CA2882018C - Substituted n-(2-methoxy-5-nitrophenyl)pyrimidin-2-amine compounds, and salts thereof - Google Patents

Substituted n-(2-methoxy-5-nitrophenyl)pyrimidin-2-amine compounds, and salts thereof Download PDF

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Publication number
CA2882018C
CA2882018C CA2882018A CA2882018A CA2882018C CA 2882018 C CA2882018 C CA 2882018C CA 2882018 A CA2882018 A CA 2882018A CA 2882018 A CA2882018 A CA 2882018A CA 2882018 C CA2882018 C CA 2882018C
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mmol
mixture
ch2c12
methoxy
vacuo
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CA2882018A1 (en
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Sam Butterworth
Maurice Raymond Verschoyle Finlay
Richard Andrew Ward
Vasantha Krishna Kadambar
Chandrasekhara Reddy Chintakuntla
Andiappan Murugan
Heather Marie Redfearn
Claudio Edmundo Chuaqui
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Liquid Crystal Substances (AREA)
  • Luminescent Compositions (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CA2882018A 2011-07-27 2012-07-25 Substituted n-(2-methoxy-5-nitrophenyl)pyrimidin-2-amine compounds, and salts thereof Active CA2882018C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161512061P 2011-07-27 2011-07-27
US61/512,061 2011-07-27
US201261591363P 2012-01-27 2012-01-27
US61/591,363 2012-01-27
CA2843109A CA2843109C (en) 2011-07-27 2012-07-25 2-(2,4,5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer

Related Parent Applications (1)

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CA2843109A Division CA2843109C (en) 2011-07-27 2012-07-25 2-(2,4,5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer

Publications (2)

Publication Number Publication Date
CA2882018A1 CA2882018A1 (en) 2013-01-31
CA2882018C true CA2882018C (en) 2017-04-25

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ID=46875901

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Application Number Title Priority Date Filing Date
CA2882018A Active CA2882018C (en) 2011-07-27 2012-07-25 Substituted n-(2-methoxy-5-nitrophenyl)pyrimidin-2-amine compounds, and salts thereof
CA2843109A Active CA2843109C (en) 2011-07-27 2012-07-25 2-(2,4,5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer
CA2881993A Active CA2881993C (en) 2011-07-27 2012-07-25 Substituted 4-methoxy-n3-(pyrimidin-2-yl)benzene-1,3-diamine compounds, and salts thereof
CA2881991A Active CA2881991C (en) 2011-07-27 2012-07-25 Substituted 3-chloro-n-[3-(pyrimidin-2-ylamino)phenyl]propanamide compound, and salts thereof
CA2881987A Active CA2881987C (en) 2011-07-27 2012-07-25 Substituted n-(4-fluoro-2-methoxy-5-nitrophenyl)pyrimidin-2-amine compounds, and salts thereof

Family Applications After (4)

Application Number Title Priority Date Filing Date
CA2843109A Active CA2843109C (en) 2011-07-27 2012-07-25 2-(2,4,5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer
CA2881993A Active CA2881993C (en) 2011-07-27 2012-07-25 Substituted 4-methoxy-n3-(pyrimidin-2-yl)benzene-1,3-diamine compounds, and salts thereof
CA2881991A Active CA2881991C (en) 2011-07-27 2012-07-25 Substituted 3-chloro-n-[3-(pyrimidin-2-ylamino)phenyl]propanamide compound, and salts thereof
CA2881987A Active CA2881987C (en) 2011-07-27 2012-07-25 Substituted n-(4-fluoro-2-methoxy-5-nitrophenyl)pyrimidin-2-amine compounds, and salts thereof

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US (8) US8946235B2 (enExample)
EP (7) EP3686194B1 (enExample)
JP (3) JP5427321B2 (enExample)
KR (3) KR101410902B1 (enExample)
CN (7) CN103702990B (enExample)
AR (1) AR087336A1 (enExample)
AU (1) AU2012288626C1 (enExample)
BR (4) BR112014001768B1 (enExample)
CA (5) CA2882018C (enExample)
CL (1) CL2013003281A1 (enExample)
CO (1) CO6811863A2 (enExample)
CR (1) CR20130629A (enExample)
CY (4) CY1117431T1 (enExample)
DK (5) DK3009431T3 (enExample)
DO (1) DOP2013000263A (enExample)
EA (3) EA024421B1 (enExample)
EC (1) ECSP13013033A (enExample)
ES (5) ES2654177T3 (enExample)
GT (1) GT201300288A (enExample)
HR (4) HRP20160135T1 (enExample)
HU (4) HUE026429T2 (enExample)
IL (6) IL229199A (enExample)
LT (3) LT3009431T (enExample)
ME (3) ME02382B (enExample)
MX (3) MX2014000528A (enExample)
MY (2) MY194532A (enExample)
NI (1) NI201300134A (enExample)
PE (1) PE20141700A1 (enExample)
PH (2) PH12013502312A1 (enExample)
PL (5) PL3333161T3 (enExample)
PT (4) PT3686193T (enExample)
RS (4) RS60190B1 (enExample)
SG (5) SG194783A1 (enExample)
SI (4) SI3333161T1 (enExample)
SM (3) SMT202100652T1 (enExample)
TW (3) TWI583386B (enExample)
UY (1) UY34219A (enExample)
WO (1) WO2013014448A1 (enExample)

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