KR102774558B1 - 장기 경피 투여를 위한 시스템 및 방법 - Google Patents
장기 경피 투여를 위한 시스템 및 방법 Download PDFInfo
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- KR102774558B1 KR102774558B1 KR1020187021924A KR20187021924A KR102774558B1 KR 102774558 B1 KR102774558 B1 KR 102774558B1 KR 1020187021924 A KR1020187021924 A KR 1020187021924A KR 20187021924 A KR20187021924 A KR 20187021924A KR 102774558 B1 KR102774558 B1 KR 102774558B1
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Classifications
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- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
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Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Chemical & Material Sciences (AREA)
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- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201662367055P | 2016-07-26 | 2016-07-26 | |
| US62/367,055 | 2016-07-26 | ||
| PCT/US2016/069558 WO2017117554A1 (en) | 2015-12-30 | 2016-12-30 | Systems and methods for long term transdermal administration |
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| KR20180127315A KR20180127315A (ko) | 2018-11-28 |
| KR102774558B1 true KR102774558B1 (ko) | 2025-03-04 |
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| WO2016123406A1 (en) | 2015-01-28 | 2016-08-04 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| CA2977814A1 (en) | 2015-03-12 | 2016-09-15 | Chrono Therapeutics Inc. | Craving input and support system |
| KR102774558B1 (ko) * | 2015-12-30 | 2025-03-04 | 코리움, 엘엘씨 | 장기 경피 투여를 위한 시스템 및 방법 |
| US11541018B2 (en) | 2016-06-23 | 2023-01-03 | Corium, Llc | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| US20180028461A1 (en) | 2016-07-27 | 2018-02-01 | Corium International, Inc. | Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery |
| CA3032044C (en) * | 2016-07-27 | 2024-10-01 | Corium, Llc | DONEPEZIL TRANSDERMAL ADMINISTRATION SYSTEM |
| EP3490544A1 (en) * | 2016-07-27 | 2019-06-05 | Corium International, Inc. | Memantine transdermal delivery systems |
| CA3049529A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| US11052054B2 (en) * | 2017-04-19 | 2021-07-06 | Inep Europe Sarl | Method for manufacturing a transdermal device |
| US20180303764A1 (en) * | 2017-04-19 | 2018-10-25 | Inep Europe Sarl | Method for manufacturing a transdermal device |
| US20190029971A1 (en) * | 2017-07-26 | 2019-01-31 | Corium International, Inc. | Transdermal delivery system with a microporous membrane having solvent-filled pores |
| CA3086163A1 (en) | 2017-12-20 | 2019-06-27 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| AU2019279884B2 (en) | 2018-05-29 | 2025-01-30 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| US20200121507A1 (en) | 2018-10-18 | 2020-04-23 | Moldex-Metric, Inc. | Foam earplug with transdermal material |
| CN109432061B (zh) * | 2018-11-09 | 2020-10-30 | 北京德默高科医药技术有限公司 | 含有布洛芬或其结构类似物的多层经皮给药系统 |
| JP2022507660A (ja) | 2018-11-16 | 2022-01-18 | モーニングサイド ベンチャー インベストメンツ リミテッド | 温度によって調節される経皮薬剤送達システム |
| WO2020264032A1 (en) * | 2019-06-28 | 2020-12-30 | Passport Technologies, Inc. | Transdermal drug delivery patch, drug delivery system and drug delivery method |
| RU2705896C1 (ru) * | 2019-07-26 | 2019-11-12 | Артем Олегович Бахметьев | Трансдермальный пластырь |
| US11471839B2 (en) * | 2019-08-06 | 2022-10-18 | Uop Llc | High selectivity membranes for hydrogen sulfide and carbon dioxide removal from natural gas |
| EP4135687A4 (en) * | 2020-04-17 | 2024-04-17 | University of Connecticut | POLYCANNABINOIDS, COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
| US20210346207A1 (en) * | 2020-05-11 | 2021-11-11 | Marc Sheldon Stevens | Four-way stretch therapeutic compress assembly, system, and method |
| US11596772B2 (en) * | 2021-02-07 | 2023-03-07 | Lumen Catheters, LLC | Antimicrobial light-emitting percutaneous site dressing |
Family Cites Families (265)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1880808A (en) | 1927-03-28 | 1932-10-04 | Eastman Kodak Co | Process of making cellulose esters of carboxylic acids |
| US1683347A (en) | 1927-08-25 | 1928-09-04 | Eastman Kodak Co | Process of making chloroform-soluble cellulose acetate |
| US1698049A (en) | 1928-01-18 | 1929-01-08 | Eastman Kodak Co | Process of making cellulosic esters containing halogen-substituted fatty-acid groups |
