HRP20050828B1 - Uv-stabilni transdermalni flaster - Google Patents

Uv-stabilni transdermalni flaster

Info

Publication number
HRP20050828B1
HRP20050828B1 HRP20050828AA HRP20050828A HRP20050828B1 HR P20050828 B1 HRP20050828 B1 HR P20050828B1 HR P20050828A A HRP20050828A A HR P20050828AA HR P20050828 A HRP20050828 A HR P20050828A HR P20050828 B1 HRP20050828 B1 HR P20050828B1
Authority
HR
Croatia
Prior art keywords
transdermal therapeutic
active substance
absorber
matrix
distant
Prior art date
Application number
HRP20050828AA
Other languages
English (en)
Inventor
Jochen Schumacher
Manfred Süsse
Michael Dittgen
Stephan Mletzko
Jan-Peter Ingwersen
Thomas Langguth
Dirk Schenk
Hubert Kaffl
Original Assignee
Bayer Intellectual Property Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03003888A external-priority patent/EP1449526A1/de
Priority claimed from EP03004061A external-priority patent/EP1452173A1/de
Application filed by Bayer Intellectual Property Gmbh filed Critical Bayer Intellectual Property Gmbh
Publication of HRP20050828A2 publication Critical patent/HRP20050828A2/xx
Publication of HRP20050828B1 publication Critical patent/HRP20050828B1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Izum se odnosi na novi UV-stabilni transdermalni terapeutski sustav (TTS), koji se sastoji od jednog površinskog sloja, najmanje jednog matriksa koji sadrži djelotvornu tvar, a može imati i jednu foliju koja se odljepljuje. Isto tako sustav sadrži UV-apsorber, pri čemu se između površinskog sloja i površine kože nalazi najviše udaljeni matriks sa djelotvornom tvari, a između ljepljivog sloja sa UV-apsorberom i površine kože, te najudaljenijeg matriksa sa djelotvornom tvari se nalazi i međusloj, koji je propustan za djelotvornu tvar, a nepropustan za UV-apsorber. Izumom predočeni transdermalni terapeutski sutav realizira visoku stabilnost, bez nedostataka komercijalno dostupnih TTS-a, koji sadrže djelotvorne tvari osjetljive na svijetlost.
HRP20050828AA 2003-02-21 2005-09-20 Uv-stabilni transdermalni flaster HRP20050828B1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03003888A EP1449526A1 (de) 2003-02-21 2003-02-21 UV-stabiles transdermales Pflaster
EP03004061A EP1452173A1 (de) 2003-02-25 2003-02-25 UV-stabiles transdermales Pflaster
PCT/EP2004/001052 WO2004073696A1 (de) 2003-02-21 2004-02-04 Uv-stabiles transdermales pflaster

Publications (2)

Publication Number Publication Date
HRP20050828A2 HRP20050828A2 (en) 2006-03-31
HRP20050828B1 true HRP20050828B1 (hr) 2013-10-25

Family

ID=32910125

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20050828AA HRP20050828B1 (hr) 2003-02-21 2005-09-20 Uv-stabilni transdermalni flaster

Country Status (31)

Country Link
US (3) US8486443B2 (hr)
EP (1) EP1594483B1 (hr)
JP (1) JP4528296B2 (hr)
KR (1) KR100704825B1 (hr)
AR (1) AR043248A1 (hr)
AT (1) ATE333271T1 (hr)
AU (1) AU2004212675B2 (hr)
BR (1) BRPI0407615B8 (hr)
CA (1) CA2515918C (hr)
CR (1) CR7952A (hr)
CY (1) CY1105716T1 (hr)
DE (1) DE502004000988D1 (hr)
DK (1) DK1594483T3 (hr)
EA (1) EA008098B1 (hr)
EC (1) ECSP056030A (hr)
ES (1) ES2270345T3 (hr)
HK (1) HK1085394A1 (hr)
HR (1) HRP20050828B1 (hr)
IL (1) IL170295A (hr)
IS (1) IS2541B (hr)
ME (2) MEP14008A (hr)
MX (1) MXPA05008778A (hr)
NO (1) NO336108B1 (hr)
NZ (1) NZ541807A (hr)
PE (1) PE20041028A1 (hr)
PL (1) PL219030B1 (hr)
PT (1) PT1594483E (hr)
RS (1) RS50428B (hr)
SI (1) SI1594483T1 (hr)
UY (1) UY28189A1 (hr)
WO (1) WO2004073696A1 (hr)

