BE2013C050I2 - - Google Patents

Download PDF

Info

Publication number
BE2013C050I2
BE2013C050I2 BE2013C050C BE2013C050C BE2013C050I2 BE 2013C050 I2 BE2013C050 I2 BE 2013C050I2 BE 2013C050 C BE2013C050 C BE 2013C050C BE 2013C050 C BE2013C050 C BE 2013C050C BE 2013C050 I2 BE2013C050 I2 BE 2013C050I2
Authority
BE
Belgium
Prior art keywords
present
fibrinolytic composition
optionally
substantially free
stabilizing agent
Prior art date
Application number
BE2013C050C
Other languages
English (en)
Original Assignee
Grifols Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23740237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2013C050(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grifols Therapeutics Inc filed Critical Grifols Therapeutics Inc
Publication of BE2013C050I2 publication Critical patent/BE2013C050I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
BE2013C050C 1999-11-13 2013-07-18 BE2013C050I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/438,331 US6355243B1 (en) 1999-11-13 1999-11-13 Method of thrombolysis by local delivery of active plasmin
PCT/US2000/031090 WO2001036608A1 (fr) 1999-11-13 2000-11-13 Plasmine acidifiee inactivee de maniere reversible

Publications (1)

Publication Number Publication Date
BE2013C050I2 true BE2013C050I2 (fr) 2019-12-11

Family

ID=23740237

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2013C050C BE2013C050I2 (fr) 1999-11-13 2013-07-18

Country Status (16)

