CA2697147A1 - Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 - Google Patents

Info

Publication number

CA2697147A1

CA2697147A1 CA2697147A CA2697147A CA2697147A1 CA 2697147 A1 CA2697147 A1 CA 2697147A1 CA 2697147 A CA2697147 A CA 2697147A CA 2697147 A CA2697147 A CA 2697147A CA 2697147 A1 CA2697147 A1 CA 2697147A1

Authority

CA

Canada

Prior art keywords

oxazinan

ethyl

halo

alkyl

alkoxy

Prior art date

2007-07-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 239000003112 inhibitor Substances 0.000 title description 9
• 101710088194 Dehydrogenase Proteins 0.000 title description 4
• 125000004122 cyclic group Chemical group 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 100
• 150000003839 salts Chemical class 0.000 claims abstract description 78
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 8
• 201000010099 disease Diseases 0.000 claims abstract description 7
• 238000000034 method Methods 0.000 claims abstract description 6
• 241000124008 Mammalia Species 0.000 claims abstract description 5
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract 5
• 125000005843 halogen group Chemical group 0.000 claims description 1017
• 125000003545 alkoxy group Chemical group 0.000 claims description 483
• 125000000217 alkyl group Chemical group 0.000 claims description 410
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 358
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 279
• -1 thiazolidine-2,4-dionyl Chemical group 0.000 claims description 274
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 232
• 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 197
• 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 183
• 125000003282 alkyl amino group Chemical group 0.000 claims description 169
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 153
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 144
• 125000004043 oxo group Chemical group O=* 0.000 claims description 133
• 125000001072 heteroaryl group Chemical group 0.000 claims description 117
• 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 114
• 125000000000 cycloalkoxy group Chemical group 0.000 claims description 110
• 125000004644 alkyl sulfinyl group Chemical group 0.000 claims description 108
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 108
• 125000005148 cycloalkylalkanesulfinyl group Chemical group 0.000 claims description 108
• 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims description 108
• 125000004414 alkyl thio group Chemical group 0.000 claims description 88
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 87
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 84
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 83
• 239000011737 fluorine Substances 0.000 claims description 83
• 229910052731 fluorine Inorganic materials 0.000 claims description 83
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 77
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 77
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 69
• 125000003368 amide group Chemical class 0.000 claims description 64
• 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 60
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 60
• 239000000460 chlorine Substances 0.000 claims description 60
• 229910052801 chlorine Inorganic materials 0.000 claims description 60
• 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims description 56
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 55
• 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims description 55
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 55
• 229910052794 bromium Inorganic materials 0.000 claims description 55
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 55
• 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims description 53
• 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 51
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 50
• 229910052736 halogen Inorganic materials 0.000 claims description 49
• 150000002367 halogens Chemical group 0.000 claims description 49
• 125000005167 cycloalkylaminocarbonyl group Chemical group 0.000 claims description 47
• 125000000623 heterocyclic group Chemical group 0.000 claims description 47
• 125000003118 aryl group Chemical group 0.000 claims description 41
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 39
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 37
• 125000002947 alkylene group Chemical group 0.000 claims description 35
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 32
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 32
• 125000001188 haloalkyl group Chemical group 0.000 claims description 30
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 29
• 125000005145 cycloalkylaminosulfonyl group Chemical group 0.000 claims description 24
• 125000004076 pyridyl group Chemical group 0.000 claims description 24
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 21
• 239000001257 hydrogen Substances 0.000 claims description 21
• 229910052739 hydrogen Inorganic materials 0.000 claims description 21
• 125000001424 substituent group Chemical group 0.000 claims description 21
• 125000001769 aryl amino group Chemical group 0.000 claims description 20
• 230000000694 effects Effects 0.000 claims description 20
• 125000005241 heteroarylamino group Chemical group 0.000 claims description 20
• 229910052760 oxygen Inorganic materials 0.000 claims description 18
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 15
• SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 claims description 15
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 14
• 125000004633 N-oxo-pyridyl group Chemical group 0.000 claims description 14
• 125000001544 thienyl group Chemical group 0.000 claims description 14
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 13
• 229910003600 H2NS Inorganic materials 0.000 claims description 12
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 12
• VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical compound [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 claims description 12
• 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 12
• 239000001301 oxygen Substances 0.000 claims description 12
• 125000003831 tetrazolyl group Chemical group 0.000 claims description 12
• 125000000335 thiazolyl group Chemical group 0.000 claims description 12
• 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims description 11
• RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 11
• WQADWIOXOXRPLN-UHFFFAOYSA-N 1,3-dithiane Chemical compound C1CSCSC1 WQADWIOXOXRPLN-UHFFFAOYSA-N 0.000 claims description 10
• LOZWAPSEEHRYPG-UHFFFAOYSA-N 1,4-dithiane Chemical compound C1CSCCS1 LOZWAPSEEHRYPG-UHFFFAOYSA-N 0.000 claims description 10
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 10
• SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 10
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 10
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 10
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 10
• 125000005529 alkyleneoxy group Chemical group 0.000 claims description 10
• WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 claims description 10
• XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 claims description 10
• 125000003386 piperidinyl group Chemical group 0.000 claims description 10
• HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 10
• 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 8
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 8
• 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims description 7
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 7
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 7
• 125000006263 dimethyl aminosulfonyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])S(*)(=O)=O 0.000 claims description 7
• 230000014509 gene expression Effects 0.000 claims description 7
• 125000006262 isopropyl amino sulfonyl group Chemical group 0.000 claims description 7
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims description 7
• 125000004193 piperazinyl group Chemical group 0.000 claims description 7
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 7
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 7
• 229920002554 vinyl polymer Chemical group 0.000 claims description 7
• 125000001207 fluorophenyl group Chemical group 0.000 claims description 6
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 6
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 6
• AGZILYNCQWRIIP-UHFFFAOYSA-N 1,2,5-thiadiazolidine 1,1-dioxide;1,2-thiazolidine 1,1-dioxide Chemical group O=S1(=O)CCCN1.O=S1(=O)NCCN1 AGZILYNCQWRIIP-UHFFFAOYSA-N 0.000 claims description 5
• CIISBYKBBMFLEZ-UHFFFAOYSA-N 1,2-oxazolidine Chemical compound C1CNOC1 CIISBYKBBMFLEZ-UHFFFAOYSA-N 0.000 claims description 5
• NQPJDJVGBDHCAD-UHFFFAOYSA-N 1,3-diazinan-2-one Chemical compound OC1=NCCCN1 NQPJDJVGBDHCAD-UHFFFAOYSA-N 0.000 claims description 5
• VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical compound C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 claims description 5
• WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 claims description 5
• IMLSAISZLJGWPP-UHFFFAOYSA-N 1,3-dithiolane Chemical compound C1CSCS1 IMLSAISZLJGWPP-UHFFFAOYSA-N 0.000 claims description 5
• OYELEBBISJGNHJ-UHFFFAOYSA-N 1,3-oxazinan-2-one Chemical compound O=C1NCCCO1 OYELEBBISJGNHJ-UHFFFAOYSA-N 0.000 claims description 5
• YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 claims description 5
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 5
• NDOVLWQBFFJETK-UHFFFAOYSA-N 1,4-thiazinane 1,1-dioxide Chemical compound O=S1(=O)CCNCC1 NDOVLWQBFFJETK-UHFFFAOYSA-N 0.000 claims description 5
• GFPOCAYEKCWFPD-UHFFFAOYSA-N 1-(2,2,2-trifluoroethyl)piperazine Chemical compound FC(F)(F)CN1CCNCC1 GFPOCAYEKCWFPD-UHFFFAOYSA-N 0.000 claims description 5
• LLAPDLPYIYKTGQ-UHFFFAOYSA-N 1-aminoethyl Chemical group C[CH]N LLAPDLPYIYKTGQ-UHFFFAOYSA-N 0.000 claims description 5
• DNCYBUMDUBHIJZ-UHFFFAOYSA-N 1h-pyrimidin-6-one Chemical compound O=C1C=CN=CN1 DNCYBUMDUBHIJZ-UHFFFAOYSA-N 0.000 claims description 5
• IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims description 5
• VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 claims description 5
• IHXNIOYEXQWUNI-UHFFFAOYSA-N 4,5-dihydro-1h-pyrimidin-6-one Chemical compound O=C1CCN=CN1 IHXNIOYEXQWUNI-UHFFFAOYSA-N 0.000 claims description 5
• GCNTZFIIOFTKIY-UHFFFAOYSA-N 4-hydroxypyridine Chemical compound OC1=CC=NC=C1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 claims description 5
• DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims description 5
• YPWFISCTZQNZAU-UHFFFAOYSA-N Thiane Chemical compound C1CCSCC1 YPWFISCTZQNZAU-UHFFFAOYSA-N 0.000 claims description 5
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 5
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
• 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 5
• 125000005347 halocycloalkyl group Chemical group 0.000 claims description 5
• YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 claims description 5
• 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 5
• 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims description 5
• VSEAAEQOQBMPQF-UHFFFAOYSA-N morpholin-3-one Chemical compound O=C1COCCN1 VSEAAEQOQBMPQF-UHFFFAOYSA-N 0.000 claims description 5
• 125000002757 morpholinyl group Chemical group 0.000 claims description 5
• 125000001715 oxadiazolyl group Chemical group 0.000 claims description 5
• IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 claims description 5
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 5
• UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims description 5
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 5
• 238000006467 substitution reaction Methods 0.000 claims description 5
• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 5
• RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical compound C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 claims description 5
• 125000001113 thiadiazolyl group Chemical group 0.000 claims description 5
• DNGMYXZLJGHHOM-UHFFFAOYSA-N thiazinane 1,1-dioxide Chemical compound O=S1(=O)CCCCN1 DNGMYXZLJGHHOM-UHFFFAOYSA-N 0.000 claims description 5
• BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims description 5
• 125000002883 imidazolyl group Chemical group 0.000 claims description 4
• 230000002401 inhibitory effect Effects 0.000 claims description 4
• 125000000304 alkynyl group Chemical group 0.000 claims description 3
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 3
• UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims description 3
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
• 125000001153 fluoro group Chemical group F* 0.000 claims description 2
• ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical compound [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 claims description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 108
• 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 claims 52
• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 52
• 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 28
• 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 22
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 8
• JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 6
• 229910052717 sulfur Inorganic materials 0.000 claims 6
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
• GRECFJMRKUEXPU-HSZRJFAPSA-N (6r)-3-[3-(4-fluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1 GRECFJMRKUEXPU-HSZRJFAPSA-N 0.000 claims 3
• OUTTUYZQIHSHQF-KTQQKIMGSA-N 6-(4-fluorophenyl)-6-(hydroxymethyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound O1C(=O)N([C@@H](C)C=2C=CC=CC=2)CCC1(CO)C1=CC=C(F)C=C1 OUTTUYZQIHSHQF-KTQQKIMGSA-N 0.000 claims 3
• DQYAEFFEMXBSCO-OOJLDXBWSA-N 6-ethenyl-6-(4-fluorophenyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound O1C(=O)N([C@@H](C)C=2C=CC=CC=2)CCC1(C=C)C1=CC=C(F)C=C1 DQYAEFFEMXBSCO-OOJLDXBWSA-N 0.000 claims 3
• 125000003107 substituted aryl group Chemical group 0.000 claims 3
• BOIJCIOTGVUZGO-MGPUTAFESA-N (6r)-3-[(1s)-1-(3-methoxyphenyl)ethyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound COC1=CC=CC([C@H](C)N2C(O[C@](C)(CC2)C=2C=CC=CC=2)=O)=C1 BOIJCIOTGVUZGO-MGPUTAFESA-N 0.000 claims 2
• SXAUUPNZZAAJOG-YCRPNKLZSA-N (6r)-3-[(1s)-1-(4-bromophenyl)ethyl]-6-(4-fluorophenyl)-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 SXAUUPNZZAAJOG-YCRPNKLZSA-N 0.000 claims 2
• AGCSHHGFMAHUIK-BXKMTCNYSA-N (6r)-3-[(1s)-1-(4-cyclopropylphenyl)ethyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C2CC2)=CC=C(F)C=C1 AGCSHHGFMAHUIK-BXKMTCNYSA-N 0.000 claims 2
• QSELYASLZRRGGG-BXKMTCNYSA-N (6r)-3-[(1s)-1-(4-cyclopropylphenyl)ethyl]-6-(4-fluorophenyl)-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C2CC2)=CC=C(F)C=C1 QSELYASLZRRGGG-BXKMTCNYSA-N 0.000 claims 2
• GIXQDYLLNHGWNS-MGPUTAFESA-N (6r)-3-[(1s)-1-(4-methoxyphenyl)ethyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C1=CC(OC)=CC=C1[C@H](C)N1C(=O)O[C@@](C)(C=2C=CC=CC=2)CC1 GIXQDYLLNHGWNS-MGPUTAFESA-N 0.000 claims 2
• SLSMHOGJKAPYQU-MRDQGFSESA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 SLSMHOGJKAPYQU-MRDQGFSESA-N 0.000 claims 2
• OTARHPTVFRBZQX-XRHLQHRESA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 OTARHPTVFRBZQX-XRHLQHRESA-N 0.000 claims 2
• JRTXHMURXROZCN-XRHLQHRESA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 JRTXHMURXROZCN-XRHLQHRESA-N 0.000 claims 2
• FDVFZPJZYBDRRS-HRAATJIYSA-N (6r)-3-[(1s)-1-cyclohexylethyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@H](C)N2C(O[C@](CCCO)(CC2)C=2C=CC(F)=CC=2)=O)CCCCC1 FDVFZPJZYBDRRS-HRAATJIYSA-N 0.000 claims 2
• BRCSKQYCZLOWED-XMMPIXPASA-N (6r)-3-[3-(2,4-difluorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F BRCSKQYCZLOWED-XMMPIXPASA-N 0.000 claims 2
• ZZNUHDXNMHQWAV-HSZRJFAPSA-N (6r)-3-[6-(2,4-difluorophenyl)pyridin-2-yl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@@](OC1=O)(CCO)C=2C(=CC=CC=2)F)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1F ZZNUHDXNMHQWAV-HSZRJFAPSA-N 0.000 claims 2
• JSLCIPMQVPVXCO-MRDQGFSESA-N (6r)-6-(2-aminoethyl)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCN)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 JSLCIPMQVPVXCO-MRDQGFSESA-N 0.000 claims 2
• XKUYBHWZCQUCGO-HFJWLAOPSA-N (6r)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=C(F)C=C1 XKUYBHWZCQUCGO-HFJWLAOPSA-N 0.000 claims 2
• XRTFMNIRZNJJHD-OXJNMPFZSA-N (6r)-6-methyl-6-(2-methylphenyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=CC=C1C XRTFMNIRZNJJHD-OXJNMPFZSA-N 0.000 claims 2
• QIMFMKBZKNFZQM-OXJNMPFZSA-N (6r)-6-methyl-6-(3-methylphenyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=CC(C)=C1 QIMFMKBZKNFZQM-OXJNMPFZSA-N 0.000 claims 2
• VQYBDAASFBMKEP-OXJNMPFZSA-N (6r)-6-methyl-6-(4-methylphenyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=C(C)C=C1 VQYBDAASFBMKEP-OXJNMPFZSA-N 0.000 claims 2
• BOIJCIOTGVUZGO-YWZLYKJASA-N (6s)-3-[(1s)-1-(3-methoxyphenyl)ethyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound COC1=CC=CC([C@H](C)N2C(O[C@@](C)(CC2)C=2C=CC=CC=2)=O)=C1 BOIJCIOTGVUZGO-YWZLYKJASA-N 0.000 claims 2
• WOQTXQOMVPEQHH-XOBRGWDASA-N (6s)-3-[(1s)-1-(4-bromophenyl)ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 WOQTXQOMVPEQHH-XOBRGWDASA-N 0.000 claims 2
• UXYULVUOOAOBIA-ZKYUUJBMSA-N (6s)-3-[(1s)-1-(4-bromophenyl)ethyl]-6-[(2r)-2,3-dihydroxypropyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C[C@@H](O)CO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 UXYULVUOOAOBIA-ZKYUUJBMSA-N 0.000 claims 2
• UXYULVUOOAOBIA-JBYOLUDKSA-N (6s)-3-[(1s)-1-(4-bromophenyl)ethyl]-6-[(2s)-2,3-dihydroxypropyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C[C@H](O)CO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 UXYULVUOOAOBIA-JBYOLUDKSA-N 0.000 claims 2
• JQRPZOWAALFXBW-FPOVZHCZSA-N (6s)-3-[(1s)-1-(4-bromophenyl)propyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](CC)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 JQRPZOWAALFXBW-FPOVZHCZSA-N 0.000 claims 2
• GIXQDYLLNHGWNS-YWZLYKJASA-N (6s)-3-[(1s)-1-(4-methoxyphenyl)ethyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C1=CC(OC)=CC=C1[C@H](C)N1C(=O)O[C@](C)(C=2C=CC=CC=2)CC1 GIXQDYLLNHGWNS-YWZLYKJASA-N 0.000 claims 2
• JYUZCHJMXCOJJR-MRDQGFSESA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-6-[2-(sulfamoylamino)ethyl]-1,3-oxazinane Chemical compound C1([C@@]2(CCNS(N)(=O)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 JYUZCHJMXCOJJR-MRDQGFSESA-N 0.000 claims 2
• ZTMCZWXIGPCMLA-JMQGSBJISA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC(C)(C)O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 ZTMCZWXIGPCMLA-JMQGSBJISA-N 0.000 claims 2
• SLSMHOGJKAPYQU-QLXKLKPCSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 SLSMHOGJKAPYQU-QLXKLKPCSA-N 0.000 claims 2
• SNDUQSURYVCBQD-JHPYAOMDSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(CC(O)C)C=2C=CC(F)=CC=2)=CC=C1C1=CC=C(F)C=C1F SNDUQSURYVCBQD-JHPYAOMDSA-N 0.000 claims 2
• FKSSIYWQQLRDKP-MYUZEXMDSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-methoxyethyl)-1,3-oxazinan-2-one Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(CCOC)C=2C=CC(F)=CC=2)=CC=C1C1=CC=C(F)C=C1F FKSSIYWQQLRDKP-MYUZEXMDSA-N 0.000 claims 2
• NDJIIYAAWZLVPP-MYUZEXMDSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-oxopropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC(C)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 NDJIIYAAWZLVPP-MYUZEXMDSA-N 0.000 claims 2
• BRCSKQYCZLOWED-DEOSSOPVSA-N (6s)-3-[3-(2,4-difluorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F BRCSKQYCZLOWED-DEOSSOPVSA-N 0.000 claims 2
• GRECFJMRKUEXPU-QHCPKHFHSA-N (6s)-3-[3-(4-fluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1 GRECFJMRKUEXPU-QHCPKHFHSA-N 0.000 claims 2
• IIAKMAWFDUBOEW-DEOSSOPVSA-N (6s)-3-[4-fluoro-3-(4-fluorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1 IIAKMAWFDUBOEW-DEOSSOPVSA-N 0.000 claims 2
• ZZNUHDXNMHQWAV-QHCPKHFHSA-N (6s)-3-[6-(2,4-difluorophenyl)pyridin-2-yl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C(=CC=CC=2)F)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1F ZZNUHDXNMHQWAV-QHCPKHFHSA-N 0.000 claims 2
• QZFTYROSXIMEHP-QHCPKHFHSA-N (6s)-3-[6-(4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1 QZFTYROSXIMEHP-QHCPKHFHSA-N 0.000 claims 2
• ZJBOOJMHWPFBRE-QHCPKHFHSA-N (6s)-6-(2-fluorophenyl)-3-[6-(4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C(=CC=CC=2)F)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1 ZJBOOJMHWPFBRE-QHCPKHFHSA-N 0.000 claims 2
• XKUYBHWZCQUCGO-QYBDOPJKSA-N (6s)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=C(F)C=C1 XKUYBHWZCQUCGO-QYBDOPJKSA-N 0.000 claims 2
• FNTHZWPWNKYVAW-YWZLYKJASA-N (6s)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=C(F)C=C1 FNTHZWPWNKYVAW-YWZLYKJASA-N 0.000 claims 2
• LVYAAPIPLDIUSX-KXBFYZLASA-N (6s)-6-methyl-6-phenyl-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=CC=C1 LVYAAPIPLDIUSX-KXBFYZLASA-N 0.000 claims 2
• QDIAPKPZNBARDD-XDBZFTIUSA-N 1-[2-[(6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl]-3-methylurea Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(CCNC(=O)NC)C=2C=CC(F)=CC=2)=CC=C1C1=CC=C(F)C=C1F QDIAPKPZNBARDD-XDBZFTIUSA-N 0.000 claims 2
• IUSPSJCBMHYEMF-QLXKLKPCSA-N 2-[(6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl dihydrogen phosphate Chemical compound C1([C@@]2(CCOP(O)(O)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 IUSPSJCBMHYEMF-QLXKLKPCSA-N 0.000 claims 2
• BRAAFKXBNFFQPW-JMQGSBJISA-N 2-[(6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl n-methylcarbamate Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(CCOC(=O)NC)C=2C=CC(F)=CC=2)=CC=C1C1=CC=C(F)C=C1F BRAAFKXBNFFQPW-JMQGSBJISA-N 0.000 claims 2
• YNFCWWDWZMSWGU-QLXKLKPCSA-N 2-[(6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl sulfamate Chemical compound C1([C@@]2(CCOS(N)(=O)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 YNFCWWDWZMSWGU-QLXKLKPCSA-N 0.000 claims 2
• FKKJWWOASDLEKD-UHFFFAOYSA-N 2-[3-(6-methyl-2-oxo-6-phenyl-1,3-oxazinan-3-yl)phenyl]benzonitrile Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC=C1C#N FKKJWWOASDLEKD-UHFFFAOYSA-N 0.000 claims 2
