CA2934028A1 - Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists - Google Patents
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists Download PDFInfo
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- CA2934028A1 CA2934028A1 CA2934028A CA2934028A CA2934028A1 CA 2934028 A1 CA2934028 A1 CA 2934028A1 CA 2934028 A CA2934028 A CA 2934028A CA 2934028 A CA2934028 A CA 2934028A CA 2934028 A1 CA2934028 A1 CA 2934028A1
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- antibody
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- cancer
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Classifications
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361917264P | 2013-12-17 | 2013-12-17 | |
| US61/917,264 | 2013-12-17 | ||
| US201462080991P | 2014-11-17 | 2014-11-17 | |
| US62/080,991 | 2014-11-17 | ||
| PCT/US2014/070998 WO2015095423A2 (en) | 2013-12-17 | 2014-12-17 | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
Publications (1)
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| CA2934028A1 true CA2934028A1 (en) | 2015-06-25 |
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| CA2934028A Abandoned CA2934028A1 (en) | 2013-12-17 | 2014-12-17 | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
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| EP (2) | EP3083687A2 (enExample) |
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| CA (1) | CA2934028A1 (enExample) |
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| MX (1) | MX2016007965A (enExample) |
| SG (1) | SG11201604979WA (enExample) |
| WO (1) | WO2015095423A2 (enExample) |
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| RU2017132160A (ru) | 2008-12-09 | 2019-02-08 | Дженентек, Инк. | Антитела к pd-l1 и их применение для усиления функции t-клеток |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| KR20200079568A (ko) | 2012-05-31 | 2020-07-03 | 제넨테크, 인크. | Pd-l1 축 결합 길항제 및 vegf 길항제를 사용하여 암을 치료하는 방법 |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| CN110981964B (zh) | 2013-01-14 | 2023-09-15 | Xencor股份有限公司 | 新型异二聚体蛋白 |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| ES2687282T3 (es) | 2013-03-18 | 2018-10-24 | Biocerox Products B.V. | Anticuerpos humanizados ANTI-CD134 (OX40) y sus usos |
| WO2015048312A1 (en) | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| DK3105246T3 (da) | 2014-02-10 | 2021-06-14 | Merck Patent Gmbh | Målrettet TGF-beta-inhibering |
| KR20240110004A (ko) | 2014-03-14 | 2024-07-12 | 노파르티스 아게 | Lag-3에 대한 항체 분자 및 그의 용도 |
| AU2015237184B2 (en) | 2014-03-28 | 2020-11-26 | Xencor, Inc. | Bispecific antibodies that bind to CD38 and CD3 |
| CN106132439A (zh) | 2014-03-31 | 2016-11-16 | 豪夫迈·罗氏有限公司 | 包含抗血管发生剂和ox40结合激动剂的组合疗法 |
| EP3195168B1 (en) * | 2014-07-31 | 2022-09-07 | The University Of Western Australia | A method for the identification of immunotherapy-drug combinations using a network approach |
| EP3191127A1 (en) | 2014-09-13 | 2017-07-19 | Novartis AG | Combination therapies of egfr inhibitors |
| BR112017006664A2 (pt) * | 2014-10-03 | 2017-12-26 | Novartis Ag | terapias de combinação |
| KR102513870B1 (ko) | 2014-10-14 | 2023-03-23 | 노파르티스 아게 | Pd-l1에 대한 항체 분자 및 그의 용도 |
| WO2016073380A1 (en) * | 2014-11-03 | 2016-05-12 | Genentech, Inc. | Method and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment |
| BR112017009151A2 (pt) | 2014-11-03 | 2018-03-06 | Genentech, Inc. | ensaios para detectar subgrupos imunológicos de célula t e métodos de uso dos mesmos |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| PE20171103A1 (es) | 2014-11-26 | 2017-08-07 | Xencor Inc | Anticuerpos heterodimericos que se unen a cd3 y cd38 |
| MX384025B (es) | 2014-11-26 | 2025-03-14 | Xencor Inc | Anticuerpos heterodimericos que se unen a cd3 y a antigenos tumorales. |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
| JP6784687B2 (ja) | 2015-02-24 | 2020-11-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 結合誘発型転写スイッチ及びその使用方法 |
| EP3262073A1 (en) | 2015-02-26 | 2018-01-03 | Merck Patent GmbH | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| KR20180015650A (ko) | 2015-05-07 | 2018-02-13 | 아게누스 인코포레이티드 | 항-ox40 항체 및 이의 사용 방법 |
| EP3298045A1 (en) * | 2015-05-21 | 2018-03-28 | Alligator Bioscience AB | Novel polypeptides |
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-
2014
- 2014-12-17 BR BR112016013963A patent/BR112016013963A2/pt not_active Application Discontinuation
- 2014-12-17 WO PCT/US2014/070998 patent/WO2015095423A2/en not_active Ceased
- 2014-12-17 EP EP14824702.6A patent/EP3083687A2/en not_active Withdrawn
- 2014-12-17 SG SG11201604979WA patent/SG11201604979WA/en unknown
- 2014-12-17 AU AU2014364606A patent/AU2014364606A1/en not_active Abandoned
- 2014-12-17 KR KR1020167018833A patent/KR20160099092A/ko not_active Withdrawn
- 2014-12-17 EP EP18206645.6A patent/EP3527587A1/en not_active Withdrawn
- 2014-12-17 CA CA2934028A patent/CA2934028A1/en not_active Abandoned
- 2014-12-17 MX MX2016007965A patent/MX2016007965A/es unknown
- 2014-12-17 US US14/574,365 patent/US20150190506A1/en not_active Abandoned
- 2014-12-17 CN CN201480073061.9A patent/CN106102774A/zh active Pending
- 2014-12-17 JP JP2016540597A patent/JP2017501167A/ja active Pending
-
2016
- 2016-06-15 IL IL246251A patent/IL246251A0/en unknown
-
2018
- 2018-02-01 US US15/886,454 patent/US20180303936A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150190506A1 (en) | 2015-07-09 |
| IL246251A0 (en) | 2016-07-31 |
| KR20160099092A (ko) | 2016-08-19 |
| MX2016007965A (es) | 2016-10-28 |
| EP3527587A1 (en) | 2019-08-21 |
| JP2017501167A (ja) | 2017-01-12 |
| BR112016013963A2 (pt) | 2017-10-10 |
| SG11201604979WA (en) | 2016-07-28 |
| AU2014364606A1 (en) | 2016-07-07 |
| CN106102774A (zh) | 2016-11-09 |
| WO2015095423A2 (en) | 2015-06-25 |
| EP3083687A2 (en) | 2016-10-26 |
| US20180303936A1 (en) | 2018-10-25 |
| WO2015095423A3 (en) | 2015-08-13 |
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