| US1984147A (en) | 1929-10-22 | 1934-12-11 | Eastman Kodak Co | Process for the production of cellulose esters and corresponding alkyl esters |
| US1880560A (en) | 1929-12-14 | 1932-10-04 | Eastman Kodak Co | Process for the hydrolysis of cellulose acetate |
| US1943119A (en) | 1929-12-17 | 1934-01-09 | Westinghouse Electric & Mfg Co | Circuitous elevator |
| US1939729A (en) | 1930-01-29 | 1933-12-19 | Thomas W Cohill | Elevator system |
| US2129052A (en) | 1936-02-04 | 1938-09-06 | Eastman Kodak Co | Hydrolyzed cellulose acetate |
| US3391142A (en) | 1966-02-09 | 1968-07-02 | Lilly Co Eli | Adamantyl secondary amines |
| NL134681C (enExample) | 1966-04-26 | |||
| US3546141A (en) | 1966-08-08 | 1970-12-08 | Mc Donnell Douglas Corp | Phosphorus-nitrogen polymers and process |
| US3493319A (en) | 1967-05-26 | 1970-02-03 | Us Agriculture | Esterification of cellulosic textiles with unsaturated long chain fatty acids in the presence of trifluoroacetic anhydride using controlled cellulose-acid-anhydride ratios |
| US4004654A (en) | 1971-07-07 | 1977-01-25 | Trebron Holdings Limited | Elevator structure supporting apparatus |
| CH603545A5 (enExample) | 1972-04-20 | 1978-08-31 | Merz & Co | |
| DE2856393C2 (de) | 1978-12-27 | 1983-04-28 | Merz + Co GmbH & Co, 6000 Frankfurt | Arzneimittel zur Behandlung von Morbus Parkinson |
| US4752478A (en) | 1984-12-17 | 1988-06-21 | Merck & Co., Inc. | Transdermal system for timolol |
| DE3572485D1 (en) | 1984-12-22 | 1989-09-28 | Thomae Gmbh Dr K | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs |
| FR2576888B1 (fr) | 1985-02-05 | 1988-04-08 | Otis Elevator Co | Ascenseur transbordeur pour voies urbaines notamment |
| US4756710A (en) | 1985-04-05 | 1988-07-12 | Merck & Co., Inc. | pH-Mediated drug delivery system |
| US4797284A (en) | 1986-03-12 | 1989-01-10 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4880633A (en) | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
| DE3634016A1 (de) * | 1986-04-17 | 1987-10-29 | Lohmann Gmbh & Co Kg | Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung |
| DE3775830D1 (de) | 1986-06-13 | 1992-02-20 | Alza Corp | Aktivierung eines transdermalen drogenabgabesystems durch feuchtigkeit. |
| US5686489A (en) | 1986-12-23 | 1997-11-11 | Tristrata Technology, Inc. | Alpha hydroxyacid esters for skin aging |
| US5071656A (en) | 1987-03-05 | 1991-12-10 | Alza Corporation | Delayed onset transdermal delivery device |
| DE3714140A1 (de) | 1987-04-28 | 1988-11-10 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges pflaster zur kontrollierten verabreichung von wirkstoffen an die haut, seine verwendung sowie verfahren zur gesteuerten verabreichung von wirkstoffen an die haut |
| US5538736A (en) * | 1987-04-28 | 1996-07-23 | Lts Lohmann Therapie-Systeme Gmbh | Active substance-containing plaster for the controlled administration of active substances to the skin |
| US4787888A (en) | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| US4837027A (en) | 1987-11-09 | 1989-06-06 | Alza Corporation | Transdermal drug delivery device |
| US4781924A (en) | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device |
| US4849224A (en) | 1987-11-12 | 1989-07-18 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5026556A (en) | 1988-11-10 | 1991-06-25 | Norwich Eaton Pharmaceuticals, Inc. | Compositions for the transdermal delivery of pharmaceutical actives |
| US5202128A (en) | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
| CA2007181C (en) | 1989-01-06 | 1998-11-24 | Angelo Mario Morella | Sustained release pharmaceutical composition |
| ES2059602T3 (es) | 1989-04-14 | 1994-11-16 | Merz & Co Gmbh & Co | Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral. |
| DE3913734C2 (de) | 1989-04-26 | 1998-08-20 | Roehm Gmbh | Verwendung einer wäßrigen Hauthaftkleberlösung zur Herstellung einer mit Wasser leicht abwaschbaren Klebschicht |
| ATE107517T1 (de) | 1989-05-25 | 1994-07-15 | Takeda Chemical Industries Ltd | Transdermales therapeutisches mittel. |
| US5252588A (en) | 1990-04-27 | 1993-10-12 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation |
| FI930272A7 (fi) | 1990-07-23 | 1993-01-22 | Alza Corp | Oraalinen osmootinen laite, joka luovuttaa nikotiinia |
| IT1243745B (it) | 1990-10-17 | 1994-06-21 | Vectorpharma Int | Composizioni terapeutiche transdermali contenenti farmaco e/o agente promotore dell'assorbimento cutaneo supportato su particelle microporose e microsfere polimeriche e loro preparazione. |
| US5614560A (en) | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| US5123900A (en) * | 1991-08-16 | 1992-06-23 | Bertek, Inc. | Moisture permeable double disk |
| US5246705A (en) | 1992-04-08 | 1993-09-21 | Cygnus Therapeutic System | Occlusive, elastomeric backing materials in transdermal drug delivery systems, and associated methods of manufacture and use |
| JPH06199659A (ja) | 1992-10-28 | 1994-07-19 | Hisamitsu Pharmaceut Co Inc | 経皮治療用装置 |
| US5612411A (en) * | 1992-11-18 | 1997-03-18 | Kimberly-Clark Corporation | Absorbent phycocolloids and a method for their manufacture |
| US5489624A (en) * | 1992-12-01 | 1996-02-06 | Minnesota Mining And Manufacturing Company | Hydrophilic pressure sensitive adhesives |
| DE4310012A1 (de) | 1993-03-27 | 1994-09-29 | Roehm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung |
| JPH06321445A (ja) | 1993-05-10 | 1994-11-22 | Toshiba Corp | エレベータ |
| US5424077A (en) | 1993-07-13 | 1995-06-13 | Church & Dwight Co., Inc. | Co-micronized bicarbonate salt compositions |
| US5567489A (en) * | 1993-09-16 | 1996-10-22 | The Dow Chemical Company | Multilayer halogen-free barrier film for ostomy and transdermal drug delivery applications |
| JP3135760B2 (ja) | 1993-10-18 | 2001-02-19 | 株式会社竹中工務店 | エレベータシステム |
| JPH07187525A (ja) | 1993-11-18 | 1995-07-25 | Masami Sakita | 複数ばこエレベータシステム |
| NZ293849A (en) | 1994-09-14 | 1998-10-28 | Minnesota Mining & Mfg | Transdermal delivery matrix comprising a macromonomer containing acrylate or metacrylate copolymer, a softener and a drug |
| US5557018A (en) | 1994-09-27 | 1996-09-17 | E. I. Du Pont De Nemours And Company | Partially flourinated polymers and process therefor |
| US5635203A (en) | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
| AU695170B2 (en) | 1994-12-21 | 1998-08-06 | Theratech, Inc. | Transdermal delivery system with adhesive overlay and peel seal disc |
| WO1996040087A2 (en) | 1995-06-07 | 1996-12-19 | Cygnus, Inc. | Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group |
| US5785991A (en) * | 1995-06-07 | 1998-07-28 | Alza Corporation | Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate |
| DE19623147B4 (de) | 1995-06-08 | 2007-05-03 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Folie, Verfahren zur Herstellung derselben und seine Verwendung in einem Flüssigkristalldisplay |
| US5651426A (en) | 1995-11-29 | 1997-07-29 | Otis Elevator Company | Synchronous elevator shuttle system |
| US5785153A (en) | 1995-11-29 | 1998-07-28 | Otis Elevator Company | Synchronizing elevator arrival at a level of a building |
| US5758748A (en) | 1995-11-29 | 1998-06-02 | Otis Elevator Company | Synchronized off-shaft loading of elevator cabs |
| US5601156A (en) | 1995-11-29 | 1997-02-11 | Otis Elevator Company | Maintaining communications and power during transfer of horizontally moveable elevator cab |
| US5702720A (en) | 1995-12-22 | 1997-12-30 | Minnesota Mining And Manufacturing Company | Transdermal device for the delivery of flurbiprofen |
| US6929801B2 (en) | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
| TW513409B (en) | 1996-06-07 | 2002-12-11 | Eisai Co Ltd | Polymorphs of donepezil hydrochloride |
| US5861586A (en) | 1996-06-19 | 1999-01-19 | Otis Elevator Company | Horizontal and vertical passenger transport |
| US6512010B1 (en) | 1996-07-15 | 2003-01-28 | Alza Corporation | Formulations for the administration of fluoxetine |
| US5752585A (en) | 1996-07-25 | 1998-05-19 | Otis Elevator Company | Elevator shuttle with auxiliary elevators at terminals |
| US5924524A (en) | 1996-07-25 | 1999-07-20 | Otis Elevator Company | Integrated, multi-level elevator shuttle |
| US5958919A (en) | 1996-09-20 | 1999-09-28 | Washington University | Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration |
| WO1998017315A2 (en) | 1996-10-24 | 1998-04-30 | Alza Corporation | Permeation enhancers for transdermal drug delivery compositions, devices, and methods |
| CN1174031A (zh) | 1997-04-23 | 1998-02-25 | 谢先运 | 双氯芬酸钠透皮控释贴膏 |
| US5866585A (en) | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
| US6174545B1 (en) * | 1997-07-01 | 2001-01-16 | Alza Corporation | Drug delivery devices and process of manufacture |