• FVYWUKYMYNOWNN-AJWVYOOVSA-N 2-[3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]acetamide Chemical compound O1C(=O)N([C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)CCC1(CC(N)=O)C1=CC=C(F)C=C1 FVYWUKYMYNOWNN-AJWVYOOVSA-N 0.000 claims 2
• NZYWGBWVFIVLPC-UHFFFAOYSA-N 2-[3-[3-(2,4-difluorophenyl)phenyl]-2-oxo-6-phenyl-1,3-oxazinan-6-yl]acetamide Chemical compound O=C1OC(CC(=O)N)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F NZYWGBWVFIVLPC-UHFFFAOYSA-N 0.000 claims 2
• PNIHGQHDPPRIPD-UHFFFAOYSA-N 3-(2-chlorophenyl)-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C1=CC=CC=C1Cl PNIHGQHDPPRIPD-UHFFFAOYSA-N 0.000 claims 2
• QZMQRSGOWWSPRH-UHFFFAOYSA-N 3-(3-bromophenyl)-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C1=CC=CC(Br)=C1 QZMQRSGOWWSPRH-UHFFFAOYSA-N 0.000 claims 2
• FCQMFQGLDUEZDD-UHFFFAOYSA-N 3-(3-bromophenyl)-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C1=CC=CC(Br)=C1 FCQMFQGLDUEZDD-UHFFFAOYSA-N 0.000 claims 2
• DFBCDSHZOKLVKU-UHFFFAOYSA-N 3-(3-bromophenyl)-6-phenyl-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound BrC1=CC=CC(N2C(OC(CC=C)(CC2)C=2C=CC=CC=2)=O)=C1 DFBCDSHZOKLVKU-UHFFFAOYSA-N 0.000 claims 2
• LSPGCFCDJOHGNZ-UHFFFAOYSA-N 3-[(2-bromophenyl)methyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1CC1=CC=CC=C1Br LSPGCFCDJOHGNZ-UHFFFAOYSA-N 0.000 claims 2
• NFVVTQZIFUGHIN-XDBZFTIUSA-N 3-[(6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]-n-methylpropanamide Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(CCC(=O)NC)C=2C=CC(F)=CC=2)=CC=C1C1=CC=C(F)C=C1F NFVVTQZIFUGHIN-XDBZFTIUSA-N 0.000 claims 2
• CJDCHYFYWWTCPZ-CBZJRKILSA-N 3-[(6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propanamide Chemical compound C1([C@@]2(CCC(N)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 CJDCHYFYWWTCPZ-CBZJRKILSA-N 0.000 claims 2
• SNDUQSURYVCBQD-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CC(O)C)(C=2C=CC(F)=CC=2)CCN1C(C)C(C=C1)=CC=C1C1=CC=C(F)C=C1F SNDUQSURYVCBQD-UHFFFAOYSA-N 0.000 claims 2
• IEQHZGFXUXYXTQ-UHFFFAOYSA-N 3-[3-(2,4-difluorophenyl)-4-fluorophenyl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C(=CC=CC=2)F)CCN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1F IEQHZGFXUXYXTQ-UHFFFAOYSA-N 0.000 claims 2
• URQVFDCWQACMSU-UHFFFAOYSA-N 3-[3-(2,4-difluorophenyl)-4-fluorophenyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC(F)=CC=2)CCN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1F URQVFDCWQACMSU-UHFFFAOYSA-N 0.000 claims 2
• VINFOQVRVMPOSN-UHFFFAOYSA-N 3-[3-(2,4-difluorophenyl)phenyl]-6-(2,3-dihydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CC(O)CO)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F VINFOQVRVMPOSN-UHFFFAOYSA-N 0.000 claims 2
• BRCSKQYCZLOWED-UHFFFAOYSA-N 3-[3-(2,4-difluorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F BRCSKQYCZLOWED-UHFFFAOYSA-N 0.000 claims 2
• TYQJYQYIJIVXSP-UHFFFAOYSA-N 3-[3-(2,4-difluorophenyl)phenyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCCO)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F TYQJYQYIJIVXSP-UHFFFAOYSA-N 0.000 claims 2
• HLIYQMYOMGNOFM-UHFFFAOYSA-N 3-[3-(2,4-difluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F HLIYQMYOMGNOFM-UHFFFAOYSA-N 0.000 claims 2
• QOHJATQGUIFXMI-UHFFFAOYSA-N 3-[3-(2,4-difluorophenyl)phenyl]-6-methyl-6-pyridin-2-yl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2N=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F QOHJATQGUIFXMI-UHFFFAOYSA-N 0.000 claims 2
• NAJQWCLNVIYERJ-UHFFFAOYSA-N 3-[3-(2,4-difluorophenyl)phenyl]-6-phenyl-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound FC1=CC(F)=CC=C1C1=CC=CC(N2C(OC(CC=C)(CC2)C=2C=CC=CC=2)=O)=C1 NAJQWCLNVIYERJ-UHFFFAOYSA-N 0.000 claims 2
• HRIFFFQIHSNZCB-UHFFFAOYSA-N 3-[3-(2,5-difluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC(F)=CC=C1F HRIFFFQIHSNZCB-UHFFFAOYSA-N 0.000 claims 2
• LFKAYPNCNLKVMW-UHFFFAOYSA-N 3-[3-(2,6-dichlorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=C(Cl)C=CC=C1Cl LFKAYPNCNLKVMW-UHFFFAOYSA-N 0.000 claims 2
• DNISDJNHMIIZEI-UHFFFAOYSA-N 3-[3-(2,6-dichlorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=C(Cl)C=CC=C1Cl DNISDJNHMIIZEI-UHFFFAOYSA-N 0.000 claims 2
• ARUZVQYBNVZOPN-UHFFFAOYSA-N 3-[3-(2-chloro-4-fluorophenyl)-4-fluorophenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1Cl ARUZVQYBNVZOPN-UHFFFAOYSA-N 0.000 claims 2
• SHPDMFSEXHSXKG-UHFFFAOYSA-N 3-[3-(2-chloro-4-fluorophenyl)-4-fluorophenyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC(F)=CC=2)CCN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1Cl SHPDMFSEXHSXKG-UHFFFAOYSA-N 0.000 claims 2
• QRKKBXBHYDCJAH-UHFFFAOYSA-N 3-[3-(2-chloro-4-fluorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1Cl QRKKBXBHYDCJAH-UHFFFAOYSA-N 0.000 claims 2
• GHNKKJSPGBEQKD-UHFFFAOYSA-N 3-[3-(2-chlorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC=C1Cl GHNKKJSPGBEQKD-UHFFFAOYSA-N 0.000 claims 2
• CJOYNVRXISNTHV-UHFFFAOYSA-N 3-[3-(2-fluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC=C1F CJOYNVRXISNTHV-UHFFFAOYSA-N 0.000 claims 2
• VZFDJCRSLBVOGH-UHFFFAOYSA-N 3-[3-(2-methoxyphenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound COC1=CC=CC=C1C1=CC=CC(N2C(OC(C)(CC2)C=2C=CC=CC=2)=O)=C1 VZFDJCRSLBVOGH-UHFFFAOYSA-N 0.000 claims 2
• MYYYYXMOOBKOJL-UHFFFAOYSA-N 3-[3-(3,5-difluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC(F)=CC(F)=C1 MYYYYXMOOBKOJL-UHFFFAOYSA-N 0.000 claims 2
• RLNXULRKOMDPDW-UHFFFAOYSA-N 3-[3-(3-chlorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC(Cl)=C1 RLNXULRKOMDPDW-UHFFFAOYSA-N 0.000 claims 2
• SFOFGISPBWRXTM-UHFFFAOYSA-N 3-[3-(3-fluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC(F)=C1 SFOFGISPBWRXTM-UHFFFAOYSA-N 0.000 claims 2
• FMFCPPMAYOGHKS-UHFFFAOYSA-N 3-[3-(3-methoxyphenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound COC1=CC=CC(C=2C=C(C=CC=2)N2C(OC(C)(CC2)C=2C=CC=CC=2)=O)=C1 FMFCPPMAYOGHKS-UHFFFAOYSA-N 0.000 claims 2
• GRECFJMRKUEXPU-UHFFFAOYSA-N 3-[3-(4-fluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1 GRECFJMRKUEXPU-UHFFFAOYSA-N 0.000 claims 2
• DGRZIUAMDOMXOF-UHFFFAOYSA-N 3-[3-(4-hydroxyphenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(O)C=C1 DGRZIUAMDOMXOF-UHFFFAOYSA-N 0.000 claims 2
• AZZYNBWIZLBWIJ-UHFFFAOYSA-N 3-[3-(6-methyl-2-oxo-6-phenyl-1,3-oxazinan-3-yl)phenyl]benzonitrile Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 AZZYNBWIZLBWIJ-UHFFFAOYSA-N 0.000 claims 2
• OGLNYJGPAHIVTG-UHFFFAOYSA-N 3-[4-fluoro-3-(4-fluorophenyl)phenyl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C(=CC=CC=2)F)CCN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1 OGLNYJGPAHIVTG-UHFFFAOYSA-N 0.000 claims 2
• IIAKMAWFDUBOEW-UHFFFAOYSA-N 3-[4-fluoro-3-(4-fluorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1 IIAKMAWFDUBOEW-UHFFFAOYSA-N 0.000 claims 2
• WVIKTKCFEJYSSM-UHFFFAOYSA-N 3-[4-fluoro-3-(4-fluorophenyl)phenyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC(F)=CC=2)CCN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1 WVIKTKCFEJYSSM-UHFFFAOYSA-N 0.000 claims 2
• WZELCWHHNLQSLR-UHFFFAOYSA-N 3-[5-chloro-6-(2,4-difluorophenyl)pyridin-2-yl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C(=CC=CC=2)F)CCN1C(N=1)=CC=C(Cl)C=1C1=CC=C(F)C=C1F WZELCWHHNLQSLR-UHFFFAOYSA-N 0.000 claims 2
• ZORLACKLJKYOJW-UHFFFAOYSA-N 3-[5-chloro-6-(4-fluorophenyl)pyridin-2-yl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C(=CC=CC=2)F)CCN1C(N=1)=CC=C(Cl)C=1C1=CC=C(F)C=C1 ZORLACKLJKYOJW-UHFFFAOYSA-N 0.000 claims 2
• ZZNUHDXNMHQWAV-UHFFFAOYSA-N 3-[6-(2,4-difluorophenyl)pyridin-2-yl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C(=CC=CC=2)F)CCN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1F ZZNUHDXNMHQWAV-UHFFFAOYSA-N 0.000 claims 2
• OFIMPNOQMXPORL-UHFFFAOYSA-N 3-[6-(2,4-difluorophenyl)pyridin-2-yl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC(F)=CC=2)CCN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1F OFIMPNOQMXPORL-UHFFFAOYSA-N 0.000 claims 2
• YUNHJSMQKKBINU-UHFFFAOYSA-N 3-[6-(2-chloro-4-fluorophenyl)pyridin-2-yl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C(=CC=CC=2)F)CCN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1Cl YUNHJSMQKKBINU-UHFFFAOYSA-N 0.000 claims 2
• IWDQXAQJBOXNQT-UHFFFAOYSA-N 3-[6-(2-chloro-4-fluorophenyl)pyridin-2-yl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC(F)=CC=2)CCN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1Cl IWDQXAQJBOXNQT-UHFFFAOYSA-N 0.000 claims 2
• QZFTYROSXIMEHP-UHFFFAOYSA-N 3-[6-(4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1 QZFTYROSXIMEHP-UHFFFAOYSA-N 0.000 claims 2
• XKLWFNZCTAICAO-UHFFFAOYSA-N 6-(2-aminoethyl)-3-[3-(2,4-difluorophenyl)phenyl]-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCN)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F XKLWFNZCTAICAO-UHFFFAOYSA-N 0.000 claims 2
• ZJBOOJMHWPFBRE-UHFFFAOYSA-N 6-(2-fluorophenyl)-3-[6-(4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C(=CC=CC=2)F)CCN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1 ZJBOOJMHWPFBRE-UHFFFAOYSA-N 0.000 claims 2
• KGJLDEILXUOVAN-UHFFFAOYSA-N 6-(3-chlorophenyl)-6-methyl-3-(3-phenylphenyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=C(Cl)C=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC=C1 KGJLDEILXUOVAN-UHFFFAOYSA-N 0.000 claims 2
• UOQBTDKXEMDAHO-UHFFFAOYSA-N 6-(3-chlorophenyl)-6-methyl-3-(6-piperidin-1-ylpyridin-2-yl)-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=C(Cl)C=CC=2)CCN1C(N=1)=CC=CC=1N1CCCCC1 UOQBTDKXEMDAHO-UHFFFAOYSA-N 0.000 claims 2
• RANVHNGWEKJNMD-UHFFFAOYSA-N 6-(4-fluorophenyl)-3-[6-(4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC(F)=CC=2)CCN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1 RANVHNGWEKJNMD-UHFFFAOYSA-N 0.000 claims 2
• YPCOLEPFZYAVIO-UHFFFAOYSA-N 6-methyl-3-(3-methylphenyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound CC1=CC=CC(N2C(OC(C)(CC2)C=2C=CC=CC=2)=O)=C1 YPCOLEPFZYAVIO-UHFFFAOYSA-N 0.000 claims 2
• IOENRSKDLFZWGE-UHFFFAOYSA-N 6-methyl-3-(3-phenoxyphenyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1OC1=CC=CC=C1 IOENRSKDLFZWGE-UHFFFAOYSA-N 0.000 claims 2
• PMNFSAGLIMRJAD-UHFFFAOYSA-N 6-methyl-6-phenyl-3-(3-phenylphenyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC=C1 PMNFSAGLIMRJAD-UHFFFAOYSA-N 0.000 claims 2
• YXAJSFREPDODKP-UHFFFAOYSA-N 6-methyl-6-phenyl-3-(3-pyridin-3-ylphenyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CN=C1 YXAJSFREPDODKP-UHFFFAOYSA-N 0.000 claims 2
• DSWZMJKPAYWMJP-UHFFFAOYSA-N 6-methyl-6-phenyl-3-(3-thiophen-2-ylphenyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CS1 DSWZMJKPAYWMJP-UHFFFAOYSA-N 0.000 claims 2
• LVYAAPIPLDIUSX-FUKCDUGKSA-N 6-methyl-6-phenyl-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound O1C(=O)N([C@@H](C)C=2C=CC=CC=2)CCC1(C)C1=CC=CC=C1 LVYAAPIPLDIUSX-FUKCDUGKSA-N 0.000 claims 2
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
• 239000003085 diluting agent Substances 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• VGTVYPMTXNOUAZ-QMHKHESXSA-N methyl 4-[(1s)-1-[(6r)-6-(4-fluorophenyl)-2-oxo-6-prop-2-enyl-1,3-oxazinan-3-yl]ethyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1[C@H](C)N1C(=O)O[C@@](CC=C)(C=2C=CC(F)=CC=2)CC1 VGTVYPMTXNOUAZ-QMHKHESXSA-N 0.000 claims 2