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DE502004000988D1 (de) 2003-02-21 2006-08-31 Schering Ag Uv-stabiles transdermales pflaster
US8668925B2 (en) 2003-12-12 2014-03-11 Bayer Intellectual Property Gmbh Transdermal delivery of hormones without the need of penetration enhancers
KR20070053267A (ko) * 2004-08-20 2007-05-23 쓰리엠 이노베이티브 프로퍼티즈 컴파니 반투명 보호 필름을 갖는 경피 약물 전달 장치
EP1719504A1 (de) 2005-05-02 2006-11-08 Schering AG Festes transdermales therapeutisches System mit UV-Absorber
US8962013B2 (en) 2005-05-02 2015-02-24 Bayer Intellectual Property Gmbh Multi-layered transdermal system with triazine UV absorber
WO2010009122A1 (en) * 2008-07-14 2010-01-21 Surmodics, Inc. Medical devices and methods for delivery of nucleic acids
DE102010040299A1 (de) * 2010-09-06 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner)
PT2613772T (pt) * 2010-09-06 2017-03-06 Bayer Ip Gmbh Emplastros transdérmicos de dose baixa com alta libertação de fármaco
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
LT2782584T (lt) 2011-11-23 2021-09-10 Therapeuticsmd, Inc. Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10835499B2 (en) 2015-12-30 2020-11-17 Corium, Inc. Systems and methods for long term transdermal administration
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
DE102020104907A1 (de) * 2020-02-25 2021-08-26 Berliner Glas GmbH Verfahren zur Herstellung eines Bauelements durch atomares Diffusionsbonden

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Also Published As

Publication number Publication date
IS8031A (is) 2005-09-15
DK1594483T3 (da) 2006-11-20
EP1594483A1 (de) 2005-11-16
US20060251707A1 (en) 2006-11-09
ES2270345T3 (es) 2007-04-01
HK1085394A1 (en) 2006-08-25
BRPI0407615A (pt) 2006-02-14
DE502004000988D1 (de) 2006-08-31
ME00147B (me) 2010-10-10
ECSP056030A (es) 2006-01-27
MEP14008A (en) 2010-06-10
AU2004212675B2 (en) 2006-06-01
US20130226113A1 (en) 2013-08-29
MXPA05008778A (es) 2006-05-25
UY28189A1 (es) 2004-04-30
IS2541B (is) 2009-09-15
CR7952A (es) 2006-02-06
SI1594483T1 (sl) 2006-12-31
CA2515918A1 (en) 2004-09-02
BRPI0407615B1 (pt) 2018-02-14
NO336108B1 (no) 2015-05-18
JP4528296B2 (ja) 2010-08-18
WO2004073696A1 (de) 2004-09-02
CY1105716T1 (el) 2010-12-22
PL378035A1 (pl) 2006-02-20
EP1594483B1 (de) 2006-07-19
IL170295A (en) 2010-05-31
US8486443B2 (en) 2013-07-16
PE20041028A1 (es) 2005-02-18
KR20050103499A (ko) 2005-10-31
US9095691B2 (en) 2015-08-04
HRP20050828A2 (en) 2006-03-31
AU2004212675A1 (en) 2004-09-02
KR100704825B1 (ko) 2007-04-09
ATE333271T1 (de) 2006-08-15
PL219030B1 (pl) 2015-03-31
PT1594483E (pt) 2006-12-29
NZ541807A (en) 2009-07-31
JP2006518348A (ja) 2006-08-10
NO20054321L (no) 2005-09-20
EA008098B1 (ru) 2007-02-27
RS50428B (sr) 2009-12-31
CA2515918C (en) 2010-11-16
AR043248A1 (es) 2005-07-20
RS20050639A (en) 2007-09-21
BRPI0407615B8 (pt) 2021-05-25
US20150335658A1 (en) 2015-11-26
EA200501224A1 (ru) 2006-04-28

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