| US20040018241A1 (en) | 1997-09-26 | 2004-01-29 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| US6193993B1 (en) | 1998-03-03 | 2001-02-27 | Eisai Co., Ltd. | Suppository containing an antidementia medicament |
| JP4205778B2 (ja) | 1998-04-17 | 2009-01-07 | 久光製薬株式会社 | 貼付製剤 |
| DE19820999A1 (de) * | 1998-05-11 | 1999-11-18 | Lohmann Therapie Syst Lts | Laminat zum Aufbringen auf einen Akzeptor |
| US6225348B1 (en) | 1998-08-20 | 2001-05-01 | Alfred W. Paulsen | Method of treating macular degeneration with a prostaglandin derivative |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| WO2001001962A1 (en) | 1999-07-05 | 2001-01-11 | Idea Ag. | A method for the improvement of transport across adaptable semi-permeable barriers |
| US20020192243A1 (en) | 1999-12-16 | 2002-12-19 | Tsung-Min Hsu | Transdermal and topical administration of drugs for the treatment of Alzheimer's disease using basic enhancers |
| US6562368B2 (en) | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
| US6455066B1 (en) | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
| EP1299494B1 (en) | 2000-07-07 | 2010-08-25 | A.V. Topchiev Institute of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
| US7276249B2 (en) | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| AU2002214364B2 (en) | 2000-11-06 | 2004-08-19 | Samyang Biopharmaceuticals Corporation | Transdermal drug delivery system with improved water absorbability and adhesion properties |
| US20040028724A1 (en) | 2000-11-07 | 2004-02-12 | Takaaki Terahara | Pharmaceutical preparation of percutaneous absorption type |
| JP4850346B2 (ja) | 2001-03-15 | 2012-01-11 | 救急薬品工業株式会社 | 粘膜貼付剤 |
| US20020182237A1 (en) | 2001-03-22 | 2002-12-05 | The Procter & Gamble Company | Skin care compositions containing a sugar amine |
| WO2002087642A2 (en) | 2001-05-01 | 2002-11-07 | A.V. Topchiev Institute Of Petrochemical Synthesis | Two-phase, water-absorbent bioadhesive composition |
| EP1390085B1 (en) | 2001-05-01 | 2009-08-05 | A.V. Topchiev Institute of Petrochemical Synthesis | Hydrogel compositions |
| US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
| US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
| US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
| US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
| US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
| US20040024028A1 (en) | 2001-08-02 | 2004-02-05 | Burton Steven L. | Method for reducing or eliminating smoking |
| NL1018729C2 (nl) | 2001-08-09 | 2003-02-11 | Tms Internat B V | Flexibele aansluitmodule en modulair systeem voor het meten en doorgeven van sensorsignalen. |
| CA2457011C (en) | 2001-08-20 | 2012-04-24 | Maiken Nedergaard | Treatment of glial tumors with glutamate antagonists |
| ATE352292T1 (de) | 2001-09-04 | 2007-02-15 | Trommsdorff Arzneimittel | Pflaster mit sertaconazol zur behandlung von nagelfunktionsstörungen und erkrankungen |
| DE10159745A1 (de) | 2001-12-05 | 2003-07-03 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit verbessertem Langzeittragekomfort |
| ITMI20012827A1 (it) | 2001-12-28 | 2003-06-28 | Fidia Farmaceutici | Formulazioni adesive transdermiche di diclofenac sodico |
| US7273619B2 (en) | 2002-01-17 | 2007-09-25 | Samyang Corporation | Transdermal composition of an antivomiting agent |
| US7217853B2 (en) | 2002-05-24 | 2007-05-15 | Corium International, Inc. | Composition for cushions, wound dressings and other skin-contacting products |
| SG102714A1 (en) | 2002-05-27 | 2004-03-26 | Inventio Ag | Elevator installation with several self-propelled cars and at least three elevator hoistways situated adjacently |
| IL166687A0 (en) | 2002-08-30 | 2006-01-15 | Alza Corp | Embossable and writable multilaminate backing construction |
| AU2003274353B2 (en) | 2002-10-24 | 2007-04-05 | Merz Pharma Gmbh & Co. Kgaa | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
| CN1668521A (zh) | 2002-11-26 | 2005-09-14 | 蒂森克虏伯电梯股份有限公司 | 用于控制电梯装置的方法及用于执行该方法的电梯装置 |
| HRP20050828B1 (hr) | 2003-02-21 | 2013-10-25 | Bayer Intellectual Property Gmbh | Uv-stabilni transdermalni flaster |
| US7294376B2 (en) | 2003-08-26 | 2007-11-13 | The Goodyear Tire & Rubber Company | Tire with indicia |
| EP1526103B1 (de) | 2003-10-09 | 2012-01-11 | Inventio AG | Aufzugsanlage mit mehrstöckigen Kabinen für den Zonenbetrieb in einem Gebäude |
| PT1670433E (pt) | 2003-10-10 | 2012-02-08 | Ferring Bv | Fórmula farmacológica transdérmica para a minimização de resíduos na pele |
| AU2004281766A1 (en) | 2003-10-14 | 2005-04-28 | Dermatrends, Inc. | Enhancing transdermal administration of hydrophilic drugs |
| ATE411015T1 (de) | 2003-10-22 | 2008-10-15 | Merz Pharma Gmbh & Co Kgaa | Verwendung von 1-aminocyclohexan-derivaten zur modifizierung der abscheidung von fibrillogenen as peptiden in amyloidpathien |
| AU2004292966A1 (en) | 2003-11-21 | 2005-06-09 | Memory Pharmaceutical Corporation | Compositions and methods of treatment using L-type calcium channel blockers and cholinesterase inhibitors |
| US7176185B2 (en) | 2003-11-25 | 2007-02-13 | Tsrl, Inc. | Short peptide carrier system for cellular delivery of agent |
| AU2005210637B2 (en) | 2004-01-30 | 2010-09-16 | A.V. Topchiev Institute Of Petrochemical Synthesis | Rapidly dissolving film for delivery of an active agent |
| US7658945B2 (en) | 2004-02-17 | 2010-02-09 | Transcept Pharmaceuticals, Inc. | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
| DE102004010516A1 (de) | 2004-03-04 | 2005-09-22 | Bayer Technology Services Gmbh | Verbessertes Verfahren zur zeitlichen Dosierung von Arzneistoffen |
| US7670838B2 (en) | 2004-05-24 | 2010-03-02 | The Board Of Trustees Of The Leland Stanford Junior University | Coupling of excitation and neurogenesis in neural stem/progenitor cells |
| WO2005115355A1 (ja) | 2004-05-28 | 2005-12-08 | Hisamitsu Pharmaceutical Co., Inc. | 貼付製剤 |
| TW200616608A (en) | 2004-07-09 | 2006-06-01 | Forest Laboratories | Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients |
| EP1616832A3 (de) | 2004-07-15 | 2006-07-12 | Inventio Ag | Auzugsanlage mit mindestens drei nebeneinander angeordneten, vertikalen Aufzugsschächten und Verfahren zum Betreiben einer solchen Aufzugsanlage |
| TWI343357B (en) | 2004-07-22 | 2011-06-11 | Inventio Ag | Elevator installation with individually movable elevator cars and method for operating such an elevator installation |
| US9242021B2 (en) | 2004-08-05 | 2016-01-26 | Corium International, Inc. | Adhesive composition |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| ES2596809T3 (es) | 2004-10-08 | 2017-01-12 | Noven Pharmaceuticals, Inc. | Dispositivo de administración transdérmica de fármacos que incluye un refuerzo oclusivo |
| US7744918B2 (en) | 2004-11-22 | 2010-06-29 | Hisamitsu Pharmaceutical Co., Inc. | Drug-containing patch |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| RU2007127716A (ru) | 2004-12-21 | 2009-01-27 | Кориум Интернэшнл, Инк. (Us) | Длительно высвобождаемые композиции и системы для отбеливания зубов |
| US20060205822A1 (en) | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| ES2334579T3 (es) | 2005-01-11 | 2010-03-12 | Teva Pharmaceutical Fine Chemicals S.R.L. | Procedimiento para la preparacion del clorhidrato de 1-amino-3,5-dimetil-adamantano. |
| US20060163008A1 (en) | 2005-01-24 | 2006-07-27 | Michael Godwin | Autonomous linear retarder/motor for safe operation of direct drive gearless, rope-less elevators |
| WO2006082728A1 (ja) | 2005-02-04 | 2006-08-10 | Hisamitsu Pharmaceutical Co., Inc. | 経皮吸収貼付剤 |
| US20060188558A1 (en) | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
| EP1874282B1 (en) | 2005-04-06 | 2010-09-15 | Adamas Pharmaceuticals, Inc. | Methods and compositions for treatment of cns disorders |
| ATE524486T1 (de) | 2005-04-27 | 2011-09-15 | Sederma S A S | Lys-thr-dipeptide und deren verwendung |
| US7888422B2 (en) | 2005-11-09 | 2011-02-15 | Mylan Technologies Inc. | Long-wearing removable pressure sensitive adhesive |
| US20100121290A1 (en) | 2006-03-28 | 2010-05-13 | Torben Rasmussen | Multilayer Film |
| CN1895242B (zh) | 2006-04-13 | 2011-08-31 | 沈阳药科大学 | 双氯芬酸盐的透皮贴剂及制备方法 |
| IL175338A0 (en) | 2006-05-01 | 2006-09-05 | Biota Ltd | Orally administrable films and preparation thereof |
| US20070259029A1 (en) | 2006-05-08 | 2007-11-08 | Mcentire Edward Enns | Water-dispersible patch containing an active agent for dermal delivery |
| JP5122445B2 (ja) | 2006-05-08 | 2013-01-16 | 帝國製薬株式会社 | 抗認知症薬物の経皮吸収製剤 |
| JP5097359B2 (ja) | 2006-05-09 | 2012-12-12 | 久光製薬株式会社 | ドネペジル経皮吸収型製剤 |
| WO2007132476A2 (en) | 2006-05-15 | 2007-11-22 | Matrix Laboratories Limited | A process for the preparation of memantine hydrochloride |
| TW200815045A (en) | 2006-06-29 | 2008-04-01 | Jazz Pharmaceuticals Inc | Pharmaceutical compositions of ropinirole and methods of use thereof |