• PUSRESMCCNQIKR-QMHKHESXSA-N methyl 4-[(1s)-1-[(6r)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-2-oxo-1,3-oxazinan-3-yl]ethyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1[C@H](C)N1C(=O)O[C@@](CCCO)(C=2C=CC(F)=CC=2)CC1 PUSRESMCCNQIKR-QMHKHESXSA-N 0.000 claims 2
• BRXUGSOLBGZIFK-XDBZFTIUSA-N n-[2-[(6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl]acetamide Chemical compound C1([C@@]2(CCNC(C)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 BRXUGSOLBGZIFK-XDBZFTIUSA-N 0.000 claims 2
• ABZQVQCOZWJEOI-UHFFFAOYSA-N n-[2-[3-[3-(2,4-difluorophenyl)phenyl]-2-oxo-6-phenyl-1,3-oxazinan-6-yl]ethyl]acetamide Chemical compound O=C1OC(CCNC(=O)C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F ABZQVQCOZWJEOI-UHFFFAOYSA-N 0.000 claims 2
• YSYWZSPOHHSHAR-UHFFFAOYSA-N n-[2-[3-[3-(2,4-difluorophenyl)phenyl]-2-oxo-6-phenyl-1,3-oxazinan-6-yl]ethyl]methanesulfonamide Chemical compound O=C1OC(CCNS(=O)(=O)C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F YSYWZSPOHHSHAR-UHFFFAOYSA-N 0.000 claims 2
• FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 claims 2
• CERIMNKGQLUDEA-LRAJWGHMSA-N (4r,6s)-3-[(1s)-1-(4-bromophenyl)ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-4-methyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)C[C@@H](C)N(C(O2)=O)[C@@H](C)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 CERIMNKGQLUDEA-LRAJWGHMSA-N 0.000 claims 1
• CERIMNKGQLUDEA-VFCRVFHLSA-N (4s,6s)-3-[(1s)-1-(4-bromophenyl)ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-4-methyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)C[C@H](C)N(C(O2)=O)[C@@H](C)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 CERIMNKGQLUDEA-VFCRVFHLSA-N 0.000 claims 1
• PNIHGQHDPPRIPD-QGZVFWFLSA-N (6r)-3-(2-chlorophenyl)-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C1=CC=CC=C1Cl PNIHGQHDPPRIPD-QGZVFWFLSA-N 0.000 claims 1
• FCQMFQGLDUEZDD-QGZVFWFLSA-N (6r)-3-(3-bromophenyl)-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C1=CC=CC(Br)=C1 FCQMFQGLDUEZDD-QGZVFWFLSA-N 0.000 claims 1
• SLSMHOGJKAPYQU-WGDIFIGCSA-N (6r)-3-[(1r)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCO)CCN(C(O2)=O)[C@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 SLSMHOGJKAPYQU-WGDIFIGCSA-N 0.000 claims 1
• DPLXTCSBFGMWCF-IFXJQAMLSA-N (6r)-3-[(1s)-1-(3-hydroxyphenyl)ethyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=C(O)C=CC=2)=CC=CC=C1 DPLXTCSBFGMWCF-IFXJQAMLSA-N 0.000 claims 1
• WOQTXQOMVPEQHH-VBKZILBWSA-N (6r)-3-[(1s)-1-(4-bromophenyl)ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 WOQTXQOMVPEQHH-VBKZILBWSA-N 0.000 claims 1
• GHMGZYVCMBQHQS-IFXJQAMLSA-N (6r)-3-[(1s)-1-(4-bromophenyl)ethyl]-6-prop-2-enyl-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(Br)=CC=2)=CC=CS1 GHMGZYVCMBQHQS-IFXJQAMLSA-N 0.000 claims 1
• JQRPZOWAALFXBW-PZJWPPBQSA-N (6r)-3-[(1s)-1-(4-bromophenyl)propyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCO)CCN(C(O2)=O)[C@@H](CC)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 JQRPZOWAALFXBW-PZJWPPBQSA-N 0.000 claims 1
• PVPCIVKTZVMNIZ-RBBKRZOGSA-N (6r)-3-[(1s)-1-(4-bromophenyl)propyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](CC)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 PVPCIVKTZVMNIZ-RBBKRZOGSA-N 0.000 claims 1
• OFTIABJUDZBFSR-AFJIDDCJSA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(3-hydroxy-3-methylbutyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCC(C)(C)O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=CC=C1 OFTIABJUDZBFSR-AFJIDDCJSA-N 0.000 claims 1
• PDBVUENMKQBWQZ-UZTOHYMASA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=CC=C1 PDBVUENMKQBWQZ-UZTOHYMASA-N 0.000 claims 1
• JJSKRJVXTUERFL-SSOJOUAXSA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=CS1 JJSKRJVXTUERFL-SSOJOUAXSA-N 0.000 claims 1
• USMSKUDZCFKKOS-URAOTHONSA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-morpholin-4-ylethyl)-1,3-oxazinan-2-one Chemical compound C([C@@]1(CCN(C(O1)=O)[C@@H](C)C=1C=CC(=CC=1)C=1C(=CC(F)=CC=1)F)C=1C=CC(F)=CC=1)CN1CCOCC1 USMSKUDZCFKKOS-URAOTHONSA-N 0.000 claims 1
• PBFRLXOIGZCFAL-HMILPKGGSA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-[2-(2-hydroxyethylamino)ethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCNCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 PBFRLXOIGZCFAL-HMILPKGGSA-N 0.000 claims 1
• HMGUNNURUKBIDA-CBZJRKILSA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-[2-(2h-tetrazol-5-yl)ethyl]-1,3-oxazinan-2-one Chemical compound C([C@@]1(CCN(C(O1)=O)[C@@H](C)C=1C=CC(=CC=1)C=1C(=CC(F)=CC=1)F)C=1C=CC(F)=CC=1)CC1=NN=NN1 HMGUNNURUKBIDA-CBZJRKILSA-N 0.000 claims 1
• SPSBLSUYVNKEHO-XRHLQHRESA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-[2-(methylamino)ethyl]-1,3-oxazinan-2-one Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(CCNC)C=2C=CC(F)=CC=2)=CC=C1C1=CC=C(F)C=C1F SPSBLSUYVNKEHO-XRHLQHRESA-N 0.000 claims 1
• PGSFCPKXIINFHZ-HMILPKGGSA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-[2-(dimethylamino)ethyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCN(C)C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 PGSFCPKXIINFHZ-HMILPKGGSA-N 0.000 claims 1
• VJKGTCLRELKTMU-AHKZPQOWSA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]propyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCO)CCN(C(O2)=O)[C@@H](CC)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 VJKGTCLRELKTMU-AHKZPQOWSA-N 0.000 claims 1
• YSMKZMNGZWBOIL-XTEPFMGCSA-N (6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]propyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](CC)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 YSMKZMNGZWBOIL-XTEPFMGCSA-N 0.000 claims 1
• UWMSFLKZKPLFMH-HFJWLAOPSA-N (6r)-3-[(1s)-1-[4-(2,4-dimethyl-1,3-thiazol-5-yl)phenyl]ethyl]-6-(4-fluorophenyl)-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C2=C(N=C(C)S2)C)=CC=C(F)C=C1 UWMSFLKZKPLFMH-HFJWLAOPSA-N 0.000 claims 1
• AOHUCFUOVXHCLK-UQBPGWFLSA-N (6r)-3-[(1s)-1-[4-(2-hydroxy-2-methylpropyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(CC(C)(C)O)=CC=2)=CC=CC=C1 AOHUCFUOVXHCLK-UQBPGWFLSA-N 0.000 claims 1
• NROKVZSKSYCFGG-MHECFPHRSA-N (6r)-3-[(1s)-1-[4-(2-hydroxypropan-2-yl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C(C)(C)O)=CC=CC=C1 NROKVZSKSYCFGG-MHECFPHRSA-N 0.000 claims 1
• NRQVLVGDMUNLPF-CCLHPLFOSA-N (6r)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CC=C1 NRQVLVGDMUNLPF-CCLHPLFOSA-N 0.000 claims 1
• KPROUAAIOYAJTP-AVRWGWEMSA-N (6r)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CS1 KPROUAAIOYAJTP-AVRWGWEMSA-N 0.000 claims 1
• LKYJOEKXRISBQL-DPOKWSEZSA-N (6r)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-[(2s)-2-hydroxypropyl]-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C1=CC([C@H](C)N2CC[C@@](OC2=O)(C[C@@H](O)C)C=2SC=CC=2)=CC=C1C1=CC=C(F)C=C1 LKYJOEKXRISBQL-DPOKWSEZSA-N 0.000 claims 1
• JVTMFWXKBGTYDB-HFJWLAOPSA-N (6r)-3-[(1s)-1-[4-(5-chloropyridin-3-yl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=C(Cl)C=NC=2)=CC=C(F)C=C1 JVTMFWXKBGTYDB-HFJWLAOPSA-N 0.000 claims 1
• QAJYZVCUZHBDBT-AFMDSPMNSA-N (6r)-3-[(1s)-1-[4-(5-fluoropyridin-3-yl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=C(F)C=NC=2)=CC=CC=C1 QAJYZVCUZHBDBT-AFMDSPMNSA-N 0.000 claims 1
• BQAHZBAZRBYQLJ-AFMDSPMNSA-N (6r)-3-[(1s)-1-[4-(5-fluoropyridin-3-yl)phenyl]ethyl]-6-phenyl-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=C(F)C=NC=2)=CC=CC=C1 BQAHZBAZRBYQLJ-AFMDSPMNSA-N 0.000 claims 1
• NYBSHWQXEOLRKC-OYHNWAKOSA-N (6r)-3-[(1s)-1-[4-(difluoromethoxy)phenyl]ethyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(OC(F)F)=CC=2)=CC=C(F)C=C1 NYBSHWQXEOLRKC-OYHNWAKOSA-N 0.000 claims 1
• HTHSEXCVPBIVRV-OYHNWAKOSA-N (6r)-3-[(1s)-1-[4-(difluoromethoxy)phenyl]ethyl]-6-(4-fluorophenyl)-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(OC(F)F)=CC=2)=CC=C(F)C=C1 HTHSEXCVPBIVRV-OYHNWAKOSA-N 0.000 claims 1
• KTAARHNIJDSONP-GWFQSRPTSA-N (6r)-3-[(1s)-1-[4-[5-(1-aminoethyl)thiophen-2-yl]phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound S1C(C(N)C)=CC=C1C1=CC=C([C@H](C)N2C(O[C@](CCCO)(CC2)C=2C=CC=CC=2)=O)C=C1 KTAARHNIJDSONP-GWFQSRPTSA-N 0.000 claims 1
• QYUKQAGVKDPREF-GXNDFRMLSA-N (6r)-3-[(1s)-1-[4-[5-(1-hydroxyethyl)thiophen-2-yl]phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound S1C(C(O)C)=CC=C1C1=CC=C([C@H](C)N2C(O[C@](CCCO)(CC2)C=2C=CC=CC=2)=O)C=C1 QYUKQAGVKDPREF-GXNDFRMLSA-N 0.000 claims 1
• LSPGCFCDJOHGNZ-GOSISDBHSA-N (6r)-3-[(2-bromophenyl)methyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1CC1=CC=CC=C1Br LSPGCFCDJOHGNZ-GOSISDBHSA-N 0.000 claims 1
• HLIYQMYOMGNOFM-HSZRJFAPSA-N (6r)-3-[3-(2,4-difluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F HLIYQMYOMGNOFM-HSZRJFAPSA-N 0.000 claims 1
• QOHJATQGUIFXMI-JOCHJYFZSA-N (6r)-3-[3-(2,4-difluorophenyl)phenyl]-6-methyl-6-pyridin-2-yl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2N=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F QOHJATQGUIFXMI-JOCHJYFZSA-N 0.000 claims 1
• HRIFFFQIHSNZCB-HSZRJFAPSA-N (6r)-3-[3-(2,5-difluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC(F)=CC=C1F HRIFFFQIHSNZCB-HSZRJFAPSA-N 0.000 claims 1
• GHNKKJSPGBEQKD-HSZRJFAPSA-N (6r)-3-[3-(2-chlorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=CC=C1Cl GHNKKJSPGBEQKD-HSZRJFAPSA-N 0.000 claims 1
• CJOYNVRXISNTHV-HSZRJFAPSA-N (6r)-3-[3-(2-fluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=CC=C1F CJOYNVRXISNTHV-HSZRJFAPSA-N 0.000 claims 1
• VZFDJCRSLBVOGH-XMMPIXPASA-N (6r)-3-[3-(2-methoxyphenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound COC1=CC=CC=C1C1=CC=CC(N2C(O[C@](C)(CC2)C=2C=CC=CC=2)=O)=C1 VZFDJCRSLBVOGH-XMMPIXPASA-N 0.000 claims 1
• RLNXULRKOMDPDW-HSZRJFAPSA-N (6r)-3-[3-(3-chlorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=CC(Cl)=C1 RLNXULRKOMDPDW-HSZRJFAPSA-N 0.000 claims 1
• SFOFGISPBWRXTM-HSZRJFAPSA-N (6r)-3-[3-(3-fluorophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=CC(F)=C1 SFOFGISPBWRXTM-HSZRJFAPSA-N 0.000 claims 1
• FMFCPPMAYOGHKS-XMMPIXPASA-N (6r)-3-[3-(3-methoxyphenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound COC1=CC=CC(C=2C=C(C=CC=2)N2C(O[C@](C)(CC2)C=2C=CC=CC=2)=O)=C1 FMFCPPMAYOGHKS-XMMPIXPASA-N 0.000 claims 1
• DGRZIUAMDOMXOF-HSZRJFAPSA-N (6r)-3-[3-(4-hydroxyphenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(O)C=C1 DGRZIUAMDOMXOF-HSZRJFAPSA-N 0.000 claims 1
• IIAKMAWFDUBOEW-XMMPIXPASA-N (6r)-3-[4-fluoro-3-(4-fluorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1 IIAKMAWFDUBOEW-XMMPIXPASA-N 0.000 claims 1
• QZFTYROSXIMEHP-HSZRJFAPSA-N (6r)-3-[6-(4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1 QZFTYROSXIMEHP-HSZRJFAPSA-N 0.000 claims 1
• XKLWFNZCTAICAO-XMMPIXPASA-N (6r)-6-(2-aminoethyl)-3-[3-(2,4-difluorophenyl)phenyl]-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCN)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F XKLWFNZCTAICAO-XMMPIXPASA-N 0.000 claims 1
• XYMFJLWCTXMXHU-UZTOHYMASA-N (6r)-6-(2-fluorophenyl)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CC=C1F XYMFJLWCTXMXHU-UZTOHYMASA-N 0.000 claims 1
• OUTJYNQORJHZGJ-HSZRJFAPSA-N (6r)-6-(2-fluorophenyl)-3-[6-(4-fluorophenyl)-1-oxidopyridin-1-ium-2-yl]-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@@](OC1=O)(CCO)C=2C(=CC=CC=2)F)CN1C([N+]=1[O-])=CC=CC=1C1=CC=C(F)C=C1 OUTJYNQORJHZGJ-HSZRJFAPSA-N 0.000 claims 1
