-18 | 1929-01-08 | Eastman Kodak Co | Process of making cellulosic esters containing halogen-substituted fatty-acid groups |
| US1984147A (en) | 1929-10-22 | 1934-12-11 | Eastman Kodak Co | Process for the production of cellulose esters and corresponding alkyl esters |
| US1880560A (en) | 1929-12-14 | 1932-10-04 | Eastman Kodak Co | Process for the hydrolysis of cellulose acetate |
| US1943119A (en) | 1929-12-17 | 1934-01-09 | Westinghouse Electric & Mfg Co | Circuitous elevator |
| US1939729A (en) | 1930-01-29 | 1933-12-19 | Thomas W Cohill | Elevator system |
| US2129052A (en) | 1936-02-04 | 1938-09-06 | Eastman Kodak Co | Hydrolyzed cellulose acetate |
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| US3546141A (en) | 1966-08-08 | 1970-12-08 | Mc Donnell Douglas Corp | Phosphorus-nitrogen polymers and process |
| US3493319A (en) | 1967-05-26 | 1970-02-03 | Us Agriculture | Esterification of cellulosic textiles with unsaturated long chain fatty acids in the presence of trifluoroacetic anhydride using controlled cellulose-acid-anhydride ratios |
| US4004654A (en) | 1971-07-07 | 1977-01-25 | Trebron Holdings Limited | Elevator structure supporting apparatus |
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| DE2856393C2 (de) | 1978-12-27 | 1983-04-28 | Merz + Co GmbH & Co, 6000 Frankfurt | Arzneimittel zur Behandlung von Morbus Parkinson |
| US4752478A (en) | 1984-12-17 | 1988-06-21 | Merck & Co., Inc. | Transdermal system for timolol |
| ATE45735T1 (de) | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
| FR2576888B1 (fr) | 1985-02-05 | 1988-04-08 | Otis Elevator Co | Ascenseur transbordeur pour voies urbaines notamment |
| US4756710A (en) | 1985-04-05 | 1988-07-12 | Merck & Co., Inc. | pH-Mediated drug delivery system |
| US4880633A (en) | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4797284A (en) | 1986-03-12 | 1989-01-10 | Merck & Co., Inc. | Transdermal drug delivery system |
| DE3634016A1 (de) * | 1986-04-17 | 1987-10-29 | Lohmann Gmbh & Co Kg | Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung |
| ATE71287T1 (de) * | 1986-06-13 | 1992-01-15 | Alza Corp | Aktivierung eines transdermalen drogenabgabesystems durch feuchtigkeit. |
| US5686489A (en) | 1986-12-23 | 1997-11-11 | Tristrata Technology, Inc. | Alpha hydroxyacid esters for skin aging |
| US5071656A (en) | 1987-03-05 | 1991-12-10 | Alza Corporation | Delayed onset transdermal delivery device |
| US5538736A (en) * | 1987-04-28 | 1996-07-23 | Lts Lohmann Therapie-Systeme Gmbh | Active substance-containing plaster for the controlled administration of active substances to the skin |
| DE3714140A1 (de) * | 1987-04-28 | 1988-11-10 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges pflaster zur kontrollierten verabreichung von wirkstoffen an die haut, seine verwendung sowie verfahren zur gesteuerten verabreichung von wirkstoffen an die haut |
| US4787888A (en) | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| US4781924A (en) | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device |
| US4837027A (en) | 1987-11-09 | 1989-06-06 | Alza Corporation | Transdermal drug delivery device |
| US4849224A (en) | 1987-11-12 | 1989-07-18 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5026556A (en) | 1988-11-10 | 1991-06-25 | Norwich Eaton Pharmaceuticals, Inc. | Compositions for the transdermal delivery of pharmaceutical actives |
| US5202128A (en) | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
| CA2007181C (en) | 1989-01-06 | 1998-11-24 | Angelo Mario Morella | Sustained release pharmaceutical composition |
| ES2059602T3 (es) | 1989-04-14 | 1994-11-16 | Merz & Co Gmbh & Co | Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral. |
| DE3913734C2 (de) | 1989-04-26 | 1998-08-20 | Roehm Gmbh | Verwendung einer wäßrigen Hauthaftkleberlösung zur Herstellung einer mit Wasser leicht abwaschbaren Klebschicht |
| ATE107517T1 (de) | 1989-05-25 | 1994-07-15 | Takeda Chemical Industries Ltd | Transdermales therapeutisches mittel. |
| US5252588A (en) | 1990-04-27 | 1993-10-12 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation |
| ATE111351T1 (de) | 1990-07-23 | 1994-09-15 | Alza Corp | Oral anzuwendende osmotische vorrichtung zur abgabe von nicotin. |
| IT1243745B (it) | 1990-10-17 | 1994-06-21 | Vectorpharma Int | Composizioni terapeutiche transdermali contenenti farmaco e/o agente promotore dell'assorbimento cutaneo supportato su particelle microporose e microsfere polimeriche e loro preparazione. |
| US5614560A (en) | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| US5123900A (en) * | 1991-08-16 | 1992-06-23 | Bertek, Inc. | Moisture permeable double disk |
| US5246705A (en) | 1992-04-08 | 1993-09-21 | Cygnus Therapeutic System | Occlusive, elastomeric backing materials in transdermal drug delivery systems, and associated methods of manufacture and use |
| JPH06199659A (ja) | 1992-10-28 | 1994-07-19 | Hisamitsu Pharmaceut Co Inc | 経皮治療用装置 |
| US5612411A (en) * | 1992-11-18 | 1997-03-18 | Kimberly-Clark Corporation | Absorbent phycocolloids and a method for their manufacture |
| US5489624A (en) | 1992-12-01 | 1996-02-06 | Minnesota Mining And Manufacturing Company | Hydrophilic pressure sensitive adhesives |
| DE4310012A1 (de) | 1993-03-27 | 1994-09-29 | Roehm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung |
| JPH06321445A (ja) | 1993-05-10 | 1994-11-22 | Toshiba Corp | エレベータ |
| US5424077A (en) | 1993-07-13 | 1995-06-13 | Church & Dwight Co., Inc. | Co-micronized bicarbonate salt compositions |
| US5567489A (en) * | 1993-09-16 | 1996-10-22 | The Dow Chemical Company | Multilayer halogen-free barrier film for ostomy and transdermal drug delivery applications |
| JP3135760B2 (ja) | 1993-10-18 | 2001-02-19 | 株式会社竹中工務店 | エレベータシステム |
| JPH07187525A (ja) | 1993-11-18 | 1995-07-25 | Masami Sakita | 複数ばこエレベータシステム |
| JP4102901B2 (ja) | 1994-09-14 | 2008-06-18 | スリーエム カンパニー | 経皮薬剤導入用マトリックス |
| US5557018A (en) | 1994-09-27 | 1996-09-17 | E. I. Du Pont De Nemours And Company | Partially flourinated polymers and process therefor |
| US5635203A (en) | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
| CN1170360A (zh) | 1994-12-21 | 1998-01-14 | 瑟垃技术有限公司 | 具有粘性贴面和剥离密封圆片的经皮输送系统 |
| US5785991A (en) * | 1995-06-07 | 1998-07-28 | Alza Corporation | Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate |
| WO1996040087A2 (en) | 1995-06-07 | 1996-12-19 | Cygnus, Inc. | Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group |
| US5730900A (en) | 1995-06-08 | 1998-03-24 | Fuji Photo Film Co., Ltd. | Film and process for preparation of the same and liquid crystal display |
| US5601156A (en) | 1995-11-29 | 1997-02-11 | Otis Elevator Company | Maintaining communications and power during transfer of horizontally moveable elevator cab |
| US5785153A (en) | 1995-11-29 | 1998-07-28 | Otis Elevator Company | Synchronizing elevator arrival at a level of a building |
| US5651426A (en) | 1995-11-29 | 1997-07-29 | Otis Elevator Company | Synchronous elevator shuttle system |
| US5758748A (en) | 1995-11-29 | 1998-06-02 | Otis Elevator Company | Synchronized off-shaft loading of elevator cabs |
| US5702720A (en) | 1995-12-22 | 1997-12-30 | Minnesota Mining And Manufacturing Company | Transdermal device for the delivery of flurbiprofen |
| US6929801B2 (en) | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
| TW513409B (en) | 1996-06-07 | 2002-12-11 | Eisai Co Ltd | Polymorphs of donepezil hydrochloride |
| US5861586A (en) | 1996-06-19 | 1999-01-19 | Otis Elevator Company | Horizontal and vertical passenger transport |
| US6512010B1 (en) | 1996-07-15 | 2003-01-28 | Alza Corporation | Formulations for the administration of fluoxetine |
| US5752585A (en) | 1996-07-25 | 1998-05-19 | Otis Elevator Company | Elevator shuttle with auxiliary elevators at terminals |
| US5924524A (en) | 1996-07-25 | 1999-07-20 | Otis Elevator Company | Integrated, multi-level elevator shuttle |
| US5958919A (en) | 1996-09-20 | 1999-09-28 | Washington University | Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration |
| ATE229817T1 (de) | 1996-10-24 | 2003-01-15 | Alza Corp | Penetrationsfördernde substanzen für die transdermale verabreichung von wirkstoffen, vorrichtungen und verfahren zur herstellung |
| CN1174031A (zh) | 1997-04-23 | 1998-02-25 | 谢先运 | 双氯芬酸钠透皮控释贴膏 |
| US5866585A (en) | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
| US6174545B1 (en) | 1997-07-01 | 2001-01-16 | Alza Corporation | Drug delivery devices and process of manufacture |
| US20040018241A1 (en) | 1997-09-26 | 2004-01-29 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| US6193993B1 (en) | 1998-03-03 | 2001-02-27 | Eisai Co., Ltd. | Suppository containing an antidementia medicament |
| JP4205778B2 (ja) | 1998-04-17 | 2009-01-07 | 久光製薬株式会社 | 貼付製剤 |
| DE19820999A1 (de) * | 1998-05-11 | 1999-11-18 | Lohmann Therapie Syst Lts | Laminat zum Aufbringen auf einen Akzeptor |
| US6225348B1 (en) | 1998-08-20 | 2001-05-01 | Alfred W. Paulsen | Method of treating macular degeneration with a prostaglandin derivative |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| AU5409699A (en) | 1999-07-05 | 2001-01-22 | Idea Ag | A method for the improvement of transport across adaptable semi-permeable barriers |
| US6562368B2 (en) | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
| US20020192243A1 (en) | 1999-12-16 | 2002-12-19 | Tsung-Min Hsu | Transdermal and topical administration of drugs for the treatment of Alzheimer's disease using basic enhancers |
| US6455066B1 (en) | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
| DE60142900D1 (de) | 2000-07-07 | 2010-10-07 | Corium Internat Inc | Herstellung von hydrophilen druckempfindlichen klebstoffen mit optimalen hafteigenschaften |
| US7276249B2 (en) | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| JP3962684B2 (ja) | 2000-11-06 | 2007-08-22 | サムヤン コーポレイション | 改善された水分吸収能および接着性を有する経皮投与剤 |
| JP4057418B2 (ja) | 2000-11-07 | 2008-03-05 | 久光製薬株式会社 | 経皮吸収型製剤 |
| JP4850346B2 (ja) | 2001-03-15 | 2012-01-11 | 救急薬品工業株式会社 | 粘膜貼付剤 |
| US20020182237A1 (en) | 2001-03-22 | 2002-12-05 | The Procter & Gamble Company | Skin care compositions containing a sugar amine |
| US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
| EP1390085B1 (en) | 2001-05-01 | 2009-08-05 | A.V. Topchiev Institute of Petrochemical Synthesis | Hydrogel compositions |
| US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
| US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
| US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
| ATE502657T1 (de) | 2001-05-01 | 2011-04-15 | Av Topchiev Inst Petrochemical | Zweiphasige, wasserabsorbierende bioadhäsive zusammenstezung |
| US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
| US20040024028A1 (en) | 2001-08-02 | 2004-02-05 | Burton Steven L. | Method for reducing or eliminating smoking |
| NL1018729C2 (nl) | 2001-08-09 | 2003-02-11 | Tms Internat B V | Flexibele aansluitmodule en modulair systeem voor het meten en doorgeven van sensorsignalen. |
| US7250394B2 (en) | 2001-08-20 | 2007-07-31 | Maiken Nedergaard | Treatment of glial tumors with glutamate antagonists |
| JP2005501883A (ja) | 2001-09-04 | 2005-01-20 | トロムスドルフ ゲーエムベーハー ウント コンパニー カーゲー アルツナイミッテル | セルタコナゾールを含む爪の機能障害および疾患の治療用の膏薬 |