| US9248104B2 (en) | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
| WO2008024408A2 (en) | 2006-08-22 | 2008-02-28 | Theraquest Biosciences, Inc. | Pharmaceutical formulations of cannabinoids for application to the skin and method of use |
| EP2117521B1 (en) | 2006-11-03 | 2012-06-27 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| US20080107719A1 (en) | 2006-11-08 | 2008-05-08 | Sukhon Likitlersuang | Transdermal drug delivery system |
| CN101605546B (zh) | 2006-12-01 | 2011-12-14 | 日东电工株式会社 | 抑制含有多奈哌齐的贴剂的经时变色的方法 |
| EP2098235B1 (en) | 2006-12-01 | 2013-08-21 | Nitto Denko Corporation | Method for prevention of discoloration with time of donepezil-containing skin adhesive preparation |
| CA2671081C (en) | 2006-12-01 | 2014-06-03 | Nitto Denko Corporation | Stabilized adhesive preparation containing donepezil |
| US20080226698A1 (en) | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
| JP2008259629A (ja) | 2007-04-11 | 2008-10-30 | Hakujuji Co Ltd | 傷保護材 |
| JP5403948B2 (ja) | 2007-06-07 | 2014-01-29 | 久光製薬株式会社 | メマンチン含有経皮吸収製剤 |
| EA020208B1 (ru) | 2007-07-10 | 2014-09-30 | Эджайл Терапьютикс, Инк. | Устройство доставки в кожу с изолирующим слоем in situ |
| WO2009026135A2 (en) | 2007-08-17 | 2009-02-26 | Alza Corporation | Controlled transdermal bisoprolol delivery system |
| US9017301B2 (en) | 2007-09-04 | 2015-04-28 | Mylan Technologies, Inc. | Transdermal drug delivery systems comprising a coated release liner |
| CN100560157C (zh) * | 2007-11-13 | 2009-11-18 | 重庆市生力医疗设备有限公司 | 超声波药贴 |
| JP2009203213A (ja) | 2008-02-28 | 2009-09-10 | Kosumedei Seiyaku Kk | 経皮吸収医薬組成物 |
| DE102008013701A1 (de) | 2008-03-11 | 2009-09-17 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System mit stabilisierter Membran |
| KR101454362B1 (ko) | 2008-03-24 | 2014-10-23 | 아이큐어 주식회사 | 도네페질을 유효성분으로 함유하는 치매 치료용경피흡수제제 |
| EP2111857A1 (de) | 2008-04-25 | 2009-10-28 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff hiervon |
| US20090291127A1 (en) | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| WO2009145177A1 (ja) | 2008-05-30 | 2009-12-03 | 日東電工株式会社 | ドネペジル含有貼付製剤およびその包装体 |
| CA2727462C (en) | 2008-06-13 | 2017-02-07 | Oragenics, Inc. | Use of hydrogen peroxide-producing bacteria for tooth whitening |
| TW201006625A (en) | 2008-08-06 | 2010-02-16 | Hou-Fei Hu | Tool chuck for screwdriver |
| PE20100371A1 (es) | 2008-10-31 | 2010-06-01 | Lexicon Pharmaceuticals Inc | Agonistas del receptor s1p para el tratamiento de malaria cerebral |
| EP2196197A1 (en) | 2008-12-15 | 2010-06-16 | Bouty S.P.A. | Antiviral patch |
| US20100178037A1 (en) | 2009-01-12 | 2010-07-15 | Te-Wei Chen | Display apparatus, video generation apparatus, and method thereof |
| CA2751884C (en) | 2009-01-14 | 2018-09-25 | Corium International, Inc. | Transdermal administration of tamsulosin |
| CN101518599A (zh) * | 2009-03-24 | 2009-09-02 | 沈阳药科大学 | 祖师麻提取物缓释贴剂及其制备方法 |
| US8512742B2 (en) | 2009-05-01 | 2013-08-20 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal preparation |
| KR101325104B1 (ko) | 2009-09-16 | 2013-11-07 | 주식회사 삼양바이오팜 | 경피 투여 제형 및 그 제조 방법 |
| MX2012004550A (es) | 2009-10-21 | 2012-05-29 | Teikoku Seiyaku Kk | Formulacion de absorcion transdermica que contiene donepezil. |
| CN102048678A (zh) | 2009-10-30 | 2011-05-11 | 北京隆旗生物科技有限公司 | 一种奥昔布宁的透皮吸收制剂及其制备方法与药物应用 |
| GB0921481D0 (en) | 2009-12-08 | 2010-01-20 | Vectura Ltd | Process and product |
| JP2012236773A (ja) | 2009-12-16 | 2012-12-06 | Goto Takeshi | 抗認知症薬物の経皮吸収製剤 |
| ES2539660T3 (es) | 2009-12-30 | 2015-07-02 | Novartis Ag | Tiras finas de nicotina extrudidas en fundido |
| US20100178307A1 (en) | 2010-01-13 | 2010-07-15 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
| US9370495B2 (en) | 2010-02-24 | 2016-06-21 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive patch |
| US20110244023A1 (en) | 2010-03-30 | 2011-10-06 | Phosphagenics Limited | Transdermal delivery patch |
| EP2564848B1 (en) | 2010-04-28 | 2015-09-02 | Hisamitsu Pharmaceutical Co., Inc. | Transdermally absorbable donepezil-containing preparation |
| US9012511B2 (en) | 2010-05-19 | 2015-04-21 | Alkermes Pharma Ireland Limited | Nanoparticulate cinacalcet compositions |
| DE102010024105A1 (de) | 2010-06-17 | 2011-12-22 | Grünenthal GmbH | Transdermale Verabreichung von Memantin |