• ZJBOOJMHWPFBRE-HSZRJFAPSA-N (6r)-6-(2-fluorophenyl)-3-[6-(4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@@](OC1=O)(CCO)C=2C(=CC=CC=2)F)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1 ZJBOOJMHWPFBRE-HSZRJFAPSA-N 0.000 claims 1
• CMLGYKTUOFEFSU-XRHLQHRESA-N (6r)-6-(3-aminopropyl)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCN)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 CMLGYKTUOFEFSU-XRHLQHRESA-N 0.000 claims 1
• KGJLDEILXUOVAN-HSZRJFAPSA-N (6r)-6-(3-chlorophenyl)-6-methyl-3-(3-phenylphenyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=C(Cl)C=CC=2)CN1C(C=1)=CC=CC=1C1=CC=CC=C1 KGJLDEILXUOVAN-HSZRJFAPSA-N 0.000 claims 1
• UOQBTDKXEMDAHO-OAQYLSRUSA-N (6r)-6-(3-chlorophenyl)-6-methyl-3-(6-piperidin-1-ylpyridin-2-yl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=C(Cl)C=CC=2)CN1C(N=1)=CC=CC=1N1CCCCC1 UOQBTDKXEMDAHO-OAQYLSRUSA-N 0.000 claims 1
• TYERBRGKZKGLIN-UZTOHYMASA-N (6r)-6-(3-fluorophenyl)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CC(F)=C1 TYERBRGKZKGLIN-UZTOHYMASA-N 0.000 claims 1
• BUIPWQYAVGFZFQ-CCLHPLFOSA-N (6r)-6-(3-hydroxypropyl)-3-[(1s)-1-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C2=CN(C)C(=O)C=C2)=CC=CC=C1 BUIPWQYAVGFZFQ-CCLHPLFOSA-N 0.000 claims 1
• KTAMXUVMJGARMG-CCLHPLFOSA-N (6r)-6-(3-hydroxypropyl)-3-[(1s)-1-[4-(6-methoxypyridin-3-yl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one Chemical compound C1=NC(OC)=CC=C1C1=CC=C([C@H](C)N2C(O[C@](CCCO)(CC2)C=2C=CC=CC=2)=O)C=C1 KTAMXUVMJGARMG-CCLHPLFOSA-N 0.000 claims 1
• XYOSDNSXPKSGEX-UQBPGWFLSA-N (6r)-6-(3-hydroxypropyl)-6-phenyl-3-[(1s)-1-(4-thiophen-2-ylphenyl)ethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2SC=CC=2)=CC=CC=C1 XYOSDNSXPKSGEX-UQBPGWFLSA-N 0.000 claims 1
• IQBOJCLDVJTOCV-MHECFPHRSA-N (6r)-6-(3-hydroxypropyl)-6-phenyl-3-[(1s)-1-[4-(1h-pyrazol-5-yl)phenyl]ethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C2=NNC=C2)=CC=CC=C1 IQBOJCLDVJTOCV-MHECFPHRSA-N 0.000 claims 1
• RDLIKGAWIOOVEL-YCRPNKLZSA-N (6r)-6-(4-fluorophenyl)-3-[(1s)-1-(4-hydroxyphenyl)ethyl]-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(O)=CC=2)=CC=C(F)C=C1 RDLIKGAWIOOVEL-YCRPNKLZSA-N 0.000 claims 1
• MKNKRKSYEVBGEW-UQBPGWFLSA-N (6r)-6-(4-fluorophenyl)-3-[(1s)-1-(4-morpholin-4-ylphenyl)ethyl]-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)N2CCOCC2)=CC=C(F)C=C1 MKNKRKSYEVBGEW-UQBPGWFLSA-N 0.000 claims 1
• UZLJFYGNQAZWLF-UZTOHYMASA-N (6r)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=C(F)C=C1 UZLJFYGNQAZWLF-UZTOHYMASA-N 0.000 claims 1
• MNMFMEQQDAIIRC-RXFWQSSRSA-N (6r)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(4-methylpiperazin-1-yl)phenyl]ethyl]-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)N2CCN(C)CC2)=CC=C(F)C=C1 MNMFMEQQDAIIRC-RXFWQSSRSA-N 0.000 claims 1
• QJNOGYQOFOQKLN-HFJWLAOPSA-N (6r)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(5-fluoropyridin-3-yl)phenyl]ethyl]-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=C(F)C=NC=2)=CC=C(F)C=C1 QJNOGYQOFOQKLN-HFJWLAOPSA-N 0.000 claims 1
• LHELAJDRZXVKOX-UPCLLVRISA-N (6r)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]ethyl]-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2OC(C)=NN=2)=CC=C(F)C=C1 LHELAJDRZXVKOX-UPCLLVRISA-N 0.000 claims 1
• QVGDKUIMKBFGRX-UPCLLVRISA-N (6r)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]ethyl]-6-prop-2-enyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2SC(C)=NN=2)=CC=C(F)C=C1 QVGDKUIMKBFGRX-UPCLLVRISA-N 0.000 claims 1
• CTRPZBRTYVJUCA-KSFYIVLOSA-N (6r)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(hydroxymethyl)phenyl]ethyl]-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(CO)=CC=2)=CC=C(F)C=C1 CTRPZBRTYVJUCA-KSFYIVLOSA-N 0.000 claims 1
• FNTHZWPWNKYVAW-MGPUTAFESA-N (6r)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=C(F)C=C1 FNTHZWPWNKYVAW-MGPUTAFESA-N 0.000 claims 1
• WXCQUJIPBJWDOE-YCRPNKLZSA-N (6r)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-3-[(1s)-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=C(C=CC=2)C(F)(F)F)=CC=C(F)C=C1 WXCQUJIPBJWDOE-YCRPNKLZSA-N 0.000 claims 1
• UJPQNTZWPPWTLB-CCLHPLFOSA-N (6r)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-3-[(1s)-1-[4-(2-methylpyridin-4-yl)phenyl]ethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=C(C)N=CC=2)=CC=C(F)C=C1 UJPQNTZWPPWTLB-CCLHPLFOSA-N 0.000 claims 1
• BGPQBTLALBOWIJ-UZTOHYMASA-N (6r)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-3-[(1s)-1-[4-(5-methoxypyridin-3-yl)phenyl]ethyl]-1,3-oxazinan-2-one Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)[C@H](C)N2C(O[C@](CCCO)(CC2)C=2C=CC(F)=CC=2)=O)=C1 BGPQBTLALBOWIJ-UZTOHYMASA-N 0.000 claims 1
• JXLOKDAJQCYRPQ-HFJWLAOPSA-N (6r)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-3-[(1s)-1-[4-[6-(trifluoromethyl)pyridin-3-yl]phenyl]ethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=NC(=CC=2)C(F)(F)F)=CC=C(F)C=C1 JXLOKDAJQCYRPQ-HFJWLAOPSA-N 0.000 claims 1
• OUTTUYZQIHSHQF-LIRRHRJNSA-N (6r)-6-(4-fluorophenyl)-6-(hydroxymethyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CO)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=C(F)C=C1 OUTTUYZQIHSHQF-LIRRHRJNSA-N 0.000 claims 1
• AYJUPGUNWJCYTA-BXKMTCNYSA-N (6r)-6-(4-fluorophenyl)-6-prop-2-enyl-3-[(1s)-1-[4-[3-(trifluoromethyl)pyrazol-1-yl]phenyl]ethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)N2N=C(C=C2)C(F)(F)F)=CC=C(F)C=C1 AYJUPGUNWJCYTA-BXKMTCNYSA-N 0.000 claims 1
• DQYAEFFEMXBSCO-YWZLYKJASA-N (6r)-6-ethenyl-6-(4-fluorophenyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@]2(C=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=C(F)C=C1 DQYAEFFEMXBSCO-YWZLYKJASA-N 0.000 claims 1
• YPCOLEPFZYAVIO-GOSISDBHSA-N (6r)-6-methyl-3-(3-methylphenyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound CC1=CC=CC(N2C(O[C@](C)(CC2)C=2C=CC=CC=2)=O)=C1 YPCOLEPFZYAVIO-GOSISDBHSA-N 0.000 claims 1
• IOENRSKDLFZWGE-HSZRJFAPSA-N (6r)-6-methyl-3-(3-phenoxyphenyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1OC1=CC=CC=C1 IOENRSKDLFZWGE-HSZRJFAPSA-N 0.000 claims 1
• XGJPEJODHXKZEZ-MGPUTAFESA-N (6r)-6-methyl-6-(4-methylsulfanylphenyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1=CC(SC)=CC=C1[C@]1(C)OC(=O)N([C@@H](C)C=2C=CC=CC=2)CC1 XGJPEJODHXKZEZ-MGPUTAFESA-N 0.000 claims 1
• PMNFSAGLIMRJAD-HSZRJFAPSA-N (6r)-6-methyl-6-phenyl-3-(3-phenylphenyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=CC=C1 PMNFSAGLIMRJAD-HSZRJFAPSA-N 0.000 claims 1
• YXAJSFREPDODKP-JOCHJYFZSA-N (6r)-6-methyl-6-phenyl-3-(3-pyridin-3-ylphenyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=CN=C1 YXAJSFREPDODKP-JOCHJYFZSA-N 0.000 claims 1
• DSWZMJKPAYWMJP-OAQYLSRUSA-N (6r)-6-methyl-6-phenyl-3-(3-thiophen-2-ylphenyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=CS1 DSWZMJKPAYWMJP-OAQYLSRUSA-N 0.000 claims 1
• LVYAAPIPLDIUSX-DNVCBOLYSA-N (6r)-6-methyl-6-phenyl-3-[(1r)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C)CCN(C(O2)=O)[C@H](C)C=2C=CC=CC=2)=CC=CC=C1 LVYAAPIPLDIUSX-DNVCBOLYSA-N 0.000 claims 1
• LVYAAPIPLDIUSX-HNAYVOBHSA-N (6r)-6-methyl-6-phenyl-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=CC=C1 LVYAAPIPLDIUSX-HNAYVOBHSA-N 0.000 claims 1
• QZMQRSGOWWSPRH-SFHVURJKSA-N (6s)-3-(3-bromophenyl)-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C1=CC=CC(Br)=C1 QZMQRSGOWWSPRH-SFHVURJKSA-N 0.000 claims 1
• SLSMHOGJKAPYQU-QUGAMOGWSA-N (6s)-3-[(1r)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 SLSMHOGJKAPYQU-QUGAMOGWSA-N 0.000 claims 1
• DPLXTCSBFGMWCF-LIRRHRJNSA-N (6s)-3-[(1s)-1-(3-hydroxyphenyl)ethyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=C(O)C=CC=2)=CC=CC=C1 DPLXTCSBFGMWCF-LIRRHRJNSA-N 0.000 claims 1
• NOZAUIHWUFKYEA-BTYIYWSLSA-N (6s)-3-[(1s)-1-(4-bromophenyl)ethyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(Br)=CC=2)=CC=C(F)C=C1 NOZAUIHWUFKYEA-BTYIYWSLSA-N 0.000 claims 1
• MBTNCMMQLDRCFF-SBUREZEXSA-N (6s)-3-[(1s)-1-[3-(2-hydroxy-2-methylpropoxy)phenyl]ethyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=C(OCC(C)(C)O)C=CC=2)=CC=CC=C1 MBTNCMMQLDRCFF-SBUREZEXSA-N 0.000 claims 1
• GGACFHDUZMTPRC-UNPBGGOKSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(2,3-dihydroxypropyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC(O)CO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 GGACFHDUZMTPRC-UNPBGGOKSA-N 0.000 claims 1
• KZJJYBHEDRKZDJ-QYBDOPJKSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=CC=C1 KZJJYBHEDRKZDJ-QYBDOPJKSA-N 0.000 claims 1
• PUCNQCMCYLVVQG-FYSMJZIKSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(2-hydroxyethyl)-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=CS1 PUCNQCMCYLVVQG-FYSMJZIKSA-N 0.000 claims 1
• JJSKRJVXTUERFL-GKVSMKOHSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=CS1 JJSKRJVXTUERFL-GKVSMKOHSA-N 0.000 claims 1
• VBBVXSDVBKDBQT-MYUZEXMDSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-methylsulfanylethyl)-1,3-oxazinan-2-one Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(CCSC)C=2C=CC(F)=CC=2)=CC=C1C1=CC=C(F)C=C1F VBBVXSDVBKDBQT-MYUZEXMDSA-N 0.000 claims 1
• WDKUSULWDUIUML-MYUZEXMDSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-methylsulfonylethyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCS(C)(=O)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 WDKUSULWDUIUML-MYUZEXMDSA-N 0.000 claims 1
• SFYBGGNXFRMOCN-VKGTZQKMSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-[2-(2-hydroxyethoxy)ethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCOCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 SFYBGGNXFRMOCN-VKGTZQKMSA-N 0.000 claims 1
• RPZWLHHFCAQIIH-QYMIHLDESA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-[2-hydroxy-3-(methylamino)propyl]-1,3-oxazinan-2-one Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(CC(O)CNC)C=2C=CC(F)=CC=2)=CC=C1C1=CC=C(F)C=C1F RPZWLHHFCAQIIH-QYMIHLDESA-N 0.000 claims 1
• GGACFHDUZMTPRC-IPZQTHRPSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-[(2s)-2,3-dihydroxypropyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C[C@H](O)CO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 GGACFHDUZMTPRC-IPZQTHRPSA-N 0.000 claims 1
• FREQEUPGLGPFPL-BATDWUPUSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-[(2s)-2-hydroxypropyl]-6-phenyl-1,3-oxazinan-2-one Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(C[C@@H](O)C)C=2C=CC=CC=2)=CC=C1C1=CC=C(F)C=C1F FREQEUPGLGPFPL-BATDWUPUSA-N 0.000 claims 1
• FXZPUQXGCUIQCC-ORWIAUPLSA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-[3-(dimethylamino)-2-hydroxypropyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CC(O)CN(C)C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 FXZPUQXGCUIQCC-ORWIAUPLSA-N 0.000 claims 1
• VJKGTCLRELKTMU-BDYUSTAISA-N (6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]propyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](CC)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 VJKGTCLRELKTMU-BDYUSTAISA-N 0.000 claims 1
• IROTYPHWZUZEAY-SIBVEZHUSA-N (6s)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CC=C1 IROTYPHWZUZEAY-SIBVEZHUSA-N 0.000 claims 1
• KPROUAAIOYAJTP-BVZFJXPGSA-N (6s)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CS1 KPROUAAIOYAJTP-BVZFJXPGSA-N 0.000 claims 1
• LKYJOEKXRISBQL-RPPIVITFSA-N (6s)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-[(2s)-2-hydroxypropyl]-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(C[C@@H](O)C)C=2SC=CC=2)=CC=C1C1=CC=C(F)C=C1 LKYJOEKXRISBQL-RPPIVITFSA-N 0.000 claims 1