| DE10159745A1 (de) | 2001-12-05 | 2003-07-03 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit verbessertem Langzeittragekomfort |
| ITMI20012827A1 (it) | 2001-12-28 | 2003-06-28 | Fidia Farmaceutici | Formulazioni adesive transdermiche di diclofenac sodico |
| US7273619B2 (en) | 2002-01-17 | 2007-09-25 | Samyang Corporation | Transdermal composition of an antivomiting agent |
| US7217853B2 (en) | 2002-05-24 | 2007-05-15 | Corium International, Inc. | Composition for cushions, wound dressings and other skin-contacting products |
| SG102714A1 (en) | 2002-05-27 | 2004-03-26 | Inventio Ag | Elevator installation with several self-propelled cars and at least three elevator hoistways situated adjacently |
| CN100340395C (zh) | 2002-08-30 | 2007-10-03 | 阿尔扎公司 | 多层层压背衬结构体 |
| CN100339070C (zh) | 2002-10-24 | 2007-09-26 | 莫茨药物股份两合公司 | 包含1-氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物 |
| ATE352508T1 (de) | 2002-11-26 | 2007-02-15 | Thyssenkrupp Elevator Ag | Verfahren zur steuerung einer aufzuganlage sowie aufzuganlage zur durchführung des verfahrens |
| ME00147B (me) | 2003-02-21 | 2010-10-10 | Schering Ag | Uv-stabilni transdermalni flasteri |
| US7294376B2 (en) | 2003-08-26 | 2007-11-13 | The Goodyear Tire & Rubber Company | Tire with indicia |
| EP1526103B1 (de) | 2003-10-09 | 2012-01-11 | Inventio AG | Aufzugsanlage mit mehrstöckigen Kabinen für den Zonenbetrieb in einem Gebäude |
| PL1670433T3 (pl) | 2003-10-10 | 2013-03-29 | Ferring Bv | Przezskórna formulacja farmaceutyczna do zmniejszania pozostałości na skórze |
| WO2005037157A1 (en) | 2003-10-14 | 2005-04-28 | Dermatrends, Inc. | Enhancing transdermal administration of hydrophilic drugs |
| CN1870984A (zh) | 2003-10-22 | 2006-11-29 | 莫茨药物股份两合公司 | 1-氨基环己烷衍生物用于调节淀粉样病变中原纤维生成Aβ肽的沉积的用途 |
| EP1952824A1 (en) | 2003-11-21 | 2008-08-06 | Memory Pharmaceuticals Corporation | Compositions and methods of treatment using L-type calcium channel blockers and cholinesterase inhibitors |
| US7176185B2 (en) | 2003-11-25 | 2007-02-13 | Tsrl, Inc. | Short peptide carrier system for cellular delivery of agent |
| CN102764247B (zh) | 2004-01-30 | 2016-04-20 | 考里安国际公司 | 递送活性剂的快速溶解膜 |
| EP1715853A4 (en) | 2004-02-17 | 2012-07-18 | Transcept Pharmaceuticals Inc | COMPOSITIONS FOR THE DISTRIBUTION OF HYPNOTICS IN THE FIELD OF MUNICHCHLEIMHÄUTE AND USE METHOD THEREOF |
| DE102004010516A1 (de) | 2004-03-04 | 2005-09-22 | Bayer Technology Services Gmbh | Verbessertes Verfahren zur zeitlichen Dosierung von Arzneistoffen |
| US7670838B2 (en) | 2004-05-24 | 2010-03-02 | The Board Of Trustees Of The Leland Stanford Junior University | Coupling of excitation and neurogenesis in neural stem/progenitor cells |
| JPWO2005115355A1 (ja) | 2004-05-28 | 2008-03-27 | 久光製薬株式会社 | 貼付製剤 |
| TW200616608A (en) | 2004-07-09 | 2006-06-01 | Forest Laboratories | Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients |
| EP1616832A3 (de) | 2004-07-15 | 2006-07-12 | Inventio Ag | Auzugsanlage mit mindestens drei nebeneinander angeordneten, vertikalen Aufzugsschächten und Verfahren zum Betreiben einer solchen Aufzugsanlage |
| TWI343357B (en) | 2004-07-22 | 2011-06-11 | Inventio Ag | Elevator installation with individually movable elevator cars and method for operating such an elevator installation |
| WO2006017807A2 (en) | 2004-08-05 | 2006-02-16 | Corium International, Inc. | Adhesive composition |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| MX2007004315A (es) | 2004-10-08 | 2008-03-11 | Noven Pharma | Dispositivo para suministro transdermico de farmaco que incluye un respaldo oclusivo. |