| US20140370076A1 (en) | 2010-06-30 | 2014-12-18 | Nal Pharmaceuticals, Ltd. | Transdermal drug delivery system containing donepezil |
| NZ605352A (en) | 2010-06-30 | 2013-10-25 | Nal Pharmaceuticals Ltd | Process for producing glycosaminoglycans |
| JP5711743B2 (ja) | 2010-07-29 | 2015-05-07 | 久光製薬株式会社 | 医療用貼付剤 |
| HUE040283T2 (hu) | 2010-07-29 | 2019-02-28 | Allergan Inc | Brimonidin és timolol tartalmú, tartósítószer-mentes oldatok |
| WO2012051333A1 (en) | 2010-10-12 | 2012-04-19 | The Johns Hopkins University | Antitussive compositions comprising memantine |
| US20130211353A1 (en) | 2010-10-28 | 2013-08-15 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneous absorption type formulation |
| JP5699554B2 (ja) | 2010-11-11 | 2015-04-15 | 富士通株式会社 | ベクトル処理回路、命令発行制御方法、及びプロセッサシステム |
| CN103200944B (zh) | 2010-11-17 | 2016-05-04 | 赫克萨尔股份公司 | 包含丁丙诺啡的经皮治疗系统 |
| WO2012084969A1 (en) | 2010-12-22 | 2012-06-28 | Hexal Ag | Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition |
| EP2658576A1 (en) | 2010-12-29 | 2013-11-06 | Pharmafilm S.R.L. | Medicated patch for improved transdermal permeation of diclofenac diethylammonium |
| TWI433904B (zh) | 2011-01-12 | 2014-04-11 | Taiwan Biotech Co Ltd | 多奈哌齊經皮貼片 |
| CN102775476B (zh) | 2011-05-12 | 2015-01-07 | 上海天伟生物制药有限公司 | 一种米卡芬净钠盐的制备方法 |
| US8673338B2 (en) | 2011-07-29 | 2014-03-18 | Massachusetts Eye And Ear Infirmary | Methods of delivering pharmaceutical agents |
| JP5820207B2 (ja) | 2011-09-13 | 2015-11-24 | 日東電工株式会社 | 経皮吸収促進用組成物および貼付製剤 |
| JP5808214B2 (ja) | 2011-09-30 | 2015-11-10 | 株式会社トクヤマ | 貼付剤 |
| WO2013078608A1 (en) | 2011-11-29 | 2013-06-06 | Ziqiang Gu | Donepezil pamoate and methods of making and using the same |
| EP2794793B1 (en) | 2011-12-21 | 2018-11-28 | 3M Innovative Properties Company | Adhesive patch assembly with overlay liner and system and method for making same |
| AU2013212005A1 (en) | 2012-01-27 | 2014-07-31 | Agile Therapeutics, Inc. | Transdermal hormone delivery |
| KR101239150B1 (ko) | 2012-02-28 | 2013-03-06 | 에스케이케미칼주식회사 | 도네페질-함유 경피흡수제제 및 그의 제조방법 |
| US9408802B1 (en) | 2012-03-22 | 2016-08-09 | Prosolus, Inc. | Seven day drug in adhesive transdermal delivery |
| US20140256690A1 (en) | 2013-03-08 | 2014-09-11 | Agile Therapeutics, Inc. | Contraceptive method |
| US20140276479A1 (en) * | 2013-03-14 | 2014-09-18 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery system with overlay |
| WO2014174564A1 (ja) | 2013-04-22 | 2014-10-30 | 祐徳薬品工業株式会社 | メマンチン含有経皮吸収型貼付製剤 |
| ITTV20130057A1 (it) | 2013-04-23 | 2014-10-24 | Tarcisio Scomparin | "sistema elevatore e traslatore con struttura a portale che impiega cremagliere e piu' vie di corsa verticali ed orizzontali di almeno una cabina di trasporto di persone e cose per il superamento di ostacoli sopraelevato e non." |
| JP5415645B1 (ja) | 2013-06-28 | 2014-02-12 | 久光製薬株式会社 | 貼付剤の製造方法、貼付剤及び包装体 |
| US20160199317A1 (en) | 2013-08-30 | 2016-07-14 | 3M Innovative Properties Company | Estradiol containing transdermal drug delivery systems and compositions |
| US20150080437A1 (en) | 2013-09-17 | 2015-03-19 | Corium International, Inc. | Topical adhesive composition, and device, for improving aesthetic appearance of skin |
| EP3054932B1 (en) | 2013-10-07 | 2020-12-09 | Teikoku Pharma USA, Inc. | Dexmedetomidine transdermal delivery devices and methods for using the same |
| WO2015053878A1 (en) | 2013-10-11 | 2015-04-16 | Teikoku Pharma Usa, Inc. | Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same |
| US11660344B2 (en) | 2013-11-17 | 2023-05-30 | Medrx Co., Ltd. | Transdermal colloidal solution agent |
| US20160304316A1 (en) | 2013-12-05 | 2016-10-20 | Otis Elevator Company | High speed ropeless elevator with different number of hoistways up and down in a group |
| CN105960369B (zh) | 2013-12-05 | 2019-03-12 | 奥的斯电梯公司 | 建造带电梯系统建筑的方法、无绳电梯系统及其操作方法 |
| KR101485822B1 (ko) | 2014-01-22 | 2015-01-23 | 주식회사 대웅제약 | 도네페질 또는 그의 염을 함유하는 경피흡수제제 |
| DE102014201804A1 (de) | 2014-01-31 | 2015-08-06 | Thyssenkrupp Elevator Ag | Verfahren zum Betreiben eines Aufzugsystems |
| JP2015151370A (ja) | 2014-02-14 | 2015-08-24 | 日東電工株式会社 | 貼付製剤 |
| CN106103329A (zh) | 2014-03-14 | 2016-11-09 | 奥的斯电梯公司 | 用于无绳电梯的稳健启动方法 |
| US20170189347A1 (en) | 2014-06-24 | 2017-07-06 | KAT Transdermals LLC | Transdermal delivery system |