• IEQHZGFXUXYXTQ-DEOSSOPVSA-N (6s)-3-[3-(2,4-difluorophenyl)-4-fluorophenyl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C(=CC=CC=2)F)CN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1F IEQHZGFXUXYXTQ-DEOSSOPVSA-N 0.000 claims 1
• VINFOQVRVMPOSN-BWKNWUBXSA-N (6s)-3-[3-(2,4-difluorophenyl)phenyl]-6-[(2r)-2,3-dihydroxypropyl]-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(C[C@@H](O)CO)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F VINFOQVRVMPOSN-BWKNWUBXSA-N 0.000 claims 1
• LFKAYPNCNLKVMW-DEOSSOPVSA-N (6s)-3-[3-(2,6-dichlorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=C(Cl)C=CC=C1Cl LFKAYPNCNLKVMW-DEOSSOPVSA-N 0.000 claims 1
• ARUZVQYBNVZOPN-DEOSSOPVSA-N (6s)-3-[3-(2-chloro-4-fluorophenyl)-4-fluorophenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(C=1)=CC=C(F)C=1C1=CC=C(F)C=C1Cl ARUZVQYBNVZOPN-DEOSSOPVSA-N 0.000 claims 1
• QRKKBXBHYDCJAH-DEOSSOPVSA-N (6s)-3-[3-(2-chloro-4-fluorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1Cl QRKKBXBHYDCJAH-DEOSSOPVSA-N 0.000 claims 1
• WZELCWHHNLQSLR-QHCPKHFHSA-N (6s)-3-[5-chloro-6-(2,4-difluorophenyl)pyridin-2-yl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C(=CC=CC=2)F)CN1C(N=1)=CC=C(Cl)C=1C1=CC=C(F)C=C1F WZELCWHHNLQSLR-QHCPKHFHSA-N 0.000 claims 1
• OLBKTRLRMUXLGL-QHCPKHFHSA-N (6s)-3-[6-(2,4-difluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1F OLBKTRLRMUXLGL-QHCPKHFHSA-N 0.000 claims 1
• OFIMPNOQMXPORL-QHCPKHFHSA-N (6s)-3-[6-(2,4-difluorophenyl)pyridin-2-yl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC(F)=CC=2)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1F OFIMPNOQMXPORL-QHCPKHFHSA-N 0.000 claims 1
• UCSYXQOCBXHUBZ-QHCPKHFHSA-N (6s)-3-[6-(2-chloro-4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1Cl UCSYXQOCBXHUBZ-QHCPKHFHSA-N 0.000 claims 1
• PMPMRWISGCWLPG-QHCPKHFHSA-N (6s)-3-[6-(4-fluorophenyl)-1-oxidopyridin-1-ium-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC=CC=2)CN1C([N+]=1[O-])=CC=CC=1C1=CC=C(F)C=C1 PMPMRWISGCWLPG-QHCPKHFHSA-N 0.000 claims 1
• XYMFJLWCTXMXHU-PPHZAIPVSA-N (6s)-6-(2-fluorophenyl)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C1([C@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CC=C1F XYMFJLWCTXMXHU-PPHZAIPVSA-N 0.000 claims 1
• OUTJYNQORJHZGJ-QHCPKHFHSA-N (6s)-6-(2-fluorophenyl)-3-[6-(4-fluorophenyl)-1-oxidopyridin-1-ium-2-yl]-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C(=CC=CC=2)F)CN1C([N+]=1[O-])=CC=CC=1C1=CC=C(F)C=C1 OUTJYNQORJHZGJ-QHCPKHFHSA-N 0.000 claims 1
• RANVHNGWEKJNMD-QHCPKHFHSA-N (6s)-6-(4-fluorophenyl)-3-[6-(4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C([C@](OC1=O)(CCO)C=2C=CC(F)=CC=2)CN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1 RANVHNGWEKJNMD-QHCPKHFHSA-N 0.000 claims 1
• ITPKJPZKIPYEII-BTYIYWSLSA-N (6s)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-3-[(1s)-1-(4-methylsulfonylphenyl)ethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(CCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)S(C)(=O)=O)=CC=C(F)C=C1 ITPKJPZKIPYEII-BTYIYWSLSA-N 0.000 claims 1
• RRBGPJIVUHQVNA-UYDITSSVSA-N (6s)-6-[(2r)-2,3-dihydroxypropyl]-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C[C@@H](O)CO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CC=C1 RRBGPJIVUHQVNA-UYDITSSVSA-N 0.000 claims 1
• CRCDKDMVWUJKOK-SLQAJWMNSA-N (6s)-6-[2-(2-aminoimidazol-1-yl)ethyl]-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C([C@]1(CCN(C(O1)=O)[C@@H](C)C=1C=CC(=CC=1)C=1C(=CC(F)=CC=1)F)C=1C=CC(F)=CC=1)CN1C=CN=C1N CRCDKDMVWUJKOK-SLQAJWMNSA-N 0.000 claims 1
• DQYAEFFEMXBSCO-MGPUTAFESA-N (6s)-6-ethenyl-6-(4-fluorophenyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@@]2(C=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=C(F)C=C1 DQYAEFFEMXBSCO-MGPUTAFESA-N 0.000 claims 1
• WHFAYDWOCGWLNV-DFBJGRDBSA-N (6s)-6-methyl-3-[(1s)-1-[3-(2-oxo-2-piperazin-1-ylethoxy)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one Chemical compound C1([C@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=C(OCC(=O)N3CCNCC3)C=CC=2)=CC=CC=C1 WHFAYDWOCGWLNV-DFBJGRDBSA-N 0.000 claims 1
• XRTFMNIRZNJJHD-JXFKEZNVSA-N (6s)-6-methyl-6-(2-methylphenyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=CC=C1C XRTFMNIRZNJJHD-JXFKEZNVSA-N 0.000 claims 1
• QIMFMKBZKNFZQM-JXFKEZNVSA-N (6s)-6-methyl-6-(3-methylphenyl)-3-[(1s)-1-phenylethyl]-1,3-oxazinan-2-one Chemical compound C1([C@]2(C)CCN(C(O2)=O)[C@@H](C)C=2C=CC=CC=2)=CC=CC(C)=C1 QIMFMKBZKNFZQM-JXFKEZNVSA-N 0.000 claims 1
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• 125000006536 (C1-C2)alkoxy group Chemical group 0.000 claims 1
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
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• RJXQJIOMWSZUGE-XDBZFTIUSA-N 3-[(6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propyl carbamate Chemical compound C1([C@@]2(CCCOC(N)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 RJXQJIOMWSZUGE-XDBZFTIUSA-N 0.000 claims 1
• MSQIRKAOYTVRLM-XDBZFTIUSA-N 3-[(6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propylurea Chemical compound C1([C@@]2(CCCNC(N)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 MSQIRKAOYTVRLM-XDBZFTIUSA-N 0.000 claims 1
• ZQBLTEOZJLNYEB-LGGPFLRQSA-N 3-[(6r)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-2-oxo-6-phenyl-1,3-oxazinan-6-yl]-2,2-dimethylpropanenitrile Chemical compound C1([C@@]2(CC(C)(C)C#N)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CC=C1 ZQBLTEOZJLNYEB-LGGPFLRQSA-N 0.000 claims 1
• LRCZGLPHNSQGRQ-CCLHPLFOSA-N 3-[(6r)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-2-oxo-6-phenyl-1,3-oxazinan-6-yl]propyl dihydrogen phosphate Chemical compound C1([C@@]2(CCCOP(O)(O)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=CC=C1 LRCZGLPHNSQGRQ-CCLHPLFOSA-N 0.000 claims 1
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• CERIMNKGQLUDEA-UHFFFAOYSA-N 3-[1-(4-bromophenyl)ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-4-methyl-1,3-oxazinan-2-one Chemical compound C=1C=C(Br)C=CC=1C(C)N(C(O1)=O)C(C)CC1(CCO)C1=CC=C(F)C=C1 CERIMNKGQLUDEA-UHFFFAOYSA-N 0.000 claims 1
• UXYULVUOOAOBIA-XGMGDGQCSA-N 3-[1-(4-bromophenyl)ethyl]-6-[(2r)-2,3-dihydroxypropyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(Br)C=CC=1C(C)N(C(O1)=O)CCC1(C[C@@H](O)CO)C1=CC=C(F)C=C1 UXYULVUOOAOBIA-XGMGDGQCSA-N 0.000 claims 1
• JQRPZOWAALFXBW-UHFFFAOYSA-N 3-[1-(4-bromophenyl)propyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound BrC1=CC=C(C=C1)C(CC)N1C(OC(CC1)(CCO)C1=CC=C(C=C1)F)=O JQRPZOWAALFXBW-UHFFFAOYSA-N 0.000 claims 1
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• GGACFHDUZMTPRC-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(2,3-dihydroxypropyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CC(O)CO)C1=CC=C(F)C=C1 GGACFHDUZMTPRC-UHFFFAOYSA-N 0.000 claims 1
• SHAJVFWHJXACEE-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(2,3-dihydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CC(O)CO)C1=CC=CC=C1 SHAJVFWHJXACEE-UHFFFAOYSA-N 0.000 claims 1
• KZJJYBHEDRKZDJ-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCO)C1=CC=CC=C1 KZJJYBHEDRKZDJ-UHFFFAOYSA-N 0.000 claims 1
• FREQEUPGLGPFPL-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(2-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CC(O)C)(C=2C=CC=CC=2)CCN1C(C)C(C=C1)=CC=C1C1=CC=C(F)C=C1F FREQEUPGLGPFPL-UHFFFAOYSA-N 0.000 claims 1
• PDBVUENMKQBWQZ-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCCO)C1=CC=CC=C1 PDBVUENMKQBWQZ-UHFFFAOYSA-N 0.000 claims 1
• JJSKRJVXTUERFL-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCCO)C1=CC=CS1 JJSKRJVXTUERFL-UHFFFAOYSA-N 0.000 claims 1
• JYUZCHJMXCOJJR-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-6-[2-(sulfamoylamino)ethyl]-1,3-oxazinane Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCNS(N)(=O)=O)C1=CC=C(F)C=C1 JYUZCHJMXCOJJR-UHFFFAOYSA-N 0.000 claims 1
• ZTMCZWXIGPCMLA-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CC(C)(C)O)C1=CC=C(F)C=C1 ZTMCZWXIGPCMLA-UHFFFAOYSA-N 0.000 claims 1
• SLSMHOGJKAPYQU-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCO)C1=CC=C(F)C=C1 SLSMHOGJKAPYQU-UHFFFAOYSA-N 0.000 claims 1
• WDKUSULWDUIUML-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-methylsulfonylethyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCS(C)(=O)=O)C1=CC=C(F)C=C1 WDKUSULWDUIUML-UHFFFAOYSA-N 0.000 claims 1
• USMSKUDZCFKKOS-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-morpholin-4-ylethyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(C=1C=CC(F)=CC=1)CCN1CCOCC1 USMSKUDZCFKKOS-UHFFFAOYSA-N 0.000 claims 1
• NDJIIYAAWZLVPP-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-oxopropyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CC(C)=O)C1=CC=C(F)C=C1 NDJIIYAAWZLVPP-UHFFFAOYSA-N 0.000 claims 1
• OTARHPTVFRBZQX-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCCO)C1=CC=C(F)C=C1 OTARHPTVFRBZQX-UHFFFAOYSA-N 0.000 claims 1
• SPSBLSUYVNKEHO-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-[2-(methylamino)ethyl]-1,3-oxazinan-2-one Chemical compound O=C1OC(CCNC)(C=2C=CC(F)=CC=2)CCN1C(C)C(C=C1)=CC=C1C1=CC=C(F)C=C1F SPSBLSUYVNKEHO-UHFFFAOYSA-N 0.000 claims 1
• RPZWLHHFCAQIIH-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-[2-hydroxy-3-(methylamino)propyl]-1,3-oxazinan-2-one Chemical compound O=C1OC(CC(O)CNC)(C=2C=CC(F)=CC=2)CCN1C(C)C(C=C1)=CC=C1C1=CC=C(F)C=C1F RPZWLHHFCAQIIH-UHFFFAOYSA-N 0.000 claims 1
• FXZPUQXGCUIQCC-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-[3-(dimethylamino)-2-hydroxypropyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CC(O)CN(C)C)C1=CC=C(F)C=C1 FXZPUQXGCUIQCC-UHFFFAOYSA-N 0.000 claims 1
• VJKGTCLRELKTMU-UHFFFAOYSA-N 3-[1-[4-(2,4-difluorophenyl)phenyl]propyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(CC)N(C(O1)=O)CCC1(CCO)C1=CC=C(F)C=C1 VJKGTCLRELKTMU-UHFFFAOYSA-N 0.000 claims 1
• IROTYPHWZUZEAY-UHFFFAOYSA-N 3-[1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(C)N(C(O1)=O)CCC1(CCO)C1=CC=CC=C1 IROTYPHWZUZEAY-UHFFFAOYSA-N 0.000 claims 1
• PDIARYFKTRBTNB-UHFFFAOYSA-N 3-[1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(2-hydroxyethyl)-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(C)N(C(O1)=O)CCC1(CCO)C1=CC=CS1 PDIARYFKTRBTNB-UHFFFAOYSA-N 0.000 claims 1
• LKYJOEKXRISBQL-UHFFFAOYSA-N 3-[1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(2-hydroxypropyl)-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound O=C1OC(CC(O)C)(C=2SC=CC=2)CCN1C(C)C(C=C1)=CC=C1C1=CC=C(F)C=C1 LKYJOEKXRISBQL-UHFFFAOYSA-N 0.000 claims 1
• NRQVLVGDMUNLPF-UHFFFAOYSA-N 3-[1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(C)N(C(O1)=O)CCC1(CCCO)C1=CC=CC=C1 NRQVLVGDMUNLPF-UHFFFAOYSA-N 0.000 claims 1
• KPROUAAIOYAJTP-UHFFFAOYSA-N 3-[1-[4-(4-fluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-thiophen-2-yl-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(C)N(C(O1)=O)CCC1(CCCO)C1=CC=CS1 KPROUAAIOYAJTP-UHFFFAOYSA-N 0.000 claims 1
• JVTMFWXKBGTYDB-UHFFFAOYSA-N 3-[1-[4-(5-chloropyridin-3-yl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C=C(Cl)C=NC=2)C=CC=1C(C)N(C(O1)=O)CCC1(CCCO)C1=CC=C(F)C=C1 JVTMFWXKBGTYDB-UHFFFAOYSA-N 0.000 claims 1
