ATE90875T1 - Gelfiltration von waermebehandeltem faktor viii. - Google Patents
Gelfiltration von waermebehandeltem faktor viii.Info
- Publication number
- ATE90875T1 ATE90875T1 AT90108993T AT90108993T ATE90875T1 AT E90875 T1 ATE90875 T1 AT E90875T1 AT 90108993 T AT90108993 T AT 90108993T AT 90108993 T AT90108993 T AT 90108993T AT E90875 T1 ATE90875 T1 AT E90875T1
- Authority
- AT
- Austria
- Prior art keywords
- gel filtration
- heat
- factor viii
- treated factor
- peg precipitation
- Prior art date
Links
- 238000002523 gelfiltration Methods 0.000 title abstract 3
- 229960000301 factor viii Drugs 0.000 title 1
- 238000001556 precipitation Methods 0.000 abstract 2
- 102100026735 Coagulation factor VIII Human genes 0.000 abstract 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract 1
- 229910001679 gibbsite Inorganic materials 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Separation By Low-Temperature Treatments (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35631589A | 1989-05-24 | 1989-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE90875T1 true ATE90875T1 (de) | 1993-07-15 |
Family
ID=23400965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90108993T ATE90875T1 (de) | 1989-05-24 | 1990-05-12 | Gelfiltration von waermebehandeltem faktor viii. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0399321B1 (de) |
| JP (1) | JP2931630B2 (de) |
| AT (1) | ATE90875T1 (de) |
| AU (1) | AU635535B2 (de) |
| CA (1) | CA2017039C (de) |
| DE (1) | DE69002033T2 (de) |
| DK (1) | DK0399321T3 (de) |
| ES (1) | ES2042138T3 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK162233C (da) * | 1989-11-09 | 1992-03-16 | Novo Nordisk As | Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii |
| HRP940645A2 (en) * | 1993-10-06 | 1996-12-31 | Immuno Ag | Process for virus deactivation in the presence of polyalkylene glycol and the pharmaceutical preparation thus obtained |
| DE4434538C2 (de) * | 1993-10-06 | 2000-08-10 | Immuno Ag | Verfahren zur Virusinaktivierung in Gegenwart eines Polyethers und eines chaotropen Agens |
| US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
| EP2193809B1 (de) | 1999-02-22 | 2015-04-08 | University of Connecticut | Albuminfreie Faktor VIII Formulierungen |
| US6964764B2 (en) | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| US6969515B2 (en) | 1999-11-13 | 2005-11-29 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| US6355243B1 (en) | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
| US7544500B2 (en) | 1999-11-13 | 2009-06-09 | Talecris Biotherapeutics, Inc. | Process for the production of a reversibly inactive acidified plasmin composition |
| NZ589557A (en) | 2008-06-04 | 2012-08-31 | Talecris Biotherapeutics Inc | Immobilised streptokinase, method and kit for preparing plasmin |
| BRPI0921429B1 (pt) | 2008-11-07 | 2022-07-12 | Takeda Pharmaceutical Company Limited | Formulação farmacêutica liofilizada estável, e, método para preparar um fator liofilizado estável |
| ES2552337T3 (es) | 2009-03-03 | 2015-11-27 | Grifols Therapeutics Inc. | Procedimientos para la preparación de plasminógeno |
| CN111183151B (zh) * | 2017-06-23 | 2024-06-07 | 武田药品工业株式会社 | 因子viii亚种的纯化 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3631018A (en) * | 1970-05-01 | 1971-12-28 | Baxter Laboratories Inc | Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate |
| US4069216A (en) * | 1975-06-16 | 1978-01-17 | Edward Shanbrom, Inc. | Simplified methods for preparation of very high purity Factor VIII concentrate |
| US4170639A (en) * | 1978-07-10 | 1979-10-09 | Warner-Lambert Company | Antihemophilic factor concentrate and its production |
| FR2460305A2 (fr) * | 1979-06-29 | 1981-01-23 | Merieux Inst | Procede de preparation d'un concentre de facteur viii |
| US4305871A (en) * | 1980-09-02 | 1981-12-15 | Edward Shanbrom | Method of selectively increasing yield and purity of certain cryoprecipitate proteins by heating |
| WO1984003628A1 (en) * | 1983-05-09 | 1984-09-27 | Nordisk Insulinlab | A concentrate of the antihemophilic factor viii and a process for producing it |
| US4543210A (en) * | 1984-10-04 | 1985-09-24 | Miles Laboratories, Inc. | Process for producing a high purity antihemophilic factor concentrate |
| AU6487286A (en) * | 1985-11-08 | 1987-05-14 | Baxter Travenol Laboratories Inc. | Antihemophilic factor by cold precipitation |
| FR2651437A1 (fr) * | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
| DK162233C (da) * | 1989-11-09 | 1992-03-16 | Novo Nordisk As | Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii |
-
1990
- 1990-05-12 ES ES199090108993T patent/ES2042138T3/es not_active Expired - Lifetime
- 1990-05-12 AT AT90108993T patent/ATE90875T1/de not_active IP Right Cessation
- 1990-05-12 EP EP90108993A patent/EP0399321B1/de not_active Expired - Lifetime
- 1990-05-12 DE DE90108993T patent/DE69002033T2/de not_active Expired - Lifetime
- 1990-05-12 DK DK90108993.8T patent/DK0399321T3/da active
- 1990-05-17 CA CA002017039A patent/CA2017039C/en not_active Expired - Lifetime
- 1990-05-23 AU AU55868/90A patent/AU635535B2/en not_active Expired
- 1990-05-23 JP JP2133691A patent/JP2931630B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU5586890A (en) | 1990-11-29 |
| CA2017039A1 (en) | 1990-11-24 |
| JPH0347199A (ja) | 1991-02-28 |
| DE69002033D1 (de) | 1993-07-29 |
| EP0399321A2 (de) | 1990-11-28 |
| DE69002033T2 (de) | 1993-09-30 |
| DK0399321T3 (da) | 1993-08-09 |
| JP2931630B2 (ja) | 1999-08-09 |
| EP0399321B1 (de) | 1993-06-23 |
| AU635535B2 (en) | 1993-03-25 |
| CA2017039C (en) | 1999-08-03 |
| EP0399321A3 (de) | 1991-07-17 |
| ES2042138T3 (es) | 1993-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |