BR0214345A - Compostos derivados de piperidin-2-ona e composições farmacêuticas contendo estes compostos como ingrediente ativo - Google Patents
Compostos derivados de piperidin-2-ona e composições farmacêuticas contendo estes compostos como ingrediente ativoInfo
- Publication number
- BR0214345A BR0214345A BR0214345-3A BR0214345A BR0214345A BR 0214345 A BR0214345 A BR 0214345A BR 0214345 A BR0214345 A BR 0214345A BR 0214345 A BR0214345 A BR 0214345A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- disease
- piperidin
- active ingredient
- pharmaceutical compositions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 title abstract 4
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 abstract 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010006895 Cachexia Diseases 0.000 abstract 1
- 208000005024 Castleman disease Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 206010018364 Glomerulonephritis Diseases 0.000 abstract 1
- 201000005569 Gout Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 208000034578 Multiple myelomas Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000001746 atrial effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 238000007887 coronary angioplasty Methods 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 208000009091 myxoma Diseases 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 abstract 1
- 208000031223 plasma cell leukemia Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
- C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
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- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
"COMPOSTOS DERIVADOS DE PIPERIDIN-2-ONA E COMPOSIçõES FARMACêUTICAS CONTENDO ESTES COMPOSTOS COMO O INGREDIENTE ATIVO". A invenção refere-se a compostos derivados de piperidin-2-ona representados pela fórmula (I): onde todos o símbolos são definidos no relatório descritivo, ou um sal não tóxico dos mesmos. O composto representado pela fórmula (I) inibe a ativação de MAP quinase p38, e é útil na prevenção e/ou tratamento de várias doenças inflamatórias, artrite rematóide, osteoartrite, artrite, osteoporose, doenças auto-imunes, doenças infecciosas, sepse, caquexia, infarto cerebral, doença de Alzheimer, asma, doenças inflamatórias pulmonares crónicas, lesão de reperfusão, trombose, glomerulonefrite, diabete, rejeição do tipo enxerto contra hospedeiro, doença inflamatória intestinal, doença de Crohn, colite ulcerativa, esclerose múltipla, crescimento tumoral e metástase, mieloma múltiplo, leucemia de células plasmáticas, doença de Castleman, mixoma atrial, psoríase, dermatites, gota, síndrome do estresse respiratório do adulto (ARDS), aterosclerose, Pós angioplastia coronariana transluminal percutânea (PTCA), restenose ou pancreatite.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001357348 | 2001-11-22 | ||
PCT/JP2002/012174 WO2003043988A1 (fr) | 2001-11-22 | 2002-11-21 | Composes derives de piperidine-2-one et medicaments contenant lesdits composes comme principes actifs |
Publications (1)
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BR0214345A true BR0214345A (pt) | 2004-09-14 |
Family
ID=19168705
Family Applications (1)
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BR0214345-3A BR0214345A (pt) | 2001-11-22 | 2002-11-21 | Compostos derivados de piperidin-2-ona e composições farmacêuticas contendo estes compostos como ingrediente ativo |
Country Status (15)
Country | Link |
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US (1) | US20050085509A1 (pt) |
EP (1) | EP1447401A1 (pt) |
JP (1) | JPWO2003043988A1 (pt) |
KR (1) | KR20050044581A (pt) |
CN (1) | CN1578767A (pt) |
AU (1) | AU2002349432A1 (pt) |
BR (1) | BR0214345A (pt) |
CA (1) | CA2467752A1 (pt) |
HU (1) | HUP0500027A2 (pt) |
IL (1) | IL161940A0 (pt) |
MX (1) | MXPA04004830A (pt) |
PL (1) | PL370636A1 (pt) |
RU (1) | RU2004118719A (pt) |
TW (1) | TW200300687A (pt) |
WO (1) | WO2003043988A1 (pt) |
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2002
- 2002-11-21 RU RU2004118719/04A patent/RU2004118719A/ru not_active Application Discontinuation
- 2002-11-21 JP JP2003545625A patent/JPWO2003043988A1/ja not_active Withdrawn
- 2002-11-21 HU HU0500027A patent/HUP0500027A2/hu unknown
- 2002-11-21 CN CNA028231104A patent/CN1578767A/zh active Pending
- 2002-11-21 WO PCT/JP2002/012174 patent/WO2003043988A1/ja not_active Application Discontinuation
- 2002-11-21 KR KR1020047007818A patent/KR20050044581A/ko not_active Application Discontinuation
- 2002-11-21 AU AU2002349432A patent/AU2002349432A1/en not_active Abandoned
- 2002-11-21 US US10/495,465 patent/US20050085509A1/en not_active Abandoned
- 2002-11-21 PL PL02370636A patent/PL370636A1/xx not_active Application Discontinuation
- 2002-11-21 MX MXPA04004830A patent/MXPA04004830A/es not_active Application Discontinuation
- 2002-11-21 IL IL16194002A patent/IL161940A0/xx unknown
- 2002-11-21 BR BR0214345-3A patent/BR0214345A/pt not_active Application Discontinuation
- 2002-11-21 CA CA002467752A patent/CA2467752A1/en not_active Abandoned
- 2002-11-21 EP EP02783591A patent/EP1447401A1/en not_active Withdrawn
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WO2003043988A1 (fr) | 2003-05-30 |
AU2002349432A1 (en) | 2003-06-10 |
RU2004118719A (ru) | 2005-03-27 |
TW200300687A (en) | 2003-06-16 |
EP1447401A1 (en) | 2004-08-18 |
CA2467752A1 (en) | 2003-05-30 |
JPWO2003043988A1 (ja) | 2005-03-10 |
MXPA04004830A (es) | 2004-07-30 |
CN1578767A (zh) | 2005-02-09 |
IL161940A0 (en) | 2005-11-20 |
HUP0500027A2 (hu) | 2005-04-28 |
KR20050044581A (ko) | 2005-05-12 |
PL370636A1 (en) | 2005-05-30 |
US20050085509A1 (en) | 2005-04-21 |
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