| CA2955247C (en) | 2014-07-18 | 2023-01-03 | Buzzz Pharmaceuticals Limited | Abuse deterrent opiod/opiod-antagonist transdermal patch |
| WO2016035808A1 (ja) | 2014-09-03 | 2016-03-10 | 日東電工株式会社 | ビスホスホネート剤を含む細胞性免疫用ワクチン医薬組成物 |
| WO2016046675A1 (en) | 2014-09-28 | 2016-03-31 | Mohan M Alapati | Compositions and methods for the treatment of neurological diseases |
| WO2016060888A1 (en) | 2014-10-16 | 2016-04-21 | Otis Elevator Company | Lateral transfer station for elevator having a magnetic screw propulsion system |
| DE102014220966A1 (de) | 2014-10-16 | 2016-04-21 | Thyssenkrupp Elevator Ag | Verfahren zum Betreiben einer Transportanlage sowie entsprechende Transportanlage |
| DK3235494T3 (da) | 2014-12-18 | 2020-03-02 | Icure Pharm Inc | Transdermalt præparat indeholdende donepezil som aktiv bestanddel |
| JP6838812B2 (ja) * | 2014-12-30 | 2021-03-03 | スリーエム イノベイティブ プロパティズ カンパニー | 吸収性接着剤シーラント層を有する負圧創傷ドレッシング |
| WO2016209982A1 (en) | 2015-06-22 | 2016-12-29 | Corium International, Inc. | Transdermal adhesive composition comprising a poorly soluble therapeutic agent |
| US10017354B2 (en) | 2015-07-10 | 2018-07-10 | Otis Elevator Company | Control system for multicar elevator system |
| US10370222B2 (en) | 2015-07-16 | 2019-08-06 | Otis Elevator Company | Ropeless elevator system and a transfer system for a ropeless elevator system |
| JP6462880B2 (ja) | 2015-07-27 | 2019-01-30 | 久光製薬株式会社 | アセナピン含有貼付剤の製造方法 |
| CN106477429B (zh) | 2015-08-25 | 2020-08-21 | 奥的斯电梯公司 | 电梯轿厢引导机构 |
| US10486940B2 (en) | 2015-08-25 | 2019-11-26 | Otis Elevator Company | Alignment system for an elevator car |
| US10135299B2 (en) | 2015-08-25 | 2018-11-20 | Otis Elevator Company | Elevator wireless power transfer system |
| AU2016222417B2 (en) | 2015-09-01 | 2017-11-02 | Otis Elevator Company | Elevator wireless communication and power transfer system |
| CN106477431B (zh) | 2015-09-01 | 2020-01-21 | 奥的斯电梯公司 | 电梯轿厢的轿厢室隔离 |
| US20170066623A1 (en) | 2015-09-04 | 2017-03-09 | Otis Elevator Company | Ropeless elevator control system |
| CN106542392B (zh) | 2015-09-16 | 2020-09-15 | 奥的斯电梯公司 | 电梯制动控制系统 |
| AU2016231585B2 (en) | 2015-09-25 | 2018-08-09 | Otis Elevator Company | Elevator component separation assurance system and method of operation |
| US10486939B2 (en) | 2015-09-27 | 2019-11-26 | Otis Elevator Company | Breaking system for a hoisted structure and method of controlling braking a hoisted structure |
| US9598265B1 (en) | 2015-09-28 | 2017-03-21 | Smart Lifts, Llc | Vertically and horizontally mobile elevator cabins |
| US10532908B2 (en) | 2015-12-04 | 2020-01-14 | Otis Elevator Company | Thrust and moment control system for controlling linear motor alignment in an elevator system |
| KR102774558B1 (ko) * | 2015-12-30 | 2025-03-04 | 코리움, 엘엘씨 | 장기 경피 투여를 위한 시스템 및 방법 |
| CN107055231A (zh) | 2016-01-04 | 2017-08-18 | 奥的斯电梯公司 | Mcrl系统中的门厅人群控制调度 |
| CN105693556A (zh) | 2016-03-01 | 2016-06-22 | 巴斯特医药科技（常州）有限公司 | 卡巴拉汀酒石酸盐的转化方法及其产物制成的贴片 |
| US11541018B2 (en) | 2016-06-23 | 2023-01-03 | Corium, Llc | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| US20180028461A1 (en) | 2016-07-27 | 2018-02-01 | Corium International, Inc. | Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery |
| EP3490544A1 (en) | 2016-07-27 | 2019-06-05 | Corium International, Inc. | Memantine transdermal delivery systems |
| CA3032044C (en) | 2016-07-27 | 2024-10-01 | Corium, Llc | DONEPEZIL TRANSDERMAL ADMINISTRATION SYSTEM |
| JP2018165790A (ja) | 2017-03-28 | 2018-10-25 | ブラザー工業株式会社 | 定着装置 |
| US20190029971A1 (en) | 2017-07-26 | 2019-01-31 | Corium International, Inc. | Transdermal delivery system with a microporous membrane having solvent-filled pores |
| US20190175520A1 (en) | 2017-12-13 | 2019-06-13 | Corium International, Inc. | Method for depot creation during transdermal drug delivery |
| CA3086163A1 (en) | 2017-12-20 | 2019-06-27 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| CA3223135A1 (en) | 2021-06-28 | 2023-01-05 | Eun Soo Lee | Combination therapy treatment using transdermal delivery system |
| CN117915897A (zh) | 2021-06-28 | 2024-04-19 | 考里安有限责任公司 | 电晕放电处理的透皮递送系统 |
| WO2024145323A1 (en) | 2022-12-28 | 2024-07-04 | Corium, Llc | Pre-mixing method of preparing transdermal delivery system |
| WO2024145319A1 (en) | 2022-12-28 | 2024-07-04 | Corium, Llc | Method of preparing transdermal delivery system |
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