| EP1661560B1 (en) | 2004-11-22 | 2008-11-05 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal patch comprising a melting point lowering agent |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| US20060171906A1 (en) | 2004-12-21 | 2006-08-03 | Corium International, Inc. | Sustained release tooth whitening formulations and systems |
| US20060205822A1 (en) | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| US7462743B2 (en) | 2005-01-11 | 2008-12-09 | Teva Pharmaceutical Fine Chemicals S.R.L. | Polymorphs of memantine hydrochloride |
| US20060163008A1 (en) | 2005-01-24 | 2006-07-27 | Michael Godwin | Autonomous linear retarder/motor for safe operation of direct drive gearless, rope-less elevators |
| JP5084496B2 (ja) | 2005-02-04 | 2012-11-28 | 久光製薬株式会社 | 経皮吸収貼付剤 |
| US20060188558A1 (en) | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
| BRPI0607017B8 (pt) | 2005-04-06 | 2021-05-25 | Adamas Pharmaceuticals Inc | composição farmacêutica compreendendo memantina e donezepil, e seu uso para o tratamento de condições relacionadas ao snc |
| EP1885741B1 (en) | 2005-04-27 | 2011-09-14 | Sederma S.A.S. | Lys-thr dipeptides and their use |
| US7888422B2 (en) | 2005-11-09 | 2011-02-15 | Mylan Technologies Inc. | Long-wearing removable pressure sensitive adhesive |
| EP2001671B1 (en) | 2006-03-28 | 2010-05-19 | Amcor Flexibles Transpac B.V.B.A. | A multilayer film free of halogens which is impermeable to aroma compounds |
| CN1895242B (zh) | 2006-04-13 | 2011-08-31 | 沈阳药科大学 | 双氯芬酸盐的透皮贴剂及制备方法 |
| IL175338A0 (en) | 2006-05-01 | 2006-09-05 | Biota Ltd | Orally administrable films and preparation thereof |
| US20070259029A1 (en) | 2006-05-08 | 2007-11-08 | Mcentire Edward Enns | Water-dispersible patch containing an active agent for dermal delivery |
| ES2466647T3 (es) | 2006-05-08 | 2014-06-10 | Teikoku Seiyaku Co., Ltd. | Preparación absorbible por vía transdérmica que comprende un agente contra la demencia |
| JP5097359B2 (ja) | 2006-05-09 | 2012-12-12 | 久光製薬株式会社 | ドネペジル経皮吸収型製剤 |
| WO2007132476A2 (en) | 2006-05-15 | 2007-11-22 | Matrix Laboratories Limited | A process for the preparation of memantine hydrochloride |
| TW200815045A (en) | 2006-06-29 | 2008-04-01 | Jazz Pharmaceuticals Inc | Pharmaceutical compositions of ropinirole and methods of use thereof |
| US9248104B2 (en) | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
| WO2008024408A2 (en) | 2006-08-22 | 2008-02-28 | Theraquest Biosciences, Inc. | Pharmaceutical formulations of cannabinoids for application to the skin and method of use |
| EP2117521B1 (en) | 2006-11-03 | 2012-06-27 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| US20080107719A1 (en) | 2006-11-08 | 2008-05-08 | Sukhon Likitlersuang | Transdermal drug delivery system |
| BRPI0719351A2 (pt) | 2006-12-01 | 2014-01-07 | Nitto Denko Corp | Preparação adesiva estabilizada contendo donezepil |
| KR101408488B1 (ko) | 2006-12-01 | 2014-06-17 | 닛토덴코 가부시키가이샤 | 도네페질 함유 접착 제제의 경시적인 변색을 억제하는 방법 |
| CN101573115B (zh) | 2006-12-01 | 2012-06-06 | 日东电工株式会社 | 抑制含有多奈哌齐的贴剂着色的方法、及降低多奈哌齐类似物的生成量的方法 |
| US20080226698A1 (en) | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
| JP2008259629A (ja) | 2007-04-11 | 2008-10-30 | Hakujuji Co Ltd | 傷保護材 |
| JP5403948B2 (ja) | 2007-06-07 | 2014-01-29 | 久光製薬株式会社 | メマンチン含有経皮吸収製剤 |
| BRPI0814697B8 (pt) | 2007-07-10 | 2021-05-25 | Agile Therapeutics Inc | dispositivo de liberação de fármacos |
| WO2009026135A2 (en) | 2007-08-17 | 2009-02-26 | Alza Corporation | Controlled transdermal bisoprolol delivery system |
| US9017301B2 (en) | 2007-09-04 | 2015-04-28 | Mylan Technologies, Inc. | Transdermal drug delivery systems comprising a coated release liner |
| CN100560157C (zh) * | 2007-11-13 | 2009-11-18 | 重庆市生力医疗设备有限公司 | 超声波药贴 |
| JP2009203213A (ja) | 2008-02-28 | 2009-09-10 | Kosumedei Seiyaku Kk | 経皮吸収医薬組成物 |