Country Link
US (6) US6355243B1 (fr)
EP (4) EP1232254B1 (fr)
JP (3) JP5025868B2 (fr)
AT (2) ATE409222T1 (fr)
AU (3) AU784800B2 (fr)
BE (1) BE2013C050I2 (fr)
CA (3) CA2389487C (fr)
CY (3) CY1108639T1 (fr)
DE (3) DE60040345D1 (fr)
DK (2) DK1232254T3 (fr)
ES (3) ES2290058T5 (fr)
FR (1) FR13C0041I2 (fr)
LU (1) LU92255I2 (fr)
NL (1) NL300603I2 (fr)
PT (2) PT1232254E (fr)
WO (3) WO2001036609A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) * 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US7308303B2 (en) * 2001-11-01 2007-12-11 Advanced Bionics Corporation Thrombolysis and chronic anticoagulation therapy
ES2558303T3 (es) 2002-09-11 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Método de purificación de proteínas
US20040116676A1 (en) * 2002-09-30 2004-06-17 Hotta Joann Methods for removal of contaminants from blood product solutions
GB0228409D0 (en) * 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
SI1740698T1 (sl) 2004-04-22 2010-11-30 Talecris Biotherapeutics Inc Rekombinantno modificiran plazmin
GB0509438D0 (en) * 2005-05-09 2005-06-15 Prometic Biosciences Ltd Affinity adsorbets for fibrinogen
US20060257391A1 (en) * 2005-05-11 2006-11-16 Bausch & Lomb Incorporated Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
JP2007068497A (ja) * 2005-09-09 2007-03-22 Nihon Pharmaceutical Co Ltd プラスミンの精製法
US20070134230A1 (en) * 2005-12-13 2007-06-14 Jani Dharmendra M Method for prolonging activity of autodegradable enzymes
US20070134231A1 (en) * 2005-12-13 2007-06-14 Jani Dharmendra M Method for prolonging activity of autodegradable enzymes and compositions thereof
US20070196350A1 (en) * 2006-02-22 2007-08-23 Bartels Stephen P Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment
US20070212358A1 (en) * 2006-03-10 2007-09-13 Bartels Stephen P Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment
JP2009544630A (ja) * 2006-07-26 2009-12-17 デイアメデイカ・インコーポレイテツド 代謝障害の診断及び治療方法
KR101529743B1 (ko) 2007-11-29 2015-06-17 그리폴스 테라퓨틱스 인코포레이티드 재조합적으로 변형된 플라스민
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
CA2726908C (fr) * 2008-06-04 2017-01-24 Talecris Biotherapeutics, Inc. Composition, methode et necessaire pour la preparation de plasmine
JP5789521B2 (ja) 2009-03-03 2015-10-07 グリフオルス・セラピユーテイクス・インコーポレーテツドＧｒｉｆｏｌｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． プラスミノーゲンを製造するための組成物、方法およびキット；ならびにそれから製造されるプラスミン
EP2435562A1 (fr) 2009-05-26 2012-04-04 Biolex Therapeutics, Inc. Compositions et procédés permettant la production de plasminogène aglycosylé
AU2010270146B9 (en) 2009-07-10 2015-04-02 Thrombogenics Nv Variants of plasminogen and plasmin
ES2534911T3 (es) 2009-08-28 2015-04-30 Thrombogenics N.V. Uso de plasmina para el tratamiento de fallo de filtración después de trabeculectomía
PL2542293T3 (pl) * 2010-03-04 2019-06-28 Grifols Therapeutics Llc Układy do dostarczania środków terapeutycznych
JPWO2012036140A1 (ja) * 2010-09-14 2014-02-03 株式会社カネカ クリングル配列を有する蛋白質またはペプチドを精製または除去するアフィニティ担体、及びそれを用いた精製方法、除去方法
KR20140015289A (ko) * 2011-01-05 2014-02-06 쓰롬보제닉스 엔.브이. 플라스미노겐 및 플라스민 변이체
CN102225197B (zh) * 2011-06-13 2013-03-27 陕西精健新星生物医药有限公司 顶体蛋白的用途及提取方法
RU2604810C2 (ru) 2011-08-12 2016-12-10 Тромбодженикс Н.В. Варианты плазминогена и плазмина
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
DK2854841T3 (en) 2012-06-04 2017-05-22 Diamedica Inc Kallikrein-1-glycosylation isoforms of human tissue
US9272593B2 (en) * 2012-09-13 2016-03-01 GM Global Technology Operations LLC Top mount with MCU isolator in inner metal
JP5868931B2 (ja) * 2013-12-05 2016-02-24 日本食品化工株式会社 水溶性食物繊維の安定化方法並びに安定化された水溶性食物繊維組成物およびその製造方法
WO2015138507A1 (fr) * 2014-03-11 2015-09-17 Valdemar Portney Système optique sans fil de correction de la presbytie
BR112016019822B1 (pt) 2014-05-06 2023-11-14 Diasys Diagnostic Systems Gmbh Método para determinar a quantidade de hemoglobina glicosilada (hba1c) em uma amostra e kit de reagentes
CN106265544B (zh) * 2016-10-09 2019-06-04 瑞阳制药有限公司 注射用左卡尼汀组合物及其制备方法
CN110446501A (zh) 2017-03-09 2019-11-12 代阿麦迪卡股份有限公司 组织激肽释放酶1的剂型
CN106913534A (zh) * 2017-04-27 2017-07-04 武汉真福医药股份有限公司 一种基于重组枯草杆菌纤溶酶的冻干粉针剂及其制备工艺
CN107760662B (zh) * 2017-11-01 2021-06-15 国药集团武汉血液制品有限公司 一种人纤维蛋白溶解酶的制备方法
CN107802828B (zh) * 2017-11-29 2018-09-11 广东天普生化医药股份有限公司 一种激肽释放酶注射液

