CA2795349C - Targeted pyrrolobenzodiazepine conjugates - Google Patents

Targeted pyrrolobenzodiazepine conjugates Download PDF

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Publication number
CA2795349C
CA2795349C CA2795349A CA2795349A CA2795349C CA 2795349 C CA2795349 C CA 2795349C CA 2795349 A CA2795349 A CA 2795349A CA 2795349 A CA2795349 A CA 2795349A CA 2795349 C CA2795349 C CA 2795349C
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Canada
Prior art keywords
group
conjugate
antibody
attachment
mmol
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CA2795349A
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English (en)
French (fr)
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CA2795349A1 (en
Inventor
Philip Wilson Howard
Scott Jeffrey
Patrick Burke
Peter Senter
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MedImmune Ltd
Seagen Inc
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MedImmune Ltd
Seattle Genetics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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