| DE102008013701A1 (de) | 2008-03-11 | 2009-09-17 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System mit stabilisierter Membran |
| KR101454362B1 (ko) | 2008-03-24 | 2014-10-23 | 아이큐어 주식회사 | 도네페질을 유효성분으로 함유하는 치매 치료용경피흡수제제 |
| EP2111857A1 (de) | 2008-04-25 | 2009-10-28 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff hiervon |
| US20090291127A1 (en) | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| EP2279739B2 (en) | 2008-05-30 | 2018-02-28 | Nitto Denko Corporation | Donepezil-containing patch preparation and packaging thereof |
| MX2010013847A (es) * | 2008-06-13 | 2011-03-15 | Oragenics Inc | Uso de bacteria productora de peroxido de hidrogeno para blanquear dientes. |
| TW201006625A (en) | 2008-08-06 | 2010-02-16 | Hou-Fei Hu | Tool chuck for screwdriver |
| PE20100371A1 (es) | 2008-10-31 | 2010-06-01 | Lexicon Pharmaceuticals Inc | Agonistas del receptor s1p para el tratamiento de malaria cerebral |
| EP2196197A1 (en) | 2008-12-15 | 2010-06-16 | Bouty S.P.A. | Antiviral patch |
| US20100178037A1 (en) | 2009-01-12 | 2010-07-15 | Te-Wei Chen | Display apparatus, video generation apparatus, and method thereof |
| AU2010204986B2 (en) | 2009-01-14 | 2016-06-02 | Corium International, Inc. | Transdermal administration of tamsulosin |
| CN101518599A (zh) * | 2009-03-24 | 2009-09-02 | 沈阳药科大学 | 祖师麻提取物缓释贴剂及其制备方法 |
| JP5758290B2 (ja) | 2009-05-01 | 2015-08-05 | 久光製薬株式会社 | 経皮吸収型製剤 |
| KR101325104B1 (ko) | 2009-09-16 | 2013-11-07 | 주식회사 삼양바이오팜 | 경피 투여 제형 및 그 제조 방법 |
| ES2652491T3 (es) | 2009-10-21 | 2018-02-02 | Teikoku Seiyaku Co., Ltd. | Preparación que contiene donepecilo de absorción transdérmica |
| CN102048678A (zh) | 2009-10-30 | 2011-05-11 | 北京隆旗生物科技有限公司 | 一种奥昔布宁的透皮吸收制剂及其制备方法与药物应用 |
| GB0921481D0 (en) | 2009-12-08 | 2010-01-20 | Vectura Ltd | Process and product |
| JP2012236773A (ja) | 2009-12-16 | 2012-12-06 | Goto Takeshi | 抗認知症薬物の経皮吸収製剤 |
| PT2519225E (pt) | 2009-12-30 | 2015-07-27 | Novartis Ag | Tiras finas de nicotina extrudidas por fusão |
| US20100178307A1 (en) | 2010-01-13 | 2010-07-15 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| US9370495B2 (en) | 2010-02-24 | 2016-06-21 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive patch |
| US20110244023A1 (en) | 2010-03-30 | 2011-10-06 | Phosphagenics Limited | Transdermal delivery patch |
| JP5665861B2 (ja) | 2010-04-28 | 2015-02-04 | 久光製薬株式会社 | ドネペジル含有経皮吸収製剤 |
| US9012511B2 (en) | 2010-05-19 | 2015-04-21 | Alkermes Pharma Ireland Limited | Nanoparticulate cinacalcet compositions |
| DE102010024105A1 (de) | 2010-06-17 | 2011-12-22 | Grünenthal GmbH | Transdermale Verabreichung von Memantin |
| US20140370076A1 (en) | 2010-06-30 | 2014-12-18 | Nal Pharmaceuticals, Ltd. | Transdermal drug delivery system containing donepezil |
| NZ605352A (en) | 2010-06-30 | 2013-10-25 | Nal Pharmaceuticals Ltd | Process for producing glycosaminoglycans |
| EP2599501B1 (en) | 2010-07-29 | 2014-11-12 | Hisamitsu Pharmaceutical Co., Inc. | Medical adhesive patch |
| EP3434257A1 (en) | 2010-07-29 | 2019-01-30 | Allergan, Inc. | Preservative free brimonidine and timolol solutions |
| BR112013008985A2 (pt) | 2010-10-12 | 2016-07-05 | Cerecor Inc | composições antitussígenas compreendendo memantina |
| JP5813652B2 (ja) | 2010-10-28 | 2015-11-17 | 久光製薬株式会社 | 経皮吸収型製剤 |
| JP5699554B2 (ja) | 2010-11-11 | 2015-04-15 | 富士通株式会社 | ベクトル処理回路、命令発行制御方法、及びプロセッサシステム |
| US9844515B2 (en) | 2010-11-17 | 2017-12-19 | Hexal Ag | Transdermal therapeutic system comprising buprenorphine |
| WO2012084969A1 (en) | 2010-12-22 | 2012-06-28 | Hexal Ag | Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition |
| EA201390980A1 (ru) | 2010-12-29 | 2013-11-29 | Фармафилм С.Р.Л. | Лекарственный пластырь для улучшенного трансдермального проникновения диклофенака диэтиламмония |