• CEJZOUPHAMHMAS-UHFFFAOYSA-N 3-[1-[4-(difluoromethoxy)phenyl]ethyl]-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one 3-[3-[1-[4-(4-fluorophenyl)phenyl]ethyl]-2-oxo-6-phenyl-1,3-oxazinan-6-yl]propyl dihydrogen phosphate Chemical compound P(=O)(OCCCC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C1=CC=C(C=C1)F)C1=CC=CC=C1)(O)O.FC(OC1=CC=C(C=C1)C(C)N1C(OC(CC1)(CCCO)C1=CC=C(C=C1)F)=O)F CEJZOUPHAMHMAS-UHFFFAOYSA-N 0.000 claims 1
• AQTFKGDWFRRIHR-UHFFFAOYSA-L 3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoate;cobalt(2+);hydron Chemical group [Co+2].[N-]1C(C=C2C(=C(C)C(C=C3C(=C(C)C(=C4)[N-]3)C=C)=N2)C=C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 AQTFKGDWFRRIHR-UHFFFAOYSA-L 0.000 claims 1
• ADNJEURANCBRSE-UHFFFAOYSA-N 3-[2-(3-chlorophenyl)pyrimidin-4-yl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(N=1)=CC=NC=1C1=CC=CC(Cl)=C1 ADNJEURANCBRSE-UHFFFAOYSA-N 0.000 claims 1
• YVYVSIJEJYEWBG-UHFFFAOYSA-N 3-[2-(3-fluorophenyl)pyrimidin-4-yl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(N=1)=CC=NC=1C1=CC=CC(F)=C1 YVYVSIJEJYEWBG-UHFFFAOYSA-N 0.000 claims 1
• XAHYWVIXJAAOQL-UHFFFAOYSA-N 3-[2-(4-fluorophenyl)pyrimidin-4-yl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(N=1)=CC=NC=1C1=CC=C(F)C=C1 XAHYWVIXJAAOQL-UHFFFAOYSA-N 0.000 claims 1
• HEWIEEBRCQEGLQ-UHFFFAOYSA-N 3-[3-(1-cyclohexylethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propanamide;3-[6-(4-fluorophenyl)-3-[1-(4-fluorophenyl)ethyl]-2-oxo-1,3-oxazinan-6-yl]propanamide Chemical compound C1CC(CCC(N)=O)(C=2C=CC(F)=CC=2)OC(=O)N1C(C)C1CCCCC1.C=1C=C(F)C=CC=1C(C)N(C(O1)=O)CCC1(CCC(N)=O)C1=CC=C(F)C=C1 HEWIEEBRCQEGLQ-UHFFFAOYSA-N 0.000 claims 1
• WHGRXCNCCXXHMZ-UHFFFAOYSA-N 3-[3-(2,4-difluorophenyl)phenyl]-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CC(C)(O)C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(F)C=C1F WHGRXCNCCXXHMZ-UHFFFAOYSA-N 0.000 claims 1
• OFSRLAPAHUPNKI-UHFFFAOYSA-N 3-[3-(3-aminophenyl)phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC(N)=C1 OFSRLAPAHUPNKI-UHFFFAOYSA-N 0.000 claims 1
• AZZYNBWIZLBWIJ-XMMPIXPASA-N 3-[3-[(6r)-6-methyl-2-oxo-6-phenyl-1,3-oxazinan-3-yl]phenyl]benzonitrile Chemical compound C([C@](OC1=O)(C)C=2C=CC=CC=2)CN1C(C=1)=CC=CC=1C1=CC=CC(C#N)=C1 AZZYNBWIZLBWIJ-XMMPIXPASA-N 0.000 claims 1
• NFVVTQZIFUGHIN-UHFFFAOYSA-N 3-[3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]-n-methylpropanamide Chemical compound O=C1OC(CCC(=O)NC)(C=2C=CC(F)=CC=2)CCN1C(C)C(C=C1)=CC=C1C1=CC=C(F)C=C1F NFVVTQZIFUGHIN-UHFFFAOYSA-N 0.000 claims 1
• QLGSZFPLVFDJGY-UHFFFAOYSA-N 3-[3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]-n-methylsulfonylpropanamide Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCC(=O)NS(C)(=O)=O)C1=CC=C(F)C=C1 QLGSZFPLVFDJGY-UHFFFAOYSA-N 0.000 claims 1
• CJDCHYFYWWTCPZ-UHFFFAOYSA-N 3-[3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propanamide Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCC(N)=O)C1=CC=C(F)C=C1 CJDCHYFYWWTCPZ-UHFFFAOYSA-N 0.000 claims 1
• LMIMSEXLHFFLIQ-UHFFFAOYSA-N 3-[3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propanoic acid Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCC(O)=O)C1=CC=C(F)C=C1 LMIMSEXLHFFLIQ-UHFFFAOYSA-N 0.000 claims 1
• RJXQJIOMWSZUGE-UHFFFAOYSA-N 3-[3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propyl carbamate Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCCOC(N)=O)C1=CC=C(F)C=C1 RJXQJIOMWSZUGE-UHFFFAOYSA-N 0.000 claims 1
• MSQIRKAOYTVRLM-UHFFFAOYSA-N 3-[3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propylurea Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCCNC(N)=O)C1=CC=C(F)C=C1 MSQIRKAOYTVRLM-UHFFFAOYSA-N 0.000 claims 1
• FNFJIBCRHWLYSA-UHFFFAOYSA-N 3-[3-[2-(hydroxymethyl)phenyl]phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC=C1CO FNFJIBCRHWLYSA-UHFFFAOYSA-N 0.000 claims 1
• XADFXYXTYUJXAP-UHFFFAOYSA-N 3-[3-[3-(hydroxymethyl)phenyl]phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=CC(CO)=C1 XADFXYXTYUJXAP-UHFFFAOYSA-N 0.000 claims 1
• HTUJSDTVPYYIOL-UHFFFAOYSA-N 3-[3-[4-(hydroxymethyl)phenyl]phenyl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(CO)C=C1 HTUJSDTVPYYIOL-UHFFFAOYSA-N 0.000 claims 1
• AOWLBUQSIRIORC-UHFFFAOYSA-N 3-[4-(2,4-difluorophenyl)pyrimidin-2-yl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(N=1)=NC=CC=1C1=CC=C(F)C=C1F AOWLBUQSIRIORC-UHFFFAOYSA-N 0.000 claims 1
• QAUVORKHMHOSKL-UHFFFAOYSA-N 3-[4-(2,6-dichlorophenyl)pyrimidin-2-yl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(N=1)=NC=CC=1C1=C(Cl)C=CC=C1Cl QAUVORKHMHOSKL-UHFFFAOYSA-N 0.000 claims 1
• HJJUIMXFUNTMKM-UHFFFAOYSA-N 3-[4-(3-chlorophenyl)pyrimidin-2-yl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(N=1)=NC=CC=1C1=CC=CC(Cl)=C1 HJJUIMXFUNTMKM-UHFFFAOYSA-N 0.000 claims 1
• PDMPLHIXXWOTGS-UHFFFAOYSA-N 3-[4-(3-fluorophenyl)pyrimidin-2-yl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(N=1)=NC=CC=1C1=CC=CC(F)=C1 PDMPLHIXXWOTGS-UHFFFAOYSA-N 0.000 claims 1
• QCKALCHGOOSBKH-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)pyrimidin-2-yl]-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(N=1)=NC=CC=1C1=CC=C(F)C=C1 QCKALCHGOOSBKH-UHFFFAOYSA-N 0.000 claims 1
• LSTDCIIMPZZXSE-UHFFFAOYSA-N 3-[6-(2,4-difluorophenyl)-1-oxidopyridin-1-ium-2-yl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C(=CC=CC=2)F)CCN1C([N+]=1[O-])=CC=CC=1C1=CC=C(F)C=C1F LSTDCIIMPZZXSE-UHFFFAOYSA-N 0.000 claims 1
• OLBKTRLRMUXLGL-UHFFFAOYSA-N 3-[6-(2,4-difluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1F OLBKTRLRMUXLGL-UHFFFAOYSA-N 0.000 claims 1
• UCSYXQOCBXHUBZ-UHFFFAOYSA-N 3-[6-(2-chloro-4-fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C(N=1)=CC=CC=1C1=CC=C(F)C=C1Cl UCSYXQOCBXHUBZ-UHFFFAOYSA-N 0.000 claims 1
• PMPMRWISGCWLPG-UHFFFAOYSA-N 3-[6-(4-fluorophenyl)-1-oxidopyridin-1-ium-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(CCO)(C=2C=CC=CC=2)CCN1C([N+]=1[O-])=CC=CC=1C1=CC=C(F)C=C1 PMPMRWISGCWLPG-UHFFFAOYSA-N 0.000 claims 1
• BGXUCYGAXBCMRB-UHFFFAOYSA-N 3-cyclohexyl-6-methyl-6-phenyl-1,3-oxazinan-2-one Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C1CCCCC1 BGXUCYGAXBCMRB-UHFFFAOYSA-N 0.000 claims 1
• UMZCDOIEKIXFIV-OYHNWAKOSA-N 4-[(1s)-1-[(6r)-6-(4-fluorophenyl)-2-oxo-6-prop-2-enyl-1,3-oxazinan-3-yl]ethyl]benzamide Chemical compound C1([C@@]2(CC=C)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C(N)=O)=CC=C(F)C=C1 UMZCDOIEKIXFIV-OYHNWAKOSA-N 0.000 claims 1
• KZFQAZSZRXTAKE-OYHNWAKOSA-N 4-[(1s)-1-[(6r)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-2-oxo-1,3-oxazinan-3-yl]ethyl]benzoic acid Chemical compound C1([C@@]2(CCCO)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C(O)=O)=CC=C(F)C=C1 KZFQAZSZRXTAKE-OYHNWAKOSA-N 0.000 claims 1
• VRPBWQFXBDFLKH-UHFFFAOYSA-N 4-[3-(6-methyl-2-oxo-6-phenyl-1,3-oxazinan-3-yl)phenyl]-n-propan-2-ylbenzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NC(C)C)=CC=C1C1=CC=CC(N2C(OC(C)(CC2)C=2C=CC=CC=2)=O)=C1 VRPBWQFXBDFLKH-UHFFFAOYSA-N 0.000 claims 1
• MZGXFDFVESYOLL-UHFFFAOYSA-N 4-[3-(6-methyl-2-oxo-6-phenyl-1,3-oxazinan-3-yl)phenyl]benzamide Chemical compound O=C1OC(C)(C=2C=CC=CC=2)CCN1C(C=1)=CC=CC=1C1=CC=C(C(N)=O)C=C1 MZGXFDFVESYOLL-UHFFFAOYSA-N 0.000 claims 1
• RRBGPJIVUHQVNA-UHFFFAOYSA-N 6-(2,3-dihydroxypropyl)-3-[1-[4-(4-fluorophenyl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C=CC(F)=CC=2)C=CC=1C(C)N(C(O1)=O)CCC1(CC(O)CO)C1=CC=CC=C1 RRBGPJIVUHQVNA-UHFFFAOYSA-N 0.000 claims 1
• JSLCIPMQVPVXCO-UHFFFAOYSA-N 6-(2-aminoethyl)-3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCN)C1=CC=C(F)C=C1 JSLCIPMQVPVXCO-UHFFFAOYSA-N 0.000 claims 1
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• XYOSDNSXPKSGEX-UHFFFAOYSA-N 6-(3-hydroxypropyl)-6-phenyl-3-[1-(4-thiophen-2-ylphenyl)ethyl]-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2SC=CC=2)C=CC=1C(C)N(C(O1)=O)CCC1(CCCO)C1=CC=CC=C1 XYOSDNSXPKSGEX-UHFFFAOYSA-N 0.000 claims 1
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• SFYBGGNXFRMOCN-UHFFFAOYSA-N FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(CCOCCO)C1=CC=C(C=C1)F)=O Chemical compound FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(CCOCCO)C1=CC=C(C=C1)F)=O SFYBGGNXFRMOCN-UHFFFAOYSA-N 0.000 claims 1
• KWDOUBQHVNZLIX-SOOMQSFWSA-N FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(OC(CC1)(C(C)C)CCCO)=O.FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(OC(CC1)(C(C)C)CCCO)=O Chemical compound FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(OC(CC1)(C(C)C)CCCO)=O.FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(OC(CC1)(C(C)C)CCCO)=O KWDOUBQHVNZLIX-SOOMQSFWSA-N 0.000 claims 1
• SNDUQSURYVCBQD-UHMYUZELSA-N FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@@](CC1)(C[C@@H](C)O)C1=CC=C(C=C1)F)=O Chemical compound FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@@](CC1)(C[C@@H](C)O)C1=CC=C(C=C1)F)=O SNDUQSURYVCBQD-UHMYUZELSA-N 0.000 claims 1
• SNDUQSURYVCBQD-VFUKXHBFSA-N FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@@](CC1)(C[C@H](C)O)C1=CC=C(C=C1)F)=O Chemical compound FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@@](CC1)(C[C@H](C)O)C1=CC=C(C=C1)F)=O SNDUQSURYVCBQD-VFUKXHBFSA-N 0.000 claims 1
• GGACFHDUZMTPRC-MUDFHLJKSA-N FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=C(C=C1)F)C[C@H](CO)O)=O Chemical compound FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=C(C=C1)F)C[C@H](CO)O)=O GGACFHDUZMTPRC-MUDFHLJKSA-N 0.000 claims 1
• FREQEUPGLGPFPL-RYTUXRKISA-N FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=CC=C1)C[C@@H](C)O)=O Chemical compound FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=CC=C1)C[C@@H](C)O)=O FREQEUPGLGPFPL-RYTUXRKISA-N 0.000 claims 1
• SHAJVFWHJXACEE-CAASOKRLSA-N FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=CC=C1)C[C@@H](CO)O)=O Chemical compound FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=CC=C1)C[C@@H](CO)O)=O SHAJVFWHJXACEE-CAASOKRLSA-N 0.000 claims 1
• SHAJVFWHJXACEE-ZPBOBRSPSA-N FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=CC=C1)C[C@H](CO)O)=O Chemical compound FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=CC=C1)C[C@H](CO)O)=O SHAJVFWHJXACEE-ZPBOBRSPSA-N 0.000 claims 1
• NQDIJTNIEODCJS-UHFFFAOYSA-N FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=C(C=CC=C1)F)CCCO.FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC(=CC=C1)F)CCCO Chemical compound FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=C(C=CC=C1)F)CCCO.FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC(=CC=C1)F)CCCO NQDIJTNIEODCJS-UHFFFAOYSA-N 0.000 claims 1
• PCSZXUNKRNBUCV-UHFFFAOYSA-N FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C(F)(F)F)CCCO.FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC(=CC=C1)C(F)(F)F)CCCO Chemical compound FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C(F)(F)F)CCCO.FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC(=CC=C1)C(F)(F)F)CCCO PCSZXUNKRNBUCV-UHFFFAOYSA-N 0.000 claims 1
• WUSUPLVXMPXSBL-UHFFFAOYSA-N FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)OC)CCO.OCC1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O Chemical compound FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)OC)CCO.OCC1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O WUSUPLVXMPXSBL-UHFFFAOYSA-N 0.000 claims 1