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3136703A (en) 1958-04-22 1964-06-09 Ortho Pharma Corp Method for obtaining fibrinolysin
US3066079A (en) * 1959-09-18 1962-11-27 American Cyanamid Co Methods for purifying plasminogen
DK98833C (da) † 1961-04-25 1964-05-25 Novo Terapeutisk Labor As Fremgangsmåde til stabilisering af terapeutisk anvendelige plasminopløsninger.
US3950513A (en) 1965-12-03 1976-04-13 Novo Terapeutisk Laboratorium A/S Process of stabilizing therapeutically useful plasmin solutions
US3434929A (en) 1966-07-12 1969-03-25 American Cyanamid Co Process for purifying plasmin
JPS5137343B2 (fr) * 1972-12-07 1976-10-15
FR2254316B1 (fr) * 1973-12-18 1977-04-22 Choay Sa
US3865692A (en) 1974-01-11 1975-02-11 Abbott Lab Method for making highly potent plasminogen
US4177262A (en) 1974-12-17 1979-12-04 Choay S.A. Plasminogen compositions containing preactivated plasminogens with or without native plasminogens, process for making same, pharmaceutical compositions and control of blood clots
US4082612A (en) 1976-09-24 1978-04-04 Michael Reese Research Foundation Plasminogen activator complex
US4259448A (en) * 1978-01-03 1981-03-31 Nippon Soda Company, Ltd. Protein adsorbent and process for the purification of urokinase
JPS56106594A (en) 1980-01-25 1981-08-24 Green Cross Corp:The Stabilizing method of plasminogen
JPS5716824A (en) 1980-07-03 1982-01-28 Green Cross Corp:The Plasminogen pharmaceutical and stabilizing method thereof
US4418052A (en) 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
SU1002356A1 (ru) 1980-12-31 1983-03-07 Всесоюзный кардиологический научный центр АМН СССР Способ получени иммобилизованного фибринолизина
IT1194135B (it) * 1981-01-05 1988-09-14 Novo Industri As Composizioni di plasmina stabilizzata e metodo per la loro preparazione
GB2090599B (en) * 1981-01-05 1984-06-13 Novo Industri As Stabilized plasmin compositions and method for preparation thereof
DE3119157A1 (de) 1981-05-14 1982-12-09 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung von und danach hergestelltes plasminogen
US4499073A (en) † 1981-08-24 1985-02-12 Cutter Laboratories, Inc. Intravenously injectable immune serum globulin
US4663146A (en) * 1983-07-29 1987-05-05 Codon Genetic Engineering Laboratories Methods and compositions for the diagnosis of bloodclots using plasminogen activator
GB8334498D0 (en) 1983-12-24 1984-02-01 Beecham Group Plc Compounds
PT82647B (pt) * 1985-05-28 1989-01-30 Wellcome Found Processo para a preparacao de uma solucao parenteral aquosa de activador de plasminogeneo de tecido
EP0266419B1 (fr) * 1986-05-15 1994-03-02 Emory University Composition fibrinolytique
JP2507339B2 (ja) 1986-08-11 1996-06-12 三井東圧化学株式会社 粗ｔＰＡの精製方法
DE3718889A1 (de) † 1987-06-05 1988-12-22 Behringwerke Ag Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin
US4774087A (en) 1987-08-14 1988-09-27 Northwestern University Micro-size fibrinolytic plasmin
AT390801B (de) 1988-07-28 1990-07-10 Immuno Ag Verfahren zur herstellung von lys-plasminogen
JPH0278633A (ja) * 1988-09-15 1990-03-19 Green Cross Corp:The ウイルス不活化方法
US5024829A (en) * 1988-11-21 1991-06-18 Centocor, Inc. Method of imaging coronary thrombi
US5104651A (en) * 1988-12-16 1992-04-14 Amgen Inc. Stabilized hydrophobic protein formulations of g-csf
RO103682B1 (ro) † 1989-01-20 1992-03-26 Institutul Cantacuzino Procedeu de izolare a ceruloplasminei umane
US5328996A (en) * 1989-03-29 1994-07-12 University Of Florida Research Foundation, Inc. Bacterial plasmin receptors as fibrinolytic agents
US5237050A (en) * 1989-03-29 1993-08-17 University Of Florida Research Foundation, Inc. Bacterial plasmin receptors as fibrinolytic agents
EP0399321B1 (fr) * 1989-05-24 1993-06-23 Miles Inc. Filtration sur gel de facteur VIII traité à la chaleur
DK408289D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Diagnostisk reagens
US5017292A (en) * 1990-05-10 1991-05-21 Millipore Corporation Membrane, process and system for isolating virus from solution