| TWI433904B (zh) | 2011-01-12 | 2014-04-11 | Taiwan Biotech Co Ltd | 多奈哌齊經皮貼片 |
| CN102775476B (zh) | 2011-05-12 | 2015-01-07 | 上海天伟生物制药有限公司 | 一种米卡芬净钠盐的制备方法 |
| US8673338B2 (en) | 2011-07-29 | 2014-03-18 | Massachusetts Eye And Ear Infirmary | Methods of delivering pharmaceutical agents |
| JP5820207B2 (ja) | 2011-09-13 | 2015-11-24 | 日東電工株式会社 | 経皮吸収促進用組成物および貼付製剤 |
| JP5808214B2 (ja) | 2011-09-30 | 2015-11-10 | 株式会社トクヤマ | 貼付剤 |
| WO2013078608A1 (en) | 2011-11-29 | 2013-06-06 | Ziqiang Gu | Donepezil pamoate and methods of making and using the same |
| JP6576039B2 (ja) | 2011-12-21 | 2019-09-18 | スリーエム イノベイティブ プロパティズ カンパニー | オーバーレイライナを有する粘着パッチ組立体、並びにそれを作製するためのシステム及び方法 |
| CA2861324A1 (en) | 2012-01-27 | 2013-08-01 | Agile Therapeutics, Inc. | Transdermal hormone delivery |
| KR101239150B1 (ko) | 2012-02-28 | 2013-03-06 | 에스케이케미칼주식회사 | 도네페질-함유 경피흡수제제 및 그의 제조방법 |
| US9408802B1 (en) | 2012-03-22 | 2016-08-09 | Prosolus, Inc. | Seven day drug in adhesive transdermal delivery |
| US20140256690A1 (en) | 2013-03-08 | 2014-09-11 | Agile Therapeutics, Inc. | Contraceptive method |
| US20140276479A1 (en) | 2013-03-14 | 2014-09-18 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery system with overlay |
| WO2014174564A1 (ja) | 2013-04-22 | 2014-10-30 | 祐徳薬品工業株式会社 | メマンチン含有経皮吸収型貼付製剤 |
| ITTV20130057A1 (it) | 2013-04-23 | 2014-10-24 | Tarcisio Scomparin | "sistema elevatore e traslatore con struttura a portale che impiega cremagliere e piu' vie di corsa verticali ed orizzontali di almeno una cabina di trasporto di persone e cose per il superamento di ostacoli sopraelevato e non." |
| JP5415645B1 (ja) | 2013-06-28 | 2014-02-12 | 久光製薬株式会社 | 貼付剤の製造方法、貼付剤及び包装体 |
| WO2015031552A1 (en) | 2013-08-30 | 2015-03-05 | 3M Innovative Properties Company | Estradiol containing transdermal drug delivery systems and compositions |
| WO2015042165A1 (en) | 2013-09-17 | 2015-03-26 | Corium International, Inc. | Topical adhesive composition, and device, for improving aesthetic appearance of skin |
| TWI704933B (zh) | 2013-10-07 | 2020-09-21 | 美商帝國製藥美國股份有限公司 | 右美托咪啶經皮輸送裝置及使用其之方法 |
| EP3054933A4 (en) | 2013-10-11 | 2017-03-15 | Teikoku Pharma USA, Inc. | Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same |
| US11660344B2 (en) | 2013-11-17 | 2023-05-30 | Medrx Co., Ltd. | Transdermal colloidal solution agent |
| WO2015084371A1 (en) | 2013-12-05 | 2015-06-11 | Otis Elevator Company | Ropeless high-rise elevator installation approach |
| US20160304316A1 (en) | 2013-12-05 | 2016-10-20 | Otis Elevator Company | High speed ropeless elevator with different number of hoistways up and down in a group |
| KR101485822B1 (ko) | 2014-01-22 | 2015-01-23 | 주식회사 대웅제약 | 도네페질 또는 그의 염을 함유하는 경피흡수제제 |
| DE102014201804A1 (de) | 2014-01-31 | 2015-08-06 | Thyssenkrupp Elevator Ag | Verfahren zum Betreiben eines Aufzugsystems |
| JP2015151370A (ja) | 2014-02-14 | 2015-08-24 | 日東電工株式会社 | 貼付製剤 |
| WO2015137967A1 (en) | 2014-03-14 | 2015-09-17 | Otis Elevator Company | Robust startup method for ropeless elevator |
| CA2951706A1 (en) | 2014-06-24 | 2015-12-30 | KAT Transdermals LLC | Transdermal delivery system |
| CA2955241C (en) | 2014-07-18 | 2023-03-28 | Buzzz Pharmaceuticals Limited | Oxymorphone transdermal patch |
| CN106687138B (zh) | 2014-09-03 | 2021-10-15 | 日东电工株式会社 | 包含双膦酸盐剂的细胞性免疫用疫苗药物组合物 |
| WO2016046675A1 (en) | 2014-09-28 | 2016-03-31 | Mohan M Alapati | Compositions and methods for the treatment of neurological diseases |
| DE102014220966A1 (de) | 2014-10-16 | 2016-04-21 | Thyssenkrupp Elevator Ag | Verfahren zum Betreiben einer Transportanlage sowie entsprechende Transportanlage |
| WO2016060888A1 (en) | 2014-10-16 | 2016-04-21 | Otis Elevator Company | Lateral transfer station for elevator having a magnetic screw propulsion system |