• TUZZDYRRVGCMFY-UHFFFAOYSA-N FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)S(=O)(=O)C)CCO.O=C1OC(CCN1C(C)C1=CC=C(C=C1)C=1C=NC=CC1)(C1=CC=CC=C1)CCNS(=O)(=O)C Chemical compound FC1=CC=C(C=C1)C1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)S(=O)(=O)C)CCO.O=C1OC(CCN1C(C)C1=CC=C(C=C1)C=1C=NC=CC1)(C1=CC=CC=C1)CCNS(=O)(=O)C TUZZDYRRVGCMFY-UHFFFAOYSA-N 0.000 claims 1
• OGLNYJGPAHIVTG-DEOSSOPVSA-N FC1=CC=C(C=C1)C1=CC(=CC=C1F)N1C(O[C@@](CC1)(CCO)C1=C(C=CC=C1)F)=O Chemical compound FC1=CC=C(C=C1)C1=CC(=CC=C1F)N1C(O[C@@](CC1)(CCO)C1=C(C=CC=C1)F)=O OGLNYJGPAHIVTG-DEOSSOPVSA-N 0.000 claims 1
• NVRMTVCFMUDQSQ-UHFFFAOYSA-N FC1=CC=C(C=C1)C1=CC=C(C=C1)C(CC)N1C(OC(CC1)(CCCO)C1=CC=C(C=C1)F)=O.NC(C)C1=CC=C(S1)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O Chemical compound FC1=CC=C(C=C1)C1=CC=C(C=C1)C(CC)N1C(OC(CC1)(CCCO)C1=CC=C(C=C1)F)=O.NC(C)C1=CC=C(S1)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O NVRMTVCFMUDQSQ-UHFFFAOYSA-N 0.000 claims 1
• PZXYQNAAEWMGCT-RVQUEUENSA-N FC1=CC=C(C=C1)C1=CC=C(C=C1)[C@H](C)N1C(O[C@@](CC1)(C1=CC=CC=C1)CCCO)=O.O=C1O[C@](CCN1[C@@H](C)C1=CC=C(C=C1)C1=CC=NC=C1)(C1=CC=CC=C1)CCC(=O)N Chemical compound FC1=CC=C(C=C1)C1=CC=C(C=C1)[C@H](C)N1C(O[C@@](CC1)(C1=CC=CC=C1)CCCO)=O.O=C1O[C@](CCN1[C@@H](C)C1=CC=C(C=C1)C1=CC=NC=C1)(C1=CC=CC=C1)CCC(=O)N PZXYQNAAEWMGCT-RVQUEUENSA-N 0.000 claims 1
• URQVFDCWQACMSU-DEOSSOPVSA-N FC1=CC=C(C=C1)[C@]1(CCN(C(O1)=O)C=1C=C(C(=CC1)F)C1=C(C=C(C=C1)F)F)CCO Chemical compound FC1=CC=C(C=C1)[C@]1(CCN(C(O1)=O)C=1C=C(C(=CC1)F)C1=C(C=C(C=C1)F)F)CCO URQVFDCWQACMSU-DEOSSOPVSA-N 0.000 claims 1
• FULRDYSTCBPKOQ-HVGACDMFSA-N FC1=CC=C(C=C1)[C@]1(CCN(C(O1)=O)[C@@H](C)C1=CC(=CC=C1)F)CCC(=O)N.ClC1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=CC=C1)CCC(=O)N)=O Chemical compound FC1=CC=C(C=C1)[C@]1(CCN(C(O1)=O)[C@@H](C)C1=CC(=CC=C1)F)CCC(=O)N.ClC1=CC=C(C=C1)[C@H](C)N1C(O[C@](CC1)(C1=CC=CC=C1)CCC(=O)N)=O FULRDYSTCBPKOQ-HVGACDMFSA-N 0.000 claims 1
• MYYYYXMOOBKOJL-HSZRJFAPSA-N FC=1C=C(C=C(C1)F)C1=CC(=CC=C1)N1C(O[C@](CC1)(C1=CC=CC=C1)C)=O Chemical compound FC=1C=C(C=C(C1)F)C1=CC(=CC=C1)N1C(O[C@](CC1)(C1=CC=CC=C1)C)=O MYYYYXMOOBKOJL-HSZRJFAPSA-N 0.000 claims 1
• KWVUDCQFEMLJHE-UHFFFAOYSA-N FC=1C=C(C=NC1)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O.FC1=CC=C(C=C1)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O Chemical compound FC=1C=C(C=NC1)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O.FC1=CC=C(C=C1)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O KWVUDCQFEMLJHE-UHFFFAOYSA-N 0.000 claims 1
• NMWHUZRIBWZTKT-UHFFFAOYSA-N N1(C=NC=C1)CCC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C1=C(C=C(C=C1)F)F)C1=CC=C(C=C1)F Chemical compound N1(C=NC=C1)CCC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C1=C(C=C(C=C1)F)F)C1=CC=C(C=C1)F NMWHUZRIBWZTKT-UHFFFAOYSA-N 0.000 claims 1
• HMGUNNURUKBIDA-UHFFFAOYSA-N N=1NN=NC=1CCC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C1=C(C=C(C=C1)F)F)C1=CC=C(C=C1)F Chemical compound N=1NN=NC=1CCC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C1=C(C=C(C=C1)F)F)C1=CC=C(C=C1)F HMGUNNURUKBIDA-UHFFFAOYSA-N 0.000 claims 1
• CRCDKDMVWUJKOK-UHFFFAOYSA-N NC=1N(C=CN=1)CCC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C1=C(C=C(C=C1)F)F)C1=CC=C(C=C1)F Chemical compound NC=1N(C=CN=1)CCC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C1=C(C=C(C=C1)F)F)C1=CC=C(C=C1)F CRCDKDMVWUJKOK-UHFFFAOYSA-N 0.000 claims 1
• HPFPXUZYFFGTST-UHFFFAOYSA-N O=C1OC(CCN1C(C)C1=CC=C(C=C1)C1=CC=NC=C1)(C1=CC=CC=C1)CCC(=O)N.O=C1OC(CCN1C(C)C1=CC=C(C=C1)C=1C=NC=CC1)(C1=CC=CC=C1)CCC(=O)N Chemical compound O=C1OC(CCN1C(C)C1=CC=C(C=C1)C1=CC=NC=C1)(C1=CC=CC=C1)CCC(=O)N.O=C1OC(CCN1C(C)C1=CC=C(C=C1)C=1C=NC=CC1)(C1=CC=CC=C1)CCC(=O)N HPFPXUZYFFGTST-UHFFFAOYSA-N 0.000 claims 1
• JPHIWYWYXAHNRV-NWGAQQMNSA-N O=C1O[C@](CCN1[C@@H](C)C1=CC=C(C=C1)C=1C=NC=CC1)(C1=CC=CC=C1)CCC(=O)N.FC1=CC=C(C=C1)[C@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)C(F)(F)F)CCCO Chemical compound O=C1O[C@](CCN1[C@@H](C)C1=CC=C(C=C1)C=1C=NC=CC1)(C1=CC=CC=C1)CCC(=O)N.FC1=CC=C(C=C1)[C@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)C(F)(F)F)CCCO JPHIWYWYXAHNRV-NWGAQQMNSA-N 0.000 claims 1
• QTRVCEILFONFSF-XHGLXQHVSA-N O=S(=O)(N(C[C@@H](C[C@@]1(CCN([C@H](C2=CC=C(C3=CC=C(F)C=C3)C=C2)C)C(=O)O1)C1=CC=C(C=C1)F)O)C)C Chemical compound O=S(=O)(N(C[C@@H](C[C@@]1(CCN([C@H](C2=CC=C(C3=CC=C(F)C=C3)C=C2)C)C(=O)O1)C1=CC=C(C=C1)F)O)C)C QTRVCEILFONFSF-XHGLXQHVSA-N 0.000 claims 1
• IMATXDIYCHNNIH-UHFFFAOYSA-N OC(C)C1=CC=C(S1)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O.FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)C(CC)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O Chemical compound OC(C)C1=CC=C(S1)C1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O.FC1=C(C=CC(=C1)F)C1=CC=C(C=C1)C(CC)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O IMATXDIYCHNNIH-UHFFFAOYSA-N 0.000 claims 1
• DRGABDAMMZHVDD-UHFFFAOYSA-N OC(CC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)OC)C1=CC=C(C=C1)F)CO.OCCC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C=1C=NC=CC1)C1=CC=CC=C1 Chemical compound OC(CC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)OC)C1=CC=C(C=C1)F)CO.OCCC1(CCN(C(O1)=O)C(C)C1=CC=C(C=C1)C=1C=NC=CC1)C1=CC=CC=C1 DRGABDAMMZHVDD-UHFFFAOYSA-N 0.000 claims 1
• DLMNGJUTCCTYTI-YBTQDOSESA-N OC(C[C@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=CC=C1)CO.O[C@H](C[C@@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=CC=C1)CO Chemical compound OC(C[C@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=CC=C1)CO.O[C@H](C[C@@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=CC=C1)CO DLMNGJUTCCTYTI-YBTQDOSESA-N 0.000 claims 1
• XFUGUEMBKDCQEY-UHFFFAOYSA-N OCCC1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O.C1(CCCCC1)C(C)N1C(OC(CC1)(C1=CC=C(C=C1)F)CC(CO)O)=O Chemical compound OCCC1=CC=C(C=C1)C(C)N1C(OC(CC1)(C1=CC=CC=C1)CCCO)=O.C1(CCCCC1)C(C)N1C(OC(CC1)(C1=CC=C(C=C1)F)CC(CO)O)=O XFUGUEMBKDCQEY-UHFFFAOYSA-N 0.000 claims 1
• GSDPZPZEXFKPGT-UHFFFAOYSA-N OCCCC1(CCN(C(O1)=O)C1C(C1)C1=CC=CC=C1)C1=CC=CC=C1.ClC1=CC=C(C=C1)C(C)N1C(OC(CC1)(C(C)C)CCCO)=O Chemical compound OCCCC1(CCN(C(O1)=O)C1C(C1)C1=CC=CC=C1)C1=CC=CC=C1.ClC1=CC=C(C=C1)C(C)N1C(OC(CC1)(C(C)C)CCCO)=O GSDPZPZEXFKPGT-UHFFFAOYSA-N 0.000 claims 1
• ICLPSGCMAXCYLJ-PGRDOPGGSA-N OCCC[C@@]1(CCN(C(O1)=O)[C@@H]1CN(CC1)C(=O)OC(C)(C)C)C1=CC=CC=C1 Chemical compound OCCC[C@@]1(CCN(C(O1)=O)[C@@H]1CN(CC1)C(=O)OC(C)(C)C)C1=CC=CC=C1 ICLPSGCMAXCYLJ-PGRDOPGGSA-N 0.000 claims 1
• YUNHJSMQKKBINU-QHCPKHFHSA-N OCC[C@@]1(CCN(C(=O)O1)c1cccc(n1)-c1ccc(F)cc1Cl)c1ccccc1F Chemical compound OCC[C@@]1(CCN(C(=O)O1)c1cccc(n1)-c1ccc(F)cc1Cl)c1ccccc1F YUNHJSMQKKBINU-QHCPKHFHSA-N 0.000 claims 1
• CQSFIHKMCHKPNB-IQJUWZMVSA-N OCC[C@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=CC=C1.OCC[C@@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=CC=C1 Chemical compound OCC[C@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=CC=C1.OCC[C@@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=CC=C1 CQSFIHKMCHKPNB-IQJUWZMVSA-N 0.000 claims 1
• RRBGPJIVUHQVNA-BYGVMDBSSA-N O[C@@H](C[C@@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)C1=CC=C(C=C1)F)C1=CC=CC=C1)CO Chemical compound O[C@@H](C[C@@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)C1=CC=C(C=C1)F)C1=CC=CC=C1)CO RRBGPJIVUHQVNA-BYGVMDBSSA-N 0.000 claims 1
• GUQMIKJYVODPJS-OHEPNIRZSA-N O[C@@H](C[C@@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=C(C=C1)F)CO Chemical compound O[C@@H](C[C@@]1(CCN(C(O1)=O)[C@@H](C)C1=CC=C(C=C1)OC)C1=CC=C(C=C1)F)CO GUQMIKJYVODPJS-OHEPNIRZSA-N 0.000 claims 1
• FSFZJVKAEMWYBE-LUJBDZGHSA-N [3-[(6s)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]-2-hydroxypropyl]urea Chemical compound C1([C@@]2(CC(O)CNC(N)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C(=CC(F)=CC=2)F)=CC=C(F)C=C1 FSFZJVKAEMWYBE-LUJBDZGHSA-N 0.000 claims 1
• FSFZJVKAEMWYBE-UHFFFAOYSA-N [3-[3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]-2-hydroxypropyl]urea Chemical compound C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CC(O)CNC(N)=O)C1=CC=C(F)C=C1 FSFZJVKAEMWYBE-UHFFFAOYSA-N 0.000 claims 1
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
• 125000004212 difluorophenyl group Chemical group 0.000 claims 1
• AVYZVIUJYJBNEJ-SBUREZEXSA-N ethyl 2-[3-[(1s)-1-[(6s)-6-methyl-2-oxo-6-phenyl-1,3-oxazinan-3-yl]ethyl]phenoxy]acetate Chemical compound CCOC(=O)COC1=CC=CC([C@H](C)N2C(O[C@@](C)(CC2)C=2C=CC=CC=2)=O)=C1 AVYZVIUJYJBNEJ-SBUREZEXSA-N 0.000 claims 1
• IXKLNUMXPLQNKY-UHFFFAOYSA-N methyl 3-[3-(6-methyl-2-oxo-6-phenyl-1,3-oxazinan-3-yl)phenyl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2C=C(C=CC=2)N2C(OC(C)(CC2)C=2C=CC=CC=2)=O)=C1 IXKLNUMXPLQNKY-UHFFFAOYSA-N 0.000 claims 1
• PUSRESMCCNQIKR-UHFFFAOYSA-N methyl 4-[1-[6-(4-fluorophenyl)-6-(3-hydroxypropyl)-2-oxo-1,3-oxazinan-3-yl]ethyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C(C)N1C(=O)OC(CCCO)(C=2C=CC(F)=CC=2)CC1 PUSRESMCCNQIKR-UHFFFAOYSA-N 0.000 claims 1
• CFGUOPROCQBABB-UHFFFAOYSA-N methyl 4-[3-(6-methyl-2-oxo-6-phenyl-1,3-oxazinan-3-yl)phenyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=CC=CC(N2C(OC(C)(CC2)C=2C=CC=CC=2)=O)=C1 CFGUOPROCQBABB-UHFFFAOYSA-N 0.000 claims 1
• KNIAWIYBGOQDSH-XDBZFTIUSA-N methyl n-[2-[(6r)-3-[(1s)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl]carbamate Chemical compound C1=CC([C@H](C)N2CC[C@](OC2=O)(CCNC(=O)OC)C=2C=CC(F)=CC=2)=CC=C1C1=CC=C(F)C=C1F KNIAWIYBGOQDSH-XDBZFTIUSA-N 0.000 claims 1
• KNIAWIYBGOQDSH-UHFFFAOYSA-N methyl n-[2-[3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl]carbamate Chemical compound O=C1OC(CCNC(=O)OC)(C=2C=CC(F)=CC=2)CCN1C(C)C(C=C1)=CC=C1C1=CC=C(F)C=C1F KNIAWIYBGOQDSH-UHFFFAOYSA-N 0.000 claims 1
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• UHEWGHSEVWDVFO-QBLOJZIGSA-N n-[(2r)-3-[(6s)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-2-oxo-1,3-oxazinan-6-yl]-2-hydroxypropyl]methanesulfonamide Chemical compound C1([C@@]2(C[C@@H](O)CNS(C)(=O)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=C(F)C=C1 UHEWGHSEVWDVFO-QBLOJZIGSA-N 0.000 claims 1
• QTRVCEILFONFSF-UZEWVABRSA-N n-[(2s)-3-[(6s)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-2-oxo-1,3-oxazinan-6-yl]-2-hydroxypropyl]-n-methylmethanesulfonamide Chemical compound C1([C@@]2(C[C@H](O)CN(C)S(C)(=O)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=C(F)C=C1 QTRVCEILFONFSF-UZEWVABRSA-N 0.000 claims 1
• UHEWGHSEVWDVFO-OOXLZHEQSA-N n-[(2s)-3-[(6s)-6-(4-fluorophenyl)-3-[(1s)-1-[4-(4-fluorophenyl)phenyl]ethyl]-2-oxo-1,3-oxazinan-6-yl]-2-hydroxypropyl]methanesulfonamide Chemical compound C1([C@@]2(C[C@H](O)CNS(C)(=O)=O)CCN(C(O2)=O)[C@@H](C)C=2C=CC(=CC=2)C=2C=CC(F)=CC=2)=CC=C(F)C=C1 UHEWGHSEVWDVFO-OOXLZHEQSA-N 0.000 claims 1
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• WKTSWRAOTUGOEY-UHFFFAOYSA-N n-[2-[3-[1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl]methanesulfonamide;6-(3-hydroxypropyl)-6-phenyl-3-[1-(4-pyridin-4-ylphenyl)ethyl]-1,3-oxazinan-2-one Chemical compound C=1C=C(C=2C=CN=CC=2)C=CC=1C(C)N(C(O1)=O)CCC1(CCCO)C1=CC=CC=C1.C=1C=C(C=2C(=CC(F)=CC=2)F)C=CC=1C(C)N(C(O1)=O)CCC1(CCNS(C)(=O)=O)C1=CC=C(F)C=C1 WKTSWRAOTUGOEY-UHFFFAOYSA-N 0.000 claims 1
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