AT402367B (de) 1990-10-11 1997-04-25 Immuno Ag Pharmazeutische zubereitung auf basis von lys-plasminogen
JP2500330B2 (ja) 1991-03-26 1996-05-29 工業技術院長 血栓溶解能を有する生体適合性材料
US5288489A (en) 1991-08-28 1994-02-22 Orion Therapeutic Systems, Inc. Fibrinolysis and fibrinogenolysis treatment
IT1260468B (it) * 1992-01-29 1996-04-09 Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
AT398004B (de) * 1992-04-14 1994-08-25 Berbi Gmbh Verfahren zur bestimmung von plasmin-alpha2- antiplasmin-komplexen unter verwendung eines komplexspezifischen monoklonalen antikörpers
JP2861655B2 (ja) * 1992-07-08 1999-02-24 吉富製薬株式会社 ヒト尿性トリプシンインヒビター含有液状製剤及びその製造方法
US5472692A (en) 1993-07-02 1995-12-05 New England Deaconess Hospital Corporation Pro-urokinase mutants
JPH0739375A (ja) * 1993-07-29 1995-02-10 Green Cross Corp:The プラスミノーゲンの精製方法
US5407678A (en) * 1993-09-01 1995-04-18 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Petroleum jelly cream
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
DE4411143C2 (de) 1994-03-30 1996-08-01 Immuno Ag Thrombosemittel
US5928218A (en) * 1994-12-16 1999-07-27 Gelbfish; Gary A. Medical material removal method and associated instrumentation
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
JP3761925B2 (ja) * 1995-06-26 2006-03-29 第一化学薬品株式会社 安定なプラスミン溶液
WO1997001631A1 (fr) 1995-06-26 1997-01-16 Daiichi Pure Chemicals Co., Ltd. Solution stable de plasmine
JPH099998A (ja) * 1995-06-26 1997-01-14 Dai Ichi Pure Chem Co Ltd 安定なプラスミン溶液
JP3622286B2 (ja) * 1995-09-01 2005-02-23 日東紡績株式会社 α２ −プラスミンインヒビタ−の測定方法及び測定試 薬
EP0843674A1 (fr) † 1995-10-25 1998-05-27 Janssen Pharmaceutica N.V. N-oxyde de lubeluzole
US6207066B1 (en) * 1996-07-23 2001-03-27 Nuvue Technologies, L.L.C. Method for purification of a blood component
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
US6372887B1 (en) * 1996-11-07 2002-04-16 Heska Corporation Flea serine protease inhibitor proteins
EP0860444A1 (fr) 1997-02-24 1998-08-26 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis (CLB) Méthode pour l'élimination de virus des solutions protéiques
CN1167823A (zh) * 1997-03-25 1997-12-17 黄成已 一种含复合活性生物酶保健酒的生产方法
US6964764B2 (en) * 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6969515B2 (en) * 1999-11-13 2005-11-29 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
JP2001175386A (ja) * 1999-12-21 2001-06-29 Fujitsu Ltd 表示装置及び表示方法並びに記憶媒体
US7181417B1 (en) * 2000-01-21 2007-02-20 Microstrategy, Inc. System and method for revenue generation in an automatic, real-time delivery of personalized informational and transactional data
EP1356392A2 (fr) * 2000-11-01 2003-10-29 Intellocity USA, Inc. Systeme et methodes pour amelioration de media a partir de regles
US6978266B2 (en) * 2001-05-07 2005-12-20 Microsoft Corporation Determining a rating for a collection of documents
US7027051B2 (en) * 2001-06-29 2006-04-11 International Business Machines Corporation Graphical user interface for visualization of sampled data compared to entitled or reference levels
US7015911B2 (en) * 2002-03-29 2006-03-21 Sas Institute Inc. Computer-implemented system and method for report generation
US8631142B2 (en) * 2002-08-07 2014-01-14 International Business Machines Corporation Inserting targeted content into a portlet content stream
US6694764B1 (en) 2003-03-21 2004-02-24 Delphi Technologies, Inc. Air conditioning system with electric compressor
US7281202B2 (en) * 2003-06-19 2007-10-09 Microsoft Corporation Framework for creating modular web applications
US6963826B2 (en) * 2003-09-22 2005-11-08 C3I, Inc. Performance optimizer system and method
US7206789B2 (en) * 2003-11-13 2007-04-17 St. Jude Children's Research Hospital, Inc. System and method for defining and collecting data in an information management system having a shared database
US8924869B2 (en) * 2005-08-12 2014-12-30 Barry Fellman Service for generation of customizable display widgets
US7496852B2 (en) * 2006-05-16 2009-02-24 International Business Machines Corporation Graphically manipulating a database