| CN107106510A (zh) | 2014-12-18 | 2017-08-29 | Icure药品株式会社 | 含有多奈哌齐为有效成分的经皮吸收制剂 |
| US11007086B2 (en) * | 2014-12-30 | 2021-05-18 | 3M Innovative Properties Company | Wound dressing with multiple adhesive layers |
| EP3310348B1 (en) | 2015-06-22 | 2020-08-05 | Corium, Inc. | Transdermal adhesive composition comprising a poorly soluble therapeutic agent |
| US10017354B2 (en) | 2015-07-10 | 2018-07-10 | Otis Elevator Company | Control system for multicar elevator system |
| US10370222B2 (en) | 2015-07-16 | 2019-08-06 | Otis Elevator Company | Ropeless elevator system and a transfer system for a ropeless elevator system |
| JP6462880B2 (ja) | 2015-07-27 | 2019-01-30 | 久光製薬株式会社 | アセナピン含有貼付剤の製造方法 |
| US10135299B2 (en) | 2015-08-25 | 2018-11-20 | Otis Elevator Company | Elevator wireless power transfer system |
| US10486940B2 (en) | 2015-08-25 | 2019-11-26 | Otis Elevator Company | Alignment system for an elevator car |
| CN106477429B (zh) | 2015-08-25 | 2020-08-21 | 奥的斯电梯公司 | 电梯轿厢引导机构 |
| CN106477431B (zh) | 2015-09-01 | 2020-01-21 | 奥的斯电梯公司 | 电梯轿厢的轿厢室隔离 |
| EP3138800B1 (en) | 2015-09-01 | 2018-12-12 | Otis Elevator Company | Elevator wireless communication and power transfer system |
| US20170066623A1 (en) | 2015-09-04 | 2017-03-09 | Otis Elevator Company | Ropeless elevator control system |
| CN106542392B (zh) | 2015-09-16 | 2020-09-15 | 奥的斯电梯公司 | 电梯制动控制系统 |
| AU2016231585B2 (en) | 2015-09-25 | 2018-08-09 | Otis Elevator Company | Elevator component separation assurance system and method of operation |
| US10486939B2 (en) | 2015-09-27 | 2019-11-26 | Otis Elevator Company | Breaking system for a hoisted structure and method of controlling braking a hoisted structure |
| US9598265B1 (en) | 2015-09-28 | 2017-03-21 | Smart Lifts, Llc | Vertically and horizontally mobile elevator cabins |
| US10532908B2 (en) | 2015-12-04 | 2020-01-14 | Otis Elevator Company | Thrust and moment control system for controlling linear motor alignment in an elevator system |
| US10966936B2 (en) | 2015-12-30 | 2021-04-06 | Corium, Inc. | Systems comprising a composite backing and methods for long term transdermal administration |
| CN107055231A (zh) | 2016-01-04 | 2017-08-18 | 奥的斯电梯公司 | Mcrl系统中的门厅人群控制调度 |
| CN105693556A (zh) | 2016-03-01 | 2016-06-22 | 巴斯特医药科技(常州)有限公司 | 卡巴拉汀酒石酸盐的转化方法及其产物制成的贴片 |
| CA3028436A1 (en) | 2016-06-23 | 2017-12-28 | Corium International, Inc. | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| MX2019001104A (es) | 2016-07-27 | 2019-10-02 | Corium Int Inc | Sistemas de suministro transdermico de memantina. |
| WO2018022814A1 (en) | 2016-07-27 | 2018-02-01 | Corium International, Inc. | Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery |
| US9993466B2 (en) | 2016-07-27 | 2018-06-12 | Corium International, Inc. | Donepezil transdermal delivery system |
| JP2018165790A (ja) | 2017-03-28 | 2018-10-25 | ブラザー工業株式会社 | 定着装置 |
| CN111132669A (zh) | 2017-07-26 | 2020-05-08 | 考里安公司 | 具有带溶剂填充孔的微孔膜的透皮递送系统 |
| CA3085342A1 (en) | 2017-12-13 | 2019-06-20 | Corium, Inc. | Method for depot creation during transdermal drug delivery |
| US11173132B2 (en) | 2017-12-20 | 2021-11-16 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| WO2023278979A2 (en) | 2021-06-28 | 2023-01-05 | Corium, Llc | Combination therapy treatment using transdermal delivery system |
| EP4362921A2 (en) | 2021-06-28 | 2024-05-08 | Corium, LLC | Corona discharge treated transdermal delivery system |
| CN120513081A (zh) | 2022-12-28 | 2025-08-19 | 考里安有限责任公司 | 制备透皮递送系统的方法 |
| IL321722A (en) | 2022-12-28 | 2025-08-01 | Corium Llc | Premixing method for preparing a transdermal delivery system |
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