CA2681974C - Bispecific antibodies and methods for production thereof - Google Patents

Bispecific antibodies and methods for production thereof Download PDF

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Publication number
CA2681974C
CA2681974C CA2681974A CA2681974A CA2681974C CA 2681974 C CA2681974 C CA 2681974C CA 2681974 A CA2681974 A CA 2681974A CA 2681974 A CA2681974 A CA 2681974A CA 2681974 C CA2681974 C CA 2681974C
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Prior art keywords
antibody
igg4
vivo method
igg1
antibodies
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CA2681974A
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English (en)
French (fr)
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CA2681974A1 (en
Inventor
Janine Schuurman
Tom Vink
Jan van de Winkel
Frank Labrijn Aran
Rob Aalberse
Marijn Van Der Neut Kolfschoten
Paul Parren
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Genmab AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2681974A 2007-03-29 2008-03-28 Bispecific antibodies and methods for production thereof Active CA2681974C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92084007P 2007-03-29 2007-03-29
DKPA200700491 2007-03-29
DKPA200700491 2007-03-29
US60/920,840 2007-03-29
PCT/DK2008/000124 WO2008119353A1 (en) 2007-03-29 2008-03-28 Bispecific antibodies and methods for production thereof

Publications (2)

Publication Number Publication Date
CA2681974A1 CA2681974A1 (en) 2008-10-09
CA2681974C true CA2681974C (en) 2019-12-31

Family

ID=39672666

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2681974A Active CA2681974C (en) 2007-03-29 2008-03-28 Bispecific antibodies and methods for production thereof

Country Status (11)

Country Link
US (2) US9212230B2 (https=)
EP (2) EP2139924B1 (https=)
JP (2) JP5681482B2 (https=)
CN (2) CN101802015B (https=)
AU (1) AU2008234248C1 (https=)
CA (1) CA2681974C (https=)
ES (2) ES2593484T3 (https=)
IL (1) IL201082A (https=)
MX (1) MX2009010282A (https=)
NZ (1) NZ614857A (https=)
WO (1) WO2008119353A1 (https=)

Families Citing this family (383)

* Cited by examiner, † Cited by third party
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JP5681482B2 (ja) 2015-03-11
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AU2008234248B2 (en) 2014-07-10
WO2008119353A1 (en) 2008-10-09
CN104497143A (zh) 2015-04-08
US10906991B2 (en) 2021-02-02
US20100105874A1 (en) 2010-04-29
CN101802015B (zh) 2015-05-06
JP2014239689A (ja) 2014-12-25
EP2626372B1 (en) 2018-03-21
US20160159930A1 (en) 2016-06-09
CA2681974A1 (en) 2008-10-09
AU2008234248C1 (en) 2015-01-22
US9212230B2 (en) 2015-12-15
CN104497143B (zh) 2020-08-25
IL201082A (en) 2017-04-30
WO2008119353A8 (en) 2009-07-30
EP2139924A1 (en) 2010-01-06
CN101802015A (zh) 2010-08-11
NZ614857A (en) 2015-04-24
AU2008234248A1 (en) 2008-10-09
EP2626372A1 (en) 2013-08-14
ES2593484T3 (es) 2016-12-09
ES2667863T3 (es) 2018-05-14
EP2139924B1 (en) 2016-07-06
JP2010522701A (ja) 2010-07-08

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