MX346146B - Metodo para detectar un aglutinante multiespecifico. - Google Patents

Metodo para detectar un aglutinante multiespecifico.

Info

Publication number
MX346146B
MX346146B MX2014014566A MX2014014566A MX346146B MX 346146 B MX346146 B MX 346146B MX 2014014566 A MX2014014566 A MX 2014014566A MX 2014014566 A MX2014014566 A MX 2014014566A MX 346146 B MX346146 B MX 346146B
Authority
MX
Mexico
Prior art keywords
detection
multispecific binder
antibody
multispecific antibody
binding
Prior art date
Application number
MX2014014566A
Other languages
English (en)
Other versions
MX2014014566A (es
Inventor
Stubenrauch Kay-Gunnar
Zadak Markus
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014014566A publication Critical patent/MX2014014566A/es
Publication of MX346146B publication Critical patent/MX346146B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a un método para la detección de un anticuerpo multiespecífico en una muestra, por lo que el anticuerpo multiespecífico específicamente se une por i) un primer anticuerpo antiidiotípico que se une a una primera especificidad de unión del anticuerpo multiespecífico, y ii) por un segundo anticuerpo anti-idiotípico que se une a una segunda especificidad de unión del anticuerpo multiespecífico y se determina el complejo formado.
MX2014014566A 2012-07-13 2013-07-11 Metodo para detectar un aglutinante multiespecifico. MX346146B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12176342 2012-07-13
PCT/EP2013/064683 WO2014009474A1 (en) 2012-07-13 2013-07-11 Method for the detection of a multispecific binder

Publications (2)

Publication Number Publication Date
MX2014014566A MX2014014566A (es) 2015-02-20
MX346146B true MX346146B (es) 2017-03-09

Family

ID=48782335

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014014566A MX346146B (es) 2012-07-13 2013-07-11 Metodo para detectar un aglutinante multiespecifico.

Country Status (12)

Country Link
US (1) US9488662B2 (es)
EP (1) EP2872893B1 (es)
JP (1) JP6226976B2 (es)
KR (1) KR20150038046A (es)
CN (1) CN104471397B (es)
BR (1) BR112015000665A2 (es)
CA (1) CA2873829A1 (es)
ES (1) ES2627482T3 (es)
HK (1) HK1208731A1 (es)
MX (1) MX346146B (es)
RU (1) RU2636822C2 (es)
WO (1) WO2014009474A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015507193A (ja) 2012-02-01 2015-03-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性結合物の結合パートナーを検出するための方法
JP6446044B2 (ja) * 2013-11-05 2018-12-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 結合分子の存在下で被検体の総量および／または総濃度を決定するための方法、ならびにそれに関係するキット、組成物および使用
RU2678108C2 (ru) * 2014-04-23 2019-01-23 Нитирей Байосайенсиз Инк. Комбинированный продукт для детекции маркера-мишени
EP4015533A1 (en) * 2015-10-29 2022-06-22 F. Hoffmann-La Roche AG Anti-variant fc-region antibodies and methods of use
AU2016363638B2 (en) 2015-11-30 2022-04-21 F. Hoffmann-La Roche Ag Immunoassay for the determination of Fc-region modified antibodies
EP3805757A4 (en) * 2018-06-04 2022-03-23 Chugai Seiyaku Kabushiki Kaisha METHOD FOR DETECTING A COMPLEX
CN113811770B (zh) * 2019-05-13 2024-06-28 豪夫迈·罗氏有限公司 抑制干扰的药代动力学免疫测定
WO2024163318A1 (en) * 2023-01-30 2024-08-08 Amgen Inc. System and method for analyzing antibody co-formulations

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ATE443259T1 (de) 2001-09-20 2009-10-15 Univ Texas Bestimmung der zirkulierenden therapeutischen antikörper, antigene sowie antigen-antikörper- komplexe mit elisa-tests
EP1861708A2 (en) * 2005-03-08 2007-12-05 Tanox, Inc. Methods for determining the bivalency of protein and antibody therapeutics
TWI541251B (zh) 2006-10-04 2016-07-11 建南德克公司 用於ｖｅｇｆ之ｅｌｉｓａ
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JP5634405B2 (ja) * 2008-10-07 2014-12-03 ユィロス・パテント・アクチボラグＧｙｒｏｓ Ｐａｔｅｎｔ ＡＢ 試料中のアナライトの検出のための半逐次アッセイ
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
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JP2015507193A (ja) 2012-02-01 2015-03-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性結合物の結合パートナーを検出するための方法

Also Published As

Publication number Publication date
US9488662B2 (en) 2016-11-08
EP2872893B1 (en) 2017-03-29
ES2627482T3 (es) 2017-07-28
CA2873829A1 (en) 2014-01-16
HK1208731A1 (en) 2016-03-11
CN104471397B (zh) 2018-03-23
JP2015522171A (ja) 2015-08-03
MX2014014566A (es) 2015-02-20
EP2872893A1 (en) 2015-05-20
RU2015104737A (ru) 2016-08-27
WO2014009474A1 (en) 2014-01-16
US20150198608A1 (en) 2015-07-16
RU2636822C2 (ru) 2017-11-28
JP6226976B2 (ja) 2017-11-08
BR112015000665A2 (pt) 2017-06-27
CN104471397A (zh) 2015-03-25
KR20150038046A (ko) 2015-04-08

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