CA2389487C - Process for the production of a reversibly inactive acidified plasmin composition - Google Patents
Process for the production of a reversibly inactive acidified plasmin composition Download PDFInfo
- Publication number
- CA2389487C CA2389487C CA2389487A CA2389487A CA2389487C CA 2389487 C CA2389487 C CA 2389487C CA 2389487 A CA2389487 A CA 2389487A CA 2389487 A CA2389487 A CA 2389487A CA 2389487 C CA2389487 C CA 2389487C
- Authority
- CA
- Canada
- Prior art keywords
- plasmin
- plasminogen
- solution
- acid
- plasminogen activator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940012957 plasmin Drugs 0.000 title claims abstract description 154
- 238000000034 method Methods 0.000 title claims abstract description 64
- 230000008569 process Effects 0.000 title abstract description 26
- 239000000203 mixture Substances 0.000 title abstract description 15
- 238000004519 manufacturing process Methods 0.000 title description 4
- 102000013566 Plasminogen Human genes 0.000 claims abstract description 56
- 108010051456 Plasminogen Proteins 0.000 claims abstract description 56
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 14
- 239000000243 solution Substances 0.000 claims description 50
- 108010023197 Streptokinase Proteins 0.000 claims description 45
- 229960005202 streptokinase Drugs 0.000 claims description 45
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 37
- 239000004472 Lysine Substances 0.000 claims description 34
- 102000001938 Plasminogen Activators Human genes 0.000 claims description 33
- 108010001014 Plasminogen Activators Proteins 0.000 claims description 33
- 229940024606 amino acid Drugs 0.000 claims description 33
- 150000001413 amino acids Chemical class 0.000 claims description 33
- 229940127126 plasminogen activator Drugs 0.000 claims description 33
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 31
- 235000001014 amino acid Nutrition 0.000 claims description 31
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims description 21
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- 229960000187 tissue plasminogen activator Drugs 0.000 claims description 10
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
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- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims description 5
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/438,331 US6355243B1 (en) | 1999-11-13 | 1999-11-13 | Method of thrombolysis by local delivery of active plasmin |
| US09/438,331 | 1999-11-13 | ||
| PCT/US2000/042143 WO2001036611A1 (en) | 1999-11-13 | 2000-11-13 | Process for the production of a reversibly inactive acidified plasmin composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2389487A1 CA2389487A1 (en) | 2001-05-25 |
| CA2389487C true CA2389487C (en) | 2013-05-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2389487A Expired - Lifetime CA2389487C (en) | 1999-11-13 | 2000-11-13 | Process for the production of a reversibly inactive acidified plasmin composition |
| CA2389345A Expired - Lifetime CA2389345C (en) | 1999-11-13 | 2000-11-13 | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| CA2389337A Expired - Lifetime CA2389337C (en) | 1999-11-13 | 2000-11-13 | Reversibly inactivated acidified plasmin |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
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| CA2389345A Expired - Lifetime CA2389345C (en) | 1999-11-13 | 2000-11-13 | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| CA2389337A Expired - Lifetime CA2389337C (en) | 1999-11-13 | 2000-11-13 | Reversibly inactivated acidified plasmin |
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| Country | Link |
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| US (6) | US6355243B1 (enExample) |
| EP (4) | EP1232251B2 (enExample) |
| JP (3) | JP2003514789A (enExample) |
| AT (2) | ATE431401T1 (enExample) |
| AU (3) | AU784800B2 (enExample) |
| BE (1) | BE2013C050I2 (enExample) |
| CA (3) | CA2389487C (enExample) |
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| LU (1) | LU92255I2 (enExample) |
| NL (1) | NL300603I2 (enExample) |
| PT (2) | PT1232252E (enExample) |
| WO (3) | WO2001036611A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6355243B1 (en) * | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
| US7544500B2 (en) * | 1999-11-13 | 2009-06-09 | Talecris Biotherapeutics, Inc. | Process for the production of a reversibly inactive acidified plasmin composition |
| US7308303B2 (en) * | 2001-11-01 | 2007-12-11 | Advanced Bionics Corporation | Thrombolysis and chronic anticoagulation therapy |
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