Also Published As

Publication number Publication date
CA2389487C (fr) 2013-05-14
WO2001036611A1 (fr) 2001-05-25
EP1232251A1 (fr) 2002-08-21
JP2003535574A (ja) 2003-12-02
ES2326616T3 (es) 2009-10-16
CA2389345C (fr) 2012-08-28
EP1232251A4 (fr) 2004-09-01
DE60040345D1 (de) 2008-11-06
EP1232252A1 (fr) 2002-08-21
US20030012778A1 (en) 2003-01-16
US20130164273A1 (en) 2013-06-27
AU3072401A (en) 2001-05-30
JP2003514789A (ja) 2003-04-22
EP1232254A1 (fr) 2002-08-21
EP1232252A4 (fr) 2004-10-20
WO2001036611A8 (fr) 2001-11-22
CY2013030I1 (el) 2015-11-04
FR13C0041I2 (fr) 2014-11-21
CA2389337A1 (fr) 2001-05-25
AU3643601A (en) 2001-05-30
PT1232252E (pt) 2009-06-12
US20130164815A1 (en) 2013-06-27
CY1110516T1 (el) 2015-04-29
EP1232251B1 (fr) 2007-08-15
CA2389337C (fr) 2012-09-25
DK1232254T3 (da) 2008-12-15
WO2001036608A1 (fr) 2001-05-25
DE60042214D1 (fr) 2009-06-25
ATE409222T1 (de) 2008-10-15
EP1956082A1 (fr) 2008-08-13
EP1232254B1 (fr) 2008-09-24
PT1232254E (pt) 2008-12-22
JP4988115B2 (ja) 2012-08-01
US6355243B1 (en) 2002-03-12
DE60036017D1 (de) 2007-09-27
DK1232252T3 (da) 2009-08-24
ES2313912T3 (es) 2009-03-16
US7871608B2 (en) 2011-01-18
US20020192794A1 (en) 2002-12-19
US9879246B2 (en) 2018-01-30
AU784534B2 (en) 2006-04-27
CA2389487A1 (fr) 2001-05-25
WO2001036609A1 (fr) 2001-05-25
WO2001036608A8 (fr) 2001-11-01
LU92255I2 (fr) 2013-09-17
AU784800B2 (en) 2006-06-22
ES2290058T3 (es) 2008-02-16
DE60036017T2 (de) 2008-04-30
CY1108639T1 (el) 2014-04-09
EP1232252B1 (fr) 2009-05-13
EP1232251B2 (fr) 2017-05-17
US20080311105A1 (en) 2008-12-18
ES2290058T5 (es) 2017-08-21
EP1232254A4 (fr) 2005-02-02
WO2001036609A8 (fr) 2001-11-01
CA2389345A1 (fr) 2001-05-25
AU784598B2 (en) 2006-05-11
FR13C0041I1 (fr) 2013-08-23
ATE431401T1 (de) 2009-05-15
JP5025868B2 (ja) 2012-09-12
AU1602501A (en) 2001-05-30
DE60036017T3 (de) 2017-08-31
JP2003514790A (ja) 2003-04-22
NL300603I2 (fr) 2016-09-22
CY2013030I2 (el) 2015-11-04

Similar Documents

Publication Publication Date Title
BE2013C050I2 (fr)
IL205695A0 (en) Compositions containing dspa alpha 1 for the treatment of stroke
FI943632A (fi) Kudosplasminogeeniaktivaattorin glykosylaatiomuunnelmat terapeuttisten ominaisuuksien parantamiseksi
NO20025463D0 (no) Antitrombotisk agens
WO2004037208A3 (fr) Methode de thrombolyse par administration locale de plasmine acidifiee inactivee de maniere reversible
ATE80308T1 (de) Thrombotische zusammensetzungen.
浦野聖子 Plasmin-mediated fibrinolysis by variant recombinant tissue plasminogen activators
AU2002320150A1 (en) Use of cross-linked, covalently bound urokinase plasminogen activator (scupa)-urokinase plasminogen activator receptor (supar) complex as a fibrinolytic agent
AU2002255784A1 (en) Antisense modulation of urokinase plasminogen activator expression